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  1. Article ; Online: Monitoring the Covid-19 epidemics in Italy from mortality data

    del Re, D. / Meridiani, P.

    Abstract: The mortality data can be used as an alternative source to monitor the status of Covid-19. We have studied a dataset including deaths up to the fourth week of April. There is a large excess, more pronounced at the beginning of the pandemic, showing a ... ...

    Abstract The mortality data can be used as an alternative source to monitor the status of Covid-19. We have studied a dataset including deaths up to the fourth week of April. There is a large excess, more pronounced at the beginning of the pandemic, showing a difference in age and gender compared to the Covid-19-confirmed cases. The study indicates that mortality information can be used to provide a less biased time profile of the pandemic.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.05.07.20092775
    Database COVID19

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  2. Article ; Online: The spread in time and space of COVID-19 pandemic waves: the Italian experience from mortality data analyses.

    Del Re, Daniele / Palla, Luigi / Meridiani, Paolo / Soffi, Livia / Loiudice, Michele Tancredi / Antinozzi, Martina / Cattaruzza, Maria Sofia

    Frontiers in public health

    2024  Volume 12, Page(s) 1324033

    Abstract: Introduction: Italy was the first European country affected by COVID-19. Thanks to governmental containment measures (9 March 2020), the spread of COVID-19 was limited. However, in this context, accurate data assessment is crucial and mortality is a ... ...

    Abstract Introduction: Italy was the first European country affected by COVID-19. Thanks to governmental containment measures (9 March 2020), the spread of COVID-19 was limited. However, in this context, accurate data assessment is crucial and mortality is a more reliable indicator of the virus spread compared to the count of positive cases. This study aimed to retrospectively evaluate the impact of the pandemic in different areas of Italy using the time series analysis of official deaths and excess COVID-19 deaths.
    Methods: Mortality data (23 February-30 April 2022) by Istituto Nazionale di Statistica (ISTAT) were analyzed, including four waves of COVID-19. Previous mortality data (January 2015-November 2019) were used to estimate a Poisson regression model of the pre-pandemic mortality pattern and derive the excess COVID-19 deaths as the difference between the actual deaths number and the extrapolation of the previous mortality pattern to the pandemic period, separately for Northern, Central, and Southern Italy, to compare the impact of mortality across time periods and geographical areas.
    Results: Estimated excess compared with official COVID-19 mortality shows that, during the first wave, there was an underestimation of deaths. COVID-19 mortality rate almost doubled the official rate in the North (1.60‰ vs. 0.86‰) and nearly tripled it in the South (0.22‰ vs. 0.08‰). In late 2020-early 2021, official and estimated mortality curves are closer, displaying just a small gap at the start of the second wave. During the fourth wave (end of 2021-early 2022), Northern and Central Italy show reasonable agreement; the South presents a large relative underestimation of deaths (+90% increase), with a large increase in its excess deaths national quota, 9% in the first wave to 42% in the fourth.
    Discussion: The results provide a measure of the COVID-19 excess deaths and an unbiased estimate of Italian mortality rates. In the first wave, the gap between official COVID-19 and excess mortality was particularly high and lockdown measures may have reduced the spread of the infection. In the fourth wave, the gap for the South increases again, probably because the healthcare system may not have coped with the prolonged pressure of the pandemic, or for a decreased compliance with the official paper-based mortality surveillance system that could be overcome in the future by digitalizing the process.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Retrospective Studies ; Communicable Disease Control ; Italy/epidemiology
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1324033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Monitoring the Covid-19 epidemics in Italy from mortality data

    del Re, Daniele / Meridiani, Paolo

    medRxiv

    Abstract: The mortality data can be used as an alternative source to monitor the status of Covid-19. We have studied a dataset including deaths up to the fourth week of April. There is a large excess, more pronounced at the beginning of the pandemic, showing a ... ...

