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Article: Place de l’immunophénotypage sanguin et de l’étude de la clonalité dans la prise en charge des lymphomes T cutanés.

Bouthemy, C / Beldi-Ferchiou, A / Ortonne, N / Delfau-Larue, M-H / Ingen-Housz-Oro, S / Molinier-Frenkel, V

Annales de dermatologie et de venereologie

2017 Volume 144, Issue 4, Page(s) 315–322

Title translation	The value of blood immunophenotyping and clonality testing in the management of cutaneous T-cell lymphomas.
MeSH term(s)	Biomarkers/blood ; Clone Cells ; Humans ; Immunophenotyping/methods ; Lymphoma, T-Cell, Cutaneous/diagnosis ; Lymphoma, T-Cell, Cutaneous/immunology ; Predictive Value of Tests ; Sensitivity and Specificity ; Skin Neoplasms/diagnosis ; Skin Neoplasms/immunology ; T-Lymphocytes/immunology
Chemical Substances	Biomarkers
Language	French
Publishing date	2017-02-24
Publishing country	France
Document type	Journal Article
ZDB-ID	391805-1
ISSN	2214-5451 ; 0151-9638
ISSN (online)	2214-5451
ISSN	0151-9638
DOI	10.1016/j.annder.2016.12.009
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Article ; Online: Acute exanthemas: a prospective study of 98 adult patients with an emphasis on cytokinic and metagenomic investigation.

Deschamps, O / Ortonne, N / Hüe, S / Rodriguez, C / Deschodt, C / Hirsch, G / Colin, A / Grégoire, L / Delfau-Larue, M-H / Chosidow, O / Wolkenstein, P / Ingen-Housz-Oro, S

The British journal of dermatology

2019 Volume 182, Issue 2, Page(s) 355–363

Abstract: Background: Acute exanthemas (AEs) are frequently seen; they can be caused by drugs or viruses but often the cause is unknown.: Objectives: To describe the clinical, virological and histological aspects of AEs and explore their cytokinic and ... ...

Abstract	Background: Acute exanthemas (AEs) are frequently seen; they can be caused by drugs or viruses but often the cause is unknown. Objectives: To describe the clinical, virological and histological aspects of AEs and explore their cytokinic and metagenomic profiles. Methods: This prospective study examined 98 patients with AE, from February to July 2014. Clinical data were recorded in a standardized chart. Virological investigation and skin biopsies were performed. In addition, blood and skin samples were analysed for cytokines and then by a shotgun metagenomic approach. We identified five groups of patients: those with maculopapular exanthemas (MPEs) that were virally induced (group 1); those with drug-induced MPEs (group 2), those with MPEs that were both viral and drug induced (group 3), those with idiopathic MPEs (group 4) and those with pityriasis rosea (group 5). Results: A virus was identified in 29 cases (human herpesvirus 6, 72%). Cytokinic analysis of the skin (n = 23 MPEs) showed higher levels of interferon-γ and interleukin-1 receptor-α in viral MPEs, higher interleukin-33 levels in idiopathic MPEs, and higher macrophage inflammatory protein 1α levels in drug-induced MPEs. By metagenomics analysis (n = 10 MPEs), viruses identified with routine practice methods were not found in group 1 (n = 4 MPEs). However, Enterovirus A was detected in two cases, especially in a group 1 patient for whom metagenomic analysis rectified the diagnosis of the culprit agent. Conclusions: Human herpesvirus 6 was the virus most frequently identified, and histology did not discriminate MPEs. In addition, the level of interleukin-33 seen in idiopathic MPEs suggests that an environmental factor may be the trigger for these. The results bring into question the utility of routine polymerase chain reaction analysis and viral serology for determining cause in AE. What's already known about this topic? Acute exanthemas, especially maculopapular exanthemas, are a frequent reason for patients consulting emergency and dermatology departments. It is difficult to evaluate the aetiology of acute exanthema based on the clinical aspects. Few data are available on the investigations needed in routine practice, and no prospective series have been published. What does this study add? Our study provides a global and prospective description of acute exanthemas. Cytokine analysis could help to investigate the pathophysiology of idiopathic eruptions. Metagenomic analysis provides new insights about the value of routine practice virological investigations. We show for the first time the feasibility of metagenomics analysis in the skin, which results question the interest of routine PCR and viral sérologies for the exploration of such acute exanthemas.
MeSH term(s)	Adult ; Exanthema/chemically induced ; Exanthema/genetics ; Humans ; Metagenomics ; Pityriasis Rosea ; Prospective Studies ; Skin
Language	English
Publishing date	2019-08-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.18166
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Article ; Online: Tracheobronchial amyloidosis: evidence for local B-cell clonal expansion.

