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  1. Book ; Thesis: Integrative Proteom- und Transkriptomanalyse der zellulären Antwort auf Photonen- und Kohlenstoffionenbestrahlung

    Rackwitz, Tilmann / Debus, Jürgen

    2021  

    Title variant Proteomanalyse Photonenbestrahlung
    Institution Universität Heidelberg
    Author's details vorgelegt von Tilmann Rackwitz ; Doktorvater: Prof. Dr. med. Dr. rer. nat. Jürgen Debus
    Language German
    Size 125, v Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    HBZ-ID HT021843098
    Database Catalogue ZB MED Medicine, Health

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    2023 E 622 order for loan Magazin

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  2. Book: Nivolumab plus Ipilimumab

    Eigentler, Thomas / Debus, Jürgen / Bluhm, Leonie

    Therapie von Melanom-bedingten Hirnmetastasen mit Fokus auf die lokale Strahlentherapie und die systemische immunonkologische Kombinationstherapie

    (Tumordiagnostik & Therapie : Praxis report ; [41, 5], Beilage (Mai 2020))

    2020  

    Author's details Herausgeber Prof. Dr. Thomas Eigentler, Prof. Dr. Dr. Jürgen Debus, Leonie Bluhm
    Series title Tumordiagnostik & Therapie : Praxis report ; [41, 5], Beilage (Mai 2020)
    Tumordiagnostik & Therapie
    Tumordiagnostik & Therapie
    Collection Tumordiagnostik & Therapie
    Tumordiagnostik & Therapie
    Language German
    Size 15 Seiten, Illustrationen, Diagramme
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020566014
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Massive circulating metastatic cells: A case of carcinocythemia.

    Farkh, Carine / Debus, Jérome / Andrieu, Valérie / Gay, Juliette

    Clinical case reports

    2024  Volume 12, Issue 2, Page(s) e8471

    Abstract: Importance of careful differential diagnosis to make the distinction between carcinocythemia and acute leukemia or lymphoma. ...

    Abstract Importance of careful differential diagnosis to make the distinction between carcinocythemia and acute leukemia or lymphoma.
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of 2D ion chamber arrays for patient specific quality assurance using a static phantom at a 0.35 T MR-Linac.

    Renkamp, C K / Eulenstein, D / Sebald, M / Schlüter, F / Buchele, C / Rippke, C / Debus, J / Klüter, S

    Zeitschrift fur medizinische Physik

    2024  

    Abstract: Introduction: Patient specific quality assurance (QA) in MR-Linacs can be performed with MR-compatible ion chamber arrays. However, the presence of a static magnetic field can alter the angular response of such arrays substantially. This works ... ...

    Abstract Introduction: Patient specific quality assurance (QA) in MR-Linacs can be performed with MR-compatible ion chamber arrays. However, the presence of a static magnetic field can alter the angular response of such arrays substantially. This works investigates the suitability of two ion chamber arrays, an air-filled and a liquid-filled array, for patient specific QA at a 0.35 T MR-Linac using a static phantom.
    Methods: In order to study the angular response, the two arrays were placed in a static, solid phantom and irradiated with 9.96 × 9.96 cm
    Results: The air-filled array showed asymmetric angular response changes of central chamber dose of up to 18% and down to local 3 mm / 3% gamma rates of 20%, while only minor differences within 3% (excluding parallel irradiation and beams through the couch edges) were found for the liquid-filled ion chamber array without rotating the phantom. Patient plan QA using the liquid-filled array yielded a median local 3 mm / 3% 3D gamma passing rate of 99.8% (range 96.9%-100%).
    Conclusion: A liquid-filled ionization chamber array in combination with a static phantom can be used for efficient patient specific plan QA in a single measurement set-up in a 0.35 T MR-Linac, while the air-filled ion chamber array phantom shows large angular response changes and has its limitations regarding patient specific QA measurements.
    Language English
    Publishing date 2024-01-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1104517-6
    ISSN 1876-4436 ; 0939-3889 ; 0040-5973
    ISSN (online) 1876-4436
    ISSN 0939-3889 ; 0040-5973
    DOI 10.1016/j.zemedi.2023.12.003
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  5. Article ; Online: Professor Dr. Dr. Michael Wannenmacher zum 75. Geburtstag.

