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  1. Book ; Online: Reducing Linear Hadwiger's Conjecture to Coloring Small Graphs

    Delcourt, Michelle / Postle, Luke

    2021  

    Abstract: In 1943, Hadwiger conjectured that every graph with no $K_t$ minor is $(t-1)$-colorable for every $t\ge 1$. In the 1980s, Kostochka and Thomason independently proved that every graph with no $K_t$ minor has average degree $O(t\sqrt{\log t})$ and hence is ...

    Abstract In 1943, Hadwiger conjectured that every graph with no $K_t$ minor is $(t-1)$-colorable for every $t\ge 1$. In the 1980s, Kostochka and Thomason independently proved that every graph with no $K_t$ minor has average degree $O(t\sqrt{\log t})$ and hence is $O(t\sqrt{\log t})$-colorable. Recently, Norin, Song and the second author showed that every graph with no $K_t$ minor is $O(t(\log t)^{\beta})$-colorable for every $\beta > 1/4$, making the first improvement on the order of magnitude of the $O(t\sqrt{\log t})$ bound. The first main result of this paper is that every graph with no $K_t$ minor is $O(t\log\log t)$-colorable. This is a corollary of our main technical result that the chromatic number of a $K_t$-minor-free graph is bounded by $O(t(1+f(G,t)))$ where $f(G,t)$ is the maximum of $\frac{\chi(H)}{a}$ over all $a\ge \frac{t}{\sqrt{\log t}}$ and $K_a$-minor-free subgraphs $H$ of $G$ that are small (i.e. $O(a\log^4 a)$ vertices). This has a number of interesting corollaries. First as mentioned, using the current best-known bounds on coloring small $K_t$-minor-free graphs, we show that $K_t$-minor-free graphs are $O(t\log\log t)$-colorable. Second, it shows that proving Linear Hadwiger's Conjecture (that $K_t$-minor-free graphs are $O(t)$-colorable) reduces to proving it for small graphs. Third, we prove that $K_t$-minor-free graphs with clique number at most $\sqrt{\log t}/ (\log \log t)^2$ are $O(t)$-colorable. This implies our final corollary that Linear Hadwiger's Conjecture holds for $K_r$-free graphs for every fixed $r$. One key to proving the main theorem is a new standalone result that every $K_t$-minor-free graph of average degree $d=\Omega(t)$ has a subgraph on $O(t \log^3 t)$ vertices with average degree $\Omega(d)$.

    Comment: 25 pages. Updated in response to referee comments. This and the two previous versions add the necessary results from arXiv:2006.11798 in order to create a self-contained standalone paper. arXiv admin note: text overlap with arXiv:2006.11798, arXiv:2010.05999
    Keywords Mathematics - Combinatorics ; Computer Science - Discrete Mathematics ; 05C15 ; 05C83
    Subject code 511
    Publishing date 2021-08-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Stérilités mystérieuses et naissances maléfiques dans l'Antiquité classique

    Delcourt, Marie

    1986  

    Size 1 electronic resource ( p.)
    Publisher Presses universitaires de Liège
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT020093533
    ISBN 9782251660837 ; 9782821828704 ; 2251660836 ; 2821828705
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Racing and Training Physiology of an Elite Ultra-Endurance Cyclist: Case Study of 2 Record-Setting Performances.

    Rothschild, Jeffrey A / Delcourt, Matthieu / Maunder, Ed / Plews, Daniel J

    International journal of sports physiology and performance

    2021  Volume 16, Issue 5, Page(s) 739–743

    Abstract: Purpose: To present a case report of an elite ultra-endurance cyclist, who was the winner and course record holder of 2 distinct races within a 4-month span: a 24-hour solo cycling race and a 2-man team multiday race (Race Across America).: Methods: ... ...

