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  1. Article ; Online: Neurospora crassa ncs-1, mid-1 and nca-2 double-mutant phenotypes suggest diverse interaction among three Ca(2+)-regulating gene products.

    Deka, Rekha / Tamuli, Ranjan

    Journal of genetics

    2013  Volume 92, Issue 3, Page(s) 559–563

    MeSH term(s) Calcium/metabolism ; Calcium Channels/genetics ; Calcium Signaling/genetics ; Calcium-Binding Proteins/genetics ; Calcium-Transporting ATPases/genetics ; Carotenoids/metabolism ; Fungal Proteins/genetics ; Genes, Fungal ; Hyphae/cytology ; Hyphae/genetics ; Hyphae/growth & development ; Mutation ; Neurospora crassa/cytology ; Neurospora crassa/genetics ; Neurospora crassa/growth & development ; Phenotype ; Protein Interaction Maps
    Chemical Substances Calcium Channels ; Calcium-Binding Proteins ; Fungal Proteins ; Carotenoids (36-88-4) ; Calcium-Transporting ATPases (EC 7.2.2.10) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2013-12-25
    Publishing country India
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3039-9
    ISSN 0973-7731 ; 0958-8361 ; 0022-1333
    ISSN (online) 0973-7731
    ISSN 0958-8361 ; 0022-1333
    DOI 10.1007/s12041-013-0270-y
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  2. Article ; Online: Calcineurin Subunits A and B Interact to Regulate Growth and Asexual and Sexual Development in Neurospora crassa.

    Tamuli, Ranjan / Deka, Rekha / Borkovich, Katherine A

    PloS one

    2016  Volume 11, Issue 3, Page(s) e0151867

    Abstract: Calcineurin is a calcium/calmodulin dependent protein phosphatase in eukaryotes that consists of a catalytic subunit A and a regulatory subunit B. Previous studies in the filamentous fungus Neurospora crassa had suggested that the catalytic subunit of ... ...

    Abstract Calcineurin is a calcium/calmodulin dependent protein phosphatase in eukaryotes that consists of a catalytic subunit A and a regulatory subunit B. Previous studies in the filamentous fungus Neurospora crassa had suggested that the catalytic subunit of calcineurin might be an essential protein. We generated N. crassa strains expressing the A (cna-1) and B (cnb-1) subunit genes under the regulation of Ptcu-1, a copper-responsive promoter. In these strains, addition of bathocuproinedisulfonic acid (BCS), a copper chelator, results in induction of cna-1 and cnb-1, while excess Cu2+ represses gene expression. Through analysis of these strains under repressing and inducing conditions, we found that the calcineurin is required for normal growth, asexual development and female fertility in N. crassa. Moreover, we isolated and analyzed cnb-1 mutant alleles generated by repeat-induced point mutation (RIP), with the results further supporting roles for calcineurin in growth and fertility in N. crassa. We demonstrated a direct interaction between the CNA-1 and CNB-1 proteins using an assay system developed to study protein-protein interactions in N. crassa.
    MeSH term(s) Calcineurin/chemistry ; Calcineurin/genetics ; Calcineurin/metabolism ; Copper/chemistry ; Copper/metabolism ; Fungal Proteins/chemistry ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression Regulation, Fungal/drug effects ; Genetic Vectors/genetics ; Genetic Vectors/metabolism ; Hyphae/growth & development ; Hyphae/metabolism ; Immunoprecipitation ; Neurospora crassa/growth & development ; Neurospora crassa/metabolism ; Phenanthrolines/pharmacology ; Point Mutation ; Promoter Regions, Genetic ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism
    Chemical Substances Fungal Proteins ; Phenanthrolines ; Protein Subunits ; bathocuproine sulfonate (73348-75-1) ; Copper (789U1901C5) ; Calcineurin (EC 3.1.3.16)
    Language English
    Publishing date 2016-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0151867
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  3. Article ; Online: Identification of critical amino acid residues and functional conservation of the Neurospora crassa and Rattus norvegicus orthologues of neuronal calcium sensor-1.

