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  1. Article ; Online: Acceptability of Sexual Violence Against Women In Spain: Demographic, Behavioral, and Attitudinal Correlates.

    Sirvent Garcia Del Valle, Elena

    Violence against women

    2019  Volume 26, Issue 10, Page(s) 1080–1100

    Abstract: Most research on the social perception of sexual violence is based on samples of university students, while it is rare to find studies with representative samples, despite the vital importance of this information in planning prevention strategies. ... ...

    Abstract Most research on the social perception of sexual violence is based on samples of university students, while it is rare to find studies with representative samples, despite the vital importance of this information in planning prevention strategies. Furthermore, in Europe, the social perception of sexual violence has been explored very marginally. Our main objective with this study was to explore, by means of a representative sample of the general population (
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Attitude ; Crime Victims/psychology ; Demography ; Female ; Humans ; Male ; Middle Aged ; Rape/psychology ; Sex Offenses/psychology ; Sex Work/psychology ; Sexism/psychology ; Sexual Behavior ; Social Perception ; Spain ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2019-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2031375-5
    ISSN 1552-8448 ; 1077-8012
    ISSN (online) 1552-8448
    ISSN 1077-8012
    DOI 10.1177/1077801219854536
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  2. Article ; Online: Heteromers Formed by GPR55 and Either Cannabinoid CB

    Menéndez-Pérez, Carlota / Rivas-Santisteban, Rafael / Del Valle, Eva / Tolivia, Jorge / Navarro, Ana / Franco, Rafael / Martínez-Pinilla, Eva

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Multiple sclerosis (MS) is an autoimmune, inflammatory, and neurodegenerative disease of the central nervous system for which there is no cure, making it necessary to search for new treatments. The endocannabinoid system (ECS) plays a very important ... ...

    Abstract Multiple sclerosis (MS) is an autoimmune, inflammatory, and neurodegenerative disease of the central nervous system for which there is no cure, making it necessary to search for new treatments. The endocannabinoid system (ECS) plays a very important neuromodulatory role in the CNS. In recent years, the formation of heteromers containing cannabinoid receptors and their up/downregulation in some neurodegenerative diseases have been demonstrated. Despite the beneficial effects shown by some phytocannabinoids in MS, the role of the ECS in its pathophysiology is unknown. The main objective of this work was to identify heteromers of cell surface proteins receptive to cannabinoids, namely GPR55, CB
    MeSH term(s) Humans ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Prefrontal Cortex/metabolism ; Receptors, Cannabinoid/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Receptor, Cannabinoid, CB1/metabolism ; Male ; Adult ; Female ; Receptors, G-Protein-Coupled/metabolism ; Middle Aged ; Up-Regulation ; Protein Multimerization
    Chemical Substances Receptors, Cannabinoid ; Receptor, Cannabinoid, CB2 ; GPR55 protein, human ; Receptor, Cannabinoid, CB1 ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084176
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  3. Article ; Online: Apolipoprotein D as a Potential Biomarker in Neuropsychiatric Disorders.

    Del Valle, Eva / Rubio-Sardón, Nuria / Menéndez-Pérez, Carlota / Martínez-Pinilla, Eva / Navarro, Ana

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Neuropsychiatric disorders (NDs) are a diverse group of pathologies, including schizophrenia or bipolar disorders, that directly affect the mental and physical health of those who suffer from them, with an incidence that is increasing worldwide. Most NDs ...

    Abstract Neuropsychiatric disorders (NDs) are a diverse group of pathologies, including schizophrenia or bipolar disorders, that directly affect the mental and physical health of those who suffer from them, with an incidence that is increasing worldwide. Most NDs result from a complex interaction of multiple genes and environmental factors such as stress or traumatic events, including the recent Coronavirus Disease (COVID-19) pandemic. In addition to diverse clinical presentations, these diseases are heterogeneous in their pathogenesis, brain regions affected, and clinical symptoms, making diagnosis difficult. Therefore, finding new biomarkers is essential for the detection, prognosis, response prediction, and development of new treatments for NDs. Among the most promising candidates is the apolipoprotein D (Apo D), a component of lipoproteins implicated in lipid metabolism. Evidence suggests an increase in Apo D expression in association with aging and in the presence of neuropathological processes. As a part of the cellular neuroprotective defense machinery against oxidative stress and inflammation, changes in Apo D levels have been demonstrated in neuropsychiatric conditions like schizophrenia (SZ) or bipolar disorders (BPD), not only in some brain areas but in corporal fluids, i.e., blood or serum of patients. What is not clear is whether variation in Apo D quantity could be used as an indicator to detect NDs and their progression. This review aims to provide an updated view of the clinical potential of Apo D as a possible biomarker for NDs.
    MeSH term(s) Humans ; Aging/metabolism ; Apolipoproteins D/metabolism ; Biomarkers/metabolism ; Lipoproteins/metabolism ; Oxidative Stress ; Mental Disorders/diagnosis
    Chemical Substances Apolipoproteins D ; Biomarkers ; Lipoproteins
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115631
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  4. Article: Nature-Inspired Nanoparticles as Paclitaxel Targeted Carrier for the Treatment of HER2-Positive Breast Cancer.