    Abstract Purpose: To present a case report of an elite ultra-endurance cyclist, who was the winner and course record holder of 2 distinct races within a 4-month span: a 24-hour solo cycling race and a 2-man team multiday race (Race Across America).
    Methods: The athlete's raw data (cycling power, heart rate [HR], speed, and distance) were obtained and analyzed for 2 ultra-endurance races and 11 weeks of training in between.
    Results: For the 24-hour race, the athlete completed 861.6 km (average speed 35.9 km·h-1, average power 210 W [2.8 W·kg-1], average HR 121 beats per minute) with a 37% decrease in power and a 22% decrease in HR throughout the race. During the 11 weeks between the 24-hour race and Race Across America, training intensity distribution (Zone 1/2/3) based on HR was 51%/39%/10%. For the Race Across America, total team time to complete the 4939-km race was 6 days, 10 hours, 39 minutes, at an average speed of 31.9 km·h-1. Of this, the athlete featured in this case study rode 75.2 hours, completing 2532 km (average speed 33.7 km·h-1, average power 203 W [2.7 W·kg-1]), with a 12% decrease in power throughout the race. Power during daytime segments was greater than nighttime (212 [25] vs 189 [18] W, P < .001, ηp2=.189).
    Conclusions: This case report highlights the performance requirements of elite ultra-endurance cycling. Although average power was similar when riding for 24 hours continuously and 75 hours intermittently over 6.5 days, there were large differences in pacing strategies and within-day power-output changes.
    MeSH term(s) Athletes ; Bicycling ; Heart Rate ; Humans ; Nutritional Status ; Physical Endurance
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1555-0273
    ISSN (online) 1555-0273
    DOI 10.1123/ijspp.2020-0515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Security Measures for Grids against Rank-1 Undetectable Time-Synchronization Attacks

    Delcourt, Marguerite / Boudec, Jean-Yves Le

    2020  

    Abstract: Time-synchronization attacks on phasor measurement units (PMU) pose a real threat to smart grids; it was shown that they are feasible in practice and that they can have a non-negligible negative impact on the state estimation, without triggering the bad- ... ...

    Abstract Time-synchronization attacks on phasor measurement units (PMU) pose a real threat to smart grids; it was shown that they are feasible in practice and that they can have a non-negligible negative impact on the state estimation, without triggering the bad-data detection mechanisms. Previous works identified vulnerability conditions when targeted PMUs measure a single phasor. Yet, PMUs are capable of measuring several quantities. We present novel vulnerability conditions in the general case where PMUs measure any number of phasors and can share the same time reference. One is a sufficient condition that does not depend on the measurement values. We propose a security requirement that prevents it and provide a greedy offline algorithm that enforces it. If this security requirement is satisfied, there is still a possibility that the grid can be attacked, although we conjecture that it is very unlikely. We identify two sufficient and necessary vulnerability conditions which depend on the measurement values. For each, we provide a metric that shows the distance between the observed and vulnerability conditions. We recommend their monitoring for security. Numerical results, on the IEEE-39 bus benchmark with real load profiles, show that the measurements of a grid satisfying our security requirement are far from vulnerable.

    Comment: 11 pages, 7 figures
    Keywords Electrical Engineering and Systems Science - Systems and Control
    Publishing date 2020-02-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: A three-minute all-out test performed in a remote setting does not provide a valid estimate of the maximum metabolic steady state.

    Maunder, Ed / Rothschild, Jeffrey A / Ramonas, Andrius / Delcourt, Matthieu / Kilding, Andrew E

    European journal of applied physiology

    2022  Volume 122, Issue 11, Page(s) 2385–2392

    Abstract: Purpose: The three-minute all-out test (3MT), when performed on a laboratory ergometer in a linear mode, can be used to estimate the heavy-severe-intensity transition, or maximum metabolic steady state (MMSS), using the end-test power output. As the 3MT ...

    Abstract Purpose: The three-minute all-out test (3MT), when performed on a laboratory ergometer in a linear mode, can be used to estimate the heavy-severe-intensity transition, or maximum metabolic steady state (MMSS), using the end-test power output. As the 3MT only requires accurate measurement of power output and time, it is possible the 3MT could be used in remote settings using personal equipment without supervision for quantification of MMSS.
    Methods: The aim of the present investigation was to determine the reliability and validity of remotely performed 3MTs (3MT
    Results: The 3MT
    Conclusion: These results suggest that the 3MT
    MeSH term(s) Anaerobic Threshold ; Bicycling ; Exercise Test/methods ; Gases ; Humans ; Lactic Acid ; Oxygen Consumption ; Reproducibility of Results
    Chemical Substances Gases ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2022-08-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-022-05020-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: TDOA Source-Localization Technique Robust to Timing Attacks

    Delcourt, Marguerite / Boudec, Jean-Yves Le

    2019  

    Abstract: In this paper, we focus on the localization of a passive source from time difference of arrival (TDOA) measurements. TDOA values are computed with respect to pairs of fixed sensors that are required to be accurately time-synchronized. This constitutes a ... ...

