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Article ; Online: The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease

Debasish Roy / Andrea Tedeschi

Cells, Vol 10, Iss 1078, p

2021 Volume 1078

Abstract: Axons in the adult mammalian nervous system can extend over formidable distances, up to one meter or more in humans. During development, axonal and dendritic growth requires continuous addition of new membrane. Of the three major kinds of membrane lipids, ...

Abstract	Axons in the adult mammalian nervous system can extend over formidable distances, up to one meter or more in humans. During development, axonal and dendritic growth requires continuous addition of new membrane. Of the three major kinds of membrane lipids, phospholipids are the most abundant in all cell membranes, including neurons. Not only immature axons, but also severed axons in the adult require large amounts of lipids for axon regeneration to occur. Lipids also serve as energy storage, signaling molecules and they contribute to tissue physiology, as demonstrated by a variety of metabolic disorders in which harmful amounts of lipids accumulate in various tissues through the body. Detrimental changes in lipid metabolism and excess accumulation of lipids contribute to a lack of axon regeneration, poor neurological outcome and complications after a variety of central nervous system (CNS) trauma including brain and spinal cord injury. Recent evidence indicates that rewiring lipid metabolism can be manipulated for therapeutic gain, as it favors conditions for axon regeneration and CNS repair. Here, we review the role of lipids, lipid metabolism and ectopic lipid accumulation in axon growth, regeneration and CNS repair. In addition, we outline molecular and pharmacological strategies to fine-tune lipid composition and energy metabolism in neurons and non-neuronal cells that can be exploited to improve neurological recovery after CNS trauma and disease.
Keywords	lipids ; axon growth and regeneration ; mitochondria transport ; myelin formation ; adipose tissue ; CNS trauma and disease ; Biology (General) ; QH301-705.5
Subject code	572 ; 571
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protocol for assessing ex vivo lipolysis of murine adipose tissue

Debasish Roy / Julia M. Myers / Andrea Tedeschi

STAR Protocols, Vol 3, Iss 3, Pp 101518- (2022)

2022

Abstract: Summary: Here, we provide a detailed protocol for assessing ex vivo lipolysis of subcutaneous and visceral white adipose tissue. We describe a robust approach to detect depot-specific changes in lipolytic potential under basal and beta-adrenergic ... ...

Abstract	Summary: Here, we provide a detailed protocol for assessing ex vivo lipolysis of subcutaneous and visceral white adipose tissue. We describe a robust approach to detect depot-specific changes in lipolytic potential under basal and beta-adrenergic receptor-stimulated conditions. Given that adipose tissue plays a critical role in systemic metabolic health, this experimental protocol can be used to determine changes in adipose tissue function in health and disease. : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Keywords	Cell-based Assays ; Metabolism ; Science (General) ; Q1-390
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An assessment of suitable landfill site selection for municipal solid waste management by GIS-based MCDA technique in Siliguri municipal corporation planning area, West Bengal, India

Debasish Roy / Satyajit Das / Surajit Paul / Surjapada Paul

Computational Urban Science, Vol 2, Iss 1, Pp 1-

2022 Volume 18

Abstract: Abstract Identification of suitable landfill sites for urban wastes with ease and economic benefits in the metropolitan area is a complex task. Most of the developing countries consider wastelands outside of the urban areas are the ideal places to ... ...

