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  1. Article: Asymptomatic bilateral obstructing ureteric calculi resulting in Lactobacillaemia and endocarditis requiring emergency aortic valve replacement.

    Minto, Thomas / Bullock, Nicholas / Deglurkar, Indu / Hughes, Owen

    Urology case reports

    2020  Volume 32, Page(s) 101218

    Abstract: Ureteric calculi are a common cause of emergency presentation to hospitals in the United Kingdom and worldwide. A significant and life threatening complication of those stones that obstruct the ureter is pyonephrosis, bacteraemia and resulting sepsis. ... ...

    Abstract Ureteric calculi are a common cause of emergency presentation to hospitals in the United Kingdom and worldwide. A significant and life threatening complication of those stones that obstruct the ureter is pyonephrosis, bacteraemia and resulting sepsis. Whilst the majority of such cases present with the typical symptoms of loin pain and fever, here we describe the case of a 57 year old patient with asymptomatic bilateral obstructing ureteric calculi that led to bacteraemia from a rare bacterial pathogen, Lactobacillus jensenii, and subsequent severe bacterial endocarditis requiring emergency aortic valve replacement.
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2020.101218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cardiocutaneous fistula 15 years postcardiac surgery: A real challenge.

    Dimitrakakis, Georgios / Kornaszewska, Malgorzata / Deglurkar, Indu

    Journal of cardiac surgery

    2020  Volume 35, Issue 5, Page(s) 1119–1121

    Abstract: Late Cardiocutaneous Fistula (CF) is an uncommon but potentially serious postoperative complication of cardiac surgery. We present the successful treatment of a 58-year-old female who developed a CF extending from the left ventricular apex into the left ... ...

    Abstract Late Cardiocutaneous Fistula (CF) is an uncommon but potentially serious postoperative complication of cardiac surgery. We present the successful treatment of a 58-year-old female who developed a CF extending from the left ventricular apex into the left breast related to mitral valve replacement 15 years ago.
    MeSH term(s) Breast ; Cardiac Surgical Procedures/methods ; Cutaneous Fistula/surgery ; Female ; Fistula/surgery ; Heart Diseases/surgery ; Heart Valve Prosthesis Implantation ; Heart Ventricles/surgery ; Humans ; Middle Aged ; Mitral Valve/surgery ; Polytetrafluoroethylene/adverse effects ; Postoperative Complications/surgery ; Thoracotomy ; Time Factors ; Treatment Outcome
    Chemical Substances Polytetrafluoroethylene (9002-84-0)
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The challenge of simultaneous major aortic surgery and pectus excavatum repair in a patient with Ehlers-Danlos type IV syndrome.

    Dimitrakakis, Georgios / Syed Nong Chek, Syed Aidil Hizman / Kornaszewska, Malgorzata / Deglurkar, Indu

    Journal of cardiac surgery

    2019  Volume 35, Issue 1, Page(s) 250–253

    Abstract: A unique case of a patient with Ehlers-Danlos type IV syndrome was referred with aortic root aneurysm and previous cosmetic primary repair of pectus excavatum (PE) through a solid silicone onlay prosthesis. The patient underwent successful removal of the ...

    Abstract A unique case of a patient with Ehlers-Danlos type IV syndrome was referred with aortic root aneurysm and previous cosmetic primary repair of pectus excavatum (PE) through a solid silicone onlay prosthesis. The patient underwent successful removal of the silicone prosthesis and one-stage ascending aortic root replacement with concomitant Nuss procedure for repair of the PE.
    MeSH term(s) Aorta/surgery ; Aortic Aneurysm/surgery ; Blood Vessel Prosthesis Implantation/methods ; Ehlers-Danlos Syndrome/surgery ; Funnel Chest/surgery ; Humans ; Male ; Silicones ; Surgery, Plastic/methods
    Chemical Substances Silicones
    Language English
    Publishing date 2019-11-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14358
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  4. Article ; Online: The impact of gender bias in cardiothoracic surgery in Europe: a European Society of Thoracic Surgeons and European Association for Cardio-Thoracic Surgery survey.

