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  1. AU="Delaflotte, Sylvie"
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  1. Article: Long-term treatment with standardized Ginkgo biloba Extract (EGb 761) attenuates cognitive deficits and hippocampal neuron loss in a gerbil model of vascular dementia

    Rocher, Marie-Noelle / Carré, Denis / Spinnewyn, Brigitte / Schulz, Jocelyne / Delaflotte, Sylvie / Pignol, Bernadette / Chabrier, Pierre-Etienne / Auguet, Michel

    Fitoterapia. 2011 Oct., v. 82, no. 7

    2011  

    Abstract: The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral ... ...

    Abstract The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral posttreatment with EGb 761 led to a significant recovery of spatial memory assessed by the object location test, inhibited the decrease in plasma SOD activity and protected the hippocampal CA1 neurons, even when administered after the insult. These data provide further evidence for the therapeutic potential of EGb 761 in the treatment of vascular dementia.
    Keywords Ginkgo biloba ; dementia ; gerbils ; memory ; models ; neurons ; oral administration ; superoxide dismutase
    Language English
    Dates of publication 2011-10
    Size p. 1075-1080.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2011.07.001
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3533: Show issues

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  2. Article ; Online: Long-term treatment with standardized Ginkgo biloba extract (EGb 761) attenuates cognitive deficits and hippocampal neuron loss in a gerbil model of vascular dementia.

    Rocher, Marie-Noelle / Carré, Denis / Spinnewyn, Brigitte / Schulz, Jocelyne / Delaflotte, Sylvie / Pignol, Bernadette / Chabrier, Pierre-Etienne / Auguet, Michel

    Fitoterapia

    2011  Volume 82, Issue 7, Page(s) 1075–1080

    Abstract: The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral ... ...

    Abstract The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral posttreatment with EGb 761 led to a significant recovery of spatial memory assessed by the object location test, inhibited the decrease in plasma SOD activity and protected the hippocampal CA1 neurons, even when administered after the insult. These data provide further evidence for the therapeutic potential of EGb 761 in the treatment of vascular dementia.
    MeSH term(s) Animals ; Brain Ischemia/blood ; Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Dementia, Vascular/blood ; Dementia, Vascular/drug therapy ; Dementia, Vascular/pathology ; Disease Models, Animal ; Gerbillinae ; Ginkgo biloba ; Hippocampus/drug effects ; Hippocampus/pathology ; Memory/drug effects ; Memory Disorders/blood ; Memory Disorders/drug therapy ; Nerve Degeneration/blood ; Nerve Degeneration/drug therapy ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Phytotherapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Superoxide Dismutase/blood
    Chemical Substances Neuroprotective Agents ; Plant Extracts ; Ginkgo biloba extract (19FUJ2C58T) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2011-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2011.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1873: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline.

    Cornet, Sylvie / Spinnewyn, Brigitte / Delaflotte, Sylvie / Charnet, Christelle / Roubert, Véronique / Favre, Christine / Hider, Hamida / Chabrier, P Etienne / Auguet, Michel

    European journal of pharmacology

    2004  Volume 505, Issue 1-3, Page(s) 111–119

    Abstract: Minocycline has been reported to exert neuroprotection through inhibition of inflammatory processes and of mitochondrial cell death pathway. To further characterize the neuroprotective effect of minocycline, we determined its efficacy in different ... ...

    Abstract Minocycline has been reported to exert neuroprotection through inhibition of inflammatory processes and of mitochondrial cell death pathway. To further characterize the neuroprotective effect of minocycline, we determined its efficacy in different neuronal damage paradigms involving inflammation or mitochondrial dysfunction. In transient global ischaemia in gerbils, minocycline reduced hippocampal neuronal damage measured by peripheral type benzodiazepine binding sites density, a marker of microglial activation. The antiinflammatory properties of minocycline were confirmed on the model of carrageenan-induced paw oedema in rats. The use of two experimental animal models involving administration of mitochondrial toxins inhibiting a different complex of the mitochondrial respiratory chain permitted the exploration of the mitochondrial impact of minocycline. Although minocycline exhibited a marked efficacy in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP; complex I inhibitor)-induced neurotoxicity in mice, it was ineffective in malonate (complex II inhibitor)-induced striatal lesion in rats. In vitro investigations on energized mitochondria isolated from rat liver showed that minocycline (1 microM) did not inhibit the swelling induced by MPP+(1-methyl-4-phenylpyridinium). Moreover, higher concentrations of minocycline induced swelling. From these experiments, the neuroprotective activity of minocycline appears more related to its antiinflammatory activity than to a direct beneficial action on mitochondria.
    MeSH term(s) Animals ; Binding, Competitive/drug effects ; Brain Ischemia/metabolism ; Brain Ischemia/prevention & control ; Carrageenan ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Dose-Response Relationship, Drug ; Edema/chemically induced ; Edema/prevention & control ; Gerbillinae ; Hindlimb ; Isoquinolines/metabolism ; MPTP Poisoning/metabolism ; MPTP Poisoning/prevention & control ; Male ; Malonates/pharmacology ; Mice ; Mice, Inbred C57BL ; Minocycline/pharmacology ; Mitochondrial Swelling/drug effects ; Neuroprotective Agents/pharmacology ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Tritium
    Chemical Substances Isoquinolines ; Malonates ; Neuroprotective Agents ; Tritium (10028-17-8) ; Carrageenan (9000-07-1) ; malonic acid (9KX7ZMG0MK) ; Minocycline (FYY3R43WGO) ; Dopamine (VTD58H1Z2X) ; PK 11195 (YNF83VN1RL)
    Language English
    Publishing date 2004-11-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2004.10.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Long-term treatment with standardized Ginkgo biloba Extract (EGb 761) attenuates cognitive deficits and hippocampal neuron loss in a gerbil model of vascular dementia

    Rocher, Marie-Noelle / Carré, Denis / Spinnewyn, Brigitte / Schulz, Jocelyne / Delaflotte, Sylvie / Pignol, Bernadette / Chabrier, Pierre-Etienne / Auguet, Michel

    Fitoterapia

    Volume v. 82,, Issue no. 7

    Abstract: The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral ... ...

    Abstract The standardized extract of Ginkgo biloba EGb 761 has been used to reduce cognitive dysfunction. The present study was designed to evaluate the effect of postischemic oral treatment with EGb 761 in a model of vascular dementia in gerbils. Daily oral posttreatment with EGb 761 led to a significant recovery of spatial memory assessed by the object location test, inhibited the decrease in plasma SOD activity and protected the hippocampal CA1 neurons, even when administered after the insult. These data provide further evidence for the therapeutic potential of EGb 761 in the treatment of vascular dementia.
    Keywords models ; Ginkgo biloba ; gerbils ; dementia ; neurons ; superoxide dismutase ; memory ; oral administration
    Language English
    Document type Article
    ISSN 0367-326X
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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