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  1. Article ; Online: Deep brain stimulation in the treatment of depression.

    Delaloye, Sibylle / Holtzheimer, Paul E

    Dialogues in clinical neuroscience

    2014  Volume 16, Issue 1, Page(s) 83–91

    Abstract: Major depressive disorder is a worldwide disease with debilitating effects on a patient's life. Common treatments include pharmacotherapy, psychotherapy, and electroconvulsive therapy. Many patients do not respond to these treatments; this has led to the ...

    Abstract Major depressive disorder is a worldwide disease with debilitating effects on a patient's life. Common treatments include pharmacotherapy, psychotherapy, and electroconvulsive therapy. Many patients do not respond to these treatments; this has led to the investigation of alternative therapeutic modalities. Deep brain stimulation (DBS) is one of these modalities. It was first used with success for treating movement disorders and has since been extended to the treatment of psychiatric disorders. Although DBS is still an emerging treatment, promising efficacy and safety have been demonstrated in preliminary trials in patients with treatment-resistant depression (TRD). Further, neuroimaging has played a pivotal role in identifying some DBS targets and remains an important tool for evaluating the mechanism of action of this novel intervention. Preclinical animal studies have broadened knowledge about the possible mechanisms of action of DBS for TRD, Given that DBS involves neurosurgery in patients with severe psychiatric impairment, ethical questions concerning capacity to consent arise; these issues must continue to be carefully considered.
    MeSH term(s) Animals ; Deep Brain Stimulation ; Depression/therapy ; Humans
    Language English
    Publishing date 2014-03-09
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2188781-0
    ISSN 1958-5969 ; 1294-8322
    ISSN (online) 1958-5969
    ISSN 1294-8322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of Left Versus Right Dorsolateral Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation on Affective Flexibility in Healthy Women: A Pilot Study.

    Lantrip, Crystal / Delaloye, Sibylle / Baird, Lauren / Dreyer-Oren, Sarah / Brady, Robert E / Roth, Robert M / Gunning, Faith / Holtzheimer, Paul

    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

    2019  Volume 32, Issue 2, Page(s) 69–75

    Abstract: Objective: To determine the antidepressant mechanism of action for repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) in healthy women. Our primary hypothesis was that a single session of left DLPFC ... ...

    Abstract Objective: To determine the antidepressant mechanism of action for repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) in healthy women. Our primary hypothesis was that a single session of left DLPFC rTMS, compared with a session of right DLPFC rTMS, would result in better (reduced) negative nonaffective switch costs in healthy women.
    Background: The antidepressant mechanism of action for rTMS is not clear. It is possible that rTMS to the DLPFC improves emotion regulation, which could be a part of its antidepressant mechanism.
    Methods: Twenty-five healthy women were randomized to receive left high-frequency (HF) rTMS versus right HF rTMS in one session and then contralateral stimulation during a second session. Emotion regulation was assessed via switch costs for reappraisal of negatively valenced information on an affective flexibility task.
    Results: For negative nonaffective switch costs, the interaction effect in the two-way ANOVA was not significant (F1,19=3.053, P=0.097). Given that left HF rTMS is the approved treatment for depression, post hoc t tests were completed with particular interest in the left-side findings. These tests confirmed that negative nonaffective switch costs significantly improved immediately after left rTMS (t1,19=2.664, P=0.015) but not right rTMS.
    Conclusions: These findings suggest that left DLPFC HF rTMS may lead to antidepressant effects by improving the regulation of emotion.
    MeSH term(s) Adult ; Affect/physiology ; Emotions/physiology ; Female ; Functional Laterality/physiology ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Photic Stimulation/methods ; Pilot Projects ; Prefrontal Cortex/physiology ; Transcranial Magnetic Stimulation/methods ; Young Adult
    Language English
    Publishing date 2019-06-17
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2108112-8
    ISSN 1543-3641 ; 1543-3633
    ISSN (online) 1543-3641
    ISSN 1543-3633
    DOI 10.1097/WNN.0000000000000190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2439: Show issues Location:
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  3. Article: Does the physical disector method provide an accurate estimation of sensory neuron number in rat dorsal root ganglia?

    Delaloye, Sibylle / Kraftsik, Rudolf / Kuntzer, Thierry / Barakat-Walter, Ibtissam

    Journal of neuroscience methods

    2009  Volume 176, Issue 2, Page(s) 290–297

    Abstract: The physical disector is a method of choice for estimating unbiased neuron numbers; nevertheless, calibration is needed to evaluate each counting method. The validity of this method can be assessed by comparing the estimated cell number with the true ... ...

