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  1. Article ; Online: Correction to: Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross‑sectional study.

    Decaix, Théodore / Kemache, Kenza / Gay, Pierre / Laprévote, Olivier / Ketz, Flora / Pautas, Éric

    Drugs & aging

    2023  Volume 41, Issue 1, Page(s) 81

    Language English
    Publishing date 2023-12-20
    Publishing country New Zealand
    Document type Published Erratum
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-023-01088-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross-sectional study.

    Decaix, Théodore / Kemache, Kenza / Gay, Pierre / Laprévote, Olivier / Ketz, Flora / Pautas, Éric

    Drugs & aging

    2023  Volume 41, Issue 1, Page(s) 55–64

    Abstract: Introduction: Atrial fibrillation (AF) is a common condition among older adults, requiring anticoagulation therapy to prevent thromboembolic events. Direct oral anticoagulants (DOACs) are now recommended as first-line therapy for this purpose. Apixaban ... ...

    Abstract Introduction: Atrial fibrillation (AF) is a common condition among older adults, requiring anticoagulation therapy to prevent thromboembolic events. Direct oral anticoagulants (DOACs) are now recommended as first-line therapy for this purpose. Apixaban and rivaroxaban are two direct-factor Xa inhibitors whose dosing is based on various factors (age, weight, creatinine, and creatinine clearance) that can affect the pharmacokinetics of the medication. This study aimed to evaluate factors associated with inappropriate dosing of apixaban or rivaroxaban based on the summary of product characteristics.
    Methods: A retrospective, single-center study included 777 hospitalizations of patients treated with apixaban or rivaroxaban for AF between 1 January 2018 and 31 December 2022. Primary endpoint assessed whether the dose of apixaban or rivaroxaban was within the summary of product characteristics used by European Medicine Agency (EMA).
    Results: Inappropriate dosing of apixaban or rivaroxaban is noted for approximately 30% of hospitalizations mostly underdosing. Factors associated with the risk of inappropriate dosing were the presence of cognitive impairment [adjusted odds ratio (OR*) 1.65, 95% confidence interval (CI) 1.19-2.29, p value (p) = 0.002], weight per kilogram increase (OR* 1.03, 95% CI 1.01-1.04, p < 0.0001), and history of bleeding under apixaban or rivaroxaban (OR* 1.94, 95% CI 1.24-3.03, p = 0.003).
    Conclusion: This study highlighted the high prevalence of inappropriate apixaban or rivaroxaban doses in older adults, particularly underdosing, which increases the risk of thromboembolism.
    MeSH term(s) Humans ; Aged ; Rivaroxaban/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Cross-Sectional Studies ; Anticoagulants/therapeutic use ; Retrospective Studies ; Stroke/prevention & control ; Prevalence ; Creatinine ; Dabigatran ; Pyridones/adverse effects ; Thromboembolism/prevention & control
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; apixaban (3Z9Y7UWC1J) ; Anticoagulants ; Creatinine (AYI8EX34EU) ; Dabigatran (I0VM4M70GC) ; Pyridones
    Language English
    Publishing date 2023-11-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1075770-3
    ISSN 1179-1969 ; 1170-229X
    ISSN (online) 1179-1969
    ISSN 1170-229X
    DOI 10.1007/s40266-023-01081-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3481: Show issues Location:
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  3. Article ; Online: Importance of cytochrome 3A4 and 2D6-mediated drug-drug interactions in oxycodone consumption among older adults hospitalized for hip fracture: a cross-sectional study.

    Decaix, Théodore / Gautier, Sylvain / Royer, Luca / Laprévote, Olivier / Tritz, Thomas / Siguret, Virginie / Teillet, Laurent / Sellier, Cyril / Pépin, Marion

    Aging clinical and experimental research

    2023  Volume 35, Issue 11, Page(s) 2471–2481

    Abstract: Hip fracture is a common injury and represents a major health problem with an increasing incidence. In older adults, opioids such as oxycodone are often preferred to other analgesics such as tramadol because of a lower risk of delirium. Different ... ...

    Abstract Hip fracture is a common injury and represents a major health problem with an increasing incidence. In older adults, opioids such as oxycodone are often preferred to other analgesics such as tramadol because of a lower risk of delirium. Different parameters, such as inhibition of cytochrome P450 (CYP450) 2D6 and/or 3A4, can potentially lead to pharmacokinetic variations of oxycodone representing a risk of adverse drugs effects or lack of drug response. There is a risk of drug-drug interactions involving CYP450 in older adults due to the high prevalence of polypharmacy. This study sought to identify patient characteristics that influence oxycodone administration. A single-center observational study included 355 patients with a hip fracture hospitalized in a geriatric postoperative unit. Composite endpoint based on form, duration, and timing to intake separated patients into three groups: "no oxycodone", "low oxycodone ", and "high oxycodone ". CYP450 interactions were studied based on a composite variable defining the most involved CYP450 pathways between CYP2D6 and CYP3A4. CYP450 interactions with CYP2D6 pathway involved were associated with the risk of "high oxycodone" [odds ratio adjusted on age and the type of hip fracture (OR*) 4.52, 95% confidence interval (CI) 1.39-16.83, p = 0.02)], as well as serum albumin levels (OR* 1.09, 95% CI 1.02-1.17, p = 0.01). Cognitive impairment was negatively associated with the risk of "high oxycodone" (OR* 0.38, 95% CI 0.18-0.77, p = 0.02). This study showed an association between CYP2D6 interactions and higher oxycodone consumption indirectly reflecting the existence of uncontrolled postoperative pain.
    MeSH term(s) Humans ; Aged ; Oxycodone/adverse effects ; Cross-Sectional Studies ; Cytochrome P-450 CYP2D6/metabolism ; Cytochrome P-450 CYP2D6 Inhibitors ; Analgesics, Opioid/adverse effects ; Drug Interactions ; Hip Fractures
    Chemical Substances Oxycodone (CD35PMG570) ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cytochrome P-450 CYP2D6 Inhibitors ; Analgesics, Opioid
    Language English
    Publishing date 2023-10-20
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-023-02569-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3343: Show issues Location:
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  4. Article: [No title information]

