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  1. AU="Deepali Jain"
  2. AU=Cimen S.
  3. AU="Laskey, Daniel"
  4. AU="Pérez, Noelia"
  5. AU="Shaf Keshavjee"
  6. AU=Stewart J. D.
  7. AU="Victor Daka"
  8. AU="Iglesias, C"
  9. AU="Williams, Howard L."
  10. AU=Tilmann Christopher
  11. AU=Stefansson Steingrimur
  12. AU="Schindler, Tobias"
  13. AU="Araújo, Cristina de O"
  14. AU=Goda Jayant S.
  15. AU="Peditto, Piera"
  16. AU="Dünn, Hans-Wilhelm"
  17. AU=Tyznik Aaron J.
  18. AU="Siddiqui, Fasih Sami"
  19. AU="Abt, S."
  20. AU="Sultana, Sufia"
  21. AU="Yuan, Shengwang"
  22. AU="Sedehizadeh, Saam"
  23. AU=Jeon Young-Woo
  24. AU=Narayanan Navaneeth
  25. AU=Beckwith Kyle A.
  26. AU=Anderson Robert H
  27. AU=Trindade P A
  28. AU=Gohil R
  29. AU="Zhengyi, Wu"
  30. AU=Wessels J A M
  31. AU="Porter, Lavinia"
  32. AU=Al-Mayman Sulaiman

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  1. Artikel ; Online: Post-COVID-19-Invasive Pulmonary Mycosis

    Satish Swain / Kunal Sharma / Animesh Ray / Surabhi Vyas / Gagandeep Singh / Mohit Joshi / Deepali Jain / Immaculata Xess / Sanjeev Sinha / Naveet Wig

    Libyan International Medical University Journal, Vol 07, Iss 01, Pp 007-

    2022  Band 011

    Abstract: Abstract COVID-19 has been associated with myriad manifestations as well as adverse outcomes. One of the less commonly reported consequences of COVID-19 is the occurrence of secondary infections in patients suffering acutely from COVID-19 or in those ... ...

    Abstract Abstract COVID-19 has been associated with myriad manifestations as well as adverse outcomes. One of the less commonly reported consequences of COVID-19 is the occurrence of secondary infections in patients suffering acutely from COVID-19 or in those recuperating. Secondary invasive fungal infections (IFIs) have also been observed earlier in other viral infections such as influenza, parainfluenza, and respiratory syncytial virus infections. Severe lung damage and immunologic derangement resulting from SARS-CoV-2 infection predispose to superinfections. Risk factors for secondary IFI includes immunologic derangement and immunoparalysis resulting from SARS-CoV-2 infection, neutropenia, or lymphopenia, poorly controlled diabetes, structural lung disease fungal colonization, and drugs such as corticosteroids or immunomodulators given as therapies for COVID-19. Invasive aspergillosis following COVID-19 is most commonly described fungal infection but other non-Aspergillus fungal infections (including mucormycosis) has also been reported. Herein we describe two interesting cases of secondary infections developing in patients beyond the acute phase of COVID-19 who had similar presentations but with different diagnoses and requiring different management strategies. Patient in case 1 developed COVID-19-associated subacute invasive pulmonary aspergillosis (SAIA) and patient in case 2 had COVID-19 associated pulmonary mucormycosis (CAPM). We have also described the various postulated immune-pathogenesis of the super-added fungal infections in COVID-19 patients.
    Schlagwörter covid-19 ; mucorales ; aspergillosis ; immune dysfunction ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Arabisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Comparison of laboratory-developed test & validated assay of programmed death ligand-1 immunohistochemistry in non-small-cell lung carcinoma

    Aruna Nambirajan / Nuzhat Husain / Saumya Shukla / Sunil Kumar / Deepali Jain

    Indian Journal of Medical Research, Vol 150, Iss 4, Pp 376-

    2019  Band 384

    Abstract: Background & objectives: Inhibitors of immune checkpoint regulators, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), improve outcome in advanced non-small-cell lung carcinoma (NSCLC). Tumours expressing PD-L1 protein are more likely to ... ...