    Pompili, Cecilia / Opitz, Isabelle / Backhus, Leah / Leschber, Gunda / Veronesi, Giulia / Lauk, Olivia / Novoa, Nuria / Daddi, Niccolo' / Deglurkar, Indu / Cleuziou, Julie / Emrich, Anna Lena / D'Auria, Francesca / Kluin, Jolanda

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2022  Volume 61, Issue 6, Page(s) 1390–1399

    Abstract: Objectives: The European Society of Thoracic Surgeons and the European Association for Cardio-Thoracic Surgery designed a questionnaire to assess the impact of gender bias on a cardiothoracic surgery career.: Methods: A 46-item survey investigating ... ...

    Abstract Objectives: The European Society of Thoracic Surgeons and the European Association for Cardio-Thoracic Surgery designed a questionnaire to assess the impact of gender bias on a cardiothoracic surgery career.
    Methods: A 46-item survey investigating gender bias was designed using online survey software from December 2020 to January 2021. All European Society of Thoracic Surgeons and European Association for Cardio-Thoracic Surgery members and non-members included in the mailing lists were invited to complete an electronic survey. Descriptive statistics and a comparison between gender groups were performed.
    Results: Our overall response rate was 11.5% (1118/9764), of which 36.14% were women and 63.69% were men. Women were more likely to be younger than men (P < 0.0001). A total of 66% of the women reported having no children compared to only 19% of the men (P < 0.0001). Only 6% of women vs 22% of men were professors. More women (72%) also reported never having been a formal mentor themselves compared to men (38%, P < 0.0001). A total of 35% of female respondents considered leaving surgery because of episodes of discrimination compared to 13% of men; 67% of women said that they experienced being unfairly treated due to gender discrimination. Of the male surgeons, 31% reported that they were very satisfied with their career compared to only 17% of women (P < 0.0001).
    Conclusions: Women in cardiothoracic surgery reported significantly high rates of experiences with bias that may prevent qualified women from advancing to positions of leadership. Efforts to mitigate bias and support the professional development of women are at the centre of newly formed European committees.
    MeSH term(s) Female ; Humans ; Male ; Sexism ; Surgeons ; Surveys and Questionnaires ; Thoracic Surgery ; Thoracic Surgical Procedures
    Language English
    Publishing date 2022-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezac034
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  5. Article ; Online: A multi-centre prospective cohort study of patients on the elective waiting list for cardiac surgery during the COVID-19 pandemic.

    Yates, Martin T / Balmforth, Damian / Kirmani, Bilal H / Acharya, Metesh / Jeganathan, Reuben / Ngaage, Dumbor / Kanani, Mayzar / Deglurkar, Indu / Lopez-Marco, Ana / Sanders, Julie / Ye Oo, Aung

    Journal of the Royal Society of Medicine

    2022  Volume 115, Issue 9, Page(s) 348–353

    Abstract: Objectives: During the worldwide COVID-19 pandemic, elective cardiac surgery was suspended to provide ICU beds for COVID-19 patients and those requiring urgent cardiac surgery. The aim of this study is to assess the effect of the pandemic on outcomes of ...

