Article: A novel encystation specific protein kinase regulates chitin synthesis in Entamoeba invadens
Molecular and biochemical parasitology. 2018 Mar., v. 220
2018
Abstract: Phosphorylation is an important post-translational modification of proteins and is involved in the regulation of a variety of cellular events. The proteome of Entamoeba invadens, the reptilian counterpart of Entamoeba histolytica consists of an ... ...
| Abstract | Phosphorylation is an important post-translational modification of proteins and is involved in the regulation of a variety of cellular events. The proteome of Entamoeba invadens, the reptilian counterpart of Entamoeba histolytica consists of an overwhelming number of putative protein kinases, and some may have a role to play in Entamoeba encystation. In this study, we have identified a novel protein kinase named as EiCSpk (Entamoeba invadenscyst specific protein kinase) which expressed almost exclusively during encystation. It is an active Protein kinase C with a characteristic substrate phosphorylation and auto-phosphorylation property. Gene silencing study has unveiled its role as a regulator of chitin synthesis through transcriptional activation of the chitin synthesis pathway genes along with glycogen phosphorylases that are involved in the influx of glucose from glycogen breakdown for chitin synthesis. |
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| Keywords | chitin ; encystment ; Entamoeba histolytica ; Entamoeba invadens ; gene silencing ; genes ; glucose ; glycogen ; phosphorylation ; post-translational modification ; protein kinase C ; proteins ; proteome ; reptiles ; transcriptional activation | |||||
| Language | English | |||||
| Dates of publication | 2018-03 | |||||
| Size | p. 19-27. | |||||
| Publishing place | Elsevier B.V. | |||||
| Document type | Article | |||||
| ZDB-ID | 756166-0 | |||||
| ISSN | 1872-9428 ; 0166-6851 | |||||
| ISSN (online) | 1872-9428 | |||||
| ISSN | 0166-6851 | |||||
| DOI | 10.1016/j.molbiopara.2018.01.003 | |||||
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| Database | NAL-Catalogue (AGRICOLA) |
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