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Article: Seasonal variation of verbascoside as a principal phenolic compound linked with antioxidant potentials of Clerodendrum glandulosum Lindl. leaves

Deb, Prashanta Kumar / Sarkar, Biswatrish

Natural product research. 2022 Sept. 1, v. 36, no. 17

2022

Abstract: This study reports the influence of seasonality on the accumulation of verbascoside as a principal phenolic compound in Clerodendrum glandulosum Lindl. leaves along with possible alteration of antioxidant potentials. Leaves were collected during winter ( ... ...

Abstract	This study reports the influence of seasonality on the accumulation of verbascoside as a principal phenolic compound in Clerodendrum glandulosum Lindl. leaves along with possible alteration of antioxidant potentials. Leaves were collected during winter (December 2018), spring (February 2019), summer (May 2019), monsoon (July 2019), autumn (October 2019), and extracted with 95% aqueous methanol by cold maceration. The total phenolic content and antioxidant capacities (DPPH, ABTS and FRAP) were estimated by spectrophotometric technique, and verbascoside content was estimated by HPLC-PDA. Results indicate that the leaves collected during summer and winter both exhibited the highest total phenolic content verbascoside accumulation and antioxidant potentials which are significantly different (p < 0.05) than other seasons. Correlation studies further demonstrated that the total polyphenol and verbascoside contents were directly proportional to the antioxidant potentials. Thus, the study concludes that winter and summer are the best seasons for collecting leaves from this plant to obtain maximum antioxidant potential.
Keywords	Clerodendrum ; antioxidant activity ; antioxidants ; autumn ; cold ; maceration ; methanol ; monsoon season ; polyphenols ; research ; seasonal variation ; spectrophotometers ; spring ; summer ; verbascoside ; winter
Language	English
Dates of publication	2022-0901
Size	p. 4415-4419.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1979542
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Seasonal variation of verbascoside as a principal phenolic compound linked with antioxidant potentials of

Deb, Prashanta Kumar / Sarkar, Biswatrish

Natural product research

2021 Volume 36, Issue 17, Page(s) 4421–4425

Abstract: This study reports the influence of seasonality on the accumulation of verbascoside as a principal phenolic compound ... ...

Abstract	This study reports the influence of seasonality on the accumulation of verbascoside as a principal phenolic compound in
MeSH term(s)	Antioxidants/chemistry ; Clerodendrum ; Glucosides ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Polyphenols ; Seasons
Chemical Substances	Antioxidants ; Glucosides ; Plant Extracts ; Polyphenols ; acteoside (3TGX09BD5B)
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.1979542
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Article ; Online: Madhuca longifolia-hydro-ethanolic-fraction reverses mitochondrial dysfunction and modulates selective GLUT expression in diabetic mice fed with high fat diet.

Jha, Dhruv / Prajapati, Santosh Kumar / Deb, Prashanta Kumar / Jaiswal, Mohit / Mazumder, Papiya Mitra

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 209

Abstract: Background: Metabolic disorder is characterized as chronic low-grade inflammation which elevates the systemic inflammatory markers. The proposed hypothesis behind this includes occurrence of hypoxia due to intake of high fat diet leading to oxidative ... ...

Abstract	Background: Metabolic disorder is characterized as chronic low-grade inflammation which elevates the systemic inflammatory markers. The proposed hypothesis behind this includes occurrence of hypoxia due to intake of high fat diet leading to oxidative stress and mitochondrial dysfunction. Aim: In the present work our aim was to elucidate the possible mechanism of action of hydroethanolic fraction of M. longifolia leaves against the metabolic disorder. Method and results: In the present investigation, effect of Madhuca longifolia hydroethanolic fraction (MLHEF) on HFD induced obesity and diabetes through mitochondrial action and selective GLUT expression has been studied. In present work, it was observed that HFD (50% of diet) on chronic administration aggravates the metabolic problems by causing reduced imbalanced oxidative stress, ATP production, and altered selective GLUT protein expression. Long term HFD administration reduced (p < 0.001) the SOD, CAT level significantly along with elevated liver function marker AST and ALT. MLHEF administration diminishes this oxidative stress. HFD administration also causes decreased ATP/ADP ratio owing to suppressed mitochondrial function and elevating LDH level. This oxidative imbalance further leads to dysregulated GLUT expression in hepatocytes, skeletal muscles and white adipose tissue. HFD leads to significant (p < 0.001) upregulation in GLUT 1 and 3 expression while significant (p < 0.001) downregulation in GLUT 2 and 4 expressions in WAT, liver and skeletal muscles. Administration of MLHEF significantly (p < 0.001) reduced the LDH level and also reduces the mitochondrial dysfunction. Conclusion: Imbalances in GLUT levels were significantly reversed in order to maintain GLUT expression in tissues on the administration of MLHEF.
MeSH term(s)	Animals ; Mice ; Diet, High-Fat/adverse effects ; Madhuca ; Diabetes Mellitus, Experimental/drug therapy ; Ethanol ; Inflammation ; Mitochondrial Diseases ; Adenosine Triphosphate
Chemical Substances	Ethanol (3K9958V90M) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08962-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sonic hedgehog signalling pathway contributes in age-related disorders and Alzheimer's disease.

