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Article ; Online: Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix

Jinhao Jia / Jianfei Chen / Guoli Wang / Minjing Li / Qiusheng Zheng / Defang Li

Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115809- (2023)

2023

Abstract: The traditional Chinese medicine (TCM) Rehmanniae Radix (RR) refers to the fresh or dried root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a traditional Chinese herbal medicine (CHM), it possesses multiple effects, ... ...

Abstract	The traditional Chinese medicine (TCM) Rehmanniae Radix (RR) refers to the fresh or dried root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a traditional Chinese herbal medicine (CHM), it possesses multiple effects, including analgesia, sedation, anti-inflammation, antioxidation, anti-tumor, immunomodulation, cardiovascular and cerebrovascular regulation, and nerve damage repair, and it has been widely used in clinical practice. In recent years, scientists have extensively studied the active components and pharmacological effects of RR. Active ingredients mainly include iridoid glycosides (such as catalpol and aucuboside), phenylpropanoid glycosides (such as acteoside), other saccharides, and unsaturated fatty acids. In addition, the Chinese patent medicine (CPM) and Chinese decoction related to RR have also become major research subjects for TCM practitioners; one example is the Bolus of Six Drugs, which includes Rehmannia, Lily Bulb and Rehmannia Decoction, and Siwu Decoction. This article reviews recent literature on RR; summarizes the studies on its chemical constituents, pharmacological effects, and clinical applications; and analyzes the progress and limitations of current investigations to provide reference for further exploration and development of RR.
Keywords	Traditional Chinese medicine ; Rehmannia glutinosa ; Catalpol ; Aucuboside ; Acteoside ; Rehmanniae Radix polysaccharides ; Therapeutics. Pharmacology ; RM1-950
Subject code	410
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CEP55 Promotes Cell Motility via JAK2–STAT3–MMPs Cascade in Hepatocellular Carcinoma

Minjing Li / Ju Gao / Defang Li / Yancun Yin

Cells, Vol 7, Iss 8, p

2018 Volume 99

Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignancies and has a poor prognosis. Novel diagnostic or prognostic biomarkers and potential therapeutic targets for HCC are thus urgently needed. CEP55 plays a crucial role in regulating ... ...

Abstract	Hepatocellular carcinoma (HCC) is one of the most common malignancies and has a poor prognosis. Novel diagnostic or prognostic biomarkers and potential therapeutic targets for HCC are thus urgently needed. CEP55 plays a crucial role in regulating physical cytokinesis. Whether, and how, CEP55 contributes to HCC development remains unclear. Herein, we demonstrate that CEP55 is abnormally upregulated in HCC tissue, and these high levels of CEP55 are closely related to the poor prognosis of HCC patients. Knockdown of CEP55 expression significantly inhibits HCC cell migration and invasion. We also demonstrate that CEP55 physiologically interacts with JAK2 and promotes its phosphorylation; thus, it is a novel regulator of JAK2–STAT3 signaling and its target genes MMP2/9. Finally, blocking JAK2 or STAT3 blunts the stimulation of migration and invasion due to CEP55 overexpression. In summary, our results suggest that CEP55, as an oncogene, promotes HCC cell migration and invasion through regulating JAK2–STAT3–MMPs signaling.
Keywords	CEP55 ; hepatocellular carcinoma ; JAK2-STAT3 ; migration ; invasion ; Biology (General) ; QH301-705.5
Subject code	550
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ailanthone Inhibits Cell Proliferation in Tongue Squamous Cell Carcinoma via PI3K/AKT Pathway

Shuhan Wang / Qixiao Cui / Xiaoyu Chen / Xuejie Zhu / Kehao Lin / Qiusheng Zheng / Yuliang Wang / Defang Li

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Tongue squamous cell carcinoma (TSCC) is the most widespread and invasive subtype of oral cancer with high recurrence rates. Ailanthone (AIL) is an active ingredient in the plant extracts of Ailanthus altissima (Mill.) Swingle. Here, we showed that AIL ... ...

