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  1. AU="Decker, Miriam"
  2. AU="Campbell, Kerry"
  3. AU="Le Deley, Marie-Cécile" AU="Le Deley, Marie-Cécile"
  4. AU="Guan, Shu"

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  1. Artikel ; Online: Early Detection of Pancreatic Cancer.

    Schwingel, Jérôme / Decker, Miriam / Schneider, Lisa / Stürmer, Carsten Johannes / Lutz, Manfred P

    Oncology research and treatment

    2023  Band 46, Heft 6, Seite(n) 259–267

    Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is increasingly common. Screening for pancreatic cancer is not well established but might increase the chance of detection in early stages.: Summary: We conducted a ... ...

    Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that is increasingly common. Screening for pancreatic cancer is not well established but might increase the chance of detection in early stages.
    Summary: We conducted a literature search to summarize current recommendations and to give an overview of patient groups that may benefit from screening. In the general population, screening is not recommended because the low prevalence of PDAC renders any diagnostic tests non-predictive and because there is no direct evidence that links early diagnosis to improved survival. To date, novel approaches like liquid biopsies and molecular markers are not yet able to improve screening in unselected individuals but offer promising potential. Screening efficiency increases considerably with increasing pretest probability. Therefore, the best way to improve early diagnosis is identifying high-risk individuals.
    Key messages: There are well-defined populations with distinct genetic alterations with an increased risk for pancreatic cancer. Those may be screened with common diagnostic methods. In addition, new-onset diabetes is increasingly recognized as an early symptom, especially in elderly patients with weight loss.
    Mesh-Begriff(e) Humans ; Aged ; Early Detection of Cancer/methods ; Pancreatic Neoplasms/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Biomarkers, Tumor/genetics ; Pancreatic Neoplasms
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2760274-6
    ISSN 2296-5262 ; 2296-5270
    ISSN (online) 2296-5262
    ISSN 2296-5270
    DOI 10.1159/000530790
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1414: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: Crizotinib: aseptic abscesses in multiple organs during treatment of EML4-ALK-positive NSCLC.

    Weber, Daniel / Decker, Miriam / Schuster, Michael / Folz, Sara / Stürmer, Carsten Johannes / Lutz, Manfred P

    Journal of cancer research and clinical oncology

    2021  Band 147, Heft 12, Seite(n) 3769–3771

    Abstract: Purpose: We report a novel side effect of Crizotinib, an oral ALK inhibitor used in the treatment of non-small cell lung cancer (NSCLC) with activating rearrangement of EML4-ALK. It expands the known spectrum of complications of Crizotinib.: Methods: ...

    Abstract Purpose: We report a novel side effect of Crizotinib, an oral ALK inhibitor used in the treatment of non-small cell lung cancer (NSCLC) with activating rearrangement of EML4-ALK. It expands the known spectrum of complications of Crizotinib.
    Methods: Clinical case report.
    Results: Multiple aseptic and recurrent abscesses were observed in the liver, thoracic wall as well as in both kidneys in a 75-year-old female patient suffering from NSCLC who had been treated with Crizotinib for almost 2 years. After discontinuation of the treatment the abscesses dissolved spontaneously and did not reoccur.
    Conclusion: Aseptic abscesses under treatment with Crizotinib are not restricted to the kidneys as described before, but can also occur in other abdominal organs as the liver and even in the thoracic wall. We postulate that this finding may point to a yet unknown not tissue-dependent mechanism of action.
    Mesh-Begriff(e) Abscess/chemically induced ; Aged ; Antineoplastic Agents/adverse effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Crizotinib/adverse effects ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Oncogene Proteins, Fusion/genetics ; Protein Kinase Inhibitors/adverse effects
    Chemische Substanzen Antineoplastic Agents ; EML4-ALK fusion protein, human ; Oncogene Proteins, Fusion ; Protein Kinase Inhibitors ; Crizotinib (53AH36668S)
    Sprache Englisch
    Erscheinungsdatum 2021-08-09
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-021-03664-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Uh III Zs.10: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel ; Online: The Asylum Seeker Integrated Healthcare Pathway: a collaborative approach to improving access to primary health care in South Eastern Melbourne, Victoria, Australia.

    Cheng, I-Hao / McBride, Jacquie / Decker, Miriam / Watson, Therese / Jakubenko, Hannah / Russo, Alana

    Australian journal of primary health

    2019  Band 25, Heft 1, Seite(n) 6–12

    Abstract: It is important to address the health needs of asylum seekers within the early stages of their arrival in Australia, as this impacts all aspects of their resettlement. However, asylum seekers face a range of barriers to accessing timely and appropriate ... ...

    Abstract It is important to address the health needs of asylum seekers within the early stages of their arrival in Australia, as this impacts all aspects of their resettlement. However, asylum seekers face a range of barriers to accessing timely and appropriate health care in the community. In 2012, the increasing number of asylum seekers in Australia placed additional demand on health and social services in high-settlement regions. Health providers experienced a substantial increase in Medicare ineligible clients and avoidable presentations to Emergency Departments, and the health needs of new asylum seeker arrivals were not being fully addressed. In response, South Eastern Melbourne Medicare Local, Monash Health, the Australian Red Cross and local settlement support agencies collaborated to develop an integrated healthcare pathway in South Eastern Melbourne to facilitate healthcare access for asylum seekers released from detention. From September 2012 to December 2014, a total of 951 asylum seekers transitioned through the pathway. Seventy-eight percent required primary healthcare assistance, and were provided with a service appointment within 3 weeks of their arrival in Melbourne. This initiative has demonstrated the value of partnership and collaboration when responding to emergent asylum seeker health needs.
    Mesh-Begriff(e) Adult ; Cooperative Behavior ; Delivery of Health Care, Integrated/methods ; Female ; Health Services Accessibility/organization & administration ; Health Services Needs and Demand ; Humans ; Interprofessional Relations ; Male ; Middle Aged ; Primary Health Care/methods ; Refugees/statistics & numerical data ; Victoria ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2019-02-13
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2566332-X
    ISSN 1836-7399 ; 1448-7527
    ISSN (online) 1836-7399
    ISSN 1448-7527
    DOI 10.1071/PY18028
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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