    Abstract Objectives: During the worldwide COVID-19 pandemic, elective cardiac surgery was suspended to provide ICU beds for COVID-19 patients and those requiring urgent cardiac surgery. The aim of this study is to assess the effect of the pandemic on outcomes of patients awaiting elective cardiac surgery.
    Design: A multi-centre prospective cohort study.
    Setting: The elective adult cardiac surgery waiting list as of 1 March 2020 across seven UK cardiac surgical centres.
    Participants: Patients on the elective adult cardiac surgery waiting list as of 1 March 2020 across seven UK cardiac surgical centres.
    Main outcome measures: Primary outcome was surgery, percutaneous therapy or death at one year.
    Methods: Data were collected prospectively on patients on the elective adult cardiac surgery waiting list as of 1 March 2020 across seven UK cardiac surgical centres. Primary outcome was surgery, percutaneous therapy or death at one year. Demographic data and outcomes were obtained from local electronic records, anonymised and submitted securely to the lead centre for analysis.
    Results: On 1 March 2020, there were 1099 patients on the elective waiting list for cardiac surgery. On 1 March 2021, 83% (n = 916) had met a primary outcome. Of these, 840 (92%) had surgery after a median of 195 (118-262) days on waiting list, 34 (3%) declined an offer of surgery, 23 (3%) had percutaneous intervention, 12 (1%) died, 7 (0.6%) were removed from the waiting list. The remainder of patients, 183 (17%) remained on the elective waiting list.
    Conclusions: This study has shown, for the first time, significant delays to treatment of patients awaiting elective cardiac surgery. Although there was a low risk of mortality or urgent intervention, important unmeasured adverse outcomes such as quality of life or increased perioperative risk may be associated with prolonged waiting times.
    MeSH term(s) Adult ; Humans ; Waiting Lists ; COVID-19 ; Pandemics ; Prospective Studies ; Quality of Life ; Cardiac Surgical Procedures
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 6731-3
    ISSN 1758-1095 ; 0141-0768 ; 0035-9157
    ISSN (online) 1758-1095
    ISSN 0141-0768 ; 0035-9157
    DOI 10.1177/01410768221089016
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  6. Article ; Online: Cardiac surgery outcome during the COVID-19 pandemic: a retrospective review of the early experience in nine UK centres.

    Sanders, Julie / Akowuah, Enoch / Cooper, Jackie / Kirmani, Bilal H / Kanani, Mazyar / Acharya, Metesh / Jeganathan, Reuben / Krasopoulos, George / Ngaage, Dumbor / Deglurkar, Indu / Yiu, Patrick / Kendall, Simon / Oo, Aung Ye

    Journal of cardiothoracic surgery

    2021  Volume 16, Issue 1, Page(s) 43

    Abstract: Background: Early studies conclude patients with Covid-19 have a high risk of death, but no studies specifically explore cardiac surgery outcome. We investigate UK cardiac surgery outcomes during the early phase of the Covid-19 pandemic.: Methods: ... ...

    Abstract Background: Early studies conclude patients with Covid-19 have a high risk of death, but no studies specifically explore cardiac surgery outcome. We investigate UK cardiac surgery outcomes during the early phase of the Covid-19 pandemic.
    Methods: This retrospective observational study included all adult patients undergoing cardiac surgery between 1st March and 30th April 2020 in nine UK centres. Data was obtained and linked locally from the National Institute for Cardiovascular Outcomes Research Adult Cardiac Surgery database, the Intensive Care National Audit and Research Centre database and local electronic systems. The anonymised datasets were analysed by the lead centre. Statistical analysis included descriptive statistics, propensity score matching (PSM), conditional logistic regression and hierarchical quantile regression.
    Results: Of 755 included individuals, 53 (7.0%) had Covid-19. Comparing those with and without Covid-19, those with Covid-19 had increased mortality (24.5% v 3.5%, p < 0.0001) and longer post-operative stay (11 days v 6 days, p = 0.001), both of which remained significant after PSM. Patients with a pre-operative Covid-19 diagnosis recovered in a similar way to non-Covid-19 patients. However, those with a post-operative Covid-19 diagnosis remained in hospital for an additional 5 days (12 days v 7 days, p = 0.024) and had a considerably higher mortality rate compared to those with a pre-operative diagnosis (37.1% v 0.0%, p = 0.005).
    Conclusions: To mitigate against the risks of Covid-19, particularly the post-operative burden, robust and effective pre-surgery diagnosis protocols alongside effective strategies to maintain a Covid-19 free environment are needed. Dedicated cardiac surgery hubs could be valuable in achieving safe and continual delivery of cardiac surgery.
    MeSH term(s) Aged ; COVID-19/epidemiology ; COVID-19 Testing ; Cardiac Surgical Procedures/statistics & numerical data ; Comorbidity ; Female ; Heart Diseases/epidemiology ; Heart Diseases/surgery ; Humans ; Length of Stay ; Male ; Middle Aged ; Pandemics ; Propensity Score ; Retrospective Studies ; SARS-CoV-2 ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-021-01424-y
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  7. Article ; Online: Surgical aortic valve replacement in the era of transcatheter aortic valve implantation: a review of the UK national database.