Abstract	Tongue squamous cell carcinoma (TSCC) is the most widespread and invasive subtype of oral cancer with high recurrence rates. Ailanthone (AIL) is an active ingredient in the plant extracts of Ailanthus altissima (Mill.) Swingle. Here, we showed that AIL inhibited the proliferation of human TSCC, the cell viability of Cal-27 and Tca8113 was significantly decreased after AIL treatment for 24 h. Hoechst 33258 staining demonstrated apoptotic characteristics (such as chromatin aggregation) after AIL treatment. The ratio of early- and late-apoptotic cells in AIL-treated Cal-27 and TCA8113 cells increased remarkably when compared with the control group. Bcl-2/Bax ratio and the levels of PARP1, caspase-9, and caspase-3 decreased after AIL treatment, accompanied by significant increase of cleaved PARP1, cleaved caspase-9, and caspase-3 in Cal-27 and TCA8113 cells. Meanwhile, AIL led to Cal-27 cell cycle arrest at G2/M phase. Western blot implied decreased levels of CDK1 and cyclin B1 after AIL treatment. The level of phospho-PI3K p55 subunit and p-Akt were significantly downregulated by AIL in both Cal-27 and TCA8113 cells. These findings implied the potential applications of AIL in the treatment of human TSCC.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Identification and validation of single-nucleotide polymorphism markers linked to first flower node in kenaf by using combined specific-locus amplified fragment sequencing and bulked segregant analysis

Li, Hui / Defang Li / Lining Zhao

Industrial crops and products. 2019 Feb., v. 128

2019

Abstract: It is important to develop DNA markers closely linked to the first flower node for molecular marker-assisted selection in kenaf breeding. Kenaf (Hibiscus cannabinus L.) is an annual, multipurpose industrial crop with a worldwide distribution. The higher ... ...

Abstract	It is important to develop DNA markers closely linked to the first flower node for molecular marker-assisted selection in kenaf breeding. Kenaf (Hibiscus cannabinus L.) is an annual, multipurpose industrial crop with a worldwide distribution. The higher the node of the first flower, the greater is the fiber yield. In this study, a population of 130 F2 individuals was constructed through the cross of K215(♀)×K89(♂). Twenty-five individuals with higher first flower node and twenty-five individuals with lower first flower node were chosen and their DNA were pooled to construct two bulked DNA pools according to the phenotype. Specific-locus amplified fragment sequencing (SLAF-seq) combined with bulked segregant analysis (BSA) was used to identify candidate DNA markers closely linked to the first flower node. Sixteen single-nucleotide polymorphism (SNP) loci were obtained from 11 related SLAF markers associated with the first flower node. SNP locus validation was performed using Sanger sequencing method. The SNP locus S961-2 in Sanger sequencing by using the primer M41961 was consistent with the SNP locus in the related SLAF-seq. The accuracy rate of the genotypes consistent with the first flower node was 91.2% (31/34). To our knowledge, S961-2 is the first SNP locus to be identified that is closely linked to the first flower node. This SNP locus may be useful for marker-assisted selection in breeding of high fiber yielding varieties of kenaf.
Keywords	DNA ; Hibiscus cannabinus ; flowers ; genetic markers ; genotype ; industrial crops ; kenaf ; loci ; marker-assisted selection ; phenotype ; single nucleotide polymorphism
Language	English
Dates of publication	2019-02
Size	p. 566-571.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2018.11.055
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway

Zengxin Jiang / Mengxuan Bian / Jingping Wu / Defang Li / Lei Ding / Qingmin Zeng

BioMed Research International, Vol

2020 Volume 2020

Abstract: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). Schwann cell (SC) apoptosis contributes to the occurrence and development of DPN. Effective drugs to prevent SC apoptosis are required to relieve and reverse ... ...

Abstract	Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). Schwann cell (SC) apoptosis contributes to the occurrence and development of DPN. Effective drugs to prevent SC apoptosis are required to relieve and reverse peripheral nerve injury caused by DM. Oltipraz [4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione], an agonist of nuclear factor erythroid derived-2-related factor 2 (Nrf2), exerts strong effect against oxidative stress in animal models or clinical patients in certain diseases, including heart failure, acute kidney injury, and liver injury. The aim of the present study was to determine the effectiveness of oltipraz in preventing SC apoptosis induced by high glucose levels. RSC96 cells pretreated with oltipraz were cultured in high-glucose medium (50 mM glucose) for 24 h, and cells cultured in medium containing 5 mM glucose were used as the control. Flow cytometry was used to evaluate the degree of apoptosis. A Cell Counting Kit-8 assay was used to assess cell viability. The mitochondrial membrane potential was assessed using JC-1 staining, and reactive oxygen species (ROS) generation was measured using 20,70-dichlorodihydrofluorescein diacetate staining. In addition, the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) levels were also evaluated using the corresponding kits. Flow cytometry was subsequently used to detect apoptosis, and western blotting was used to measure the expression levels of nuclear factor erythroid derived-2-related factor 2 and NADPH quinone oxidoreductase 1. The results showed that high glucose concentration increased oxidative stress and apoptosis in RSC96 cells. Oltipraz improved cell viability and reduced apoptosis of RSC96 cells in the high glucose environment. Additionally, oltipraz exhibited a significant antioxidative effect, as shown by the decrease in MDA levels, increased SOD levels, and reduced ROS generation in RSC96 cells. The results of the present study suggest that oltipraz exhibits potential as an effective drug for ...
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Metal-Free C(sp3)–H Allylation via Aryl Carboxyl Radicals Enabled by Donor–Acceptor Complex

