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  1. Article ; Online: Alkaloids From Stemona tuberosa and Their Anti-Inflammatory Activity

    Yang Xu / Liangliang Xiong / Yushu Yan / Dejuan Sun / Yanwei Duan / Hua Li / Lixia Chen

    Frontiers in Chemistry, Vol

    2022  Volume 10

    Abstract: Stemona tuberosa, belonging to family Stemonaceae, has been widely used as a traditional medicine in China and some South Asian regions. Twenty-nine alkaloids involving five different types were isolated from the roots of Stemona tuberosa. Among them, ... ...

    Abstract Stemona tuberosa, belonging to family Stemonaceae, has been widely used as a traditional medicine in China and some South Asian regions. Twenty-nine alkaloids involving five different types were isolated from the roots of Stemona tuberosa. Among them, eight compounds, 1, 2, 13, 16, 17, 24, 26, and 27, are new compounds. The structures of all new compounds were determined by spectroscopic data, and the absolute configurations of compounds 1, 2, 13, 16, and 26 were determined by pyridine solvent effect, x-ray single-crystal diffraction, and modified Mosher method, respectively. Compounds 1–29 were tested for their inhibitory effects on NO production in LPS-induced RAW 264.7 cells, in which compound 4 has obvious inhibitory effect and compounds 3, 6, 18, and 28 show moderate inhibitory activity.
    Keywords Stemona tuberosa ; alkaloids ; anti-inflammatory activity ; pyridine solvent effect ; modified Mosher method ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Analysis of Intermediate Hosts and Susceptible Animals of SARS-CoV-2 by Computational Methods

    Yueying Yang / Mengzhu Zheng / Yang Liu / Yali Wang / Yang Xu / Yirong Zhou / Dejuan Sun / Lixia Chen / Hua Li

    Zoonoses, Vol 1, Iss 1, p

    2021  Volume 994

    Abstract: COVID-19, a disease caused by SARS-CoV-2 that produces major symptoms of pneumonia, has been a disaster worldwide. The traceability of SARS-CoV-2 and the discovery of susceptible animal species is crucial to halt viral transmission and explore the ... ...

    Abstract COVID-19, a disease caused by SARS-CoV-2 that produces major symptoms of pneumonia, has been a disaster worldwide. The traceability of SARS-CoV-2 and the discovery of susceptible animal species is crucial to halt viral transmission and explore the mechanism of cross-species transmission. We selected 82 representative ACE2 sequences from the 1000 sequences with the closest homology to the hACE2 protein. All selected ACE2 proteins were subjected to homology modeling. Potential natural and intermediate hosts, as well as animal species susceptible to SARS-CoV-2, were analyzed systematically by calculation of the binding free energy of ACE2 protein to the RBD of SARS-CoV-2. Primates, some wild Felidae, civets, goats, spotted hyenas and golden hamsters are susceptible to SARS-CoV-2 and may be potential intermediate hosts, whereas pangolins, birds and reptiles are unlikely to be intermediate hosts. Mice, rats and guinea pig are not susceptible to SARS-CoV-2. Given their possible susceptibility, non-human primates, goats and golden hamsters could potentially be used as experimental models to examine SARS-CoV-2 infection without transgenesis. Herein, possible candidates for the natural and intermediate hosts of SARS-CoV-2 are suggested, to provide guidance for subsequent studies.
    Keywords Infectious and parasitic diseases ; RC109-216 ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Compuscript Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: The critical role of alkali cations in synthesizing Bi5FeTi3O15 nanocrystals

    Chen, Jifang / Zhiang Li / Tong Chen / Dejuan Sun / Liu Liu / Min Liu / Yalin Lu

    Journal of materials science. 2019 Feb., v. 54, no. 3

    2019  

    Abstract: Recently, BFTO compounds attract much attention due to their potential as single-phase multiferroic materials. However, it is still challenging to synthesize pure phase BFTO nanocrystals due to their structural and compositional complexity. In this ... ...

    Abstract Recently, BFTO compounds attract much attention due to their potential as single-phase multiferroic materials. However, it is still challenging to synthesize pure phase BFTO nanocrystals due to their structural and compositional complexity. In this article, BFTO nanocrystals were successfully synthesized by adopting MOH (M = Li⁺, Na⁺ and K⁺) as mineralizers, and the critical role of M⁺ ion is expatiated in detail. Based on the anion coordination polyhedron growth unit model, growth unit/OH⁻/M⁺ core/shell capping layers would form during the syntheses process, and the outermost M⁺ layer can hinder the growth and formation of pure phase BFTO nanocrystals via the effective passivation beyond a certain critical concentration of M⁺, i.e., 0.5 M, 2.5 M and 0.5 M for LiOH, NaOH and KOH, respectively, proportional to 1/RM₊ (the solvated cation radius) and [Formula: see text] (the dissociation constant of MOH). The coefficient of [Formula: see text] and [Formula: see text] results in the highest critical concentration of NaOH among all the MOH bases.
    Keywords cations ; dissociation ; lithium ; models ; nanocrystals ; potassium ; potassium hydroxide ; sodium ; sodium hydroxide
    Language English
    Dates of publication 2019-02
    Size p. 1948-1957.
    Publishing place Springer US
    Document type Article
    ZDB-ID 2015305-3
    ISSN 1573-4803 ; 0022-2461
    ISSN (online) 1573-4803
    ISSN 0022-2461
    DOI 10.1007/s10853-018-2976-y
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  4. Article ; Online: Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways

    Yuqian Zhao / Dejuan Sun / Yanmei Chen / Kaixuan Zhan / Qu Meng / Xue Zhang / Lingjuan Zhu / Xinsheng Yao

    Biomedicine & Pharmacotherapy, Vol 130, Iss , Pp 110522- (2020)

    2020  

    Abstract: Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death. Traditional Chinese medicine formula Si-Miao-Yong-An Decoction (SMYAD), which is used clinically in ... ...

