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Article: A brief summary of endoscopic classifications in the upper gastrointestinal tract and their clinical relevance.

Jiménez Sánchez, Javier / Delgado-Guillena, Pedro / Moreira, Leticia / Martínez Crespo, Juan José

2024 Volume 47, Issue 2, Page(s) 194–198

MeSH term(s)	Humans ; Clinical Relevance ; Upper Gastrointestinal Tract/diagnostic imaging ; Endoscopy ; Endoscopy, Gastrointestinal
Language	Spanish
Publishing date	2024-01-03
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2024.01.001
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Article ; Online: Curative criteria for endoscopic treatment of gastric cancer.

Cunha Neves, João A / Delgado-Guillena, Pedro G / Queirós, Patrícia / Libânio, Diogo / Rodríguez de Santiago, Enrique

Best practice & research. Clinical gastroenterology

2024 Volume 68, Page(s) 101884

Abstract: Endoscopic treatment, particularly endoscopic submucosal dissection, has become the primary treatment for early gastric cancer. A comprehensive optical assessment, including white light endoscopy, image-enhanced endoscopy, and magnification, are the ... ...

Abstract	Endoscopic treatment, particularly endoscopic submucosal dissection, has become the primary treatment for early gastric cancer. A comprehensive optical assessment, including white light endoscopy, image-enhanced endoscopy, and magnification, are the cornerstones for clinical staging and determining the resectability of lesions. This paper discusses factors that influence the indication for endoscopic resection and the likelihood of achieving a curative resection. Our review stresses the critical need for interpreting the histopathological report in accordance with clinical guidelines and the imperative of tailoring decisions based on the patients' and lesions' characteristics and preferences. Moreover, we offer guidance on managing complex scenarios, such as those involving non-curative resection. Finally, we identify future research avenues, including the role of artificial intelligence in estimating the depth of invasion and the urgent need to refine predictive scores for lymph node metastasis and metachronous lesions.
MeSH term(s)	Humans ; Stomach Neoplasms/diagnostic imaging ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Artificial Intelligence ; Gastric Mucosa/pathology ; Gastric Mucosa/surgery ; Endoscopy, Gastrointestinal ; Endoscopic Mucosal Resection ; Retrospective Studies
Language	English
Publishing date	2024-02-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2048181-0
ISSN	1532-1916 ; 1521-6918
ISSN (online)	1532-1916
ISSN	1521-6918
DOI	10.1016/j.bpg.2024.101884
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Article: Gastric intestinal metaplasia with a novel high-definition endoscopic system and optical and digital chromoendoscopy.

Delgado-Guillena, Pedro / Vinagre-Rodríguez, Gema / Gutiérrez-Cierco, Juan Luis / Rosón-Rodríguez, Pedro

Gastroenterologia y hepatologia

2021 Volume 45, Issue 4, Page(s) 286–288

Title translation	Metaplasia intestinal gástrica con un nuevo sistema endoscópico de alta definición y cromoendoscopia óptica y digital.
MeSH term(s)	Endoscopy ; Gastric Mucosa ; Humans ; Metaplasia ; Precancerous Conditions ; Stomach Diseases ; Stomach Neoplasms
Language	Spanish
Publishing date	2021-02-02
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2020.12.003
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Article: History and clinical guidelines for chronic atrophic gastritis and the assessment of gastric cancer risk.

Delgado-Guillena, Pedro / Velamazan-Sandalinas, Raúl / Jiménez Sánchez, Javier / Fuentes-Valenzuela, Esteban / García-Morales, Natalia / Cuatrecasas, Miriam / Jimeno, Mireya / Moreira, Leticia / Albéniz, Eduardo

Gastroenterologia y hepatologia

2023 Volume 46, Issue 9, Page(s) 727–731

MeSH term(s)	Humans ; Gastritis, Atrophic/complications ; Gastritis, Atrophic/diagnosis ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/etiology ; Gastritis ; Risk ; Helicobacter pylori ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Gastric Mucosa
Language	Spanish
Publishing date	2023-09-13
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2023.09.001
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Article: Diagnostic accuracy of gastric premalignant conditions in a community setting using high-definition endoscopes and digital chromoendoscopy developed by Sonoscape.