    Abstract Background & objectives: Inhibitors of immune checkpoint regulators, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), improve outcome in advanced non-small-cell lung carcinoma (NSCLC). Tumours expressing PD-L1 protein are more likely to benefit from this targeted therapy. Multiple concurrent clinical trials evaluating different anti-PD-1/PD-L1 therapies have validated five different immunohistochemistry (IHC) assays using varied antibody clones and staining conditions. This study was aimed at identification of a single harmonized PD-L1 assay for tumour tissue conservation and cost-effectiveness in patients with NSCLC. Methods: The performance of low-cost, manual, laboratory-developed technique (LDT) PD-L1 IHC assay using the easily available SP142 clone was compared with trial validated Ventana SP263 IHC performed on automated Ventana staining platform on tumour sections of NSCLCs. Results: Eighty cases of NSCLC were included. SP263 and SP142 stained both tumour cells and immune cells. The concordance rate of tumour cell staining was about 76 per cent, with SP263 detecting more tumour cells in 16 per cent of cases. The concordance rate of immune cell staining was only 61 per cent, with SP142 detecting more immune cells in 24 per cent of cases. The sensitivity, specificity, positive and negative predictive values of manual SP142 LDT assay against gold standard SP263 Ventana assay were 70, 94, 86 and 86 per cent, respectively, at positivity thresholds of ≥1 per cent tumour cell staining. Interpretation & conclusions: The study findings suggested that LDT using SP142 clone showed only moderate concordance with SP263 Ventana assay, and the two assays were not interchangeable. More such validation studies need to be done to generate information that can complement patient therapy in cases of NSCLC.
    Schlagwörter immunohistochemistry - non-small-cell lung carcinoma - programmed cell death ligand-1 - resection - sp142 - sp263 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Composite tumor of the larynx

    Madhu Rajeshwari / Pirabu Sakthivel / Rijendra Yogal / Smriti Panda / Chirom Amit Singh / Deepali Jain

    Journal of Nepal Medical Association, Vol 58, Iss

    A Case Report

    2020  Band 221

    Abstract: Composite tumor of larynx, a recently included entity in the current WHO classification, is often a difficult pathological diagnosis, especially in small biopsies. We report a case of laryngeal composite tumor, initially misdiagnosed as squamous cell ... ...

    Abstract Composite tumor of larynx, a recently included entity in the current WHO classification, is often a difficult pathological diagnosis, especially in small biopsies. We report a case of laryngeal composite tumor, initially misdiagnosed as squamous cell carcinoma, which later turned out to be composite in nature, with associated neuroendocrine (small cell carcinoma) component. This report emphasizes the need for obtaining deeper biopsies and their thorough pathological examination to improve the diagnostic accuracy.
    Schlagwörter combined small cell carcinoma ; composite tumor ; larynx ; small cell carcinoma ; squamous cell carcinoma ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Nepal Medical Association
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Generating Trust Based Recommendations for Multiple Independent Domains

    Harmeet Kaur / Deepali Jain

    International Journal of Advanced Computer Research, Vol 3, Iss 13, Pp 88-

    2013  Band 97

    Abstract: Recommender systems generate responses and suggest items in the required domain. This paper proposes a domain independent trust based recommender system where personalized recommendations can be generated for any domain known to the recommenders. In this ...

    Abstract Recommender systems generate responses and suggest items in the required domain. This paper proposes a domain independent trust based recommender system where personalized recommendations can be generated for any domain known to the recommenders. In this recommender system, there exists a web of trust which is formed on the basis of trust among agents in application domain. Here each user captures his likes and tastes for various domains in the form of upper or lower bound of each attribute of items belonging to domain under consideration and stores this information in his profile which then forwarded to his recommender agents. The recommender agents pass on only those recommendations to the user agent that matches its tastes leading to the personalization of recommendations. Experiments were conducted on a real dataset and results illustrate the proficiency and effectiveness of the proposed method.
    Schlagwörter Trust ; Domain independent ; Science ; Q ; Mathematics ; QA1-939 ; Instruments and machines ; QA71-90 ; Electronic computers. Computer science ; QA75.5-76.95
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2013-12-01T00:00:00Z
    Verlag Association of Computer Communication Education for National Triumph (ACCENT)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Metastatic renal cell carcinoma of gall bladder

    Deepali Jain / Prem Chopra

    Saudi Journal of Kidney Diseases and Transplantation, Vol 24, Iss 1, Pp 100-

    2013  Band 104

    Abstract: Renal cell carcinoma (RCC) is well known for its propensity to metastasize to unusual sites. Metastasis to the gall bladder (GB) has been reported in the literature rarely. We herein report an interesting case of metastatic RCC, which presented with ... ...