    Abstract The mortality data can be used as an alternative source to monitor the status of Covid-19. We have studied a dataset including deaths up to the fourth week of April. There is a large excess, more pronounced at the beginning of the pandemic, showing a difference in age and gender compared to the Covid-19-confirmed cases. The study indicates that mortality information can be used to provide a less biased time profile of the pandemic.
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.05.07.20092775
    Database COVID19

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  4. Article ; Online: Injectable Peptide Hydrogels Loaded with Murine Embryonic Stem Cells Relieve Ischemia

    Roy, Abhishek / Hao, Lei / Francisco, Jamie / Guan, Jin / Mareedu, Satvik / Zhai, Peiyong / Dodd-O, Joseph / Heffernan, Corey / Del Re, Dominic / Lee, Eun Jung A / Kumar, Vivek A

    Biomacromolecules

    2024  Volume 25, Issue 2, Page(s) 1319–1329

    Abstract: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, especially in aging and metabolically unhealthy populations. A major target of regenerative tissue engineering is the restoration of viable cardiomyocytes to preserve ... ...

    Abstract Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide, especially in aging and metabolically unhealthy populations. A major target of regenerative tissue engineering is the restoration of viable cardiomyocytes to preserve cardiac function and circumvent the progression to heart failure post-MI. Amelioration of ischemia is a crucial component of such restorative strategies. Angiogenic β-sheet peptides can self-assemble into thixotropic nanofibrous hydrogels. These syringe aspiratable cytocompatible gels were loaded with stem cells and showed excellent cytocompatibility and minimal impact on the storage and loss moduli of hydrogels. Gels with and without cells were delivered into the myocardium of a mouse MI model (LAD ligation). Cardiac function and tissue remodeling were evaluated up to 4 weeks
    MeSH term(s) Mice ; Animals ; Hydrogels/pharmacology ; Myocardial Infarction/therapy ; Myocardium ; Peptides/pharmacology ; Embryonic Stem Cells
    Chemical Substances Hydrogels ; Peptides
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.

    Shao, Dan / Zhai, Peiyong / Hu, Chengchen / Mukai, Risa / Sciarretta, Sebastiano / Del Re, Dominic / Sadoshima, Junichi

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 23469

    Abstract: The Hippo pathway plays a wide variety of roles in response to stress in the heart. Lats2, a component of the Hippo pathway, is phosphorylated by Mst1/2 and, in turn, phosphorylates YAP, causing inactivation of YAP. Lats2 stimulates apoptosis and ... ...

    Abstract The Hippo pathway plays a wide variety of roles in response to stress in the heart. Lats2, a component of the Hippo pathway, is phosphorylated by Mst1/2 and, in turn, phosphorylates YAP, causing inactivation of YAP. Lats2 stimulates apoptosis and negatively affects hypertrophy in cardiomyocytes. However, the role of Lats2 during cardiac stress is poorly understood in vivo. Lats2 is activated in the mouse heart in response to transverse aortic constriction (TAC). We used systemic Lats2 +/- mice to elucidate the role of endogenous Lats2. Cardiac hypertrophy and dysfunction induced by 4 weeks of TAC were attenuated in Lats2 +/- mice, and interstitial fibrosis and apoptosis were suppressed. Although TAC upregulated the Bcl-2 family proapoptotic (Bax and Bak) and anti-apoptotic (Bcl-2 and Bcl-xL) molecules in non-transgenic mice, TAC-induced upregulation of Bax and Bak was alleviated and that of Bcl-2 was enhanced in Lats2 +/- mice. TAC upregulated p53, but this upregulation was abolished in Lats2 +/- mice. Lats2-induced increases in apoptosis and decreases in survival in cardiomyocytes were inhibited by Pifithrin-α, a p53 inhibitor, suggesting that Lats2 stimulates apoptosis via a p53-dependent mechanism. In summary, Lats2 is activated by pressure overload, thereby promoting heart failure by stimulating p53-dependent mechanisms of cell death.
    MeSH term(s) Animals ; Apoptosis/physiology ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Female ; Heart Failure/metabolism ; Heart Failure/pathology ; Hippo Signaling Pathway/physiology ; Male ; Mice ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Phosphorylation/physiology ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Wistar ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Proteins/metabolism ; Up-Regulation/physiology
    Chemical Substances Proto-Oncogene Proteins c-bcl-2 ; Trp53 protein, mouse ; Tumor Suppressor Protein p53 ; Tumor Suppressor Proteins ; LATS2 protein, mouse (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-02846-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A screening and treatment programme to deal with perinatal anxiety and depression during the COVID-19 pandemic.