Parashar, Arun / Jha, Dhruv / Mehta, Vineet / Chauhan, Bonney / Ghosh, Pappu / Deb, Prashanta Kumar / Jaiswal, Mohit / Prajapati, Santosh Kumar

Ageing research reviews

2024 Volume 96, Page(s) 102271

Abstract: Alzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD ... ...

Abstract	Alzheimer's disease (AD) is caused by the aging process and manifested by cognitive deficits and progressive memory loss. During aging, several conditions, including hypertension, diabetes, and cholesterol, have been identified as potential causes of AD by affecting Sonic hedgehog (Shh) signalling. In addition to being essential for cell differentiation and proliferation, Shh signalling is involved in tissue repair and the prevention of neurodegeneration. Neurogenesis is dependent on Shh signalling; inhibition of this pathway results in neurodegeneration. Several protein-protein interactions that are involved in Shh signalling are implicated in the pathophysiology of AD like overexpression of the protein nexin-1 inhibits the Shh pathway in AD. A protein called Growth Arrest Specific-1 works with another protein called cysteine dioxygenase (CDO) to boost Shh signalling. CDO is involved in the development of the central nervous system (CNS). Shh signalling strengthened the blood brain barrier and therefore prevent the entry of amyloid beta and other toxins to the brain from periphery. Further, several traditional remedies used for AD and dementia, including Epigallocatechin gallate, yokukansan, Lycium barbarum polysaccharides, salvianolic acid, and baicalin, are known to stimulate the Shh pathway. In this review, we elaborated that the Shh signalling exerts a substantial influence on the pathogenesis of AD. In this article, we have tried to explore the various possible connections between the Shh signalling and various known pathologies of AD.
MeSH term(s)	Humans ; Hedgehog Proteins/metabolism ; Alzheimer Disease ; Amyloid beta-Peptides ; Signal Transduction ; Cell Differentiation
Chemical Substances	Hedgehog Proteins ; Amyloid beta-Peptides
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2024.102271
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Zs.A 5579: Show issues

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Article: Phenolic enriched fraction of Clerodendrum glandulosum Lindl. leaf extract ameliorates hyperglycemia and oxidative stress in streptozotocin-nicotinamide induced diabetic rats.

Khound, Puspanjali / Deb, Prashanta Kumar / Bhattacharjee, Swarnali / Medina, Karla Damián / Sarma, Partha Pratim / Sarkar, Biswatrish / Devi, Rajlakshmi

Journal of Ayurveda and integrative medicine

2024 Volume 15, Issue 3, Page(s) 100906

Abstract: Background: Clerodendrum glandulosum Lindl. is an important ethnomedicinal shrub of Northeast India, used by traditional healers to control various ailments like diabetes, hypertension, arthritis, etc. OBJECTIVES: The present study was conducted to ... ...

Abstract	Background: Clerodendrum glandulosum Lindl. is an important ethnomedicinal shrub of Northeast India, used by traditional healers to control various ailments like diabetes, hypertension, arthritis, etc. OBJECTIVES: The present study was conducted to explore the anti-hyperglycemic and antioxidative effects of the polyphenol-rich fraction (PRF) of C. glandulosum leaf extract and identification of its major bioactive compounds. Further, an in-silico molecular docking study was also performed to understand the molecular interactions of the identified major compounds with some target proteins associated with diabetic complications. Materials and methods: PRF was purified from the hydromethanolic (80% MeOH) extract of leaves and subjected to assessment of in-vitro antioxidant and anti-diabetic properties. It was also subjected to evaluate the ameliorative effect during streptozotocin-nicotinamide-induced hyperglycemia in Wistar albino rats. An in-silico molecular docking study was also performed to complement the in-vitro/in-vivo studies. Results: Chemical analysis of PRF showed the presence of phenolics like caffeic acid, verbascoside, isoverbascoside, and apigenin, of which verbascoside (598.14 ± 1.24 mg/g) was found to be the principal compound. In-vitro studies showed potent antioxidant (IC Conclusion: This study revealed the antihyperglycemic and antioxidant potential of partially purified fraction PRF of C. glandulosum leaves.
Language	English
Publishing date	2024-05-17
Publishing country	United States
Document type	Journal Article
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2024.100906
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Article: Cardioprotective potential of the antioxidant-rich bioactive fraction of

Bhattacharjee, Swarnali / Elancheran, R / Dutta, Kasturi / Deb, Prashanta Kumar / Devi, Rajlakshmi

Frontiers in pharmacology

2022 Volume 13, Page(s) 1009023

Abstract: This Study aimed to characterise the phenolic compounds ... ...

