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  1. Article ; Online: Non-pharmacological pain relief interventions in preterm neonates undergoing screening for retinopathy of prematurity: a systematic review.

    Fajolu, Iretiola Bamikeolu / Dedeke, Iyabode Olabisi Florence / Ezenwa, Beatrice Nkolika / Ezeaka, Veronica Chinyere

    BMJ open ophthalmology

    2023  Volume 8, Issue 1

    Abstract: Objective: The objective of this review was to determine the efficacy of non-pharmacological interventions for pain management during retinopathy of prematurity (ROP) screening.: Methods and analysis: Electronic search of Ovid MEDLINE, PubMed, EMBASE, ...

    Abstract Objective: The objective of this review was to determine the efficacy of non-pharmacological interventions for pain management during retinopathy of prematurity (ROP) screening.
    Methods and analysis: Electronic search of Ovid MEDLINE, PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature, Google Scholar and ClinicalTrials.gov (USA) was conducted. Search terms from the research question and inclusion criteria were used to select randomised control trials (RCT) published from January 2000 to May 2023. Relevant data were extracted, and risk of bias was assessed using the Cochrane Risk of Bias tool V.2. Critical appraisal and grading of the quality of evidence were done using the Critical Appraisal Skills Programme tool for RCTs and the Grading of Recommendations Assessment, Development and Evaluation, respectively.
    Results: Twenty-one RCTs were included; 14 used sweet taste, while 7 used modified developmental care, touch or positioning, multisensory stimulation, non-nutritive sucking or music. Six studies on sweet taste and all seven latter studies showed a difference in the pain scores in favour of the interventions. The quality of evidence was however judged low and moderate due to some concerns in the randomisation process, measurement of outcome assessment and selection of reported results domains.
    Conclusion: The use of gentle touch, nesting, positioning, music, multisensory stimulation and developmental care in reducing pain during ROP screening is promising, however, larger studies designed to eliminate the identified concerns are needed. More evidence is also needed before sweet taste interventions can be recommended in routine practice.
    MeSH term(s) Humans ; Infant, Newborn ; Pain/diagnosis ; Pain Management ; Retinopathy of Prematurity/diagnosis ; Systematic Reviews as Topic
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ISSN 2397-3269
    ISSN (online) 2397-3269
    DOI 10.1136/bmjophth-2023-001271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Anthropometric measurements of term babies delivered in a mission hospital in Southwest Nigeria.

    Olafimihan, Victoria Iyabo / Ariba, Adekunle Joseph / Florence Dedeke, Iyabode Olabisi

    The Nigerian postgraduate medical journal

    2022  Volume 29, Issue 2, Page(s) 131–137

    MeSH term(s) Birth Weight ; Cross-Sectional Studies ; Female ; Hospitals ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Male ; Nigeria ; Retrospective Studies
    Language English
    Publishing date 2022-04-29
    Publishing country Nigeria
    Document type Journal Article
    ZDB-ID 2171096-X
    ISSN 1117-1936
    ISSN 1117-1936
    DOI 10.4103/npmj.npmj_556_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Can Clean Delivery Kits Prevent Infections? Lessons from Traditional Birth Attendants in Nigeria.

    Arowosegbe, Adediwura Oladunni / Dedeke, Iyabode Olabisi / Shittu, Olufunke Bolatito / Ojo, David Ajiboye / Amusan, Joy Stephen / Iwaloye, Opeoluwa / Ekpo, Uwemedimo Friday

    Annals of global health

    2023  Volume 89, Issue 1, Page(s) 85

    Abstract: Background: In resource-poor settings, perinatal infections contribute significantly to maternal and neonatal deaths, and the use of clean delivery kits (CDKs) has been proposed as a tool to reduce the risk of infection-related deaths. This study aims ... ...