Abstract	Abstract Identification of suitable landfill sites for urban wastes with ease and economic benefits in the metropolitan area is a complex task. Most of the developing countries consider wastelands outside of the urban areas are the ideal places to dispose of urban wastes. Landfill site selection is an essential planning procedure that helps to avoid environmental concerns such as water contamination, public health degradation caused by unsanitary landfills. So, employing a geographic information system (GIS) and multi-criteria decision analysis (MCDA), this study was carried out to find an appropriate planning waste dump site. Nine thematic layers were evaluated as key criteria, including elevation, slope, geology, lineament, land value, distance from river, roads, residence, and Land use and land cover (LULC) weights assigned using Analytical Hierarchical Process (AHP) method analysis. The relative relevance of each parameter was calculated using Saaty’s 1 to 9 priority scale. The consistency ratio was used to check the weighting of each parameter, allowing the efficiency of the chosen parameters to be justified. The overlay analysis of all parameters with aid of GIS provides suitable sites that were marked and refined after the comprehensive field visits were performed. According to the findings, in the study area, 35.61% area is very low suitable for landfilling, 32.64% area is low suitable, 19.37% area is moderate suitable, 8.90% area is highly suitable and certainly, 3.48% area is very high suitable by Natural breaks classification. The very high suitable site belongs to Dhadagoch, Gadheaganj, and its surroundings in the study area. Nevertheless, the present study can help urban planners and concerned authorities to better succeed in urban waste management in the Siliguri municipal corporation planning area.
Keywords	MCDA ; Geographical information system ; Landfill site selection ; Multicollinearity test ; Cities. Urban geography ; GF125
Subject code	710 ; 910
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Springer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of cytogenotoxic potential and embryotoxicity of KRS-Cauvery River water in zebrafish (Danio rerio)

Abass Toba Anifowoshe / Debasish Roy / Somit Dutta / Upendra Nongthomba

Ecotoxicology and Environmental Safety, Vol 233, Iss , Pp 113320- (2022)

2022

Abstract: In the Cauvery River (CR), indiscriminate discharge of waste causes unexplained skeletal deformity in some fish species present in the water. To investigate this phenomenon, we analyzed the biological, physical, and chemical parameters present in the ... ...

Abstract	In the Cauvery River (CR), indiscriminate discharge of waste causes unexplained skeletal deformity in some fish species present in the water. To investigate this phenomenon, we analyzed the biological, physical, and chemical parameters present in the water and then evaluated the toxicity effects on the zebrafish (Danio rerio) model. The zebrafish were treated with KRS-CR water samples collected from three stations (fast-flowing water [X], slow-flowing [Y], and stagnant [Z] water), before and after filtration. Firstly, we detected microscopic organisms (MO) such as Cyclops, Daphnia, Spirogyra, Spirochaeta, and total coliform (Escherichia coli), which are bioindicators of water pollution present in the samples. All physicochemical parameters analyzed, including heavy metals before and after filtration of the water with Millipore filter paper (0.45 µm), were within the acceptable limits set by standard organizations, except for decreased dissolved oxygen (DO), and increased biochemical oxygen demand (BOD), and chemical oxygen demand (COD), which are indicators of hypoxic water conditions, as well as the presence of microplastics (polybutene (< 15 µm), polyisobutene (≤ 20 µm), and polymethylpentene (≤3 mm)) and cyclohexyl in CR water samples. Zebrafish embryos treated with the water samples, both before and after filtration exerts the same cytogenotoxic effects by inducing increased reactive oxygen species (ROS) production, which triggers subcellular organelle dysfunctions, DNA damage, apoptosis, pericardial edema, skeletal deformities, and increased mortality. As a result, we observed that both water samples and zebrafish larvae had significantly less oxygen using SEM and EDS. Our findings show that KRS-CR water can induce cytogenotoxic and embryotoxic defects in zebrafish due to hypoxic water conditions triggered by the microplastics influx. The present study would provide valuable insights for health hazards evaluation and future river water treatment strategies.
Keywords	Confocal microscopy ; Developmental defects ; Microplastics ; Oxidative stress ; ROS (Reactive oxygen species) ; Zebrafish ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An ensemble of evidence belief function (EBF) with frequency ratio (FR) using geospatial data for landslide prediction in Darjeeling Himalayan region of India

Debasish Roy / Amit Sarkar / Priyanka Kundu / Surajit Paul / Bipul Chandra Sarkar

Quaternary Science Advances, Vol 11, Iss , Pp 100092- (2023)

2023

Abstract: Landslide is a natural hazards that can be extremely difficult to control without continuous monitoring. The research area is in the Himalayan Mountains region, characterized by complicated geological structures. Landslide occurs in this area and damages ...