Li, Yang / Defang Li / Jing Zhang / Yiyun Chen

Organic letters. 2018 May 16, v. 20, no. 11

2018

Abstract: The first aryl carboxyl radical generation by the donor–acceptor complex with N-acyloxyphthalimides and Hantzsch esters is reported. Regio- and chemoselective C(sp3)–H bond allylation is enabled by aryl carboxyl radicals with visible light irradiation ... ...

Abstract	The first aryl carboxyl radical generation by the donor–acceptor complex with N-acyloxyphthalimides and Hantzsch esters is reported. Regio- and chemoselective C(sp3)–H bond allylation is enabled by aryl carboxyl radicals with visible light irradiation under mild and metal-free conditions.
Keywords	allylation ; chemical structure ; chemoselectivity ; esters ; free radicals ; irradiation
Language	English
Dates of publication	2018-0516
Size	p. 3296-3299.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.8b01172
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Improved antibacterial activity of hemp fibre by covalent grafting of quaternary ammonium groups

Li Chang / Wenjie Duan / Siqi Huang / Anguo Chen / Jianjun Li / Huijuan Tang / Gen Pan / Yong Deng / Lining Zhao / Defang Li

Royal Society Open Science, Vol 8, Iss

2021 Volume 3

Abstract: In this study, a novel antibacterial hemp fibre grafted with quaternary ammonium groups (HF–GTA), were prepared by alkalization, oxidation, amination and quaternization multistage reactions. The chemical structure and micromorphology of the fibre were ... ...

Abstract	In this study, a novel antibacterial hemp fibre grafted with quaternary ammonium groups (HF–GTA), were prepared by alkalization, oxidation, amination and quaternization multistage reactions. The chemical structure and micromorphology of the fibre were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis and X-ray diffraction. The grafting and reaction mechanism proved to be successful, which indicated that the grafting reaction primarily occurred on the hydroxyl group of cellulose and hemicellulose in the hemp fibre, where it retained good fibrous morphology, thermal stability and hygroscopicity. HF–GTA exhibited the best antibacterial activity, where the antibacterial ratios against Escherichia coli and Staphylococcus aureus were 95.41% and 99.64%, respectively. Even after washing 30 times, the antibacterial activity was retained at 89.78% and 91.12%, indicating that HF–GTA was endowed with good washing resistance. The antibacterial activity was owing to the electrostatic reaction reducing the electrochemical potential on the cell membrane, leading to the release of cytoplasmic substances and the dissolution of cells. This study is significantly important for guaranteeing textile quality and preventing disease transmission.
Keywords	hemp fibre ; quaternary ammonium groups ; covalent grafting ; antibacterial activity ; Science ; Q
Subject code	540
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	The Royal Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Myricetin Suppresses the Propagation of Hepatocellular Carcinoma via Down-Regulating Expression of YAP

Minjing Li / Jinliang Chen / Xiaofei Yu / Sen Xu / Defang Li / Qiusheng Zheng / Yancun Yin

Cells, Vol 8, Iss 4, p

2019 Volume 358

Abstract: Myricetin is a naturally occurring flavonoid with protective effects against a variety of cancers. However, the molecular mechanism of myricetin against hepatocellular carcinoma (HCC) has still not been fully elucidated. Previous studies have indicated ... ...

Abstract	Myricetin is a naturally occurring flavonoid with protective effects against a variety of cancers. However, the molecular mechanism of myricetin against hepatocellular carcinoma (HCC) has still not been fully elucidated. Previous studies have indicated that YAP is essential for cancer initiation and progression. However, whether YAP contributes to the anti-cancer effects of myricetin remains unclear. Herein, we aimed to investigate the effect of myricetin on HCC, and identify the underlying mechanisms. We report that myricetin induced apoptosis and proliferation inhibition in HepG2 and Huh-7 cells. Myricetin inhibited expression of YAP by promoting its phosphorylation and subsequent degradation. Myricetin inhibited YAP expression by stimulating kinase activation of LATS1/2. Knockdown expression of LATS1/2 by shRNA attenuated myricetin-induced phosphorylation and degradation of YAP. Furthermore, myricetin sensitized HCC cells to cisplatin treatment through inhibiting YAP and its target genes, both in vitro and in vivo. The identification of the LATS1/2-YAP pathway as a target of myricetin may help with the design of novel strategies for human HCC prevention and therapy.
Keywords	hepatocellular carcinoma ; myricetin ; LATS1/2-YAP ; sensitization ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Physiological response to cadmium stress in kenaf (Hibiscus cannabinus L.) seedlings