    Gohain, Dibakar / Deka, Rekha / Tamuli, Ranjan

    Genetica

    2016  Volume 144, Issue 6, Page(s) 665–674

    Abstract: Neuronal calcium sensor-1 (NCS-1) is a member of neuronal calcium sensor family of proteins consisting of an amino terminal myristoylation domain and four conserved calcium ( ... ...

    Abstract Neuronal calcium sensor-1 (NCS-1) is a member of neuronal calcium sensor family of proteins consisting of an amino terminal myristoylation domain and four conserved calcium (Ca
    MeSH term(s) Amino Acid Sequence ; Animals ; Calcium/pharmacology ; Fungal Proteins/chemistry ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Mutation ; Neuronal Calcium-Sensor Proteins/chemistry ; Neuronal Calcium-Sensor Proteins/genetics ; Neuronal Calcium-Sensor Proteins/metabolism ; Neuropeptides/chemistry ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Neurospora crassa/drug effects ; Neurospora crassa/metabolism ; Neurospora crassa/radiation effects ; Rats ; Sequence Homology, Amino Acid ; Ultraviolet Rays
    Chemical Substances Fungal Proteins ; Neuronal Calcium-Sensor Proteins ; Neuropeptides ; frequenin calcium sensor proteins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2165-9
    ISSN 1573-6857 ; 0016-6707
    ISSN (online) 1573-6857
    ISSN 0016-6707
    DOI 10.1007/s10709-016-9933-y
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  4. Article ; Online: Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi.

    Tamuli, Ranjan / Kumar, Ravi / Deka, Rekha

    Journal of basic microbiology

    2011  Volume 51, Issue 2, Page(s) 120–128

    Abstract: The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca(2+)-binding sites, and mediates the effects of cytosolic Ca(2+). Minute changes in free intracellular Ca(2+) are quickly transformed into ...

    Abstract The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca(2+)-binding sites, and mediates the effects of cytosolic Ca(2+). Minute changes in free intracellular Ca(2+) are quickly transformed into changes in the activity of several kinases including calcium/calmodulin-dependent protein kinases (Ca(2+)/CaMKs) that are involved in regulating many eukaryotic cell functions. However, our current knowledge of NCS-1 and Ca(2+)/CaMKs comes mostly from studies of the mammalian enzymes. Thus far very few fungal homologues of NCS-1 and Ca(2+)/CaMKs have been characterized and little is known about their cellular roles. In this minireview, we describe the known sequences, interactions with target proteins and cellular roles of NCS-1 and Ca(2+)/CaMKs in fungi.
    MeSH term(s) Amino Acid Sequence ; Calcium Signaling/physiology ; Calcium-Calmodulin-Dependent Protein Kinases/genetics ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; EF Hand Motifs/genetics ; EF Hand Motifs/physiology ; Fungi/enzymology ; Fungi/genetics ; Fungi/metabolism ; Molecular Sequence Data ; Neuronal Calcium-Sensor Proteins/genetics ; Neuronal Calcium-Sensor Proteins/metabolism ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Phylogeny ; Sequence Alignment
    Chemical Substances Neuronal Calcium-Sensor Proteins ; Neuropeptides ; frequenin calcium sensor proteins ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17)
    Language English
    Publishing date 2011-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632513-0
    ISSN 1521-4028 ; 0233-111X
    ISSN (online) 1521-4028
    ISSN 0233-111X
    DOI 10.1002/jobm.201000184
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  5. Article ; Online: Neurospora crassa homologue of Neuronal Calcium Sensor-1 has a role in growth, calcium stress tolerance, and ultraviolet survival.

