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Article ; Online: Endocarditis in the intensive care unit: an update.

Lakbar, Ines / Delamarre, Louis / Einav, Sharon / Leone, Marc

2022 Volume 28, Issue 5, Page(s) 503–512

Abstract: Purpose of review: The incidence of infective endocarditis (IE) is increasing worldwide, resulting in a higher number of patients with IE being admitted to intensive care units (ICU). Nearly half of patients with IE develop a complication during their ... ...

Abstract	Purpose of review: The incidence of infective endocarditis (IE) is increasing worldwide, resulting in a higher number of patients with IE being admitted to intensive care units (ICU). Nearly half of patients with IE develop a complication during their clinical course. However, few well conducted studies or reviews are devoted to critically ill IE patients. This review discusses the contemporary perioperative and intensive care literature. Recent findings: IE epidemiology is changing towards elderly and frail patients. ICU patients are at risk of risk of developing IE because they are often in a pro-inflammatory state and many also have several indwelling catheters, which favors infection. Increased performance and recent advances in cardiac imaging allow for easier diagnosis of EI, but the applicability of these techniques to ICU patients is still relatively limited. New developments in antibiotic treatment and adjunctive therapies are explored further in this review. Summary: The lack of evidence on ICU patients with IE highlights the critical importance of multidisciplinary decision-making and the need for further research.
MeSH term(s)	Aged ; Critical Care ; Critical Illness ; Endocarditis/diagnosis ; Endocarditis/epidemiology ; Endocarditis/therapy ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/surgery ; Humans ; Intensive Care Units
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1235629-3
ISSN	1531-7072 ; 1070-5295
ISSN (online)	1531-7072
ISSN	1070-5295
DOI	10.1097/MCC.0000000000000973
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Zs.A 4999: Show issues

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Article: Compliance with a Procalcitonin-Based Protocol in Patients with Ventilation-Associated Pneumonia: An Observational, Retrospective Study.

Rossi, Matthieu / Delamarre, Louis / Duclos, Gary / Lakbar, Ines / Hammad, Emmanuelle / Arbelot, Charlotte / Zieleskiewicz, Laurent / Leone, Marc

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: Background: Procalcitonin (PCT) protocols to guide antibiotic treatment for ventilator-associated pneumonia (VAP) in the intensive care unit aim at reducing antibiotic exposure. Our study goal was to measure compliance with a PCT protocol for VAP and to ...

Abstract	Background: Procalcitonin (PCT) protocols to guide antibiotic treatment for ventilator-associated pneumonia (VAP) in the intensive care unit aim at reducing antibiotic exposure. Our study goal was to measure compliance with a PCT protocol for VAP and to determine the associated variables. Methods: From 2017 to 2021, we conducted a retrospective, monocentric study including patients treated for VAP. In our PCT protocol, PCT was measured at the initiation of antibiotic treatment and every 48 h until treatment completion; antibiotics were stopped if PCT decreased by more than 80% from its highest value or fell below 0.5 ng/mL. We assessed the compliance with the PCT protocol and compared the compliant and noncompliant groups. Results: Among the 177 included patients, compliance with the PCT protocol was assessed at 58%. Noncompliance was due to lack of PCT measurements in 76% of cases. Compliance was higher in the medical patients ( Conclusion: This study assessed real-life compliance with the PCT protocol to monitor antibiotic treatment for VAP. Improving the measurement of PCT at the bedside would increase the rate.
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12071208
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Article ; Online: The association between regional guidelines compliance and mortality in severe trauma patients: an observational, retrospective study.

Duclos, Gary / Heireche, Fouzia / Siroutot, Manon / Delamarre, Louis / Sartorius, Max-Antoine / Mergueditchian, Celine / Velly, Lionel / Carvelli, Julien / Bordais, Aurelia / Pilarczyk, Estelle / Leone, Marc

European journal of emergency medicine : official journal of the European Society for Emergency Medicine

2024 Volume 31, Issue 3, Page(s) 208–215

Abstract: Background and importance: Trauma is a major cause of mortality and morbidity. Regional trauma systems are the cornerstones of healthcare systems, helping to improve outcomes and avoid preventable deaths in severe trauma patients.: Objectives: The ... ...