Borie, R / Danel, C / Molinier-Frenkel, V / Prevot, G / Deslee, G / Debray, M P / Delfau-Larue, M H / Crestani, B

The European respiratory journal

2012 Volume 39, Issue 4, Page(s) 1042–1045

MeSH term(s)	Adult ; Amyloidosis/immunology ; Amyloidosis/pathology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Bronchi/immunology ; Bronchi/pathology ; Cell Division/immunology ; Female ; Humans ; Trachea/immunology ; Trachea/pathology
Language	English
Publishing date	2012-04
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/09031936.00101811
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study.

Ortonne, N / Valeyrie-Allanore, L / Bastuji-Garin, S / Wechsler, J / de Feraudy, S / Duong, T-A / Delfau-Larue, M-H / Chosidow, O / Wolkenstein, P / Roujeau, J-C

The British journal of dermatology

2015 Volume 173, Issue 1, Page(s) 50–58

Abstract: Background: The histopathological features of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome remain poorly characterized.: Objectives: To better characterize the histopathological features of DRESS syndrome, and define the ... ...

Abstract	Background: The histopathological features of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome remain poorly characterized. Objectives: To better characterize the histopathological features of DRESS syndrome, and define the phenotype of the effector cells in the skin and compare it with maculopapular rash (MPR). Methods: We conducted a retrospective study on 50 skin biopsies from patients with DRESS syndrome (n = 36). Histopathological and immunophenotypical features were studied and compared with a series of MPRs (n = 20). Results: Foci of interface dermatitis, involving cutaneous adnexae, were frequently seen in cases of DRESS. Eosinophils were seen in only 20% of cases and neutrophils in 42%. Eczematous (40%), interface dermatitis (74%), acute generalized exanthematic pustulosis-like (20%) and erythema multiforme-like (24%) patterns were observed. The association of two or three of these patterns in a single biopsy was significantly more frequent in cases of DRESS than in a series of nondrug-induced dermatoses (P < 0.01), and appeared to be more marked in DRESS syndrome with severe cutaneous lesions (P = 0.01) than in less severe cases of DRESS and MPR. A higher proportion of CD8(+) and granzyme B(+) lymphocytes was observed in cases of DRESS with severe cutaneous eruptions (erythroderma and/or bullae). Atypical lymphocytes were found in 28% of biopsies, and expressed CD8 in most cases; a cutaneous T-cell clone was rarely found (6%). Conclusions: The histopathology of DRESS syndrome highlights various associated inflammatory patterns in a single biopsy. Cutaneous effector lymphocytes comprise a high proportion of polyclonal CD8(+) granzyme B(+) T lymphocytes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Allopurinol/adverse effects ; Anti-Bacterial Agents/adverse effects ; B-Lymphocytes/immunology ; Carbamazepine/adverse effects ; Drug Hypersensitivity Syndrome/immunology ; Drug Hypersensitivity Syndrome/pathology ; Exanthema/chemically induced ; Exanthema/immunology ; Exanthema/pathology ; Female ; Gout Suppressants/adverse effects ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Minocycline/adverse effects ; Phenotype ; Retrospective Studies ; Sulfasalazine/adverse effects ; T-Lymphocytes/immunology ; Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Gout Suppressants ; Carbamazepine (33CM23913M) ; Sulfasalazine (3XC8GUZ6CB) ; Allopurinol (63CZ7GJN5I) ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Minocycline (FYY3R43WGO)
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.13683
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Article: Specific antibodies modulate the interactions of adenovirus type 5 with dendritic cells.

Mercier, S / Rouard, H / Delfau-Larue, M H / Eloit, M

Virology

2004 Volume 322, Issue 2, Page(s) 308–317

Abstract: Adenovirus type 5 (Ad5) is able to induce an efficient CD8+ T lymphocyte (CTL) response against a transgene product, a property thought to be linked to its ability to transduce dendritic cells (DCs). Little, however, is known about the capacity of Ad5 to ...