Abstract	Landslide is a natural hazards that can be extremely difficult to control without continuous monitoring. The research area is in the Himalayan Mountains region, characterized by complicated geological structures. Landslide occurs in this area and damages property, life, infrastructure, and others. So it is essential to study the susceptible areas for planning and decision-makers. Primarily, 1582 landslides were identified and divided into two distinct groups: the training dataset consisting of 1092 (70%) landslides used to develop the model and the validation dataset consisting of 490 (30%) landslides used to validate the utilized model. In this research, we have used sixteen spatial datasets, viz, topographic datasets are elevation, slope, profile curvature, topographic ruggedness index (TRI), topographic position index (TPI), topographic wetness index (TWI), stream power index (SPI), sediment transport index (STI); hydrological datasets are rainfall and distance to drainage; geological datasets are lithology, geomorphology, distance to fault; landcover datasets are NDVI, distance to road, LULC. This study aims to perform the landslide susceptibility zonation using the performance of evidence belief function (EBF) and frequency ratio (FR) model in the Darjeeling Himalayan region. The susceptibility models have been categorized into five classes, i.e., very low, low, moderate, high, and very high, where EBF model accounting 4.51, 1.22, 25.60, 38.27, and 40.41 percent, respectively, and FR model accounting 5.02, 22.14, 31.61, 33.51, and 7.71 percent, respectively. The receiver operating characteristic and area under the curve (ROC-AUC) was used to measure the success and prediction rates for validation. The result revealed that the success rate of the EBF and FR models is 0.937 and 0.936, and the prediction rate is 0.949 and 0.953, respectively.
Keywords	Evidence belief function ; Frequency ratio ; Darjeeling Himalaya ; Landslide susceptibility ; Geography. Anthropology. Recreation ; G ; Archaeology ; CC1-960
Subject code	550
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gene Signature Associated with Nervous System in an Experimental Radiation- and Estrogen-Induced Breast Cancer Model

Gloria M. Calaf / Debasish Roy / Lilian Jara / Francisco Aguayo / Leodan A. Crispin

Biomedicines, Vol 11, Iss 12, p

2023 Volume 3111

Abstract: Breast cancer is frequently the most diagnosed female cancer in the world. The experimental studies on cancer seldom focus on the relationship between the central nervous system and cancer. Despite extensive research into the treatment of breast cancer, ... ...

Abstract	Breast cancer is frequently the most diagnosed female cancer in the world. The experimental studies on cancer seldom focus on the relationship between the central nervous system and cancer. Despite extensive research into the treatment of breast cancer, chemotherapy resistance is an important issue limiting the efficacy of treatment. Novel biomarkers to predict prognosis or sensitivity to chemotherapy are urgently needed. This study examined nervous-system-related genes. The profiling of differentially expressed genes indicated that high-LET radiation, such as that emitted by radon progeny, in the presence of estrogen, induced a cascade of events indicative of tumorigenicity in human breast epithelial cells. Bioinformatic tools allowed us to analyze the genes involved in breast cancer and associated with the nervous system. The results indicated that the gene expression of the Ephrin A1 gene ( EFNA1) , the roundabout guidance receptor 1 ( ROBO1) , and the kallikrein-related peptidase 6 (KLK6) was greater in T2 and A5 than in the A3 cell line; the LIM domain kinase 2 gene ( LIMK2) was greater in T2 than A3 and A5; the kallikrein-related peptidase 7 ( KLK7), the neuroligin 4 X-linked gene ( NLGN4X), and myelin basic protein ( MBP) were greater than A3 only in T2; and the neural precursor cell expressed, developmentally down-regulated 9 gene ( NEDD9) was greater in A5 than in the A3 and E cell lines. Concerning the correlation, it was found a positive correlation between ESR1 and EFNA1 in BRCA-LumA patients; with ROBO1 in BRCA-Basal patients, but this correlation was negative with the kallikrein-related peptidase 6 ( KLK6) in BRCA-LumA and –LumB, as well as with LIMK2 and ROBO1 in all BRCA. It was also positive with neuroligin 4 X-linked ( NLGN4X) in BRCA-Her2 and BRCA-LumB, and with MBP in BRCA-LumA and –LumB, but negative with KLK7 in all BRCA and BRCA-LumA and NEDD9 in BRCA-Her2. The differential gene expression levels between the tumor and adjacent tissue indicated that the ROBO1 , KLK6 , LIMK2, KLK7 , NLGN4X , ...
Keywords	axon guidance ; neural precursors ; neurotransmitter ; neuronal markers ; breast cancer ; radiation ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Susceptibility analysis of landslide in Chittagong City Corporation Area, Bangladesh