    Jahangiri, Marjan / Bilkhu, Rajdeep / Embleton-Thirsk, Andrew / Dehbi, Hakim-Moulay / Mani, Krishna / Anderson, Jon / Avlonitis, Vassilios / Baghai, Max / Birdi, Inderpaul / Booth, Karen / Bose, Amal / Briffa, Norman / Buchan, Keith / Bhudia, Sunil / Cale, Alex / Deglurkar, Indu / Farid, Shakil / Hadjinikolaou, Leonidas / Jarvis, Martin /
    Javadpour, Seyed Hossein / Jeganathan, Reubendra / Kuduvalli, Manoj / Lall, Kulvinder / Mascaro, Jorge / Mehta, Dheeraj / Ohri, Sunil / Punjabi, Prakash / Venkateswaran, Rajamiyer / Ridley, Paul / Satur, Christopher / Stoica, Serban / Trivedi, Uday / Zaidi, Afzal / Yiu, Patrick / Moorjani, Narain / Kendall, Simon / Freemantle, Nick

    BMJ open

    2021  Volume 11, Issue 10, Page(s) e046491

    Abstract: Objectives: To date the reported outcomes of surgical aortic valve replacement (SAVR) are mainly in the settings of trials comparing it with evolving transcatheter aortic valve implantation. We set out to examine characteristics and outcomes in people ... ...

    Abstract Objectives: To date the reported outcomes of surgical aortic valve replacement (SAVR) are mainly in the settings of trials comparing it with evolving transcatheter aortic valve implantation. We set out to examine characteristics and outcomes in people who underwent SAVR reflecting a national cohort and therefore 'real-world' practice.
    Design: Retrospective analysis of prospectively collected data of consecutive people who underwent SAVR with or without coronary artery bypass graft (CABG) surgery between April 2013 and March 2018 in the UK. This included elective, urgent and emergency operations. Participants' demographics, preoperative risk factors, operative data, in-hospital mortality, postoperative complications and effect of the addition of CABG to SAVR were analysed.
    Setting: 27 (90%) tertiary cardiac surgical centres in the UK submitted their data for analysis.
    Participants: 31 277 people with AVR were identified. 19 670 (62.9%) had only SAVR and 11 607 (37.1%) had AVR+CABG.
    Results: In-hospital mortality for isolated SAVR was 1.9% (95% CI 1.6% to 2.1%) and was 2.4% for AVR+CABG. Mortality by age category for SAVR only were: <60 years=2.0%, 60-75 years=1.5%, >75 years=2.2%. For SAVR+CABG these were; 2.2%, 1.8% and 3.1%. For different categories of EuroSCORE, mortality for SAVR in low risk people was 1.3%, in intermediate risk 1% and for high risk 3.9%. 74.3% of the operations were elective, 24% urgent and 1.7% emergency/salvage. The incidences of resternotomy for bleeding and stroke were 3.9% and 1.1%, respectively. Multivariable analyses provided no evidence that concomitant CABG influenced outcome. However, urgency of the operation, poor ventricular function, higher EuroSCORE and longer cross clamp and cardiopulmonary bypass times adversely affected outcomes.
    Conclusions: Surgical SAVR±CABG has low mortality risk and a low level of complications in the UK in people of all ages and risk factors. These results should inform consideration of treatment options in people with aortic valve disease.
    MeSH term(s) Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis Implantation ; Humans ; Middle Aged ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Transcatheter Aortic Valve Replacement ; Treatment Outcome ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-10-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-046491
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  8. Article: Role of stem cell homing in myocardial regeneration.