    Abstract Background: In resource-poor settings, perinatal infections contribute significantly to maternal and neonatal deaths, and the use of clean delivery kits (CDKs) has been proposed as a tool to reduce the risk of infection-related deaths. This study aims to assess the acceptability and effectiveness of CDKs in preventing infections in deliveries attended by traditional birth attendants (TBAs) in Abeokuta, Nigeria.
    Methods: The study was a cluster-randomized trial with 67 birth centres/clusters, 453 births/mothers, and 457 babies randomized to intervention or control arms; intervention involved supplementation of delivery with JANMA CDKs. Interviews were conducted at the birth homes, and the primary outcomes were neonatal infection and puerperal fever. The association between infection and perinatal risk factors was tested using the Chi-square and Fisher's exact tests.
    Results: CDKs were well accepted by TBAs. The incidence of puerperal fever and neonatal infection was 1.1% and 11.2%, respectively. Concurrent infection was found in 1 (0.22%) of the mother-neonate pair. There was no significant association between any of the sociodemographic factors and infection for both mothers and neonates. PROM and prolonged labour were significantly associated with puerperal infection. All mothers with puerperal fever were from the control group. Compared to the control group, the relative risk of puerperal infection and neonatal infection in the intervention group was 0.08 (0.004 -1.35, p = 0.079) and 0.64 (0.37 to 1.1, p = 0.10), respectively.
    Conclusion: CDKs hold promising results in attenuating maternal infections in resource-poor settings. Larger studies with greater statistical power are required to establish statistically reliable information.
    MeSH term(s) Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Home Childbirth ; Midwifery ; Nigeria/epidemiology ; Parturition ; Puerperal Infection/epidemiology ; Puerperal Infection/prevention & control
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2821756-1
    ISSN 2214-9996 ; 2214-9996
    ISSN (online) 2214-9996
    ISSN 2214-9996
    DOI 10.5334/aogh.4015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Prevalence of Group B

    Ojo, Oluwole Olutola / Awonuga, D O / Dedeke, Iyabode Olabisi Florence / Nwadike, Victor Ugochukwu / Adenaya, Olaide Rufus / Odelola, Oluwaseyi Isaiah

    Journal of the West African College of Surgeons

    2022  Volume 9, Issue 3, Page(s) 8–14

    Abstract: Background: Genital colonisation by group B : Aim: The aim of the study was to determine the prevalence of GBS colonisation among pregnant women in Abeokuta, its associated sociodemographic factors, and the neonatal outcome among exposed babies.: ... ...

    Abstract Background: Genital colonisation by group B
    Aim: The aim of the study was to determine the prevalence of GBS colonisation among pregnant women in Abeokuta, its associated sociodemographic factors, and the neonatal outcome among exposed babies.
    Design: Longitudinal cohort study.
    Setting: Department of Obstetrics and Gynaecology, Federal Medical Centre, Abeokuta, Ogun State.
    Methodology: One hundred sixty pregnant women presenting for routine antenatal care between 35 and 41 weeks were recruited consecutively. Swabs were taken from the vagina and then the rectum using a single swab. The samples were processed at the hospital's Medical Microbiology Laboratory using standard microbiological methods. Babies whose mothers were positive had their bodies swabbed and the samples sent for GBS isolates. They were also screened for early-onset neonatal sepsis with C-reactive protein.
    Results: Prevalence of GBS vaginal colonisation was 4.3%. There was no significant association between GBS colonisation status and age, level of education, or occupation; however, women of parity ≤1 had significantly higher prevalence of GBS colonisation than those of parity ≥2. There was no incidence of GBS infection observed in the babies. The GBS isolates were 100% sensitive to cefuroxime and 83.3% resistant to ampicillin.
    Conclusion: The prevalence of GBS is low in our environment. The organisms were highly sensitive to cefuroxime, erythromycin, and ceftriaxone. Routine screening of all pregnant women may be unnecessary. However, women at risk of GBS who present in labour without a recent GBS screening should be offered intrapartum prophylactic cefuroxime.
    Language English
    Publishing date 2022-01-05
    Publishing country India
    Document type Journal Article
    ISSN 2276-6944
    ISSN 2276-6944
    DOI 10.4103/jwas.jwas_26_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Human milk banking acceptability among pregnant and nursing mothers in Southwest Nigeria.