    Nieto, Celia / Vega, Milena A / Martín Del Valle, Eva

    Cancers

    2021  Volume 13, Issue 11

    Abstract: Despite the advances made in the fight against HER2-positive breast cancer, the need for less toxic therapies and strategies that avoid the apparition of resistances is indisputable. For this reason, a targeted nanovehicle for paclitaxel and trastuzumab, ...

    Abstract Despite the advances made in the fight against HER2-positive breast cancer, the need for less toxic therapies and strategies that avoid the apparition of resistances is indisputable. For this reason, a targeted nanovehicle for paclitaxel and trastuzumab, used in the first-line treatment of this subtype of breast cancer, had already been developed in a previous study. It yielded good results in vitro but, with the aim of further reducing paclitaxel effective dose and its side effects, a novel drug delivery system was prepared in this work. Thus, polydopamine nanoparticles, which are gaining popularity in cancer nanomedicine, were novelty loaded with paclitaxel and trastuzumab. The effectiveness and selectivity of the nanoparticles obtained were validated in vitro with different HER2-overexpressing tumor and stromal cell lines. These nanoparticles showed more remarkable antitumor activity than the nanosystem previously designed and, in addition, to affect stromal cell viability rate less than the parent drug. Moreover, loaded polydopamine nanoparticles, which notably increased the number of apoptotic HER2-positive breast cancer cells after treatment, also maintained an efficient antineoplastic effect when validated in tumor spheroids. Thereby, these bioinspired nanoparticles charged with both trastuzumab and paclitaxel may represent an excellent approach to improve current HER2-positive breast cancer therapies.
    Language English
    Publishing date 2021-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13112526
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  5. Article ; Online: Genetic identification and subsequent LC-QTOF MS analysis of plant remains (Oenanthe spp.) could prove the cause of an undetermined sudden death.

    Martínez, Pilar / Quintela, Oscar / Del Valle, Eulalia / Pérez-Gómez, Belén

    International journal of legal medicine

    2021  Volume 135, Issue 4, Page(s) 1407–1411

    Abstract: In recent years, recorded cases related to forensic botany and, in particular, of plant poisoning have become rare. We report on the medicolegal characteristics of an undetermined sudden death (USD) of a woman in which scene there were remnants of a ... ...

    Abstract In recent years, recorded cases related to forensic botany and, in particular, of plant poisoning have become rare. We report on the medicolegal characteristics of an undetermined sudden death (USD) of a woman in which scene there were remnants of a vegetal peeling. After the autopsy, macroscopic findings reported multiorgan failure and requested the investigation of the cause of death. Postmortem blood was firstly investigated on cyanide toxicity presumptively coming from a yucca-like root; however, found cyanide levels were under normality. Because of the lack of morphological features of the encountered plant remains, a genetic nrDNA ITS2 sequence investigation was followed. The resulting DNA sequence could identify the evidence as the water dropwort (Oenanthe spp.) which contains oenanthotoxin, a potent toxin that may be fatal, similar to the more commonly found in hemlock Conium or cowbane Cicuta species. A liquid chromatography-tandem high resolution mass spectrometry (LC-QTOF MS) was later applied to analyse the vegetal extract and stomach content and successfully confirmed the toxin existence. Medicolegal and analytical findings at the forensic laboratory were described, where both biological and chemical techniques could successfully conjugate, as an interdisciplinary research, and explain premortem symptoms and postmortem findings. Present data can be helpful in future investigation on poisoning cases by conjugated polyacetylenes . The present work tries to emphasize the often undervalued plant evidence in legal medicine diagnosis in the context of an unexplained death.
    MeSH term(s) Aged, 80 and over ; Chromatography, Liquid ; DNA Barcoding, Taxonomic ; Death, Sudden/etiology ; Enediynes/poisoning ; Fatty Alcohols/poisoning ; Female ; Forensic Genetics ; Forensic Toxicology ; Humans ; Oenanthe/poisoning ; Plant Poisoning ; Tandem Mass Spectrometry
    Chemical Substances Enediynes ; Fatty Alcohols ; enanthotoxin (4GD5A2RG2N)
    Language English
    Publishing date 2021-01-27
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 1055109-8
    ISSN 1437-1596 ; 0937-9827
    ISSN (online) 1437-1596
    ISSN 0937-9827
    DOI 10.1007/s00414-020-02488-6
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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.312: Show issues Location:
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  6. Article: Post-Chemoradiation Metastatic, Persistent and Resistant Nodes in Locally Advanced Rectal Cancer: Metrics and Their Impact on Long-Term Outcome.

    Calvo, Felipe A / Tudela, María / Serrano, Javier / Muñoz-Fernández, Mercedes / Peligros, María Isabel / Garcia-Alfonso, Pilar / Del Valle, Emilio

    Cancers

    2023  Volume 15, Issue 18

    Abstract: Background: The purpose of this study was to evaluate the long-term oncological progression pattern of locally advanced rectal cancer patients with post-neoadjuvant nodal metastatic disease (ypN+) and correlate potential prognostic features associated ... ...