    Deka, Rekha / Kumar, Ravi / Tamuli, Ranjan

    Genetica

    2011  Volume 139, Issue 7, Page(s) 885–894

    Abstract: NCU04379 gene encodes a conserved Ca(2+) and/or calmodulin binding protein that possesses a consensus signal for N-terminal myristoylation and four EF-hands, characteristics of Neuronal Calcium Sensor-1proteins. The NCU04379.2 knockout mutant shows slow ... ...

    Abstract NCU04379 gene encodes a conserved Ca(2+) and/or calmodulin binding protein that possesses a consensus signal for N-terminal myristoylation and four EF-hands, characteristics of Neuronal Calcium Sensor-1proteins. The NCU04379.2 knockout mutant shows slow growth rate, increased sensitivity to calcium and ultraviolet (UV) irradiation, and a wild-type fragment carrying NCU04379 gene complements the mutant. Therefore, NCU04379 gene has a role in growth, calcium stress tolerance, and UV survival. Crosses homozygous for ΔNCU04379.2 mutant strains were fully fertile; however, we found evidence for involvement of Ca(2+)/calmodulin-dependent protein kinase encoding genes NCU02283 and NCU09123 in sexual development.
    MeSH term(s) Adaptation, Physiological ; Amino Acid Sequence ; Calcium/metabolism ; Calcium Signaling/physiology ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Genetic Complementation Test ; Molecular Sequence Data ; Myristic Acid/metabolism ; Neuronal Calcium-Sensor Proteins/genetics ; Neuronal Calcium-Sensor Proteins/metabolism ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Neurospora crassa/genetics ; Neurospora crassa/growth & development ; Neurospora crassa/physiology ; Neurospora crassa/radiation effects ; Phylogeny ; Sensitivity and Specificity ; Sequence Alignment ; Sequence Deletion ; Sequence Homology, Amino Acid ; Stress, Physiological ; Ultraviolet Rays
    Chemical Substances Calcium-Binding Proteins ; Fungal Proteins ; Neuronal Calcium-Sensor Proteins ; Neuropeptides ; frequenin calcium sensor proteins ; Myristic Acid (0I3V7S25AW) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2011-07-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2165-9
    ISSN 1573-6857 ; 0016-6707
    ISSN (online) 1573-6857
    ISSN 0016-6707
    DOI 10.1007/s10709-011-9592-y
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  6. Article: Cellular roles of neuronal calcium sensor-1 and calcium/calmodulin-dependent kinases in fungi

    Tamuli, Ranjan / Kumar, Ravi / Deka, Rekha

    Journal of basic microbiology. 2011 Apr., v. 51, no. 2

    2011  

    Abstract: The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca²⁺-binding sites, and mediates the effects of cytosolic Ca²⁺. Minute changes in free intracellular Ca²⁺ are quickly transformed into ... ...

    Abstract The neuronal calcium sensor-1 (NCS-1) possesses a consensus signal for N-terminal myristoylation and four EF-hand Ca²⁺-binding sites, and mediates the effects of cytosolic Ca²⁺. Minute changes in free intracellular Ca²⁺ are quickly transformed into changes in the activity of several kinases including calcium/calmodulin-dependent protein kinases (Ca²⁺/CaMKs) that are involved in regulating many eukaryotic cell functions. However, our current knowledge of NCS-1 and Ca²⁺/CaMKs comes mostly from studies of the mammalian enzymes. Thus far very few fungal homologues of NCS-1 and Ca²⁺/CaMKs have been characterized and little is known about their cellular roles. In this minireview, we describe the known sequences, interactions with target proteins and cellular roles of NCS-1 and Ca²⁺/CaMKs in fungi. (© 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
    Keywords calcium ; eukaryotic cells ; fungi ; myristoylation ; protein kinases ; proteins
    Language English
    Size p. 120-128.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 632513-0
    ISSN 1521-4028 ; 0233-111X
    ISSN (online) 1521-4028
    ISSN 0233-111X
    DOI 10.1002/jobm.201000184
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