Abstract	Background and importance: Trauma is a major cause of mortality and morbidity. Regional trauma systems are the cornerstones of healthcare systems, helping to improve outcomes and avoid preventable deaths in severe trauma patients. Objectives: The goal of this study was to evaluate the association between compliance with the guidelines of a regional trauma management system and survival at 28 days of severe trauma patients. Design, settings and participants: We conducted a retrospective observational study from 1 January 2019 to 31 December 2019. All adult patients admitted for trauma at the University Hospital of Marseille (France) and requiring a pre-hospital medical team were analysed. Compliance with a list of 30 items based on the regional guidelines for the trauma management was evaluated. Each item was classified as compliant, not compliant or not applicable. The global compliance was calculated for each patient as the ratio between the number of compliant items over the number of applicable items. Outcome measures and analysis: The primary aim was to measure the association between compliance with the guidelines and survival at 28 days using a logistic regression. Secondary objectives were to measure the association between compliance with the guidelines and survival at 28 days and 6 months according to the severity of the patients, using a cut-off of the injury severity score at 24. Main results: A total of 494 patients with a median age of 35.0 (25.0-50.0) years were analysed. Global compliance with guidelines was 63%. Mortality at 28 days and 6 months was assessed at 33 (6.7%) and 37 (7.5%) patients, respectively. The level of compliance was associated with reduced mortality at 28 days [odds ratio (OR) at 0.94 and 95% confidence interval (CI) at 0.89-0.98]. In the subgroup of 122 patients with an injury severity score above 23, the level of compliance was associated with reduced mortality at 28 days [OR: 0.93 (95% CI: 0.88-0.99)] and 6 months [OR: 0.93 (95% CI: 0.87-0.99)]. Conclusion: Increased levels of compliance with the guidelines in severe trauma patients were associated with an increase in survival, notably in the most severe patients.
MeSH term(s)	Humans ; Guideline Adherence/statistics & numerical data ; Retrospective Studies ; Male ; Female ; Middle Aged ; Wounds and Injuries/mortality ; Wounds and Injuries/therapy ; Adult ; Injury Severity Score ; France ; Aged
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1233544-7
ISSN	1473-5695 ; 0969-9546
ISSN (online)	1473-5695
ISSN	0969-9546
DOI	10.1097/MEJ.0000000000001122
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Zs.A 4264: Show issues

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Article ; Online: Anaesthesiologists' clinical judgment accuracy regarding preoperative full stomach: Diagnostic study in urgent surgical adult patients.

Delamarre, Louis / Srairi, Mohamed / Bouvet, Lionel / Conil, Jean-Marie / Fourcade, Olivier / Minville, Vincent

Anaesthesia, critical care & pain medicine

2021 Volume 40, Issue 3, Page(s) 100836

Abstract: Background: In urgent situations, preoperative full stomach assessment mostly relies on clinical judgment. Our primary objective was to assess the diagnostic performance of clinical judgment for the preoperative assessment of full stomach in urgent ... ...