Abstract	This Study aimed to characterise the phenolic compounds in
Language	English
Publishing date	2022-10-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1009023
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Article: Anti-Proliferative Naphthalene Glucoside from Aerial Part of Neanotis wightiana

Das, Niranjan / Deb, Prashanta Kumar / Ali, Eunus S. / Das, Manash C. / Sarkar, Biswatrish / Mishra, Siddhartha Kumar

Chemistry of natural compounds. 2022 Jan., v. 58, no. 1

2022

Abstract: A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3- ... ...

Abstract	A new bioactive naphthalene glucoside, named neanoside C (1), was isolated from the aerial part of Neanotis wightiana. The structure of neanoside C (1) was elucidated as 1,4-dihydroxy-2-(6′-Omethylglucopyranosyloxymethyl)-naphthalene-3-vinyloxyglucopyranoside by interpretation of the spectroscopic data, including 2D NMR and chemical studies. Neanoside C (1) was further subjected to screening for anticancer potential using MTT based cytotoxicity assay, LDH leakage assay, and estimation of intracellular ROS production in two human breast cancer cell line. The compound exhibited promising anti-proliferative and cytotoxic effect against MCF-7 and MDA-MB-231 cell lines with an IC₅₀ value of 22.77 nM and 35.71 nM, respectively. Neanoside C (1) also exhibited concentration-dependent intracellular LDH leakage and ROS production.
Keywords	aerial parts ; breast neoplasms ; chemistry ; cytotoxicity ; glucosides ; humans ; naphthalene ; neoplasm cells ; spectral analysis
Language	English
Dates of publication	2022-01
Size	p. 21-26.
Publishing place	Springer US
Document type	Article
ZDB-ID	213866-9
ISSN	0009-3130
ISSN	0009-3130
DOI	10.1007/s10600-022-03591-3
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 3107: Show issues

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Article ; Online: Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns.

Khan, Johra / Deb, Prashanta Kumar / Priya, Somi / Medina, Karla Damián / Devi, Rajlakshmi / Walode, Sanjay G / Rudrapal, Mithun

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 13

Abstract: Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy products, red wine, etc. Major classes of flavonoids include flavonols, ...

Abstract	Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy products, red wine, etc. Major classes of flavonoids include flavonols, flavones, flavanones, flavanols, anthocyanidins, isoflavones, and chalcones. Owing to their potential health benefits and medicinal significance, flavonoids are now considered as an indispensable component in a variety of medicinal, pharmaceutical, nutraceutical, and cosmetic preparations. Moreover, flavonoids play a significant role in preventing cardiovascular diseases (CVDs), which could be mainly due to their antioxidant, antiatherogenic, and antithrombotic effects. Epidemiological and in vitro/in vivo evidence of antioxidant effects supports the cardioprotective function of dietary flavonoids. Further, the inhibition of LDL oxidation and platelet aggregation following regular consumption of food containing flavonoids and moderate consumption of red wine might protect against atherosclerosis and thrombosis. One study suggests that daily intake of 100 mg of flavonoids through the diet may reduce the risk of developing morbidity and mortality due to coronary heart disease (CHD) by approximately 10%. This review summarizes dietary flavonoids with their sources and potential health implications in CVDs including various redox-active cardioprotective (molecular) mechanisms with antioxidant effects. Pharmacokinetic (oral bioavailability, drug metabolism), toxicological, and therapeutic aspects of dietary flavonoids are also addressed herein with future directions for the discovery and development of useful drug candidates/therapeutic molecules.
MeSH term(s)	Antioxidants/chemistry ; Antioxidants/pharmacokinetics ; Antioxidants/therapeutic use ; Biological Availability ; Cardiotonic Agents/chemistry ; Cardiotonic Agents/pharmacokinetics ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Cardiovascular Diseases/prevention & control ; Flavonoids/chemistry ; Flavonoids/pharmacokinetics ; Flavonoids/therapeutic use ; Fruit/chemistry ; Humans ; Vegetables/chemistry
Chemical Substances	Antioxidants ; Cardiotonic Agents ; Flavonoids
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26134021
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Article: Protective Effects of Diets Rich in Polyphenols in Cigarette Smoke (CS)-Induced Oxidative Damages and Associated Health Implications

Rudrapal, Mithun / Maji, Siddhartha / Prajapati, Shiv Kumar / Kesharwani, Payal / Deb, Prashanta Kumar / Khan, Johra / Mohamed Ismail, Randa / Kankate, Rani S. / Sahoo, Ranjan Kumar / Khairnar, Shubham J. / Bendale, Atul R.