    Abstract In this paper, we focus on the localization of a passive source from time difference of arrival (TDOA) measurements. TDOA values are computed with respect to pairs of fixed sensors that are required to be accurately time-synchronized. This constitutes a weakness as all synchronization techniques are vulnerable to delay injections. Attackers are able either to spoof the signal or to inject asymmetric delays in the communication channel. By nature, TDOA measurements are highly sensitive to time-synchronization offsets between sensors. Our first contribution is to show that timing attacks can severely affect the localization process. With a delay of a few microseconds injected on one sensor, the resulting estimate might be several kilometers away from the true location of the unknown source. We also show that residual analysis does not enable the detection and identification of timing attacks. Our second contribution is to propose a two-step TDOA-localization technique that is robust against timing attacks. It uses a known source to define a weight for each pair of sensors, reflecting the confidence in their time synchronization. Our solution then uses the weighted least-squares estimator with the newly created weights and the TDOA measurements received from the unknown source. As a result, our method either identifies the network as being too corrupt to localize, or gives a corrected estimate of the unknown position along with a confidence metric. Numerical results illustrate the performance of our technique.

    Comment: 13 pages, 10 figures, submitted not published
    Keywords Electrical Engineering and Systems Science - Systems and Control ; Electrical Engineering and Systems Science - Signal Processing
    Subject code 006
    Publishing date 2019-12-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Sexual selection on Drosophila serrata male pheromones does not vary with female age or mating status.

    Gershman, S / Delcourt, M / Rundle, H D

    Journal of evolutionary biology

    2014  Volume 27, Issue 6, Page(s) 1279–1286

    Abstract: Mate preferences are costly and are thought to evolve due to the direct and/or indirect benefits they provide. Such costs and benefits may vary in response to intrinsic and extrinsic factors with important evolutionary consequences. Limited attention has ...

    Abstract Mate preferences are costly and are thought to evolve due to the direct and/or indirect benefits they provide. Such costs and benefits may vary in response to intrinsic and extrinsic factors with important evolutionary consequences. Limited attention has been given to quantifying such variation and understanding its causes, most notably with respect to the direction and strength of preferences for multivariate sexual displays. In Drosophila serrata, female preferences target a pheromone blend of long-chain cuticular hydrocarbons (CHCs). We used a factorial design to test whether female age and mating status generated variation in the strength and direction of sexual selection on male CHCs. Replicate choice mating trials were conducted using young and old females (4 or 10 days post-emergence) that were either virgin or previously mated. The outcome of such trials is known to capture variation in female mate preferences, although male-male interactions may also contribute. Directional sexual selection on male CHCs was highly significant within each treatment, but there was little evidence of any variation among treatments. The absence of treatment effects implies that the multivariate combination of male CHCs preferred by females was constant with respect to female age and mating status. To the extent that male-male interactions may also contribute, our results similarly imply that these did not vary among treatments groups. With respect to D. serrata mate preferences, our results suggest that either plasticity with respect to age and mating status is not beneficial to females, or preference expression is somehow constrained.
    MeSH term(s) Animals ; Choice Behavior ; Drosophila/physiology ; Female ; Male ; Mating Preference, Animal ; Regression Analysis ; Sex Attractants ; Time Factors
    Chemical Substances Sex Attractants
    Language English
    Publishing date 2014-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1465318-7
    ISSN 1420-9101 ; 1010-061X
    ISSN (online) 1420-9101
    ISSN 1010-061X
    DOI 10.1111/jeb.12407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Investigation of Mitochondrial Adaptations to Modulation of Carbohydrate Supply during Adipogenesis of 3T3-L1 Cells by Targeted

    Delcourt, Manon / Delsinne, Virginie / Colet, Jean-Marie / Declèves, Anne-Emilie / Tagliatti, Vanessa

    Biomolecules

    2021  Volume 11, Issue 5

    Abstract: 1) Background: White adipose tissue (WAT) is a dynamic and plastic tissue showing high sensitivity to carbohydrate supply. In such a context, the WAT may accordingly modulate its mitochondrial metabolic activity. We previously demonstrated that a ... ...

    Abstract (1) Background: White adipose tissue (WAT) is a dynamic and plastic tissue showing high sensitivity to carbohydrate supply. In such a context, the WAT may accordingly modulate its mitochondrial metabolic activity. We previously demonstrated that a partial replacement of glucose by galactose in a culture medium of 3T3-L1 cells leads to a poorer adipogenic yield and improved global mitochondrial health. In the present study, we investigate key mitochondrial metabolic actors reflecting mitochondrial adaptation in response to different carbohydrate supplies. (2) Methods: The metabolome of 3T3-L1 cells was investigated during the differentiation process using different glucose/galactose ratios and by a targeted approach using
    Language English
    Publishing date 2021-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11050662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prognostic Value of Preoperative Serological Biomarkers in Patients Undergoing Curative-Intent Cytoreductive Surgery for Colorectal Cancer Peritoneal Metastases.