    Ogundare, Ezra Olatunde / Dedeke, Iyabode Olabisi Florence / Babatola, Adefunke Olarinre / Adeniyi, Adewuyi Temidayo / Ajite, Adebukola Bidemi / Lawal, Olubunmi Adeola / Taiwo, Adekunle Bamidele / Fatunla, Odunayo Adebukola / Ajibola, Ayotunde Emmanuel / Bolaji, Olufunke Bosede / Olatunya, Oladele Simeon

    Journal of public health research

    2023  Volume 12, Issue 3, Page(s) 22799036231197190

    Abstract: Background: Human milk bank is a sustainable source of donor human milk (DHM) which is an acceptable alternative to the mother's milk and it is not routinely available in Nigeria, a multi-ethnically diverse country.The study aimed to assess the ... ...

    Abstract Background: Human milk bank is a sustainable source of donor human milk (DHM) which is an acceptable alternative to the mother's milk and it is not routinely available in Nigeria, a multi-ethnically diverse country.The study aimed to assess the willingness to donate or accept human milk among pregnant women and mothers attending the antenatal, immunization, outpatient, under-five, and neonatal follow-up clinics in selected health facilities in Ekiti State, Southwest Nigeria.
    Study design and methods: A descriptive cross-sectional, mixed methods study design was used to collect data in selected health facilities in Ekiti State. Questionnaires and focus group discussions were used to collect quantitative and qualitative data respectively while data analysis was done using the IBM® Statistical Package for Social Science SPSS version 26® and thematic analysis respectively.
    Results: Of the 798 respondents, 529 (66.3%) and 626 (78.4%) did not know about wet nursing or human milk banking (HMB) respectively and 139 (17.4%) were willing to donate their breastmilk for a stipend. In the focus group discussion, 50% had heard about wet nursing but none heard about HMB. Maternal educational level had a significant impact on their willingness to donate or accept DHM (
    Conclusions: Awareness and perception of HMB are poor. Appropriate information, education, and counselling on HMB are needed to drive the adoption and establishment of HMB in Nigeria.
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 2279-9028
    ISSN 2279-9028
    DOI 10.1177/22799036231197190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Burden and outcomes of postpartum haemorrhage in Nigerian referral-level hospitals.

    Adebayo, Tajudeen / Adefemi, Ayodeji / Adewumi, Idowu / Akinajo, Opeyemi / Akinkunmi, Bola / Awonuga, David / Aworinde, Olufemi / Ayegbusi, Ekundayo / Dedeke, Iyabode / Fajolu, Iretiola / Imam, Zainab / Jagun, Olusoji / Kuku, Olumide / Ogundare, Ezra / Oluwasola, Timothy / Oyeneyin, Lawal / Adebanjo-Aina, Damilola / Adenuga, Emmanuel / Adeyanju, Alaruru /
    Akinsanya, Olufemi / Campbell, Ibijoke / Kuti, Bankole / Olofinbiyi, Babatunde / Salau, Qasim / Tongo, Olukemi / Ezekwe, Bosede / Lavin, Tina / Oladapo, Olufemi T / Tukur, Jamilu / Adesina, Olubukola

    BJOG : an international journal of obstetrics and gynaecology

    2024  

    Abstract: Objective: To determine the prevalence of primary postpartum haemorrhage (PPH), risk factors, and maternal and neonatal outcomes in a multicentre study across Nigeria.: Design: A secondary data analysis using a cross-sectional design.: Setting: ... ...