    Abstract The physical disector is a method of choice for estimating unbiased neuron numbers; nevertheless, calibration is needed to evaluate each counting method. The validity of this method can be assessed by comparing the estimated cell number with the true number determined by a direct counting method in serial sections. We reconstructed a 1/5 of rat lumbar dorsal root ganglia taken from two experimental conditions. From each ganglion, images of 200 adjacent semi-thin sections were used to reconstruct a volumetric dataset (stack of voxels). On these stacks the number of sensory neurons was estimated and counted respectively by physical disector and direct counting methods. Also, using the coordinates of nuclei from the direct counting, we simulate, by a Matlab program, disector pairs separated by increasing distances in a ganglion model. The comparison between the results of these approaches clearly demonstrates that the physical disector method provides a valid and reliable estimate of the number of sensory neurons only when the distance between the consecutive disector pairs is 60 microm or smaller. In these conditions the size of error between the results of physical disector and direct counting does not exceed 6%. In contrast when the distance between two pairs is larger than 60 microm (70-200 microm) the size of error increases rapidly to 27%. We conclude that the physical dissector method provides a reliable estimate of the number of rat sensory neurons only when the separating distance between the consecutive dissector pairs is no larger than 60 microm.
    MeSH term(s) Animals ; Cell Count/methods ; Computer Simulation ; Dissection/methods ; Ganglia, Spinal/cytology ; Imaging, Three-Dimensional/methods ; Models, Neurological ; Rats ; Rats, Wistar ; Sensory Receptor Cells/cytology ; Sensory Receptor Cells/physiology
    Language English
    Publishing date 2009-01-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2008.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The importance of quality of life in patients with alcohol abuse and dependence.

    Ugochukwu, Chio / Bagot, Kara Simone / Delaloye, Sibylle / Pi, Sarah / Vien, Linda / Garvey, Tim / Bolotaulo, Nestor Ian / Kumar, Nishant / Ishak, Waguih William

    Harvard review of psychiatry

    2013  Volume 21, Issue 1, Page(s) 1–17

    Abstract: Learning objectives: After participating in this educational activity, the reader should be better able to identify the instruments that are currently being used to measure quality of life (QoL) in alcohol abuse and dependence; determine the impact of ... ...

    Abstract Learning objectives: After participating in this educational activity, the reader should be better able to identify the instruments that are currently being used to measure quality of life (QoL) in alcohol abuse and dependence; determine the impact of alcohol abuse and dependence on QoL; and evaluate the impact of treating alcohol abuse and dependence on QoL.
    Objective: Quality of life, which consists of the physical, mental, and social domains, has been shown to be negatively affected by alcohol abuse and dependence. This review aims to examine QoL in alcohol abuse and dependence by reviewing the instruments used to measure it and by analyzing the impact of alcohol abuse and dependence and of treatment on QoL.
    Methods: Studies were identified using a database search of PubMed and PsycINFO from the past 40 years (1971-2011) using the following keywords: abuse OR dependence, OR use AND alcohol, AND Quality of Life, QoL, Health-related quality of life, HRQOL. Two authors agreed independently on including 50 studies that met specific selection criteria.
    Results: Although several global measures of QoL have established reliability and validity, many alcohol-specific measures of QoL have not yet been validated. Nevertheless, QoL has been shown to be significantly impaired in those with alcohol abuse and dependence, particularly in the domains of mental health and social functioning, the very areas that show the greatest improvement with abstinence and its maintenance. Moreover, the literature demonstrates the utility of using QoL measures throughout assessment and treatment as a motivational tool and as a marker for treatment efficacy.
    Conclusions: Measuring and monitoring QoL during assessment and treatment can add important value to patient recovery, for QoL improves with treatment and successful abstinence. Therefore, targeted, disease-specific assessments of QoL are warranted to address the impairments in the physical, mental, and social domains in alcohol abuse and dependence, thereby improving long-term outcomes.
    MeSH term(s) Alcoholism/prevention & control ; Alcoholism/psychology ; Attitude to Health ; Child ; Clinical Trials as Topic ; Female ; Health Status ; Humans ; Interpersonal Relations ; Personal Satisfaction ; Quality of Life/psychology ; Reproducibility of Results ; Self Efficacy ; Surveys and Questionnaires
    Language English
    Publishing date 2013-05-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1174775-4
    ISSN 1465-7309 ; 1067-3229
    ISSN (online) 1465-7309
    ISSN 1067-3229
    DOI 10.1097/HRP.0b013e31827fd8aa
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3888: Show issues Location:
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  5. Article ; Online: Quality of life in borderline personality disorder.