Antioxidants. 2022 June 21, v. 11, no. 7

2022

Abstract: Cigarette smoking has been responsible for causing many life-threatening diseases such as pulmonary and cardiovascular diseases as well as lung cancer. One of the prominent health implications of cigarette smoking is the oxidative damage of cellular ... ...

Abstract	Cigarette smoking has been responsible for causing many life-threatening diseases such as pulmonary and cardiovascular diseases as well as lung cancer. One of the prominent health implications of cigarette smoking is the oxidative damage of cellular constituents, including proteins, lipids, and DNA. The oxidative damage is caused by reactive oxygen species (ROS, oxidants) present in the aqueous extract of cigarette smoke (CS). In recent years, there has been considerable interest in the potential health benefits of dietary polyphenols as natural antioxidant molecules. Epidemiological studies strongly suggest that long-term consumption of diets (fruits, vegetables, tea, and coffee) rich in polyphenols offer protective effects against the development of cancer, cardiovascular diseases, diabetes, osteoporosis, and neurodegenerative diseases. For instance, green tea has chemopreventive effects against CI-induced lung cancer. Tea might prevent CS-induced oxidative damages in diseases because tea polyphenols, such as catechin, EGCG, etc., have strong antioxidant properties. Moreover, apple polyphenols, including catechin and quercetin, provide protection against CS-induced acute lung injury such as chronic obstructive pulmonary disease (COPD). In CS-induced health problems, the antioxidant action is often accompanied by the anti-inflammatory effect of polyphenols. In this narrative review, the CS-induced oxidative damages and the associated health implications/pathological conditions (or diseases) and the role of diets rich in polyphenols and/or dietary polyphenolic compounds against various serious/chronic conditions of human health have been delineated.
Keywords	DNA ; anti-inflammatory activity ; antioxidant activity ; apples ; catechin ; chemoprevention ; cigarettes ; diabetes ; epigallocatechin gallate ; green tea ; human health ; lung neoplasms ; lungs ; osteoporosis ; polyphenols ; quercetin ; reactive oxygen species ; smoke
Language	English
Dates of publication	2022-0621
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11071217
Database	NAL-Catalogue (AGRICOLA)

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Article: Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action.

Rudrapal, Mithun / Khairnar, Shubham J / Khan, Johra / Dukhyil, Abdulaziz Bin / Ansari, Mohammad Azam / Alomary, Mohammad N / Alshabrmi, Fahad M / Palai, Santwana / Deb, Prashanta Kumar / Devi, Rajlakshmi

Frontiers in pharmacology

2022 Volume 13, Page(s) 806470

Abstract: Dietary polyphenols including phenolic acids, flavonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins are widely found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, and beverages like fruit juices, tea, coffee and ... ...

Abstract	Dietary polyphenols including phenolic acids, flavonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins are widely found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, and beverages like fruit juices, tea, coffee and wine. In recent years, dietary polyphenols have gained significant interest among researchers due to their potential chemopreventive/protective functions in the maintenance of human health and diseases. It is believed that dietary polyphenols/flavonoids exert powerful antioxidant action for protection against reactive oxygen species (ROS)/cellular oxidative stress (OS) towards the prevention of OS-related pathological conditions or diseases. Pre-clinical and clinical evidence strongly suggest that long term consumption of diets rich in polyphenols offer protection against the development of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases (CVDs), cancer, diabetes, inflammatory disorders and infectious illness. Increased intake of foods containing polyphenols (for example, quercetin, epigallocatechin-3-gallate, resveratrol, cyanidin etc.) has been claimed to reduce the extent of a majority of chronic oxidative cellular damage, DNA damage, tissue inflammations, viral/bacterial infections, and neurodegenerative diseases. It has been suggested that the antioxidant activity of dietary polyphenols plays a pivotal role in the prevention of OS-induced human diseases. In this narrative review, the biological/pharmacological significance of dietary polyphenols in the prevention of and/or protection against OS-induced major human diseases such as cancers, neurodegenerative diseases, CVDs, diabetes mellitus, cancer, inflammatory disorders and infectious diseases have been delineated. This review specifically focuses a current understanding on the dietary sources of polyphenols and their protective effects including mechanisms of action against various major human diseases.
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.806470
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