    Abstract Background: The purpose of this study was to evaluate the long-term oncological progression pattern of locally advanced rectal cancer patients with post-neoadjuvant nodal metastatic disease (ypN+) and correlate potential prognostic features associated with proven radiochemoresistant nodal biology.
    Methods: Individual patient data (100 variables) from a 20-year consecutive single-institution multidisciplinary experience (1995-2015), delivering multimodal therapy to rectal cancer patient candidates for radical treatment, including a neoadjuvant component and surgical resection with or without intraoperative radiotherapy followed by optional adjuvant chemotherapy. The ypN+ disease data was registered in the context of initial staging categories post-neoadjuvant T status (ypT).
    Results: Data on 487 patients showed histologically confirmed diagnoses of metastatic nodal disease in 108 specimens (ypN+, 22.1). There was a significant age difference (
    Conclusions: The presence of nodal metastases (ypN+) after neoadjuvant therapy containing long-course pelvic irradiation severely impacts the long-term outcome for patients with locally advanced rectal cancer and correlates with multiple clinical and therapeutic variable metrics. Implementation of local and systemic therapies should be adapted and intensified in relation to the finding of ypN+ category in surgical specimens.
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15184591
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  7. Article ; Online: Supercritical impregnation of starch aerogels with quercetin: Fungistatic effect and release modelling with a compartmental model.

    Mottola, Stefania / Iannone, Giovanna / Giordano, Maria / González-Garcinuño, Álvaro / Jiménez, Alejandro / Tabernero, Antonio / Martín Del Valle, Eva / De Marco, Iolanda

    International journal of biological macromolecules

    2023  Volume 253, Issue Pt 6, Page(s) 127406

    Abstract: This work proposes the use of supercritical ... ...

    Abstract This work proposes the use of supercritical CO
    MeSH term(s) Starch/chemistry ; Drug Carriers/chemistry ; Amylose ; Quercetin ; Amylopectin ; Epidemiological Models ; Carbon Dioxide ; Hydrogels
    Chemical Substances Starch (9005-25-8) ; Drug Carriers ; Amylose (9005-82-7) ; Quercetin (9IKM0I5T1E) ; Amylopectin (9037-22-3) ; Carbon Dioxide (142M471B3J) ; Hydrogels
    Language English
    Publishing date 2023-10-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127406
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  8. Article: Recycling of Waste Toner Powder as Adsorbent to Remove Aqueous Heavy Metals.

    Fernández, Begoña / Ayala, Julia / Del Valle, Elena / Martínez-Blanco, David / Castañón, Ana María / Menéndez-Aguado, Juan M

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 12

    Abstract: The removal of ... ...

    Abstract The removal of Cd
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15124150
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  9. Article ; Online: Validation of a compartmental model to predict drug release from porous structures produced by ScCO

    González-Garcinuño, Álvaro / Baldino, Lucia / Tabernero, Antonio / Guastaferro, Mariangela / Cardea, Stefano / Reverchon, Ernesto / Martín Del Valle, Eva

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

    2022  Volume 180, Page(s) 106325

    Abstract: A global release model is proposed to study the drug release from porous materials for pharmaceutical applications. This model is defined by implementing a compartmental model where the release profile could be explained as the combination of mass ... ...

    Abstract A global release model is proposed to study the drug release from porous materials for pharmaceutical applications. This model is defined by implementing a compartmental model where the release profile could be explained as the combination of mass transfer phenomena through three compartments as well as a desorption process or dissolution process from the support. This model was validated with five different systems produced with supercritical CO
    Language English
    Publishing date 2022-11-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1154366-8
    ISSN 1879-0720 ; 0928-0987
    ISSN (online) 1879-0720
    ISSN 0928-0987
    DOI 10.1016/j.ejps.2022.106325
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Quasichiral Interactions between Quantum Emitters at the Nanoscale.

    Downing, C A / Carreño, J C López / Laussy, F P / Del Valle, E / Fernández-Domínguez, A I

    Physical review letters

    2019  Volume 122, Issue 5, Page(s) 57401

    Abstract: We present a combined classical and quantum electrodynamics description of the coupling between two circularly polarized quantum emitters held above a metal surface supporting surface plasmons. Depending on their position and their natural frequency, the ...

    Abstract We present a combined classical and quantum electrodynamics description of the coupling between two circularly polarized quantum emitters held above a metal surface supporting surface plasmons. Depending on their position and their natural frequency, the emitter-emitter interactions evolve from being reciprocal to nonreciprocal, which makes the system a highly tunable platform for chiral coupling at the nanoscale. By relaxing the stringent material and geometrical constraints for chirality, we explore the interplay between coherent and dissipative coupling mechanisms in the system. Thus, we reveal a quasichiral regime in which its quantum optical properties are governed by its subradiant state, giving rise to extremely sharp spectral features and strong photon correlations.
    Language English
    Publishing date 2019-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.057401
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    In stock of ZB MED Bonn / Germany

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