Abstract	Adenovirus type 5 (Ad5) is able to induce an efficient CD8+ T lymphocyte (CTL) response against a transgene product, a property thought to be linked to its ability to transduce dendritic cells (DCs). Little, however, is known about the capacity of Ad5 to interact with DCs in the presence of specific antibodies, although most people test positive for antibodies directed against Ad5. In the present study, we found that in the presence of Ad5 antibodies, a large fraction of Ad5 binds very efficiently to DCs, and that this binding is FcgammaRII/FcgammaRIII dependent. Nevertheless, in the presence of high levels of antibodies against the whole virion, Ad5 entry was inhibited. Increased binding led to increased entry in DCs in the presence of fiber-specific antibodies or in the presence of low amounts of a whole antiserum raised against whole virions, showing that the relative concentration of antibodies directed against fiber and penton base plays a major role in entry efficacy. Nevertheless, mice previously immunized with virions or purified fiber developed a lower transgene-specific CD8+ T cell response than naive mice, although their serum appeared to increase virus entry into DCs in vitro.
MeSH term(s)	Adenoviruses, Human/genetics ; Adenoviruses, Human/immunology ; Adenoviruses, Human/physiology ; Animals ; Antibodies, Viral/immunology ; Antibody Specificity ; CD8-Positive T-Lymphocytes/immunology ; Capsid Proteins/genetics ; Capsid Proteins/immunology ; Capsid Proteins/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/virology ; Female ; Genetic Vectors ; Humans ; Immunization ; Mice ; Mice, Inbred C57BL ; Neutralization Tests ; Receptors, IgG/metabolism ; Transduction, Genetic
Chemical Substances	Antibodies, Viral ; Capsid Proteins ; Receptors, IgG ; hexon capsid protein, Adenovirus ; penton protein, adenovirus
Language	English
Publishing date	2004-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2004.01.031
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Article ; Online: Subcutaneous panniculitis-like T-cell lymphoma αβ: complete sustained remission with corticosteroids and methotrexate.

Briki, H / Bouaziz, J D / Molinier-Frenkel, V / Delfau-Larue, M-H / Ortonne, N / Bagot, M

The British journal of dermatology

2010 Volume 163, Issue 5, Page(s) 1136–1138

MeSH term(s)	Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Antigens, CD/analysis ; Antimetabolites, Antineoplastic/therapeutic use ; Female ; Humans ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Lymphoma, T-Cell, Cutaneous/immunology ; Lymphoma, T-Cell, Cutaneous/pathology ; Male ; Methotrexate/therapeutic use ; Panniculitis/drug therapy ; Panniculitis/immunology ; Panniculitis/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology ; T-Lymphocytes/immunology ; Treatment Outcome ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Antigens, CD ; Antimetabolites, Antineoplastic ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2010-11
Publishing country	England
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/j.1365-2133.2010.09951.x
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Article: Coproporphyrinogen oxidase: gene organization and description of a mutation leading to exon 6 skipping.

Delfau-Larue, M H / Martasek, P / Grandchamp, B

Human molecular genetics

1994 Volume 3, Issue 8, Page(s) 1325–1330

Abstract: Genomic clones containing a human coproporphyrinogen oxidase gene, were isolated. DNA sequencing indicates that the human CPX gene spans about 14 kb and consists of seven exons and six introns. Sequences were determined for all the exons, exon-intron ... ...

Abstract	Genomic clones containing a human coproporphyrinogen oxidase gene, were isolated. DNA sequencing indicates that the human CPX gene spans about 14 kb and consists of seven exons and six introns. Sequences were determined for all the exons, exon-intron junctions and for 800 bp of promoter region. Introns vary in size from 269 bp to 5 kb and they all have consensus sequences at their boundaries. Primer extension and ribonuclease protection experiments revealed multiple transcriptional initiation sites in a region with sequence motifs characteristic of a promoter. The promoter region is GC-rich and contains multiple potential Sp 1 elements, CACCC boxes and potential GATA-1 binding sites. The availability of the CPX genomic sequence allowed us to determine the mutation in a patient with a hereditary coproporphyria. AG to A mutation was found at the last position of exon 6. This mutation results in exon skipping.
MeSH term(s)	Amino Acid Sequence ; Base Sequence ; Chromosome Mapping ; Coproporphyrinogen Oxidase/genetics ; Exons ; Humans ; Introns ; Male ; Molecular Sequence Data ; Point Mutation ; Polymerase Chain Reaction ; Transcription, Genetic
Chemical Substances	Coproporphyrinogen Oxidase (EC 1.3.3.3)
Language	English
Publishing date	1994-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/3.8.1325
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Article: Identification of circulating CD10 positive T cells in angioimmunoblastic T-cell lymphoma.