    Abstract Renal cell carcinoma (RCC) is well known for its propensity to metastasize to unusual sites. Metastasis to the gall bladder (GB) has been reported in the literature rarely. We herein report an interesting case of metastatic RCC, which presented with cholecystitis. Gall bladder is a rare site of metastasis of RCC. Polypoid lesions of the GB in patients who have a synchronous or a prior history of RCC should be considered as metastatic lesions. It needs to be differentiated from primary clear cell carcinoma of the GB with the help of immunohistochemistry.
    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
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  6. Artikel ; Online: Histotyping of Indian thymomas

    Prerna Guleria / Rajinder Parshad / Prabhat Singh Malik / Ruma Ray / R M Pandey / Deepali Jain

    Indian Journal of Medical Research, Vol 150, Iss 2, Pp 153-

    A clinicopathologic study from north India

    2019  Band 160

    Abstract: Background & objectives: Thymomas are rare, but most common anterior mediastinal lesions. The histomorphologic spectrum of thymic epithelial tumours (TETs) in Indian population has not been explored in depth. This study was aimed to assess the ... ...

    Abstract Background & objectives: Thymomas are rare, but most common anterior mediastinal lesions. The histomorphologic spectrum of thymic epithelial tumours (TETs) in Indian population has not been explored in depth. This study was aimed to assess the histomorphology of TETs in the Indian patients and correlate clinical parameters with pathological features. Methods: It was a retrospective study conducted in a tertiary referral hospital in north India. All morphologically confirmed cases of TETs since 2009 were included. Clinical details and histology slides were reviewed using the Modified Masaoka-Koga staging system and WHO 2015 classification. Clinicopathological correlation and survival analysis were done. A comparative review from other published Indian studies was performed. Results: A total of 219 cases of TETs (138 resections and 81 biopsies) were identified. The most common histomorphologic type was B2, and the most frequent stage was I. Types A/AB were common in older age (P<0.01). Clinically, higher stage tumours were found mostly in men (P<0.01), and these were Type B thymomas (P<0.01). Myasthenia gravis was more common in women (P<0.02) and in lower stages (P<0.05). Survival analysis revealed significant association between recurrence and tumour stage. Although thymic carcinoma was diagnosed on biopsy, no resectable case was identified. Interpretation & conclusions: Our findings showed that the thymomas in Indian patients were most commonly Stage I tumours of B2 and AB histotypes. Resected thymic carcinomas were conspicuously absent in our study. More studies need to be done to establish the frequency and biology of TETs from India.
    Schlagwörter histomorphology - thymic carcinoma - thymic epithelial tumours - thymoma - world health organization 2015 classification ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Wolters Kluwer Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Synchronous existence of granular cell tumor and small cell carcinoma of lung

    Devajit Nath / Aashish Gupta / Sudheer Arava / Deepali Jain / Karan Madan

    Indian Journal of Pathology and Microbiology, Vol 59, Iss 1, Pp 90-

    An unusual entity

    2016  Band 92

    Abstract: Granular cell tumor (GCT) is a rare benign mesenchymal tumor that uncommonly occurs in the lung and tracheobronchial tree. Small cell carcinoma of lung is a centrally located malignant neoplasm that commonly occurs in elderly smokers. Concomitant ... ...

    Abstract Granular cell tumor (GCT) is a rare benign mesenchymal tumor that uncommonly occurs in the lung and tracheobronchial tree. Small cell carcinoma of lung is a centrally located malignant neoplasm that commonly occurs in elderly smokers. Concomitant existence of both the neoplasm in lung is extremely rare with only one reported case in the literature. Few rare combinations of GCT with other primary bronchogenic carcinomas have also been reported. Clinical symptoms depend upon the site and size of the tumor. Definitive diagnosis is by histopathological and proper immunohistochemical analysis. Identification of this entity is important as treatment requires individual therapy protocols that depend on the presence of metastasis, location of the tumors, and type of bronchogenic carcinoma.
    Schlagwörter Granular cell tumor ; lung ; small cell carcinoma ; synchronous tumor ; Pathology ; RB1-214 ; Medicine ; R ; Microbiology ; QR1-502 ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Neurofibroma of the maxillary antrum

    Deepali Jain / Minal Chaudhary / Swati Patil

    Contemporary Clinical Dentistry, Vol 5, Iss 1, Pp 115-

    A rare case

    2014  Band 118

    Abstract: Neurofibromas are benign tumors of peripheral nerve tissue, frequently associated with neurofibromatosis type 1. Their isolated occurrence in the maxillary antrum is rare, with only 6 cases described in the English literature to the best of our knowledge. ...