    Penn, Marc S / Zhang, Ming / Deglurkar, Indu / Topol, Eric J

    International journal of cardiology

    2004  Volume 95 Suppl 1, Page(s) S23–5

    Abstract: Recent studies have demonstrated the potential for myocardial regeneration at the time of myocardial infarction. Our lab focuses on understanding how stem cells home to injured tissue. We believe that a detailed analysis of the biological responses to ... ...

    Abstract Recent studies have demonstrated the potential for myocardial regeneration at the time of myocardial infarction. Our lab focuses on understanding how stem cells home to injured tissue. We believe that a detailed analysis of the biological responses to tissue injury not only gives us insight into how damage occurs, but can also yield insight into how the body attempts to repair itself. In the case of the heart, we have shown that these "healing pathways" are only expressed for a short time following injury, and this may be why myocardial damage is usually irreversible. Furthermore, work suggests that deciphering these "healing pathways" and re-establishing their expression at time remote from injury offers an avenue for developing novel therapeutics that ultimately may allow us to orchestrate and exaggerate the healing process at time remote from tissue injury.
    MeSH term(s) Animals ; Cell Movement/physiology ; Chemokine CXCL12 ; Chemokines, CXC/physiology ; Genetic Therapy ; Hematopoietic Stem Cell Mobilization ; Humans ; Mesenchymal Stem Cells/physiology ; Multipotent Stem Cells/physiology ; Myoblasts, Skeletal/transplantation ; Myocardial Infarction/pathology ; Myocardium/pathology ; Regeneration/physiology ; Stem Cells/physiology ; Stromal Cells/metabolism
    Chemical Substances CXCL12 protein, human ; Chemokine CXCL12 ; Chemokines, CXC
    Language English
    Publishing date 2004-08-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/s0167-5273(04)90007-1
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  9. Article: Aortic valve repair and root preservation by remodeling, reimplantation, and tailoring: technical aspects and early outcome.

    Svensson, Lars G / Deglurkar, Indu / Ung, Jin / Pettersson, Gosta / Gillinov, A Marc / D'Agostino, Richard S / Lytle, Bruce W

    Journal of cardiac surgery

    2007  Volume 22, Issue 6, Page(s) 473–479

    Abstract: Objectives: Evaluate aortic root preserving/sparing procedures for various pathologies associated with ascending aortic aneurysms, including aortic valve regurgitation.: Methods: From the end of 1990 through end of 2004, 388 patients had aortic root ... ...

    Abstract Objectives: Evaluate aortic root preserving/sparing procedures for various pathologies associated with ascending aortic aneurysms, including aortic valve regurgitation.
    Methods: From the end of 1990 through end of 2004, 388 patients had aortic root preserving procedures (reimplantation 72, remodeling 77, tailoring 239) +/- leaflet repair. Preoperatively, in-house grade aortic regurgitation was 1(+) in 58, 2(+) in 110, 3(+) in 101, and 4(+) in 66. Concurrent leaflet repairs were done in 197 (50.8%, Cabrol/Trusler commissure stitch 158, leaflet plication 36, supracommissure stitch 42, leaflet resection and repair 16, perforation repair 18, and debridement 11). Additional procedures included arch repair in 227 (58%), coronary bypass in 83 (21.4%), elephant trunk in 33 (8.5%), and minimally invasive approach in 30 (7.7%). Pathologies included dissection in 140 (36%; 86 acute), Marfan syndrome in 39 (10%), bicuspid valve in 78 (20%), and degenerative aneurysm in 142 (36.6%). The CLASS (Commissure, Leaflet, Annulus, Sinuses, Sinotubular) evaluation schema is described that is used for selecting either reimplantation, remodeling, or tailoring of the aortic root according to underlying pathology.
    Results: Hospital survival was 97.4% (378/388) and stroke occurred in 4.6% (18/388, four permanent, [1%]). On postoperative echocardiography, patients had either no (0) or 1(+) regurgitation (1(+)= 98);13 (3.4%) had 2(+). Three patients (1%) required reoperation for aortic valve failure before discharge (two tailoring, one remodeling).
    Conclusions: Excellent early results can be achieved by aortic root preserving procedures and concurrent aortic valve leaflet repairs when appropriately selected for a diverse class of pathologies.
    MeSH term(s) Algorithms ; Aorta/surgery ; Aortic Aneurysm, Thoracic/mortality ; Aortic Aneurysm, Thoracic/surgery ; Aortic Valve/surgery ; Cardiovascular Surgical Procedures/methods ; Female ; Health Status Indicators ; Heart Valve Prosthesis Implantation/methods ; Humans ; Male ; Middle Aged ; Postoperative Period ; Prospective Studies ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2007-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/j.1540-8191.2007.00467.x
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  10. Article: Mechanical and electrical effects of cell-based gene therapy for ischemic cardiomyopathy are independent.