Baseggio, L / Berger, F / Morel, D / Delfau-Larue, M-H / Goedert, G / Salles, G / Magaud, J-P / Felman, P

Leukemia

2006 Volume 20, Issue 2, Page(s) 296–303

Abstract: In most cases of lymphomas with blood dissemination, the careful cytological analysis of peripheral blood smears provides a rapid orientation to diagnosis, even if the final subtyping is achieved by histology and eventually other techniques. Here, we ... ...

Abstract	In most cases of lymphomas with blood dissemination, the careful cytological analysis of peripheral blood smears provides a rapid orientation to diagnosis, even if the final subtyping is achieved by histology and eventually other techniques. Here, we evaluated if the analysis of blood smears may suggest the blood dissemination of angioimmunoblastic T-cell lymphoma (AITL) and if CD10 expression on neoplastic T cells, as recently reported on AITL, may contribute to the diagnosis. In all, 11 lymph nodes and six peripheral blood samples from 12 patients with AITL were studied using four-colour flow cytometry associated to histological, cytological and molecular data. According to previous results, a fraction of T cells expressed CD10 in 10/11 lymph nodes. Interestingly, all blood smears showed atypical lymphoid cells and a fraction of T cells expressed CD10 with a mean percentage of 18.75% (range 5.00-47.00%), regardless of lymphocytosis level and of rate of CD10 T cells in corresponding lymph node. In contrast, in all control samples (100), none CD10-positive T cell was identified. This is to our knowledge the first description of circulating CD10 neoplastic T cells in AITL. Therefore, they ought to be explored in further studies when aggressive lymphoma, in particular with lymphopenia and circulating atypical cells, is suspected.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Flow Cytometry ; Gene Rearrangement ; Genes, T-Cell Receptor gamma/genetics ; Humans ; Immunoglobulin Heavy Chains/genetics ; Immunohistochemistry ; Immunophenotyping ; Lymphoma, T-Cell/blood ; Lymphoma, T-Cell/diagnosis ; Lymphoma, T-Cell/pathology ; Male ; Middle Aged ; Neoplastic Cells, Circulating/immunology ; Neoplastic Cells, Circulating/pathology ; Neprilysin/biosynthesis ; Sensitivity and Specificity ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
Chemical Substances	Immunoglobulin Heavy Chains ; Neprilysin (EC 3.4.24.11)
Language	English
Publishing date	2006-02
Publishing country	England
Document type	Journal Article
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/sj.leu.2404013
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Article ; Online: Folliculotropic T-cell infiltrates associated with B-cell chronic lymphocytic leukaemia or MALT lymphoma may reveal either true mycosis fungoides or pseudolymphomatous reaction: seven cases and review of the literature.

Ingen-Housz-Oro, S / Franck, N / Beneton, N / Fauconneau, A / Do-Pham, G / Carlotti, A / Petit, T / Liolios, I / Bara, C / Carpentier, H / Storelli, D / Prophette, B / Garderet, L / Haioun, C / Petit, E / Delfau-Larue, M-H / Vergier, B / Chosidow, O / Beylot-Barry, M /

Ortonne, N

Journal of the European Academy of Dermatology and Venereology : JEADV

2015 Volume 29, Issue 1, Page(s) 77–85

Abstract: Background: Mycosis fungoides (MF) and pseudo-MF (or MF simulant) can be associated with B-cell malignancies, but distinction between a true neoplasm and a reactive process may be difficult.: Objectives: To report seven patients with B-cell ... ...