    IsHak, Waguih William / Elbau, Immanuel / Ismail, Ashraf / Delaloye, Sibylle / Ha, Khanh / Bolotaulo, Nestor Ian / Nashawati, Rama / Cassmassi, Brian / Wang, Charles

    Harvard review of psychiatry

    2013  Volume 21, Issue 3, Page(s) 138–150

    Abstract: Objective: To review the literature on quality of life (QoL) in borderline personality disorder (BPD) by examining the use of QoL instruments, the extent of QoL impairments in BPD, and the impact of treatment on QoL in BPD.: Methods: Studies were ... ...

    Abstract Objective: To review the literature on quality of life (QoL) in borderline personality disorder (BPD) by examining the use of QoL instruments, the extent of QoL impairments in BPD, and the impact of treatment on QoL in BPD.
    Methods: Studies were identified through PubMed and PsycINFO searches for articles from 1980 to 2011 using the following keywords: quality of life OR health-related quality of life OR QOL OR HRQOL AND borderline personality disorder. We focused our search on studies that actually measured QoL. Two authors agreed independently on including 25 studies that met specific selection criteria.
    Results: The data on QoL in BPD are still sparse, with high heterogeneity in the instruments used to measure QoL, which decreases the comparability of existing studies. EQ-5D, WHOQOL, SF-36, Satisfaction Profile, and Q-LESQ have been utilized as QoL measures in BPD research. The reviewed studies uniformly demonstrated grave impairments in QoL of BPD patients. The available evidence indicates that BPD treatments improve not only psychiatric symptoms but also QoL, as shown by psychotherapy and pharmacotherapy studies. Nevertheless, it remains unclear whether current treatments are able to restore QoL to community norms.
    Conclusions: QoL is gaining more importance as an outcome measure of psychiatric interventions. Research evidence confirms that QoL is seriously impaired in BPD and that QoL improves with treatment. Further research is needed to build a consensus on the utilization of QoL measures and to improve their validity in BPD. More importantly, future studies need to develop and test interventions to improve QoL in BPD.
    MeSH term(s) Borderline Personality Disorder/drug therapy ; Borderline Personality Disorder/psychology ; Borderline Personality Disorder/therapy ; Combined Modality Therapy ; Female ; Humans ; Male ; Psychiatric Status Rating Scales ; Psychological Tests ; Psychotherapy ; Psychotropic Drugs/therapeutic use ; Quality of Life/psychology ; Treatment Outcome
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1174775-4
    ISSN 1465-7309 ; 1067-3229
    ISSN (online) 1465-7309
    ISSN 1067-3229
    DOI 10.1097/HRP.0b013e3182937116
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  6. Article: 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy.

    Chen, Wei / Silverman, Daniel H S / Delaloye, Sibylle / Czernin, Johannes / Kamdar, Nirav / Pope, Whitney / Satyamurthy, Nagichettiar / Schiepers, Christiaan / Cloughesy, Timothy

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2006  Volume 47, Issue 6, Page(s) 904–911

    Abstract: Unlabelled: We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA) and (18)F-FDG.: Methods: Eighty-one patients undergoing evaluation for brain tumors were ... ...