    Debus, J

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2013  Volume 189, Issue 8, Page(s) 708

    Title translation Professor Dr. Dr. Michael Wannenmacher's 75th birthday.
    MeSH term(s) Germany ; History, 20th Century ; History, 21st Century ; Radiation Oncology/history ; Radiotherapy/history
    Language German
    Publishing date 2013-08
    Publishing country Germany
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-013-0374-6
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  6. Article ; Online: Verlängerung des Gesamtüberlebens durch die Impfung von autologen tumorlysatbeladenen dendritischen Zellen (DCVax-L) bei Patienten mit neu diagnostiziertem und rezidivierendem Glioblastom.

    Deng, Maximilian Y / Debus, Jürgen / König, Laila

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 199, Issue 3, Page(s) 327–329

    Title translation Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma.
    MeSH term(s) Humans ; Glioblastoma/radiotherapy ; Neoplasm Recurrence, Local ; Brain Neoplasms ; Dendritic Cells ; Vaccination
    Language German
    Publishing date 2023-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02049-x
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  7. Article ; Online: Im Gedenken an Professor Dr. Dr. Michael Wannenmacher.

    Debus, Jürgen

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2016  Volume 192, Issue 10, Page(s) 745

    Title translation In memoriam of Professor Dr. Dr. Michael Wannenmacher.
    MeSH term(s) Germany ; History, 20th Century ; History, 21st Century ; Neoplasms/history ; Radiation Oncology/history ; Radiotherapy/history ; Societies, Medical/history
    Language German
    Publishing date 2016-10
    Publishing country Germany
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-016-1027-3
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  8. Article: Effects of Ionizing Radiation on Cardiac Implantable Electronic Devices (CIEDs) in Patients with Esophageal Cancer Undergoing Radiotherapy: A Pilot Study.

    Uzun, Davut D / Salatzki, Janek / Xynogalos, Panagiotis / Frey, Norbert / Debus, Juergen / Lang, Kristin

    Cancers

    2024  Volume 16, Issue 3

    Abstract: 1) Background: The prevalence of cancer patients relying on cardiac implantable electronic device (CIED) is steadily rising. The aim of this study was to evaluate RT-related malfunctions of CIEDs. (2) Methods: We retrospectively analyze sixteen patients ...

    Abstract (1) Background: The prevalence of cancer patients relying on cardiac implantable electronic device (CIED) is steadily rising. The aim of this study was to evaluate RT-related malfunctions of CIEDs. (2) Methods: We retrospectively analyze sixteen patients with esophageal cancer who were treated with radiotherapy between 2012 and 2022 at the University Hospital Heidelberg. All patients underwent systemic evaluation including pre-therapeutic cardiological examinations of the CIED functionality and after every single irradiation. (3) Results: Sixteen patients, predominantly male (14) with a mean age of 77 (range: 56-85) years were enrolled. All patients received 28 fractions of radiotherapy with a cumulative total dose 58.8 Gy. The mean maximum dose at the CIEDs was 1.8 Gy. Following radiotherapy and during the one-year post-radiation follow-up period, there were no registered events associated with the treatment in this evaluation. (4) Conclusion: The study did not observe any severe CIED malfunctions following each radiation fraction or after completion of RT. Strict selection of photon energy and alignment with manufacturer-recommended dose limits appear to be important. Our study showed no major differences in the measured values of the pacing threshold, sensing threshold and lead impedance after RT.
    Language English
    Publishing date 2024-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16030555
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  9. Article ; Online: Effects of Photon versus Carbon-Ion Irradiation in the Rat Cervical Spinal Cord - a Serial T2 and Diffusion-weighted Magnetic Resonance Imaging Study.

    Welzel, Thomas / Saager, Maria / Peschke, Peter / Debus, Jürgen / Karger, Christian P

    Radiation research

    2024  

    Abstract: Carbon-ion irradiation is increasingly used at the skull base and spine near the radiation-sensitive spinal cord. To better characterize the in vivo radiation response of the cervical spinal cord, radiogenic changes in the high-dose area were measured in ...