Abstract	Background: In urgent situations, preoperative full stomach assessment mostly relies on clinical judgment. Our primary objective was to assess the diagnostic performance of clinical judgment for the preoperative assessment of full stomach in urgent patients compared to gastric point-of-care ultrasound (PoCUS). Our secondary objective was to identify risk factors associated with PoCUS full stomach in urgent patients. Methods: We led a prospective observational study at our Hospital, between January and July 2016. Adult patients admitted for urgent surgery were eligible. Patients with altered gastric sonoanatomy, interventions reducing stomach content, impossible lateral decubitus were excluded. Clinical judgment and risk factors of full stomach were collected before gastric PoCUS measurements. Ultrasonographic full stomach was defined by solid contents or liquid volume ≥ 1.5 ml kg Results: The prevalence of clinical and PoCUS full stomach in 196 included patients was 29% and 27%, respectively. Positive and negative predictive values were 42% (95% CI: 32.3-52.6%) and 79% (95% CI: 74.9-83.4%), respectively. Patients with PoCUS full stomach were clinically misdiagnosed in 55% of cases. PoCUS full stomach was associated with abdominal or gynaecological-obstetrical surgery (OR 3.6, 95% CI: 1.5-8.8, P < 0.01) but not with fasting durations. Positive solid intake after illness onset with respect to 6-h solid fasting rule was associated with PoCUS low-risk gastric content (OR 0.4, 95% CI: 0.2-0.9, P = 0.03). Conclusions: Clinical judgment showed poor-to-moderate performance in urgent surgical patients for the diagnosis of full stomach. Gastric PoCUS should be used to assess risk of full stomach in this population.
MeSH term(s)	Adult ; Emergency Service, Hospital ; Gastrointestinal Contents/diagnostic imaging ; Humans ; Judgment ; Point-of-Care Systems ; Stomach/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2021-03-19
Publishing country	France
Document type	Journal Article ; Observational Study
ISSN	2352-5568
ISSN (online)	2352-5568
DOI	10.1016/j.accpm.2021.100836
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Article: Acute ischemic stroke complicating common carotid artery thrombosis during a severe COVID-19 infection.

Viguier, Alain / Delamarre, Louis / Duplantier, Julien / Olivot, Jean-Marc / Bonneville, Fabrice

Journal of neuroradiology = Journal de neuroradiologie

2020 Volume 47, Issue 5, Page(s) 393–394

MeSH term(s)	Aged ; Anticoagulants/therapeutic use ; Betacoronavirus ; Biomarkers/blood ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/drug therapy ; Brain Ischemia/etiology ; COVID-19 ; Carotid Artery Thrombosis/diagnostic imaging ; Carotid Artery Thrombosis/etiology ; Computed Tomography Angiography ; Contrast Media ; Coronavirus Infections/complications ; Humans ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Infarction, Middle Cerebral Artery/etiology ; Iohexol/analogs & derivatives ; Magnetic Resonance Imaging ; Male ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/drug therapy ; Stroke/etiology ; Tomography, X-Ray Computed
Chemical Substances	Anticoagulants ; Biomarkers ; Contrast Media ; iobitridol (182ECH14UH) ; Iohexol (4419T9MX03)
Keywords	covid19
Language	English
Publishing date	2020-05-04
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	131763-5
ISSN	1773-0406 ; 0150-9861
ISSN (online)	1773-0406
ISSN	0150-9861
DOI	10.1016/j.neurad.2020.04.003
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Zs.A 1062: Show issues

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Article ; Online: Myopia and Near Work: A Systematic Review and Meta-Analysis.

Dutheil, Frédéric / Oueslati, Tharwa / Delamarre, Louis / Castanon, Joris / Maurin, Caroline / Chiambaretta, Frédéric / Baker, Julien S / Ugbolue, Ukadike C / Zak, Marek / Lakbar, Ines / Pereira, Bruno / Navel, Valentin

International journal of environmental research and public health

2023 Volume 20, Issue 1

Abstract: Background: Myopia is a global public health problem affecting quality of life and work productivity. Data is scarce regarding the effects of near work on myopia. Providing a larger meta-analysis with life-long perspective, including adults and ... ...