    Abstract Objective: To determine the prevalence of primary postpartum haemorrhage (PPH), risk factors, and maternal and neonatal outcomes in a multicentre study across Nigeria.
    Design: A secondary data analysis using a cross-sectional design.
    Setting: Referral-level hospitals (48 public and six private facilities).
    Population: Women admitted for birth between 1 September 2019 and 31 August 2020.
    Methods: Data collected over a 1-year period from the Maternal and Perinatal Database for Quality, Equity and Dignity programme in Nigeria were analysed, stratified by mode of delivery (vaginal or caesarean), using a mixed-effects logistic regression model.
    Main outcome measures: Prevalence of PPH and maternal and neonatal outcomes.
    Results: Of 68 754 women, 2169 (3.2%, 95% CI 3.07%-3.30%) had PPH, with a prevalence of 2.7% (95% CI 2.55%-2.85%) and 4.0% (95% CI 3.75%-4.25%) for vaginal and caesarean deliveries, respectively. Factors associated with PPH following vaginal delivery were: no formal education (aOR 2.2, 95% CI 1.8-2.6, P < 0.001); multiple pregnancy (aOR 2.7, 95% CI 2.1-3.5, P < 0.001); and antepartum haemorrhage (aOR 11.7, 95% CI 9.4-14.7, P < 0.001). Factors associated with PPH in a caesarean delivery were: maternal age of >35 years (aOR 1.7, 95% CI 1.5-2.0, P < 0.001); referral from informal setting (aOR 2.4, 95% CI 1.4-4.0, P = 0.002); and antepartum haemorrhage (aOR 3.7, 95% CI 2.8-4.7, P < 0.001). Maternal mortality occurred in 4.8% (104/2169) of deliveries overall, and in 8.5% (101/1182) of intensive care unit admissions. One-quarter of all infants were stillborn (570/2307), representing 23.9% (429/1796) of neonatal intensive care unit admissions.
    Conclusions: A PPH prevalence of 3.2% can be reduced with improved access to skilled birth attendants.
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.17822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The international Perinatal Outcomes in the Pandemic (iPOP) study

    Sarah J. Stock / Helga Zoega / Meredith Brockway / Rachel H. Mulholland / Jessica E. Miller / Jasper V. Been / Rachael Wood / Ishaya I. Abok / Belal Alshaikh / Adejumoke I. Ayede / Fabiana Bacchini / Zulfiqar A. Bhutta / Bronwyn K. Brew / Jeffrey Brook / Clara Calvert / Marsha Campbell-Yeo / Deborah Chan / James Chirombo / Kristin L. Connor /
    Mandy Daly / Kristjana Einarsdóttir / Ilaria Fantasia / Meredith Franklin / Abigail Fraser / Siri Eldevik Håberg / Lisa Hui / Luis Huicho / Maria C. Magnus / Andrew D. Morris / Livia Nagy-Bonnard / Natasha Nassar / Sylvester Dodzi Nyadanu / Dedeke Iyabode Olabisi / Kirsten R. Palmer / Lars Henning Pedersen / Gavin Pereira / Amy Racine-Poon / Manon Ranger / Tonia Rihs / Christoph Saner / Aziz Sheikh / Emma M. Swift / Lloyd Tooke / Marcelo L. Urquia / Clare Whitehead / Christopher Yilgwan / Natalie Rodriguez / David Burgner / Meghan B. Azad / iPOP Study Team

    Wellcome Open Research, Vol

    protocol [version 1; peer review: 2 approved]

    2021  Volume 6

    Abstract: Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases ... ...

    Abstract Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread “natural experiment” of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 306
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Wellcome
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries.