    Decaix, Théodore / Grognet, Alix / Cudennec, Tristan / Pépin, Marion

    Soins. Gerontologie

    2019  Volume 24, Issue 140, Page(s) 43–44

    Title translation 42. Un diagnostic différentiel d’hémorragie digestive haute : l’épistaxis déglutie.
    MeSH term(s) Diagnosis, Differential ; Epistaxis ; Gastrointestinal Hemorrhage/diagnosis ; Humans
    Language French
    Publishing date 2019-12-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 2246755-5
    ISSN 1268-6034
    ISSN 1268-6034
    DOI 10.1016/j.sger.2019.09.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6353: Show issues Location:
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  5. Article: Cardiologie interventionnelle chez le sujet âgé.

    Pépin, Marion / Hauguel-Moreau, Marie / Grognet, Alix / Decaix, Théodore

    Soins. Gerontologie

    2020  Volume 26, Issue 147, Page(s) 12–15

    Abstract: Interventional cardiology is increasingly being offered to frail elderly people thanks to significant technical progress. Transcatheter aortic valve implantation allows the treatment of aortic stenosis by implanting an aortic bioprosthesis through a ... ...

    Title translation Interventional cardiology in the elderly, at the time of TAVI and left atrial appendage occlusion.
    Abstract Interventional cardiology is increasingly being offered to frail elderly people thanks to significant technical progress. Transcatheter aortic valve implantation allows the treatment of aortic stenosis by implanting an aortic bioprosthesis through a catheter, without surgery. The left atrial appendage occlusion limits the risk of ischemic stroke in patients with atrial fibrillation who have a contraindication to anticoagulants. These procedures remain invasive and must be proposed after multidisciplinary consultation.
    MeSH term(s) Aged ; Aortic Valve Stenosis/surgery ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Atrial Fibrillation/complications ; Atrial Fibrillation/therapy ; Cardiology ; Humans ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language French
    Publishing date 2020-11-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 2246755-5
    ISSN 1268-6034
    ISSN 1268-6034
    DOI 10.1016/j.sger.2020.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6353: Show issues Location:
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  6. Article ; Online: Plasma lipidomic analysis to investigate putative biomarkers of P-glycoprotein activity in healthy volunteers.

    Decaix, Théodore / Magny, Romain / Gouin-Thibaut, Isabelle / Delavenne, Xavier / Mismetti, Patrick / Salem, Joe-Elie / Narjoz, Céline / Blanchard, Anne / Pépin, Marion / Auzeil, Nicolas / Loriot, Marie-Anne / Laprévote, Olivier

    Clinical and translational science

    2023  Volume 16, Issue 10, Page(s) 1935–1946

    Abstract: P-glycoprotein (P-gp) is an efflux transporter involved in the bioavailability of many drugs currently on the market. P-gp is responsible for several drug-drug interactions encountered in clinical practice leading to iatrogenic hospital admissions, ... ...

    Abstract P-glycoprotein (P-gp) is an efflux transporter involved in the bioavailability of many drugs currently on the market. P-gp is responsible for several drug-drug interactions encountered in clinical practice leading to iatrogenic hospital admissions, especially in polypharmacy situations. ABCB1 genotyping only reflects an indirect estimate of P-gp activity. Therefore, it would be useful to identify endogenous biomarkers to determine the P-gp phenotype to predict in vivo activity prior to the initiation of treatment and to assess the effects of drugs on P-gp activity. The objective of this study was to assess changes in plasma lipidome composition among healthy volunteers selected on the basis of their ABCB1 genotype and who received clarithromycin, a known inhibitor of P-gp. Untargeted lipidomic analysis based on liquid chromatography-tandem mass spectrometry was performed before and after clarithromycin administration. Our results revealed changes in plasma levels of some ceramides (Cers) {Cer(d18:1/22:0), Cer(d18:1/22:1), and Cer(d18:1/20:0) by ~38% (p < 0.0001), 13% (p < 0.0001), and 13% (p < 0.0001), respectively} and phosphatidylcholines (PCs) {PC(17:0/14:1), PC(16:0/18:3), and PC(14:0/18:3) by ~24% (p < 0.001), 10% (p < 0.001), and 23.6% (p < 0.001)} associated with both ABCB1 genotype and clarithromycin intake. Through the examination of plasma lipids, our results highlight the relevance of untargeted lipidomics for studying in vivo P-gp activity and, more generally, to safely phenotyping transporters.
    MeSH term(s) Humans ; Lipidomics ; Clarithromycin/pharmacology ; Healthy Volunteers ; Biomarkers ; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B/genetics
    Chemical Substances Clarithromycin (H1250JIK0A) ; Biomarkers ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; ATP Binding Cassette Transporter, Subfamily B
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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