    Abstract Neurofibromas are benign tumors of peripheral nerve tissue, frequently associated with neurofibromatosis type 1. Their isolated occurrence in the maxillary antrum is rare, with only 6 cases described in the English literature to the best of our knowledge. Primary neurogenic tumors in the maxillary sinus are unusual entities. The majority of the reported cases that have dealt with neurilemmomas and isolated neurofibromas are extremely rare. Here, a case of neurofibroma of the maxillary sinus. We present the case of a 60-year-old female patient with the chief complain of growth in the upper right back region of the jaw, which was preceded by exfoliation of teeth in the same region 1 month back.
    Schlagwörter Maxillary sinus ; neurofibroma ; neurofibromatosis type 1 ; Dentistry ; RK1-715 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Laryngeal metastasis from lung cancer

    Umasankar Kalai / Karan Madan / Deepali Jain / Anant Mohan / Randeep Guleria

    Lung India, Vol 32, Iss 3, Pp 268-

    2015  Band 270

    Abstract: Metastatic tumors of the larynx are rare. The most common tumors metastasizing to the larynx are melanoma and renal cell carcinoma. Bronchogenic carcinoma metastasizing to the larynx has been rarely described. Herein, we report the case of a 49-year-old, ...

    Abstract Metastatic tumors of the larynx are rare. The most common tumors metastasizing to the larynx are melanoma and renal cell carcinoma. Bronchogenic carcinoma metastasizing to the larynx has been rarely described. Herein, we report the case of a 49-year-old, chronic smoker, who incidentally had a laryngeal growth detected during flexible bronchoscopy examination for evaluation of suspected lung cancer. Histopathological examination of the laryngeal nodule and the biopsy obtained from the main bronchus growth confirmed the diagnosis of metastatic squamous cell carcinoma to the larynx from primary lung cancer.
    Schlagwörter Carcinoma ; laryngeal neoplasms ; lung cancer ; metastasis ; squamous cell ; Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Medknow Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: ACE2 protein expression in lung tissues of severe COVID-19 infection

    Atish Gheware / Animesh Ray / Deeksha Rana / Prashant Bajpai / Aruna Nambirajan / S. Arulselvi / Purva Mathur / Anjan Trikha / Sudheer Arava / Prasenjit Das / Asit Ranjan Mridha / Geetika Singh / Manish Soneja / Neeraj Nischal / Sanjeev Lalwani / Naveet Wig / Chitra Sarkar / Deepali Jain

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 10

    Abstract: Abstract Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung is hypothesised to correlate with an ... ...

    Abstract Abstract Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung is hypothesised to correlate with an increased risk of severe infection and complications in COrona VIrus Disease 2019 (COVID-19). To test this hypothesis, we compared the protein expression status of ACE2 by immunohistochemistry (IHC) in post-mortem lung samples of patients who died of severe COVID-19 and lung samples obtained from non-COVID-19 patients for other indications. IHC for CD61 and CD163 was performed for the assessment of platelet-rich microthrombi and macrophages, respectively. IHC for SARS-CoV-2 viral antigen was also performed. In a total of 55, 44 COVID-19 post-mortem lung samples were tested for ACE2, 36 for CD163, and 26 for CD61, compared to 15 non-covid 19 control lung sections. Quantification of immunostaining, random sampling, and correlation analysis were used to substantiate the morphologic findings. Our results show that ACE2 protein expression was significantly higher in COVID-19 post-mortem lung tissues than in controls, regardless of sample size. Histomorphology in COVID-19 lungs showed diffuse alveolar damage (DAD), acute bronchopneumonia, and acute lung injury with SARS-CoV-2 viral protein detected in a subset of cases. ACE2 expression levels were positively correlated with increased expression levels of CD61 and CD163. In conclusion, our results show significantly higher ACE2 protein expression in severe COVID-19 disease, correlating with increased macrophage infiltration and microthrombi, suggesting a pathobiological role in disease severity.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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