    Deglurkar, Indu / Mal, Niladri / Mills, William R / Popovic, Zoran B / McCarthy, Patrick / Blackstone, Eugene H / Laurita, Kenneth R / Penn, Marc S

    Human gene therapy

    2005  Volume 17, Issue 11, Page(s) 1144–1151

    Abstract: Cell-based gene therapy to alter the myocardial tissue microenvironment has been shown to improve mechanical cardiac function, but little is known regarding its effects on arrhythmogenic risk. Clinical studies with skeletal myoblasts (SKMBs) have ... ...

    Abstract Cell-based gene therapy to alter the myocardial tissue microenvironment has been shown to improve mechanical cardiac function, but little is known regarding its effects on arrhythmogenic risk. Clinical studies with skeletal myoblasts (SKMBs) have suggested a potential increase in arrhythmogenic risk. Therefore, we studied the functional mechanical and electrical effects of transient reestablishment of stem cell homing via transplantation of stromal-cell derived factor-1 (SDF-1)-expressing SKMBs. Eight weeks after anterior myocardial infarction, rats received in five divided doses into the periinfarct zone 1 million SKMBs transfected with AdSDF-1 (n=15) or AdGFP (n=8). Echocardiography was used to quantify changes in cardiac function, and optical mapping was used to determine the arrhythmogenic risk. Eight weeks after cell therapy, we observed a 54% (p=0.004) increase in shortening fraction in AdSDF-1:SKMB-treated rats, but only an 18.8% increase (p=not significant) with GFP:SKMB. SDF-1-treated hearts exhibited an increase in vascular density compared with control SKMBs (34.9+/-7.1 vs. 20.7+/-5.6 vessels/mm2; p<0.01). Optical mapping performed 8 weeks after cell therapy revealed that all animals that received SKMBs regardless of viral transfection had inducible ventricular tachycardia (VT) whereas only 50% of saline-treated animals had inducible VT (p<0.05). Transient reestablishment of stem cell homing via transplantation of modified SKMBs is sufficient to improve cardiac function. However, despite improved mechanical function, the risk of ventricular tachycardia increased. We propose that future studies on functional effects of cell-based gene therapies should address both mechanical and electrical consequences.
    MeSH term(s) Adenoviridae/genetics ; Animals ; Chemokine CXCL12 ; Chemokines, CXC/genetics ; Disease Models, Animal ; Echocardiography ; Genetic Therapy/adverse effects ; Genetic Vectors ; Myoblasts, Skeletal/transplantation ; Myocardial Infarction/therapy ; Rats ; Recombinant Proteins/genetics ; Tachycardia, Ventricular/etiology ; Transfection
    Chemical Substances Chemokine CXCL12 ; Chemokines, CXC ; Recombinant Proteins
    Language English
    Publishing date 2005-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2006.17.1144
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