    Calvert, Clara / Brockway, Meredith Merilee / Zoega, Helga / Miller, Jessica E / Been, Jasper V / Amegah, Adeladza Kofi / Racine-Poon, Amy / Oskoui, Solmaz Eradat / Abok, Ishaya I / Aghaeepour, Nima / Akwaowo, Christie D / Alshaikh, Belal N / Ayede, Adejumoke I / Bacchini, Fabiana / Barekatain, Behzad / Barnes, Rodrigo / Bebak, Karolina / Berard, Anick / Bhutta, Zulfiqar A /
    Brook, Jeffrey R / Bryan, Lenroy R / Cajachagua-Torres, Kim N / Campbell-Yeo, Marsha / Chu, Dinh-Toi / Connor, Kristin L / Cornette, Luc / Cortés, Sandra / Daly, Mandy / Debauche, Christian / Dedeke, Iyabode Olabisi F / Einarsdóttir, Kristjana / Engjom, Hilde / Estrada-Gutierrez, Guadalupe / Fantasia, Ilaria / Fiorentino, Nicole M / Franklin, Meredith / Fraser, Abigail / Gachuno, Onesmus W / Gallo, Linda A / Gissler, Mika / Håberg, Siri E / Habibelahi, Abbas / Häggström, Jonas / Hookham, Lauren / Hui, Lisa / Huicho, Luis / Hunter, Karen J / Huq, Sayeeda / Kc, Ashish / Kadambari, Seilesh / Kelishadi, Roya / Khalili, Narjes / Kippen, Joanna / Le Doare, Kirsty / Llorca, Javier / Magee, Laura A / Magnus, Maria C / Man, Kenneth K C / Mburugu, Patrick M / Mediratta, Rishi P / Morris, Andrew D / Muhajarine, Nazeem / Mulholland, Rachel H / Bonnard, Livia Nagy / Nakibuuka, Victoria / Nassar, Natasha / Nyadanu, Sylvester D / Oakley, Laura / Oladokun, Adesina / Olayemi, Oladapo O / Olutekunbi, Olanike A / Oluwafemi, Rosena O / Ogunkunle, Taofik O / Orton, Chris / Örtqvist, Anne K / Ouma, Joseph / Oyapero, Oyejoke / Palmer, Kirsten R / Pedersen, Lars H / Pereira, Gavin / Pereyra, Isabel / Philip, Roy K / Pruski, Dominik / Przybylski, Marcin / Quezada-Pinedo, Hugo G / Regan, Annette K / Rhoda, Natasha R / Rihs, Tonia A / Riley, Taylor / Rocha, Thiago Augusto Hernandes / Rolnik, Daniel L / Saner, Christoph / Schneuer, Francisco J / Souter, Vivienne L / Stephansson, Olof / Sun, Shengzhi / Swift, Emma M / Szabó, Miklós / Temmerman, Marleen / Tooke, Lloyd / Urquia, Marcelo L / von Dadelszen, Peter / Wellenius, Gregory A / Whitehead, Clare / Wong, Ian C K / Wood, Rachael / Wróblewska-Seniuk, Katarzyna / Yeboah-Antwi, Kojo / Yilgwan, Christopher S / Zawiejska, Agnieszka / Sheikh, Aziz / Rodriguez, Natalie / Burgner, David / Stock, Sarah J / Azad, Meghan B

    Nature human behaviour

    2023  Volume 7, Issue 4, Page(s) 529–544

    Abstract: Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from -90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this ... ...

    Abstract Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from -90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this variation reflects real differences in lockdown impacts, or perhaps differences in stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data from 52 million births in 26 countries, 18 of which had representative population-based data, with overall PTB rates ranging from 6% to 12% and stillbirth ranging from 2.5 to 10.5 per 1,000 births. We show small reductions in PTB in the first (odds ratio 0.96, 95% confidence interval 0.95-0.98, P value <0.0001), second (0.96, 0.92-0.99, 0.03) and third (0.97, 0.94-1.00, 0.09) months of lockdown, but not in the fourth month of lockdown (0.99, 0.96-1.01, 0.34), although there were some between-country differences after the first month. For high-income countries in this study, we did not observe an association between lockdown and stillbirths in the second (1.00, 0.88-1.14, 0.98), third (0.99, 0.88-1.12, 0.89) and fourth (1.01, 0.87-1.18, 0.86) months of lockdown, although we have imprecise estimates due to stillbirths being a relatively rare event. We did, however, find evidence of increased risk of stillbirth in the first month of lockdown in high-income countries (1.14, 1.02-1.29, 0.02) and, in Brazil, we found evidence for an association between lockdown and stillbirth in the second (1.09, 1.03-1.15, 0.002), third (1.10, 1.03-1.17, 0.003) and fourth (1.12, 1.05-1.19, <0.001) months of lockdown. With an estimated 14.8 million PTB annually worldwide, the modest reductions observed during early pandemic lockdowns translate into large numbers of PTB averted globally and warrant further research into causal pathways.
    MeSH term(s) Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Communicable Disease Control ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics/prevention & control ; Premature Birth/epidemiology ; Stillbirth/epidemiology
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-023-01522-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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