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  1. Article ; Online: T-bet

    Rauch, Eileen / Amendt, Timm / Lopez Krol, Aleksandra / Lang, Fabian B / Linse, Vincent / Hohmann, Michelle / Keim, Ann-Christin / Kreutzer, Susanne / Kawengian, Kevin / Buchholz, Malte / Duschner, Philipp / Grauer, Saskia / Schnierle, Barbara / Ruhl, Andreas / Burtscher, Ingo / Dehnert, Sonja / Kuria, Chege / Kupke, Alexandra / Paul, Stephanie /
    Liehr, Thomas / Lechner, Marcus / Schnare, Markus / Kaufmann, Andreas / Huber, Magdalena / Winkler, Thomas H / Bauer, Stefan / Yu, Philipp

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1229

    Abstract: Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we generate mouse- ... ...

    Abstract Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we generate mouse-strains where Moloney-Murine Leukemia Virus tagged with GFP (ERV-GFP) infected the mouse germline. This enables us to analyze the role of genetic, epigenetic and cell intrinsic restriction factors in ERV activation and control. We identify an autoreactive B cell response against the neo-self/ERV antigen GFP as a key mechanism of ERV control. Hallmarks of this response are spontaneous ERV-GFP
    MeSH term(s) Animals ; Mice ; Autoimmune Diseases/genetics ; B-Lymphocytes/immunology ; Endogenous Retroviruses/genetics ; Mammals/genetics
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45201-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis.

    Lübben, Wolger / Turqueti-Neves, Adriana / Okhrimenko, Anna / Stöberl, Christian / Schmidt, Volker / Pfeffer, Klaus / Dehnert, Sonja / Wünsche, Sarah / Storsberg, Silke / Paul, Stefanie / Bauer, Stefan / Riethmüller, Gert / Voehringer, David / Yu, Philipp

    European journal of immunology

    2013  Volume 43, Issue 5, Page(s) 1231–1242

    Abstract: Immunoglobulin E (IgE) production is tightly regulated at the cellular and genetic levels and is believed to be central to allergy development. At least two cellular pathways exist that lead to systemic anaphylaxis reactions in vivo: IgE-sensitized mast ... ...

    Abstract Immunoglobulin E (IgE) production is tightly regulated at the cellular and genetic levels and is believed to be central to allergy development. At least two cellular pathways exist that lead to systemic anaphylaxis reactions in vivo: IgE-sensitized mast cells and IgG1-sensitized basophils. Passive anaphylaxis, by application of allergen and allergen-specific antibodies in mice, indicates a differential contribution of immunoglobulin isotypes to anaphylaxis. However, analysis of a dynamic immunization-mediated antibody response in anaphylaxis is difficult. Here, we generated IgE knock-in mice (IgE(ki) ), which express the IgE heavy chain instead of IgG1, in order to analyze the contribution of IgG1 and IgE to active anaphylaxis in vivo. IgE(ki) mice display increased IgE production both in vitro and in vivo. The sensitization of IgE(ki) mice by immunization followed by antigen challenge leads to increased anaphylaxis. Homozygous IgE(ki) mice, which lack IgG1 due to the knock-in strategy, are most susceptible to active systemic anaphylaxis. The depletion of basophils demonstrates their importance in IgE-mediated anaphylaxis. Therefore, we propose that an enhanced, antigen-specific, polyclonal IgE response, as is the case in allergic patients, is probably the most efficient way to sensitize basophils to contribute to systemic anaphylaxis in vivo.
    MeSH term(s) Allergens/administration & dosage ; Allergens/immunology ; Anaphylaxis/genetics ; Anaphylaxis/immunology ; Anaphylaxis/pathology ; Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/immunology ; Basophils/immunology ; Basophils/pathology ; Gene Knock-In Techniques ; Homozygote ; Humans ; Immunization ; Immunoglobulin E/genetics ; Immunoglobulin E/immunology ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Mast Cells/immunology ; Mast Cells/pathology ; Mice ; Ovalbumin/administration & dosage ; Ovalbumin/immunology ; Severity of Illness Index
    Chemical Substances Allergens ; Antibodies, Monoclonal ; Immunoglobulin G ; Immunoglobulin E (37341-29-0) ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2013-03-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201242675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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  3. Article ; Online: Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors.

    Yu, Philipp / Lübben, Wolger / Slomka, Heike / Gebler, Janine / Konert, Madlen / Cai, Chengcong / Neubrandt, Luisa / Prazeres da Costa, Olivia / Paul, Stephanie / Dehnert, Sonja / Döhne, Karolin / Thanisch, Michael / Storsberg, Silke / Wiegand, Lisa / Kaufmann, Andreas / Nain, Marianne / Quintanilla-Martinez, Leticia / Bettio, Sabrina / Schnierle, Barbara /
    Kolesnikova, Larissa / Becker, Stephan / Schnare, Markus / Bauer, Stefan

    Immunity

    2012  Volume 37, Issue 5, Page(s) 867–879

    Abstract: The genome of vertebrates contains endogenous retroviruses (ERVs) that are largely nonfunctional relicts of ancestral germline infection by exogenous retroviruses. However, in some mouse strains ERVs are actively involved in disease. Here we report that ... ...

    Abstract The genome of vertebrates contains endogenous retroviruses (ERVs) that are largely nonfunctional relicts of ancestral germline infection by exogenous retroviruses. However, in some mouse strains ERVs are actively involved in disease. Here we report that nucleic acid-recognizing Toll-like receptors 3, 7, and 9 (TLR 3, TLR7, and TLR9) are essential for the control of ERVs. Loss of TLR7 function caused spontaneous retroviral viremia that coincided with the absence of ERV-specific antibodies. Importantly, additional TLR3 and TLR9 deficiency led to acute T cell lymphoblastic leukemia, underscoring a prominent role for TLR3 and TLR9 in surveillance of ERV-induced tumors. Experimental ERV infection induced a TLR3-, TLR7-, and TLR9-dependent group of "acute-phase" genes previously described in HIV and SIV infections. Our study suggests that in addition to their role in innate immunity against exogenous pathogens, nucleic acid-recognizing TLRs contribute to the immune control of activated ERVs and ERV-induced tumors.
    MeSH term(s) Animals ; Antibodies, Viral/genetics ; Antibodies, Viral/immunology ; Cell Line ; Endogenous Retroviruses/genetics ; Endogenous Retroviruses/immunology ; Endogenous Retroviruses/metabolism ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nucleic Acids/genetics ; Nucleic Acids/immunology ; Nucleic Acids/metabolism ; Oncogenes/genetics ; Oncogenes/immunology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Toll-Like Receptors/genetics ; Toll-Like Receptors/immunology ; Toll-Like Receptors/metabolism ; Viremia/genetics ; Viremia/immunology ; Viremia/metabolism
    Chemical Substances Antibodies, Viral ; Nucleic Acids ; Toll-Like Receptors
    Language English
    Publishing date 2012-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2012.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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