    Camoni, Laura / Mirabella, Fiorino / Palumbo, Gabriella / Del Re, Debora / Gigantesco, Antonella / Calamandrei, Gemma / Barbano, Gina / Cattaneo, Marina / Brescianini, Sonia

    Epidemiologia e prevenzione

    2021  Volume 44, Issue 5-6 Suppl 2, Page(s) 369–373

    Abstract: During a pandemic, pregnancy and the postnatal period are complicated by multiple factors. On the one hand, worries about one's own health and the health of loved ones, in particular of the newborn child, can increase the risk of some mental disorders, ... ...

    Title translation Indicazioni di un programma di screening e trattamento per la gestione dell’ansia e della depressione perinatale nell’emergenza e post-emergenza COVID-19.
    Abstract During a pandemic, pregnancy and the postnatal period are complicated by multiple factors. On the one hand, worries about one's own health and the health of loved ones, in particular of the newborn child, can increase the risk of some mental disorders, such as depression and anxiety in the pregnant woman. On the other hand, as happened for the COVID-19 epidemic in Italy, given the need for physical distancing, the maintenance of the social and family network, so important for new parents in the perinatal period, is lacking. In addition, health services are forced to reorganize their offerings to ensure maximum safety for their operators and patients. This work proposes a model of screening and treatment aimed at identifying women at risk and providing them with effective and safe treatment.
    MeSH term(s) Adult ; Anxiety/diagnosis ; Anxiety/epidemiology ; COVID-19/epidemiology ; COVID-19/psychology ; Depression/diagnosis ; Depression/etiology ; Depression/therapy ; Depression, Postpartum/diagnosis ; Depression, Postpartum/epidemiology ; Depression, Postpartum/psychology ; Depression, Postpartum/therapy ; Diagnostic Self Evaluation ; Empowerment ; Evidence-Based Medicine ; Female ; Follow-Up Studies ; Humans ; Italy/epidemiology ; Mass Screening/organization & administration ; Pandemics ; Perinatal Care/methods ; Perinatal Care/organization & administration ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/epidemiology ; Pregnancy Complications/psychology ; Pregnancy Complications/therapy ; Pregnant Women/psychology ; Program Evaluation ; Puerperal Disorders/diagnosis ; Puerperal Disorders/epidemiology ; Puerperal Disorders/psychology ; Puerperal Disorders/therapy ; Risk Factors ; SARS-CoV-2 ; Stress, Psychological/epidemiology ; Stress, Psychological/etiology ; Stress, Psychological/psychology ; Telemedicine
    Language English
    Publishing date 2021-01-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1038112-0
    ISSN 1120-9763
    ISSN 1120-9763
    DOI 10.19191/EP20.5-6.S2.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An international study of middle school students' preferences about digital interactive education activities for promoting psychological well-being and mental health.

    Gigantesco, Antonella / Palumbo, Gabriella / Zadworna-Cieślak, Magdalena / Cascavilla, Isabella / Del Re, Debora / Kossakowska, Karolina

    Annali dell'Istituto superiore di sanita

    2019  Volume 55, Issue 2, Page(s) 108–117

    Abstract: Introduction: The present study investigated students' preferences about technology tools and digital education activities to be used in classroom to facilitate the implementation of a mental health promotion program.: Method: Students' preferences ... ...