Deng, Yong / Defang Li / Siqi Huang / Yumin Huang

Industrial crops and products. 2017 Nov. 15, v. 107

2017

Abstract: Kenaf (Hibiscus cannabinus) has the potential to treat widespread heavy-metal contamination, as well as achieving high economic benefits. To investigate the physiological mechanism of kenaf in response to cadmium stress, China Kenaf 13 was grown in a ... ...

Abstract	Kenaf (Hibiscus cannabinus) has the potential to treat widespread heavy-metal contamination, as well as achieving high economic benefits. To investigate the physiological mechanism of kenaf in response to cadmium stress, China Kenaf 13 was grown in a hydroponic system and treated with various Cd concentrations (10, 50, 100, 150, and 200μmolL−1) and different time (1–6days). The results show that the malondialdehyde (MDA) content was positively-correlated with Cd concentration and stress time. Cd stress of low-concentration had a stimulated effect on kenaf seedlings, with increased ascorbate (AsA) and reduced glutathione (GSH) contents as well as enhanced superoxide dismutase (SOD) and peroxidase (POD) activities. While under Cd treatment with high-concentration, SOD and POD activities were inhibited, which perhaps accounted for the oxidative damages. SOD seemed more sensitive to Cd stress than POD. A key target for kenaf breeding programs to treat contaminated soils is to select new genotypes with higher activities of SOD and POD.
Keywords	breeding programs ; cadmium ; financial economics ; genotype ; glutathione ; heavy metals ; Hibiscus cannabinus ; hydroponics ; kenaf ; malondialdehyde ; peroxidase ; physiological response ; polluted soils ; seedlings ; superoxide dismutase ; China
Language	English
Dates of publication	2017-1115
Size	p. 453-457.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1132158-1
ISSN	1872-633X ; 0926-6690
ISSN (online)	1872-633X
ISSN	0926-6690
DOI	10.1016/j.indcrop.2017.06.008
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analysis of Xanthine Oxidase Inhibitors from Clerodendranthus spicatus with Xanthine Oxidase Immobilized Silica Coated Fe3O4 Nanoparticles

Liangliang Liu / Mengmeng Yuan / Siqi Huang / Jianjun Li / Defang Li / Lining Zhao

Applied Sciences, Vol 8, Iss 2, p

2018 Volume 158

Abstract: In this study, xanthine oxidase immobilized silica coated Fe3O4 nanoparticles (Fe3O4@SiO2-XO) were successfully prepared and characterized by transmission electron microscope, X-ray powder diffraction, Fourier transform infrared spectroscopy and ... ...

Abstract	In this study, xanthine oxidase immobilized silica coated Fe3O4 nanoparticles (Fe3O4@SiO2-XO) were successfully prepared and characterized by transmission electron microscope, X-ray powder diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The average diameter of the Fe3O4 nanoparticles was about 300 nm to 350 nm with a shell thickness of 60 nm. The maximum saturation magnetization of the Fe3O4@SiO2-XO nanoparticles was 44.9 emu/g, which ensured the separation from the medium within one minute by using an ordinary magnet. A xanthine oxidase (XO) inhibitor screening method using Fe3O4@SiO2-XO nanoparticles was established and utilized in the extract of Clerodendranthus spicatus. Under the optimized conditions, two compounds were screened out and identified as gardenin B and eupatorin. The half maximal inhibitory concentration (IC50) values of these two compounds were 1.488 μg/mL and 11.197 μg/mL, respectively. The interactions between these two compounds and XO were investigated by the fluorescence spectroscopic method. The results suggested that the quenching effects of gardenin B and eupatorin were due to a static quenching mechanism. Furthermore, gardenin B showed stronger binding capacity than that of eupatorin. In conclusion, this screening method exhibited efficiency and reusability in screening, identification and analysis of enzyme inhibitors from complex mixtures.
Keywords	Clerodendranthus spicatus ; inhibitors ; magnetic nanoparticles ; silica ; xanthine oxidase ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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