Sourav Das / Debasish Roy Raja

International Journal of Environment, Vol 4, Iss 2, Pp 157-

2015 Volume 181

Abstract: In Chittagong city, landslide phenomena is the most burning issue which causes great problems to the life and properties and it is increasing day by day and becoming one of the main problems of city life. On 11 June 2007, a massive landslide happened in ... ...

Abstract	In Chittagong city, landslide phenomena is the most burning issue which causes great problems to the life and properties and it is increasing day by day and becoming one of the main problems of city life. On 11 June 2007, a massive landslide happened in Chittagong City Corporation (CCC) area, a large number of foothill settlements and slums were demolished; more than 90 people died and huge resource destruction took place. It is therefore essential to analyze the landslide susceptibility for CCC area to prepare mitigation strategies as well as assessing the impacts of climate change. To assess community susceptibility of landslide hazard, a landslide susceptibility index map has been prepared using analytical hierarchy process (AHP) model based on geographic information system (GIS) and remote sensing (RS) and its susceptibility is analyzed through community vulnerability assessment tool (CVAT). The major findings of the research are 27% of total CCC area which is susceptible to landslide hazard and whereas 6.5 sq.km areas are found very highly susceptible. The landslide susceptible areas of CCC have also been analyzed in respect of physical, social, economic, environmental and critical facilities and it is found that the overall CCC area is highly susceptible to landslide hazard. So the findings of the research can be utilized to prioritize risk mitigation investments, measures to strengthen the emergency preparedness and response mechanisms for reducing the losses and damages due to future landslide events. DOI: http://dx.doi.org/10.3126/ije.v4i2.12635 International Journal of Environment Vol.4(2) 2015: 157-181
Keywords	Analytical Hierarchy Process (AHP) ; CVAT tool ; Geographic Information System (GIS) ; Landslide ; Remote Sensing (RS) and Susceptibility ; Agriculture (General) ; S1-972 ; Environmental sciences ; GE1-350
Subject code	710
Language	English
Publishing date	2015-06-01T00:00:00Z
Publisher	Progressive Sustainable Developers Nepal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatial distribution of heatwave vulnerability in a coastal city of Bangladesh

Debasish Roy Raja / Md Shah Naim Hredoy / Md. Kamrul Islam / K.M. Ashraful Islam / Mohammed Sarfaraz Gani Adnan

Environmental Challenges, Vol 4, Iss , Pp 100122- (2021)

2021

Abstract: While extreme heat events received wider attention in recent years, understanding heatwave vulnerability is still a challenging task that requires a clear understanding of a range of location-dependent climatic, socio-economic, physiological, and ... ...

Abstract	While extreme heat events received wider attention in recent years, understanding heatwave vulnerability is still a challenging task that requires a clear understanding of a range of location-dependent climatic, socio-economic, physiological, and environmental parameters. This study investigates the spatial distribution of heatwave vulnerability in Chattogram City Corporation (CCC) — the commercial capital of Bangladesh. A heatwave vulnerability index (HVI) was developed, including various parameters related to three latent variables — exposure, sensitivity, and adaptive capacity — derived using remote sensing and socio-economic data. Factor analysis was performed to assess all parameters related to HVI. Besides, spatial autocorrelation, cluster and outlier analyses, and hot spot analysis were carried out to investigate the spatial distribution of HVI. This study shows a spatial distribution of HVI in CCC, which is spatially associated with various individual parameters. A total of seven wards (smallest administrative zone of CCC) were found to be very highly vulnerable to the heatwave. This study further reveals that heatwave vulnerability is randomly distributed throughout the city, although the high land surface temperature is concentrated in the existing built-up areas. It also identified three major hot spots of heatwave vulnerability in CCC. The methodology and findings of this study will be of interest to the policymakers and city planners to prepare mitigation plans, policies, and strategies to mitigate this hazard.
Keywords	Heatwave hazard ; Exposure ; Sensitivity ; Adaptive capacity ; Factor Analysis ; Spatial Statistics Analysis ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlates of COVID-19 incidence