    Abstract Introduction: The present study investigated students' preferences about technology tools and digital education activities to be used in classroom to facilitate the implementation of a mental health promotion program.
    Method: Students' preferences have been elicited during one session focus group lasting 60 minutes. Overall, 26 focus groups, facilitated by 33 teachers, were organized in 9 schools of five European countries. Overall, 283 students who attended the first, second and third year of middle school (aged 10-15 years) volunteered to participate in the focus groups.
    Results: The majority of preferences indicated smartphone to communicate or to get information and tablet for a better use in classroom. Collaborative games have been considered as more useful and beneficial compared to the other digital educational activities proposed.
    Conclusions: Teachers require further insight into the pedagogical role of ICT and training. There is a need to encourage them to provide opportunities to allow students to use technology to solve problems or develop abilities for a better socio-emotional functioning and, ultimately, mental health.
    MeSH term(s) Adolescent ; Audiovisual Aids ; Child ; Computers, Handheld ; Consumer Behavior ; Europe ; Female ; Focus Groups ; Health Promotion/methods ; Humans ; Male ; Mental Health/education ; Multimedia ; Psychology, Adolescent ; Psychology, Child ; Smartphone ; Students/psychology
    Language English
    Publishing date 2019-08-27
    Publishing country Italy
    Document type Journal Article ; Multicenter Study
    ZDB-ID 950344-4
    ISSN 2384-8553 ; 0021-2571
    ISSN (online) 2384-8553
    ISSN 0021-2571
    DOI 10.4415/ANN_19_02_02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effects of macrophages on cardiomyocyte calcium-handling function using in vitro culture models.

    Hitscherich, Pamela G / Xie, Lai-Hua / Del Re, Dominic / Lee, Eun Jung

    Physiological reports

    2019  Volume 7, Issue 13, Page(s) e14137

    Abstract: Following myocardial infarction (MI), myocardial inflammation plays a crucial role in the pathogenesis of MI injury and macrophages are among the key cells activated during the initial phases of the host response regulating the healing process. While ... ...

    Abstract Following myocardial infarction (MI), myocardial inflammation plays a crucial role in the pathogenesis of MI injury and macrophages are among the key cells activated during the initial phases of the host response regulating the healing process. While macrophages have emerged as attractive effectors in tissue injury and repair, the contribution of macrophages on cardiac cell function and survival is not fully understood due to complexity of the in vivo inflammatory microenvironment. Understanding the key cells involved and how they communicate with one another is of paramount importance for the development of effective clinical treatments. Here, novel in vitro myocardial inflammation models were developed to examine how both direct and indirect interactions with polarized macrophage subsets present in the post-MI microenvironment affect cardiomyocyte function. The indirect model using conditioned medium from polarized macrophage subsets allowed examination of the effects of macrophage-derived factors on stem cell-derived cardiomyocyte function for up to 3 days. The results from the indirect model demonstrated that pro-inflammatory macrophage-derived factors led to a significant downregulation of cardiac troponin T (cTnT) and sarcoplasmic/endoplasmic reticulum calcium ATPase (Serca2) gene expression. It also demonstrated that inhibition of macrophage-secreted matricellular protein, osteopontin (OPN), led to a significant decrease in cardiomyocyte store-operated calcium entry (SOCE). In the direct model, stem cell-derived cardiomyocytes were co-cultured with polarized macrophage subsets for up to 3 days. It was demonstrated that anti-inflammatory macrophages significantly increased cardiomyocyte Ca
    MeSH term(s) Animals ; Calcium Signaling ; Cellular Microenvironment ; Coculture Techniques ; Culture Media, Conditioned/pharmacology ; Mice ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Osteopontin/genetics ; Osteopontin/metabolism ; RAW 264.7 Cells ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Troponin I/genetics ; Troponin I/metabolism
    Chemical Substances Culture Media, Conditioned ; Troponin I ; Osteopontin (106441-73-0) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8)
    Language English
    Publishing date 2019-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Feasibility and effectiveness of the Australian perinatal mental health approach in the Italian health services: progress and challenges.

