Artikel ; Online: Molecular epidemiology and mechanisms of carbapenem and colistin resistance in Klebsiella and other Enterobacterales from treated wastewater in Croatia.
2024 Band 185, Seite(n) 108554
Abstract: Among the most problematic bacteria with clinical relevance are the carbapenem-resistant Enterobacterales (CRE), as there are very limited options for their treatment. Treated wastewater can be a route for the release of these bacteria into the ... ...
| Abstract | Among the most problematic bacteria with clinical relevance are the carbapenem-resistant Enterobacterales (CRE), as there are very limited options for their treatment. Treated wastewater can be a route for the release of these bacteria into the environment and the population. The aim of this study was to isolate CRE from treated wastewater from the Zagreb wastewater treatment plant and to determine their phenotypic and genomic characteristics. A total of 200 suspected CRE were isolated, 148 of which were confirmed as Enterobacterales by MALDI-TOF MS. The predominant species was Klebsiella spp. (n = 47), followed by Citrobacter spp. (n = 40) and Enterobacter cloacae complex (cplx.) (n = 35). All 148 isolates were carbapenemase producers with a multidrug-resistant phenotype. Using multi-locus sequence typing and whole-genome sequencing (WGS), 18 different sequence types were identified among these isolates, 14 of which were associated with human-associated clones. The virulence gene analysis of the sequenced Klebsiella isolates (n = 7) revealed their potential pathogenicity. PCR and WGS showed that the most frequent carbapenemase genes in K. pneumoniae were bla |
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| Mesh-Begriff(e) | Humans ; Colistin/pharmacology ; Carbapenems/pharmacology ; Wastewater ; Klebsiella/genetics ; Molecular Epidemiology ; Multilocus Sequence Typing ; Croatia ; Anti-Bacterial Agents/pharmacology ; beta-Lactamases/genetics ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests |
| Chemische Substanzen | Colistin (Z67X93HJG1) ; Carbapenems ; Wastewater ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-03-11 |
| Erscheinungsland | Netherlands |
| Dokumenttyp | Journal Article |
| ZDB-ID | 554791-x |
| ISSN | 1873-6750 ; 0160-4120 |
| ISSN (online) | 1873-6750 |
| ISSN | 0160-4120 |
| DOI | 10.1016/j.envint.2024.108554 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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