Abstract	Background: Mycosis fungoides (MF) and pseudo-MF (or MF simulant) can be associated with B-cell malignancies, but distinction between a true neoplasm and a reactive process may be difficult. Objectives: To report seven patients with B-cell malignancy and folliculotropic MF or pseudo-MF and emphasize on criteria allowing distinction between the two conditions. Methods: We retrospectively and prospectively included seven patients with B-cell malignancy who presented skin lesions histologically consisting in a folliculotropic T-cell infiltrate and reviewed the literature on the topic. Results: Four men and three women had a chronic lymphocytic leukaemia (n = 6) or a MALT-type lymphoma (n = 1). Five patients had localized papules, and two had patches and plaques. Histological examination showed in all cases a diffuse dermal T-cell infiltrate with folliculotropic involvement and follicular mucinosis associated with clusters of the B-cell lymphoma, without significant expression of follicular helper T-cell markers. T-cell rearrangement studies showed a polyclonal pattern in the patients with papules and a monoclonal pattern in the cases of patches and plaques. Papular lesions had an indolent evolution, whereas patches and plaques persisted or worsened into transformed MF. Conclusion: Folliculotropic T-cell infiltrates associated with B-cell malignancies can be either a true folliculotropic MF or a pseudo-MF. The distinction between both conditions cannot rely only on the histopathological aspect, but needs both a clinical pathological correlation and the search for a dominant T-cell clone. Whether the neoplastic T and B cells derive from a common ancestor or the T-cell proliferation is promoted by the underlying B-cell lymphoma remains unsolved, but interaction between B and T cell in the skin does not appear to be dependent on a TFH differentiation of the T-cell infiltrate.
MeSH term(s)	Aged ; Diagnosis, Differential ; Female ; Hair Follicle ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphoma, B-Cell, Marginal Zone/complications ; Lymphoma, B-Cell, Marginal Zone/immunology ; Lymphoma, B-Cell, Marginal Zone/pathology ; Male ; Middle Aged ; Mycosis Fungoides/complications ; Mycosis Fungoides/pathology ; Prospective Studies ; Pseudolymphoma/complications ; Pseudolymphoma/pathology ; Retrospective Studies ; Skin Neoplasms/complications ; Skin Neoplasms/pathology ; T-Lymphocytes
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.12454
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Prise en charge des lymphomes B cutanés : recommandations du Groupe français d'étude des lymphomes cutanés.

Grange, F / D'Incan, M / Ortonne, N / Dalac, S / Laroche, L / Beylot-Barry, M / Delfau-Larue, M-H / Vergier, B / Bagot, M

Annales de dermatologie et de venereologie

2010 Volume 137, Issue 8-9, Page(s) 523–531

Abstract: Aims: To provide recommendations for the treatment of cutaneous B-cell lymphomas (CBCL).: Methods: Literature review and expert opinions from the French Cutaneous Lymphoma Study Group.: Results: Diagnosis of marginal zone BCL (MZ BCL), ... ...

Title translation	Management of cutaneous B-cell lymphoma: recommendations of the French cutaneous lymphoma study group.
Abstract	Aims: To provide recommendations for the treatment of cutaneous B-cell lymphomas (CBCL). Methods: Literature review and expert opinions from the French Cutaneous Lymphoma Study Group. Results: Diagnosis of marginal zone BCL (MZ BCL), centrofollicular BCL (CF BCL) or cutaneous large B-cell lymphoma, leg type (CLBCL, LT) is based on combination of clinical signs and histopathological features, together with B-cell clonality analyses whenever possible. Staging relies on straightforward laboratory examinations and imaging, completed in selected cases with bone marrow biopsy. Treatment may be topical, including excision, curative radiotherapy (30Gray) or adjunctive/low dose (4Gray) radiotherapy, topical corticosteroids, interferon or intralesional rituximab; or systemic, using chemotherapy and/or intravenous rituximab. For indolent forms of the disease (MZ CBCL and CF CBCL), curative (30Gray) may be given as first-line treatment in patients with localized lesions or few scattered skin lesions. For more numerous slow-growing lesions with a low tumour burden, simple monitoring with adjunctive ad hoc local treatment of individual lesions is acceptable. For multiple growing lesions, systemic rituximab or chlorambucil may be proposed. Polychemotherapy should only be used for progressive forms unresponsive to previous therapies. CLBCL LT forms are more aggressive and occur in older subjects. These lymphomas are best treated with age-adapted combinations of polychemotherapies and rituximab. Conclusion: Appropriate clinical trials are still needed to strengthen the levels of evidence of current recommendations.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Humans ; Interferon-alpha/therapeutic use ; Leg ; Lymphoma, B-Cell/classification ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/pathology ; Lymphoma, B-Cell/radiotherapy ; Lymphoma, B-Cell/surgery ; Lymphoma, B-Cell/therapy ; Lymphoma, B-Cell, Marginal Zone/therapy ; Radioimmunotherapy ; Radiotherapy/methods ; Rituximab ; Skin Neoplasms/diagnosis ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Skin Neoplasms/radiotherapy ; Skin Neoplasms/surgery ; Skin Neoplasms/therapy
Chemical Substances	Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Antibodies, Monoclonal, Murine-Derived ; Antineoplastic Agents ; Interferon-alpha ; Rituximab (4F4X42SYQ6)
Language	French
Publishing date	2010-08
Publishing country	France
Document type	English Abstract ; Journal Article ; Practice Guideline
ZDB-ID	391805-1
ISSN	2214-5451 ; 0151-9638
ISSN (online)	2214-5451
ISSN	0151-9638
DOI	10.1016/j.annder.2010.04.016
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In stock of ZB MED Cologne/Königswinter

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