Abstract	Background: Myopia is a global public health problem affecting quality of life and work productivity. Data is scarce regarding the effects of near work on myopia. Providing a larger meta-analysis with life-long perspective, including adults and occupational exposure seemed needed. Methods: We searched PubMed, Cochrane Library, Embase and Science Direct for studies reporting myopia prevalence in near work. Myopia was defined as a mean spherical equivalent ≤ -0.50 diopter. We performed a meta-analysis using random-effects model on myopia prevalence, myopia progression per year, and odds ratio (OR) of myopia in near work, completed by subgroup analyses and meta-regressions on patients' characteristics, type of work in adults, geographic zones, time and characteristics of near work. Results: We included 78 studies, representing a total of 254,037 participants, aged from 6 to 39 years. The global prevalence of myopia in near work was 35% (95% CI: 30 to 41%), with a prevalence of 31% (95% CI: 26 to 37%) in children and 46% (95% CI: 30 to 62%) in adults. Myopia progression was -0.39 diopters per year (-0.53 to -0.24 D/year), ranging from -0.44 (-0.57 to -0.31) in children to -0.25 D/year (-0.56 to 0.06) in adults. The odds of myopia in workers exposed vs. non-exposed to near work were increased by 26% (18 to 34%), by 31% (21 to 42%) in children and 21% (6 to 35%) in adults. Prevalence of myopia was higher in adults compared to children (Coefficient 0.15, 95% CI: 0.03 to 0.27). Conclusions: Near work conditions, including occupational exposure in adults, could be associated with myopia. Targeted prevention should be implemented in the workplace.
MeSH term(s)	Adult ; Child ; Humans ; Quality of Life ; Myopia/epidemiology ; Myopia/prevention & control ; Refraction, Ocular ; Odds Ratio ; Prevalence
Language	English
Publishing date	2023-01-03
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20010875
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Article: Case Report: Late Successful Thrombectomy for Ischemic Stroke in a 2-Year-Old Child.

Nasr, Nathalie / Delamarre, Louis / Cheuret, Emmanuel / Chausseray, Gerald / Olivot, Jean Marc / Acar, Philippe / Bonneville, Fabrice

Frontiers in neurology

2021 Volume 12, Page(s) 670565

Abstract: Despite extensive evidence of benefit of thrombectomy in adult ischemic stroke due to large-vessel occlusion in the 6-h window, its role remains uncertain in very young children. We describe hereafter the case of a 2-year-old female child who had a ... ...

Abstract	Despite extensive evidence of benefit of thrombectomy in adult ischemic stroke due to large-vessel occlusion in the 6-h window, its role remains uncertain in very young children. We describe hereafter the case of a 2-year-old female child who had a successful thrombectomy 9 h after stroke onset. The patient presented with right hemiplegia, central facial palsy, a normal level of consciousness, and speech difficulties. The PedNIHS score was 11. CT scan without contrast injection displayed spontaneous hyperdensity of the middle cerebral artery (MCA), with only limited early signs of ischemia (ASPECTS 8). CT angiography demonstrated occlusion of the proximal MCA with good collaterals. Thrombectomy was realized. Complete recanalization (TICI 3) was obtained under general anesthesia after two passes of a stent retriever. Time from symptoms onset to full recanalization was 9 h. The acute ischemic stroke was caused by embolic thrombus from a congenital heart disease. Clinical recovery was complete. Three months after the thrombectomy, the young patient was doing well without any neurological sequelae (PedNIHSS 0; modified Rankin Scale: 0). This case report is an example of a decision-making process to perform thrombectomy in a very young child, which included cardio-embolic etiology as a parameter that potentially might have participated to the successful outcome of the therapeutic procedure.
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.670565
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Article: Antimicrobial Stewardship during COVID-19 Outbreak: A Retrospective Analysis of Antibiotic Prescriptions in the ICU across COVID-19 Waves.

Lakbar, Ines / Delamarre, Louis / Curtel, Fanny / Duclos, Gary / Bezulier, Karine / Gragueb-Chatti, Ines / Martin-Loeches, Ignacio / Forel, Jean-Marie / Leone, Marc

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: The demographics and outcomes of ICU patients admitted for a COVID-19 infection have been characterized in extensive reports, but little is known about antimicrobial stewardship for these patients. We designed this retrospective, observational study to ... ...