Delgado-Guillena, Pedro Genaro / Sánchez-Jara, Valeria / Henao-Carrasco, Almudena / Gutiérrez-Cierco, Juan Luis / Pabón-Carrasco, Sara / Vinagre-Rodríguez, Gema

Gastroenterologia y hepatologia

2021 Volume 45 Suppl 1, Page(s) 89–91

MeSH term(s)	Coloring Agents ; Endoscopes ; Endoscopy ; Humans ; Precancerous Conditions/diagnosis
Chemical Substances	Coloring Agents
Language	Spanish
Publishing date	2021-10-08
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2021.09.007
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Article: Identifying the gastric atrophic border according to Kimura-Takemoto classification by using high-definition endoscopes and a new virtual chromoendoscopy modality.

Delgado-Guillena, Pedro Genaro / Borrallo-Cruz, Juan Antonio / Sánchez-Jara, Cristina Valeria / Gutiérrez-Cierco, Juan Luis / Pabón-Carrasco, Sara / Murube-Jiménez, Adrián / Vinagre-Rodríguez, Gema / Quach, Duc T

Gastroenterologia y hepatologia

2022 Volume 46, Issue 7, Page(s) 557–559

MeSH term(s)	Humans ; Gastritis, Atrophic ; Endoscopy ; Endoscopes ; Gastric Mucosa ; Stomach Neoplasms
Language	Spanish
Publishing date	2022-05-21
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2022.05.007
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Article: Frequency and clinical characteristics of early gastric cancer in comparison to advanced gastric cancer in a health area of Spain.

Delgado-Guillena, Pedro / Morales-Alvarado, Víctor / Ramírez Salazar, Consuelo / Jimeno Ramiro, Mireya / Llibre Nieto, Gemma / Galvez-Olortegui, Jose / Uchima, Hugo

Gastroenterologia y hepatologia

2020 Volume 43, Issue 9, Page(s) 506–514

Abstract: Introduction: Gastric cancer (GC) incidence is currently decreasing; however, survival is still low. Early GC (EGC) has better prognosis and it could be cured by endoscopic methods.: Patients and methods: Observational study of a retrospective cohort ...

Title translation	Frecuencia y aspectos clínicos del cáncer gástrico precoz en relación con el avanzado en un área sanitaria de España.
Abstract	Introduction: Gastric cancer (GC) incidence is currently decreasing; however, survival is still low. Early GC (EGC) has better prognosis and it could be cured by endoscopic methods. Patients and methods: Observational study of a retrospective cohort of all patients with GC during a five-year period in a health area of Spain. EGC diagnosis was defined as mucosal or submucosal (T1) cancers regardless of lymph node involvement, whereas the advanced GC were T2-T4. Results: 209 patients were included, and 26 (12%) of them were EGC. There was no difference between EGC and advanced GC in age, sex, HP infection, precancerous lesions or histological type. Other characteristics of EGC were different from advanced GC: location (antrum and incisura in 76% vs 38%, p=0.01), alarm symptoms (69% vs 90%, p<0.01), curative treatment (100% vs 30%, p<0.01), performance status (PS 0-1: 92% vs 75%, p=0.03) and survival (85% vs 20%, p<0.001). Among patients who received curative treatment, 98% (79/81) underwent surgery and 2% (2/81) were treated by mucosectomy. Seven (27%) patients with EGC could have benefited from treatment by endoscopic submucosal resection. Discussion: EGC frequency was low (12% of GCs) in our health area. EGC had a high percentage of alarm symptoms, and was located in the distal third of the stomach (antrum and incisura) and had better prognosis compared to advanced GC. Strategies to increase detection and endoscopic treatment of EGC should be implemented.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/pathology
Language	Spanish
Publishing date	2020-08-19
Publishing country	Spain
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2020.01.015
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Article ; Online: Gastroenterologists' attitudes on the detection and management of gastric premalignant conditions: results of a nationwide survey in Spain.