    El Asmar, Antoine / Delcourt, Martin / Kamden, Leonel / Khaled, Charif / Bohlok, Ali / Moreau, Michel / Sclafani, Francesco / Donckier, Vincent / Liberale, Gabriel

    Annals of surgical oncology

    2022  Volume 30, Issue 3, Page(s) 1863–1869

    Abstract: Background: Cytoreductive surgery (CRS) for peritoneal metastases of colorectal cancer (PMCRC) is associated with a high risk of postoperative morbidity, thus making patient selection of upmost importance. Further to data showing an association between ... ...

    Abstract Background: Cytoreductive surgery (CRS) for peritoneal metastases of colorectal cancer (PMCRC) is associated with a high risk of postoperative morbidity, thus making patient selection of upmost importance. Further to data showing an association between preoperative serological biomarkers and patient outcome in various solid tumors, in this study we aim to evaluate their prognostic value in patients with PMCRC treated with curative intent.
    Patients and methods: This is a retrospective study including patients with PMCRC treated by complete CRS ± HIPEC at our institution between 2011 and 2020. Preoperative serological biomarkers, along with other standard clinicopathological variables, were studied to determine their prognostic value.
    Results: A total of 94 out of 108 patients met the inclusion criteria. Forty-three patients (46%) presented with synchronous PM. The median peritoneal cancer index (PCI) was 6. On univariate analysis, a higher neutrophil-to-lymphocyte ratio (NLR) was associated with poor prognosis in terms of overall survival (OS) [cutoff 3.567, hazard ratio (HR) 2.8 (1.4-5.3), p = 0.002], whereas a higher platelet-to-lymphocyte ratio (PLR) predicted favorable prognosis in terms of disease-free survival (DFS) [cutoff 185.4, HR 1.9 (1.07-3.53), p = 0.030]. On multivariate analysis, NLR > 3.567, positive lymph nodes (LNs), and PCI > 7 were independent predictive factors for worse OS, whereas NLR > 3.567 and positive LNs were significantly associated with worse DFS. PLR > 185.4 was associated with better DFS.
    Conclusion: High preoperative NLR (> 3.567) and PLR (> 185.4) can predict outcome of patients with PMCRC treated by complete CRS ± HIPEC.
    MeSH term(s) Humans ; Prognosis ; Peritoneal Neoplasms/pathology ; Retrospective Studies ; Cytoreduction Surgical Procedures ; Colonic Neoplasms/pathology ; Rectal Neoplasms/pathology ; Neutrophils/pathology ; Biomarkers ; Colorectal Neoplasms/pathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12736-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: (with research data) Comparing the intersex genetic correlation for fitness across novel environments in the fruit fly, Drosophila serrata.

    Punzalan, D / Delcourt, M / Rundle, H D

    Heredity

    2013  Volume 112, Issue 2, Page(s) 143–148

    Abstract: Sexually antagonistic genetic variation can pose limits to the independent evolution and adaptation of the sexes. The extent of sexually antagonistic variation is reflected in the intersex genetic correlation for fitness (rw(FM)). Previous estimates of ... ...

    Abstract Sexually antagonistic genetic variation can pose limits to the independent evolution and adaptation of the sexes. The extent of sexually antagonistic variation is reflected in the intersex genetic correlation for fitness (rw(FM)). Previous estimates of this correlation have been mostly limited to populations in environments to which they are already well adapted, making it difficult to gauge the importance of sexually antagonistic genetic variance during the early stages of adaptation, such as that occurring following abrupt environmental change or upon the colonization of new habitat. Here we assayed male and female lifetime fitness in a population of Drosophila serrata in four novel laboratory environments. We found that rw(FM) varied significantly across environments, with point estimates ranging from positive to negative values of considerable magnitude. We also found that the variability among estimates was because, at least in part, of significant differences among environments in the genetic variances of both male and female fitness, with no evidence of any significant changes in the intersex covariance itself, although standard errors of these estimates were large. Our results illustrate the unpredictable nature of rw(FM) in novel environments and suggest that, although sexually antagonistic genetic variance can be pronounced in some novel environments, it may have little effect in constraining the early stages of adaptation in others.
    MeSH term(s) Animals ; Crosses, Genetic ; Drosophila/genetics ; Environment ; Female ; Gene-Environment Interaction ; Genetic Fitness ; Genetic Variation ; Genetics, Population ; Inbreeding ; Male ; Phenotype
    Language English
    Publishing date 2013-09-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423-5
    ISSN 1365-2540 ; 0018-067X
    ISSN (online) 1365-2540
    ISSN 0018-067X
    DOI 10.1038/hdy.2013.85
    Database MEDical Literature Analysis and Retrieval System OnLINE

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