Abstract	The demographics and outcomes of ICU patients admitted for a COVID-19 infection have been characterized in extensive reports, but little is known about antimicrobial stewardship for these patients. We designed this retrospective, observational study to investigate our hypothesis that the COVID-19 pandemic has disrupted antimicrobial stewardship practices and likely affected the rate of antibiotic de-escalation (ADE), patient outcomes, infection recurrence, and multidrug-resistant bacteria acquisition. We reviewed the prescription of antibiotics in three ICUs during the pandemic from March 2020 to December 2021. All COVID-19 patients with suspected or proven bacterial superinfections who received antibiotic treatment were included. The primary outcome was the rate of ADE, and secondary outcomes included the rate of appropriate empirical treatment, mortality rates and a comparison with a control group of infected patients before the COVID-19 pandemic. We included 170 COVID-19 patients who received antibiotic treatment for a suspected or proven superinfection, of whom 141 received an empirical treatment. For the latter, antibiotic treatment was de-escalated in 47 (33.3%) patients, escalated in 5 (3.5%) patients, and continued in 89 (63.1%) patients. The empirical antibiotic treatment was appropriate for 87.2% of cases. ICU, hospital, and day 28 and day 90 mortality rates were not associated with the antibiotic treatment strategy. The ADE rate was 52.2% in the control group and 27.6% in the COVID-19 group (p < 0.001). Our data suggest that empirical antibiotic treatment was appropriate in most cases. The ADE rates were lower in the COVID-19 group than in the control group, suggesting that the stress associated with COVID-19 affected our practices.
Language	English
Publishing date	2022-10-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11111517
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Article: Effects of a Chair Positioning Session on Awake Non-Intubated COVID-19 Pneumonia Patients: A Multicenter, Observational, and Pilot Study Using Lung Ultrasound.

Lopez, Alexandre / Simeone, Pierre / Delamarre, Louis / Duclos, Gary / Arbelot, Charlotte / Lakbar, Ines / Pastene, Bruno / Bezulier, Karine / Dahan, Samuel / Joffredo, Emilie / Jay, Lucille / Velly, Lionel / Allaouchiche, Bernard / Hraiech, Sami / Leone, Marc / Zieleskiewicz, Laurent

Journal of clinical medicine

2022 Volume 11, Issue 19

Abstract: Background: LUS is a validated tool for the management of COVID-19 pneumonia. Chair positioning (CP) may have beneficial effects on oxygenation and lung aeration, and may be an easier alternative to PP. This study assessed the effects of a CP session on ...

Abstract	Background: LUS is a validated tool for the management of COVID-19 pneumonia. Chair positioning (CP) may have beneficial effects on oxygenation and lung aeration, and may be an easier alternative to PP. This study assessed the effects of a CP session on oxygenation and lung aeration (LA) changes in non-intubated COVID-19 patients. Methods: A retrospective multicenter study was conducted in an ICU. We analyzed data from LUS exams and SpO Results: Thirty-three patients were included in the study; fourteen (44%) were oxygenation non-responders and eighteen (56%) were oxygenation responders, while thirteen (40.6%) and nineteen (59.4%) patients were classified as LA non-responders and responders, respectively. Changes in oxygenation and LA before/after a CP session were not correlated (r = -0.19, Conclusion: A CP session was associated with improved oxygenation and LA in more than half of the non-intubated COVID-19 patients.
Language	English
Publishing date	2022-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11195885
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Article: Acute ischemic stroke complicating common carotid artery thrombosis during a severe COVID-19 infection

Viguier, Alain / Delamarre, Louis / Duplantier, Julien / Olivot, Jean-Marc / Bonneville, Fabrice

J Neuroradiol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #165267
Database	COVID19

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