Delgado-Guillena, Pedro Genaro / Morales-Alvarado, Victor Jair / Elosua-González, Alfonso / Murcia Pomares, Oscar / Pérez-Aisa, Angeles / Córdova, Henry / Alcedo, Javier / Calvet, Xavier / Fernández-Esparrach, Gloria

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

2020 Volume 30, Issue 6, Page(s) 431–436

Abstract: Introduction: Gastric premalignant conditions (GPC) surveillance has been proposed to improve the prognosis of gastric cancer (GC), but the early GC detection rate remaining low, and missing GC during an esophago-gastro-duodenoscopy is still a problem. ... ...

Abstract	Introduction: Gastric premalignant conditions (GPC) surveillance has been proposed to improve the prognosis of gastric cancer (GC), but the early GC detection rate remaining low, and missing GC during an esophago-gastro-duodenoscopy is still a problem. We aimed to explore the gastroenterologists' attitudes on the detection and management of GPC. Methods: A cross-sectional study was designed based on a survey among gastroenterologists from Asociación Española de Gastroenterología. Results: The participation rate was 12% (146/1243). Eighty-one percent worked at secondary or tertiary-care hospitals with the capability to perform mucosectomy (80%), but with a lesser availability of endoscopic submucosal dissection (35%). Most respondents had high-definition endoscopes (88%), and virtual chromoendoscopy (86%), but during performing an upper endoscopy, 34% never or rarely use chromoendoscopy, and 73% apply a biopsy protocol often/very often when atrophy or intestinal metaplasia (IM) is suspected. Half of the respondents self-reported their ability to recognize atrophy or IM ≤7 (on a scale from 0 to 10), whereas ≤6 for dysplasia or early GC. Helicobacter pylori infection is eradicated and verified by ≥90%. Endoscopic surveillance of atrophy/IM is performed by 62%. An immediate endoscopy for dysplasia is not always performed. For low-grade dysplasia, 97.6% consider endoscopic management, but for high-grade dysplasia, 23% regard gastric surgery. Conclusion: There is a wide variability in the detection and management of GPC among Spanish gastroenterologists, and compliance with guidelines and biopsy protocols could be improved. Performance of high-quality gastroscopies including use of virtual chromoendoscopy, that might allow an improvement in the GPC detection, needs also to be generalized.
MeSH term(s)	Atrophy ; Attitude ; Cross-Sectional Studies ; Gastroenterologists ; Helicobacter Infections/pathology ; Helicobacter pylori ; Humans ; Metaplasia ; Precancerous Conditions/diagnosis ; Precancerous Conditions/pathology ; Spain/epidemiology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/therapy ; Surveys and Questionnaires
Language	English
Publishing date	2020-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1137033-6
ISSN	1473-5709 ; 0959-8278
ISSN (online)	1473-5709
ISSN	0959-8278
DOI	10.1097/CEJ.0000000000000648
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Article ; Online: Diagnosis of Helicobacter pylori Infection by the Arrangement of Collecting Venules Using White Light Endoscopy: Evaluation of Interobserver Agreement.

Garcés-Durán, Rodrigo / Galdín-Ferreyra, Martín / Delgado-Guillena, Pedro Genaro / Cuatrecasas, Miriam / Córdova, Henry / García-Rodríguez, Ana / Rodrigo-Calvo, Maria-Teresa / Jimeno-Ramiro, Mireya / Araujo, Isis Karina / Ginès, Angels / Llach, Josep / Fernandez-Esparrach, Gloria

Digestive diseases (Basel, Switzerland)

2021 Volume 40, Issue 3, Page(s) 376–384

Abstract: Background: Regular arrangement of collecting venules (RAC) in gastric mucosa accurately identifies patients without Helicobacter pylori (H pylori) infection. The aim of our study was to evaluate the reproducibility of RAC using white light endoscopy ... ...