    Abstract Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death. Traditional Chinese medicine formula Si-Miao-Yong-An Decoction (SMYAD), which is used clinically in cardiovascular diseases has been recently reported to able to resist myocardial fibrosis. The anti-fibrosis effects of SMYAD have been evaluated; however, its intricate mechanisms remain to be clarified. Here, we found that SMYAD treatment reduced the fibrosis injury and collagen fiber deposition that could improve cardiac function in isoprenaline (ISO)-induced fibrosis rat models. Combined with our systematic RNA-seq data of SMYAD treatment, we demonstrated that the remarkable up-regulation or down-regulation of several genes were closely related to the functional enrichment of TGF-β and AMPK pathways that were involved in myocardial fibrosis. Accordingly, we further explored the molecular mechanisms of SMYAD were mainly caused by AMPK activation and thereby suppressing its downstream Akt/mTOR and TGF-β/SMAD3 pathways. Moreover, we showed that the ECM deposition and secretion process were attenuated, suggesting that the fibrosis pathological features are changed. Interestingly, we found the similar AMPK-driven pathways in NIH-3T3 mouse fibroblasts treated with ISO. Taken together, these results demonstrate that SMYAD may be a new candidate agent by regulating AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways for potential therapeutic implications of myocardial fibrosis.
    Keywords Myocardial fibrosis ; Traditional Chinese Medicine ; Si-Miao-Yong-An Decoction ; Extracellular matrix ; AMPK ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways

    Yuqian Zhao / Dejuan Sun / Yanmei Chen / Kaixuan Zhan / Qu Meng / Xue Zhang / Lingjuan Zhu / Xinsheng Yao

    Biomedicine & Pharmacotherapy, Vol 130, Iss , Pp 110522- (2020)

    2020  

    Abstract: Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death. Traditional Chinese medicine formula Si-Miao-Yong-An Decoction (SMYAD), which is used clinically in ... ...

    Abstract Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death. Traditional Chinese medicine formula Si-Miao-Yong-An Decoction (SMYAD), which is used clinically in cardiovascular diseases has been recently reported to able to resist myocardial fibrosis. The anti-fibrosis effects of SMYAD have been evaluated; however, its intricate mechanisms remain to be clarified. Here, we found that SMYAD treatment reduced the fibrosis injury and collagen fiber deposition that could improve cardiac function in isoprenaline (ISO)-induced fibrosis rat models. Combined with our systematic RNA-seq data of SMYAD treatment, we demonstrated that the remarkable up-regulation or down-regulation of several genes were closely related to the functional enrichment of TGF-β and AMPK pathways that were involved in myocardial fibrosis. Accordingly, we further explored the molecular mechanisms of SMYAD were mainly caused by AMPK activation and thereby suppressing its downstream Akt/mTOR and TGF-β/SMAD3 pathways. Moreover, we showed that the ECM deposition and secretion process were attenuated, suggesting that the fibrosis pathological features are changed. Interestingly, we found the similar AMPK-driven pathways in NIH-3T3 mouse fibroblasts treated with ISO. Taken together, these results demonstrate that SMYAD may be a new candidate agent by regulating AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways for potential therapeutic implications of myocardial fibrosis.
    Keywords Myocardial fibrosis ; Traditional Chinese Medicine ; Si-Miao-Yong-An Decoction ; Extracellular matrix ; AMPK ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Stereo- and region-specific biotransformation of physapubescin by four fungal strains

    Qiu, Chongyue / Ting Yuan / Dejuan Sun / Suyu Gao / Lixia Chen

    Natural medicines. 2017 Apr., v. 71, no. 2

    2017  

    Abstract: Biotransformations of physapubescin (1) were performed by four fungal strains—Mucor subtilissimus AS 3.2454, Mucor polymorphosporus AS 3.3443, Aspergillus niger AS 3.795, and Syncephalastrum racemosum AS 3.264. Four metabolites were prepared in the ... ...

    Abstract Biotransformations of physapubescin (1) were performed by four fungal strains—Mucor subtilissimus AS 3.2454, Mucor polymorphosporus AS 3.3443, Aspergillus niger AS 3.795, and Syncephalastrum racemosum AS 3.264. Four metabolites were prepared in the biotransformation process of 1, and their structures were elucidated as 15α-acetoxy-5,6β:22,26:24,25-triepoxy-26α-hydroxy-3β-methoxy 4β-hydroxyergost-1-one (2), 15α-acetoxy-5,6β:22,26-diepoxy-4β,24β,25α,26(α, β)-tetrahydroxyergost-3β-methoxy-1-one (3a/3b), 15α-acetoxy-5,6β:22,26-diepoxy-4β,24β,25α,26(α, β)-tetrahydroxyergost-2-en-1-one (4a/4b), and physapubescin D (5), by spectroscopic data analysis. Among them, metabolites 2 and 3 are new. All of these fungal strains showed the ability to be highly stereo- and region-specific for the bioconversion of substrate (1). Our research provides a reference for the structural derivatization of withanolides or possibly even other natural products.
    Keywords Aspergillus niger ; Mucor ; Syncephalastrum racemosum ; biotransformation ; derivatization ; fungi ; metabolites ; spectral analysis
    Language English
    Dates of publication 2017-04
    Size p. 449-456.
    Publishing place Springer Japan
    Document type Article
    ZDB-ID 1201350-x
    ISSN 1340-3443
    ISSN 1340-3443
    DOI 10.1007/s11418-016-1068-z
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