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  1. Article: The virulence factor regulator and quorum sensing regulate the type I-F CRISPR-Cas mediated horizontal gene transfer in

    Dela Ahator, Stephen / Liu, Yang / Wang, Jianhe / Zhang, Lian-Hui

    Frontiers in microbiology

    2022  Volume 13, Page(s) 987656

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.987656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in

    Fellner, Matthias / Walsh, Annabel / Dela Ahator, Stephen / Aftab, Nadia / Sutherland, Ben / Tan, Eng W / Bakker, Alexander T / Martin, Nathaniel I / van der Stelt, Mario / Lentz, Christian S

    ACS infectious diseases

    2023  Volume 9, Issue 11, Page(s) 2119–2132

    Abstract: The development of new treatment options for bacterial infections requires access to new targets for antibiotics and antivirulence strategies. Chemoproteomic approaches are powerful tools for profiling and identifying novel druggable target candidates, ... ...

    Abstract The development of new treatment options for bacterial infections requires access to new targets for antibiotics and antivirulence strategies. Chemoproteomic approaches are powerful tools for profiling and identifying novel druggable target candidates, but their functions often remain uncharacterized. Previously, we used activity-based protein profiling in the opportunistic pathogen
    MeSH term(s) Humans ; Staphylococcus aureus/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Fusidic Acid ; Endopeptidases/metabolism ; Staphylococcal Infections/microbiology
    Chemical Substances hydrolase H (EC 3.4.22.40) ; Anti-Bacterial Agents ; Fusidic Acid (59XE10C19C) ; Endopeptidases (EC 3.4.-)
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bacterial quorum-sensing signal IQS induces host cell apoptosis by targeting POT1-p53 signalling pathway.

    Wang, Jianhe / Wang, Chao / Yu, Hong-Bing / Dela Ahator, Stephen / Wu, Xiaoyan / Lv, Shumei / Zhang, Lian-Hui

    Cellular microbiology

    2019  Volume 21, Issue 10, Page(s) e13076

    Abstract: Pseudomonas aeruginosa, an opportunistic life-threatening human bacterial pathogen, employs quorum-sensing (QS) signal molecules to modulate virulence gene expression. 2-(2-hydroxyphenyl)-thiazole-4-carbaldehyde (IQS) is a recently identified QS signal ... ...

    Abstract Pseudomonas aeruginosa, an opportunistic life-threatening human bacterial pathogen, employs quorum-sensing (QS) signal molecules to modulate virulence gene expression. 2-(2-hydroxyphenyl)-thiazole-4-carbaldehyde (IQS) is a recently identified QS signal that integrates the canonical lasR-type QS of P. aeruginosa and host phosphate stress response to fine-tune its virulence production for a successful infection. To address the role of IQS in pathogen-host interaction, we here present that IQS inhibits host cell growth and stimulates apoptosis in a dosage-dependent manner. By downregulating the telomere-protecting protein POT1 in host cells, IQS activates CHK1, CHK2, and p53 in an Ataxia telangiectasia mutated (ATM)/ATM and RAD3-related (ATR)-dependent manner and induces DNA damage response. Overexpression of POT1 in host cells presents a resistance to IQS treatment. These results suggest a pivotal role of IQS in host apoptosis, highlighting the complexity of pathogenesis mechanisms developed by P. aeruginosa during infection.
    MeSH term(s) A549 Cells ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Bacterial Proteins/metabolism ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Checkpoint Kinase 1/genetics ; Checkpoint Kinase 1/metabolism ; Checkpoint Kinase 2/genetics ; Checkpoint Kinase 2/metabolism ; DNA Damage/drug effects ; DNA Damage/genetics ; Humans ; Mice ; Phenols/chemistry ; Phenols/pharmacology ; Proteolysis ; Pseudomonas Infections/genetics ; Pseudomonas Infections/metabolism ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/chemistry ; Pseudomonas aeruginosa/pathogenicity ; Quorum Sensing ; Telomere-Binding Proteins/genetics ; Telomere-Binding Proteins/metabolism ; Thiazoles/chemistry ; Thiazoles/pharmacology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Virulence/genetics
    Chemical Substances Bacterial Proteins ; POT1 protein, human ; Phenols ; Telomere-Binding Proteins ; Thiazoles ; Tumor Suppressor Protein p53 ; aeruginaldehyde ; Checkpoint Kinase 2 (EC 2.7.1.11) ; CHEK1 protein, human (EC 2.7.11.1) ; CHEK2 protein, human (EC 2.7.11.1) ; Checkpoint Kinase 1 (EC 2.7.11.1)
    Language English
    Publishing date 2019-07-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1468320-9
    ISSN 1462-5822 ; 1462-5814
    ISSN (online) 1462-5822
    ISSN 1462-5814
    DOI 10.1111/cmi.13076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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