Abstract	Background: Regular arrangement of collecting venules (RAC) in gastric mucosa accurately identifies patients without Helicobacter pylori (H pylori) infection. The aim of our study was to evaluate the reproducibility of RAC using white light endoscopy without magnification, in a European country, and to assess the impact of proton pump inhibitors (PPIs). Methods: A multicenter prospective study with image capture of the distal lesser gastric curvature and gastric biopsies was performed. The presence of starfish-like minute points regularly distributed throughout lesser curvature was considered as RAC positive (RAC+). A set of 20 images was used for the training phase and inter and intra-observer agreements were calculated. Results: 174 patients were included and 85 (48.9%) were taking PPIs. Kappa values for interobserver and intra-observer agreements were substantial (0.786) and excellent (0.906), respectively. H. pylori infection was diagnosed in 29 patients (16.7%): 10/85 with PPIs and 19/89 without PPIs (11.8% vs. 21.3%; p = 0.09). All RAC + patients were free of H. pylori infection, with a sensitivity and negative predictive value of 100%, regardless of PPI intake. Conclusion: The endoscopic diagnosis of H. pylori by RAC is an easy-to-learn and highly reproducible technique, even with PPI intake. Our results warrant RAC as a real-time diagnostic method for H. pylori-negative infection in Western practice.
MeSH term(s)	Gastric Mucosa/pathology ; Gastroscopy/methods ; Helicobacter Infections/diagnosis ; Helicobacter pylori ; Humans ; Observer Variation ; Prospective Studies ; Reproducibility of Results ; Venules/pathology
Language	English
Publishing date	2021-06-30
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000518100
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Article: Applicability of the Barcelona scale to assess the quality of cleanliness of mucosa at esophagogastroduodenoscopy.

Córdova, Henry / Barreiro-Alonso, Eva / Castillo-Regalado, Edgar / Cubiella, Joaquín / Delgado-Guillena, Pedro / Díez Redondo, Pilar / Galdín, Martin / García-Rodríguez, Ana / Hernández, Luis / Huerta, Alain / Jover, Rodrigo / Núñez, Henar / Rodríguez-D'Jesús, Antonio / Seoane, Agustín / Surís, Gerard / Tejedor-Tejada, Javier / Jiménez Sánchez, Javier / Martín, Francisco / Moreira, Leticia /

Carballal, Sabela / Rivero, Liseth / Da Fieno, Angella / Casanova, Gherzon / Luzko Scheid, Irina / Llach, Joan / Fernández-Esparrach, Gloria

Gastroenterologia y hepatologia

2023 Volume 47, Issue 3, Page(s) 246–252

Abstract: Background and objectives: There are few scales with prospective validation for the assessment of the upper gastrointestinal mucosal cleanliness during an esophagogastroduodenoscopy (EGD). The aim of this study was to develop a valid and reproducible ... ...

Abstract	Background and objectives: There are few scales with prospective validation for the assessment of the upper gastrointestinal mucosal cleanliness during an esophagogastroduodenoscopy (EGD). The aim of this study was to develop a valid and reproducible cleanliness scale for use during an EGD. Methods: We developed a cleanliness scale (Barcelona scale) with a score (0-2 points) of five segments of the upper gastrointestinal tract with thorough cleaning techniques (esophagus, fundus, body, antrum, and duodenum). First, 125 photos (25 of each area) were assessed, and a score was assigned to each image by consensus among 7 experts endoscopists. Subsequently, 100 of the 125 images were selected and the inter- and intra-observer variability of 15 previously trained endoscopists was evaluated using the same images at two different times. Results: In total, 1500 assessments were performed. In 1336/1500 observations (89%) there was agreement with the consensus score, with a mean kappa value of 0.83 (0.45-0.96). In the second evaluation, in 1330/1500 observations (89%) there was agreement with the consensus score, with a mean kappa value of 0.82 (0.45-0.93). The intra-observer variability was 0.89 (0.76-0.99). Conclusions: The Barcelona cleanliness scale is a valid measure and reproducible with minimal training. Its application in clinical practice is a significant step to standardize the quality of the EGD.
MeSH term(s)	Humans ; Mucous Membrane ; Consensus ; Duodenum ; Endoscopy, Digestive System
Language	Spanish
Publishing date	2023-05-24
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2023.05.011
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