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  1. Article ; Online: Hypophosphatemia also increases the risk.

    Deixler, Elisabeth

    Deutsches Arzteblatt international

    2012  Volume 109, Issue 27-28, Page(s) 492–3; author reply 493

    MeSH term(s) Food Additives/adverse effects ; Humans ; Hyperphosphatemia/chemically induced ; Phosphates/adverse effects
    Chemical Substances Food Additives ; Phosphates
    Language English
    Publishing date 2012-07-09
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2012.0492b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19.

    van Kempen, Theo A T G / Deixler, Elisabeth

    American journal of physiology. Endocrinology and metabolism

    2020  Volume 320, Issue 1, Page(s) E2–E6

    Abstract: The use of vitamin D to reduce the severity of COVID-19 complications is receiving considerable attention, backed by encouraging data. Its purported mode of action is as an immune modulator. Vitamin D, however, also affects the metabolism of phosphate ... ...

    Abstract The use of vitamin D to reduce the severity of COVID-19 complications is receiving considerable attention, backed by encouraging data. Its purported mode of action is as an immune modulator. Vitamin D, however, also affects the metabolism of phosphate and Mg, which may well play a critical role in SARS-CoV-2 pathogenesis. SARS-CoV-2 may induce a cytokine storm that drains ATP whose regeneration requires phosphate and Mg. These minerals, however, are often deficient in conditions that predispose people to severe COVID-19, including older age (especially males), diabetes, obesity, and usage of diuretics. Symptoms observed in severe COVID-19 also fit well with those seen in classical hypophosphatemia and hypomagnesemia, such as thrombocytopenia, coagulopathy, dysfunction of liver and kidneys, neurologic disturbances, immunodeficiency, failure of heart and lungs, delayed weaning from a respirator, cardiac arrhythmia, seizures, and, finally, multiorgan failure. Deficiencies of phosphate and Mg can be amplified by kidney problems commonly observed in patients with COVID-19 resulting in their wastage into urine. Available data show that phosphate and Mg are deficient in COVID-19, with phosphate showing a remarkable correlation with its severity. In one experiment, patients with COVID-19 were supplemented with a cocktail of vitamin D
    MeSH term(s) COVID-19/complications ; COVID-19/drug therapy ; COVID-19/metabolism ; Dietary Supplements ; Humans ; Magnesium/therapeutic use ; Magnesium Deficiency/drug therapy ; Magnesium Deficiency/etiology ; Magnesium Deficiency/metabolism ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/drug therapy ; Vitamin B 12 Deficiency/etiology ; Vitamin B 12 Deficiency/metabolism ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/etiology ; Vitamin D Deficiency/metabolism ; Vitamins/therapeutic use
    Chemical Substances Vitamins ; Vitamin D (1406-16-2) ; Magnesium (I38ZP9992A) ; Vitamin B 12 (P6YC3EG204)
    Keywords covid19
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00474.2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: WIRKUNG UNTERSCHIEDLICH HERGESTELLTER I.V. APPLIZIERBARER SERUMEIWEISSKONSERVEN UND GAMMAGLOBULINPRAEPARATE AUF DIE IN-VITRO-PHAGOZYTOSE VON ECOLI DURCH NEUTROPHILE GRANULOZYTEN

    Deixler, Elisabeth

    1983  

    Title variant WIRKUNG UNTERSCHIEDLICH HERGESTELLTER INTRAVENOES APPLIZIERBARER SERUMEIWEISSKONSERVEN UND GAMMAGLOBULINPRAEPARATE AUF DIE IN-VITRO-PHAGOZYTOSE VON ESCHERICHIA COLI DURCH NEUTROPHILE GRANULOZYTEN
    Size 61 S. : GRAPH. DARST.
    Document type Book
    Note MUENCHEN, UNIV., DISS., 1983
    HBZ-ID HT002609219
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    83 D 2853 order for loan Magazin

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  4. Article: SARS-CoV-2: Influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP)-metabolism and on severity of COVID-19

    van Kempen, Theo Atg / Deixler, Elisabeth

    Am. j. physiol. endocrinol. metab

    Abstract: The use of vitamin D to reduce the severity of COVID-19 complications is receiving considerable attention, backed by encouraging data. Its purported mode of action is as an immune modulator. Vitamin D, however, also affects metabolism of phosphate and Mg, ...

    Abstract The use of vitamin D to reduce the severity of COVID-19 complications is receiving considerable attention, backed by encouraging data. Its purported mode of action is as an immune modulator. Vitamin D, however, also affects metabolism of phosphate and Mg, which may well play a critical role in SARS-CoV-2 pathogenesis. SARS-CoV-2 may induce a cytokine storm that drains ATP whose regeneration requires phosphate and Mg. These minerals, however, are often deficient in conditions that predispose people to severe COVID-19, including older age (especially males), diabetes, obesity, and usage of diuretics. Symptoms observed in severe COVID-19 also fit well with those seen in classical hypophosphatemia and hypomagnesemia, such as thrombocytopenia, coagulopathy, dysfunction of liver and kidneys, neurologic disturbances, immunodeficiency, failure of heart and lungs, delayed weaning from a respirator, cardiac arrhythmia, seizures, and finally multi-organ failure. Deficiencies of phosphate and Mg can be amplified by kidney problems commonly observed in COVID-19 patients resulting in their wastage into urine. Available data show that phosphate and Mg are deficient in COVID-19 with phosphate showing a remarkable correlation with its severity. In one experiment, COVID-19 patients were supplemented with a cocktail of vitamin D3, Mg, and vitamin B12, with very encouraging results. We thus argue that COVID-19 patients should be monitored and treated for phosphate and Mg deficiencies, ideally already in the early phases of infection. Supplementation of phosphate and Mg combined with vitamin D could also be implemented as a preventative strategy in populations at risk.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #919087
    Database COVID19

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  5. Article ; Online: Hypophosphatemia as a key factor in sudden infant death syndrome (SIDS)?

    Van Kempen, Theo A T G / Deixler, Elisabeth / Crook, Martin A

    Upsala journal of medical sciences

    2013  Volume 118, Issue 2, Page(s) 143–144

    MeSH term(s) Diaphragm/physiology ; Diaphragm/physiopathology ; Female ; Humans ; Male ; Sudden Infant Death/etiology ; Sudden Infant Death/pathology
    Language English
    Publishing date 2013-04-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 183949-4
    ISSN 2000-1967 ; 0300-9734
    ISSN (online) 2000-1967
    ISSN 0300-9734
    DOI 10.3109/03009734.2013.781252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.426: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Book ; Thesis: Wirkung unterschiedlich hergestellter i.v. applizierbarer Serumeiweißkonserven und Gammaglobulinpräparate auf die in-vitro-Phagozytose von E.coli durch neutrophile Granulozyten

    Deixler, Elisabeth

    1983  

    Author's details Elisabeth Deixler
    Language Undetermined
    Size 61 S, graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @München, Univ., Diss. : 1983
    Database Former special subject collection: coastal and deep sea fishing

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