    Camoni, Laura / Mirabella, Fiorino / La Sala, Liliana / Romano, Giovanna / Barbano, Gina / Cattaneo, Marina / Cena, Loredana / Michielin, Paolo / Ialenti, Valentina / Veltro, Franco / Cascavilla, Isabella / Del Re, Debora / Palumbo, Gabriella / Gigantesco, Antonella

    Annali dell'Istituto superiore di sanita

    2021  Volume 57, Issue 1, Page(s) 51–56

    Abstract: The perinatal depression is one of the leading pathologies in the world causing disabilities and represents an important public health problem. Since 2003, the Center for Behavioral Sciences and Mental Health (Istituto Superiore di Sanità - ISS) has ... ...

    Abstract The perinatal depression is one of the leading pathologies in the world causing disabilities and represents an important public health problem. Since 2003, the Center for Behavioral Sciences and Mental Health (Istituto Superiore di Sanità - ISS) has promoted studies and research on the mental health of women, children, partners and family in the perinatal period, leading to the realization of a structured program adopted in many Italian services. In this article, we describe the feasibility and effectiveness of the perinatal mental health approach in Italian health services and discuss the progress and new challenges.
    MeSH term(s) Anxiety/diagnosis ; Anxiety/therapy ; Australia ; Depression/diagnosis ; Depression/therapy ; Depression, Postpartum/diagnosis ; Depression, Postpartum/therapy ; Feasibility Studies ; Female ; Health Services ; Humans ; Italy ; Mental Health ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/therapy ; Puerperal Disorders/diagnostic imaging ; Puerperal Disorders/therapy ; Treatment Outcome
    Language English
    Publishing date 2021-04-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 950344-4
    ISSN 2384-8553 ; 0021-2571
    ISSN (online) 2384-8553
    ISSN 0021-2571
    DOI 10.4415/ANN_21_01_08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A structured program for perinatal depression and anxiety to be adopted in the emergencies.

    Camoni, Laura / Brescianini, Sonia / Mirabella, Fiorino / Calamandrei, Gemma / Barbano, Gina / Cattaneo, Marina / Del Re, Debora / Michielin, Paolo / Palumbo, Gabriella / Gigantesco, Antonella

    Annali dell'Istituto superiore di sanita

    2021  Volume 57, Issue 1, Page(s) 67–71

    Abstract: Quarantine, loss of routine and social support can negatively impact mothers who have just given birth and their babies, generating concerns and reactions of intense fear. Following the COVID-19 emergency, we described a structured program for screening ... ...

    Abstract Quarantine, loss of routine and social support can negatively impact mothers who have just given birth and their babies, generating concerns and reactions of intense fear. Following the COVID-19 emergency, we described a structured program for screening and treatment of perinatal depression and anxiety as a medium for constant monitoring of perinatal risk factors and early screening, which can also be implemented in emergencies with remote intervention methods, to offer women an appropriate, timely and effective treatment. In this scenario, it is desirable that the monitoring of the psychological well-being of women in postpartum is maintained over time, with the participation of all the professional figures with whom the woman comes into contact, to intercept any forms of psychological distress related to the epidemic and that could occur even after some time.
    MeSH term(s) Anxiety/prevention & control ; COVID-19 ; Depression/prevention & control ; Depression, Postpartum/prevention & control ; Emergencies ; Female ; Humans ; Pregnancy ; Pregnancy Complications/prevention & control ; Pregnancy Complications/psychology
    Language English
    Publishing date 2021-04-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 950344-4
    ISSN 2384-8553 ; 0021-2571
    ISSN (online) 2384-8553
    ISSN 0021-2571
    DOI 10.4415/ANN_21_01_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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