    Abstract Unlabelled: We evaluated the amino acid and glucose metabolism of brain tumors by using PET with 3,4-dihydroxy-6-(18)F-fluoro-l-phenylalanine ((18)F-FDOPA) and (18)F-FDG.
    Methods: Eighty-one patients undergoing evaluation for brain tumors were studied. Initially, 30 patients underwent PET with (18)F-FDOPA and (18)F-FDG within the same week. Tracer kinetics in normal brain and tumor tissues were estimated. PET uptake was quantified by use of standardized uptake values and the ratio of tumor uptake to normal hemispheric tissue uptake (T/N). In addition, PET uptake with (18)F-FDOPA was quantified by use of ratios of tumor uptake to striatum uptake (T/S) and of tumor uptake to white matter uptake. The accuracies of (18)F-FDOPA and (18)F-FDG PET were determined by comparing imaging data with histologic findings and findings of clinical follow-up of up to 31 mo (mean, 20 mo). To further validate the accuracy of (18)F-FDOPA PET, (18)F-FDOPA PET was performed with an additional 51 patients undergoing brain tumor evaluation.
    Results: Tracer uptake in tumors on (18)F-FDOPA scans was rapid, peaking at approximately 15 min after intravenous injection. Tumor uptake could be distinguished from that of the striatum by the difference in peak times. Both high-grade and low-grade tumors were well visualized with (18)F-FDOPA. The sensitivity for identifying tumors was substantially higher with (18)F-FDOPA PET than with (18)F-FDG PET at comparable specificities, as determined by simple visual inspection, especially for the assessment of low-grade tumors. Using receiver-operating-characteristic curve analysis, we found the optimal threshold for (18)F-FDOPA to be a T/S of greater than 1.0 (sensitivity, 96%; specificity, 100%) or a T/N of greater than 1.3 (sensitivity, 96%; specificity, 86%). The high diagnostic accuracy of (18)F-FDOPA PET at these thresholds was confirmed with the additional 51 patients (a total of 81 patients: sensitivity, 98%; specificity, 86%; positive predictive value, 95%; negative predictive value, 95%). No significant difference in tumor uptake on (18)F-FDOPA scans was seen between low-grade and high-grade tumors (P = 0.40) or between contrast-enhancing and nonenhancing tumors (P = 0.97). Radiation necrosis was generally distinguishable from tumors on (18)F-FDOPA scans (P < 0.00001).
    Conclusion: (18)F-FDOPA PET was more accurate than (18)F-FDG PET for imaging of low-grade tumors and evaluating recurrent tumors. (18)F-FDOPA PET may prove especially useful for imaging of recurrent low-grade tumors and for distinguishing tumor recurrence from radiation necrosis.
    MeSH term(s) Adult ; Aged ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/epidemiology ; California/epidemiology ; Dihydroxyphenylalanine/analogs & derivatives ; Female ; Fluorodeoxyglucose F18 ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Male ; Middle Aged ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/statistics & numerical data ; Radiopharmaceuticals ; Reproducibility of Results ; Sensitivity and Specificity
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; fluorodopa F 18 (2C598205QX) ; Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2006-06
    Publishing country United States
    Document type Controlled Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0161-5505 ; 0097-9058 ; 0022-3123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 114: Show issues Location:
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  7. Article ; Online: Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study.

    Chen, Wei / Delaloye, Sibylle / Silverman, Daniel H S / Geist, Cheri / Czernin, Johannes / Sayre, James / Satyamurthy, Nagichettiar / Pope, Whitney / Lai, Albert / Phelps, Michael E / Cloughesy, Timothy

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2007  Volume 25, Issue 30, Page(s) 4714–4721

    Abstract: Purpose: Evaluation of treatment effects in malignant brain tumors is challenging because of the lack of reliable response predictors of tumor response. This study examines the predictive value of positron emission tomography (PET) using [18F] ... ...

    Abstract Purpose: Evaluation of treatment effects in malignant brain tumors is challenging because of the lack of reliable response predictors of tumor response. This study examines the predictive value of positron emission tomography (PET) using [18F] fluorothymidine (FLT), an imaging biomarker of cell proliferation, in patients with recurrent malignant gliomas treated with bevacizumab in combination with irinotecan.
    Patients and methods: Patients with recurrent malignant gliomas treated with biweekly cycles of bevacizumab and irinotecan were prospectively studied with FLT-PET at baseline, after 1 to 2 weeks, and after 6 weeks from start of treatment. A more than 25% reduction in tumor FLT uptake as measured by standardized uptake value was defined as a metabolic response. FLT responses were compared with response as shown by magnetic resonance imaging (MRI) and patient survival.
    Results: Twenty-one patients were included, and 19 were assessable for metabolic response evaluation with FLT-PET. There were nine responders (47%) and 10 nonresponders (53%). Metabolic responders survived three times as long as nonresponders (10.8 v 3.4 months; P = .003), and tended to have a prolonged progression-free survival (P = .061). Both early and later FLT-PET responses were more significant predictors of overall survival (1 to 2 weeks, P = .006; 6 weeks, P = .002), compared with the MRI responses (P = .060 for both 6-week and best responses).
    Conclusion: FLT-PET as an imaging biomarker seems to be predictive of overall survival in bevacizumab and irinotecan treatment of recurrent gliomas. Whether FLT-PET performed as early as 1 to 2 week after starting treatment is as predictive as the study indicates at 6 weeks warrants further investigation.
    MeSH term(s) Adult ; Aged ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bevacizumab ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Cell Proliferation ; Female ; Fluorine Radioisotopes/pharmacokinetics ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Staging ; Pilot Projects ; Positron-Emission Tomography ; Prognosis ; Prospective Studies ; Radiography ; Radiopharmaceuticals/pharmacokinetics ; Survival Rate ; Thymidine/pharmacokinetics
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Fluorine Radioisotopes ; Radiopharmaceuticals ; Bevacizumab (2S9ZZM9Q9V) ; irinotecan (7673326042) ; Thymidine (VC2W18DGKR) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2007-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2006.10.5825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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