Dibakar Haldar / Baisakhi Maji / Samir Kumar Ray / Tanushree Mondal / Anjan Adhikary / Parthapratim Pradhan / Debasish Roy Burman

CHRISMED Journal of Health and Research, Vol 8, Iss 3, Pp 163-

A descriptive study

2021 Volume 168

Abstract: Background and Objectives: The enigma COVID-19 pandemic already involved major parts of globe with toll of 2,074,529 victims and 139,378 deaths from 213 countries/territories as on April 14, 2020. It cripples nations by the loss of human resources, ... ...

Abstract	Background and Objectives: The enigma COVID-19 pandemic already involved major parts of globe with toll of 2,074,529 victims and 139,378 deaths from 213 countries/territories as on April 14, 2020. It cripples nations by the loss of human resources, economic decline, hunger, unemployment insecurities giving way to mental morbidities, and still many others to be discovered. Till it completes its trajectory, a systematic investigation, a prerequisite of any epidemic control, is warranted. Materials and Methods: A cross-sectional survey over 2 weeks (April 15, 2020–April 28, 2020) has been conducted at a teaching institution at Kolkata aiming to describe the magnitude, pattern, severity, and correlates of coronavirus pandemic 2020. Data pertaining to COVID-19 cases, deaths of affected countries, and their reported and or potential correlates were retrieved from various public domains, for example, https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, worldpopulationreview.com, data.worldbank.org. Results: Multiple linear regression analysis revealed a maximum R2 of 32.3% (P = 0.013) with a significant model fit (P = 0.000) for COVID-19 incidence rate per million which is associated positively with the proportion of the urban population (b = 0.024) and the percentage of the population aged 65 years or higher (b = 0.112) and negatively with current universal Bacille Calmette-Guérin vaccination (b = −1.021) policy of countries. Conclusion: Against this viral catastrophe evidence-based classical public health measures are underway. Notwithstanding variations in testing and reporting policy, the findings of this research ignite further study.
Keywords	bacille calmette-guérin ; covid-19 pandemic ; novel coronavirus ; public health ; urban population ; Medicine ; R ; Nursing ; RT1-120
Subject code	360
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish

Arunita Chatterjee / Debasish Roy / Esha Patnaik / Upendra Nongthomba

Disease Models & Mechanisms, Vol 9, Iss 6, Pp 697-

2016 Volume 705

Abstract: Muscle contraction brings about movement and locomotion in animals. However, muscles have also been implicated in several atypical physiological processes including immune response. The role of muscles in immunity and the mechanism involved has not yet ... ...

Abstract	Muscle contraction brings about movement and locomotion in animals. However, muscles have also been implicated in several atypical physiological processes including immune response. The role of muscles in immunity and the mechanism involved has not yet been deciphered. In this paper, using Drosophila indirect flight muscles (IFMs) as a model, we show that muscles are immune-responsive tissues. Flies with defective IFMs are incapable of mounting a potent humoral immune response. Upon immune challenge, the IFMs produce anti-microbial peptides (AMPs) through the activation of canonical signaling pathways, and these IFM-synthesized AMPs are essential for survival upon infection. The trunk muscles of zebrafish, a vertebrate model system, also possess the capacity to mount an immune response against bacterial infections, thus establishing that immune responsiveness of muscles is evolutionarily conserved. Our results suggest that physiologically fit muscles might boost the innate immune response of an individual.
Keywords	Muscle ; Drosophila ; Zebrafish ; Infection ; Immunity ; Anti-microbial peptides ; Medicine ; R ; Pathology ; RB1-214
Subject code	570
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	The Company of Biologists
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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