    Abstract Carbon-ion irradiation is increasingly used at the skull base and spine near the radiation-sensitive spinal cord. To better characterize the in vivo radiation response of the cervical spinal cord, radiogenic changes in the high-dose area were measured in rats using magnetic resonance imaging (MRI) diffusion measurements in comparison to conventional photon irradiations. In this longitudinal MRI study, we examined the gray matter (GM) of the cervical spinal cord in 16 female Sprague-Dawley rats after high-dose photon (n = 8) or carbon-ion (12C) irradiation (n = 8) and in 6 sham-exposed rats until myelopathy occurred. The differences in the diffusion pattern of the GM of the cervical spinal cord were examined until the endpoint of the study, occurrence of paresis grade II of both forelimbs was reached. In both radiation techniques, the same order of the occurrence of MR-morphological pathologies was observed - from edema formation to a blood spinal cord barrier (BSCB) disruption to paresis grade II of both forelimbs. However, carbon-ion irradiation showed a significant increase of the mean apparent diffusion coefficient (ADC; P = 0.031) with development of a BSCB disruption in the GM. Animals with paresis grade II as a late radiation response had a highly significant increase in mean ADC (P = 0.0001) after carbon-ion irradiation. At this time, a tendency was observed for higher mean ADC values in the GM after 12C irradiation as compared to photon irradiation (P = 0.059). These findings demonstrated that carbon-ion irradiation leads to greater structural damage to the GM of the rat cervical spinal cord than photon irradiation due to its higher linear energy transfer (LET) value.
    Language English
    Publishing date 2024-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80322-4
    ISSN 1938-5404 ; 0033-7587
    ISSN (online) 1938-5404
    ISSN 0033-7587
    DOI 10.1667/RADE-23-00151.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Whole-pelvic irradiation with boost to involved nodes and prostate in node-positive prostate cancer-long-term data from the prospective PLATIN-2 trial.

    Fink, C A / Wegener, D / Sauer, L D / Jäkel, C / Zips, D / Debus, J / Herfarth, K / Koerber, S A

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 200, Issue 3, Page(s) 202–207

    Abstract: Purpose: Node-positive prostate cancer is a potentially curable disease. Definitive radiotherapy to the prostate and lymphatic drainage is an effective treatment option but prospective long-term outcome data are scarce. Thus, the current study aimed to ... ...

    Abstract Purpose: Node-positive prostate cancer is a potentially curable disease. Definitive radiotherapy to the prostate and lymphatic drainage is an effective treatment option but prospective long-term outcome data are scarce. Thus, the current study aimed to evaluate the toxicity and efficacy of definitive radiation therapy for men with prostate cancer and nodal metastases using modern irradiation techniques.
    Methods: A total of 40 treatment-naïve men with node-positive prostate cancer were allocated to the trial. All patients received definitive radiation therapy at two German university hospitals between 2009 and 2018. Radiation was delivered as intensity-modulated radiation therapy (IMRT) with 51 Gy to the lymphatic drainage with simultaneous integrated boost (SIB) up to 61.2 Gy to involved nodes and 76.5 Gy to the prostate in 34 fractions. Feasibility and safety, overall and progression-free survival, toxicity, and quality of life measurements were analyzed.
    Results: During a median follow-up of 79 months, median overall survival was 107 months and progression-free survival was 78 months. Based on imaging follow-up, no infield relapse was reported during the first 24 months of follow-up. There were 3 (8%) potentially treatment-related grade 3 toxicities. Common iliac node involvement was associated with a higher risk of progression (HR 15.8; 95% CI 2.1-119.8; p = 0.007).
    Conclusion: Definitive radiation to the lymphatic drainage with SIB to the involved nodes and prostate is a safe and effective treatment approach for patients with treatment-naïve, node-positive prostate cancer with excellent infield tumor control rates and tolerable toxicity. Location rather than number of involved nodes is a major risk factor for progression.
    MeSH term(s) Male ; Humans ; Prostate/pathology ; Prospective Studies ; Quality of Life ; Neoplasm Recurrence, Local/etiology ; Prostatic Neoplasms/pathology ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods
    Language English
    Publishing date 2023-08-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02129-y
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