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  1. Article ; Online: Tracheobronchomalacia in Neonates: The "New Bronchopulmonary Dysplasia" Is Not Just about the Alveoli.

    Dell, Sharon D

    Annals of the American Thoracic Society

    2017  Volume 14, Issue 9, Page(s) 1387–1388

    Language English
    Publishing date 2017-08-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201706-507ED
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    Zs.A 5828: Show issues Location:
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  2. Article ; Online: Efficacy of Antibiotic Eradication Therapy of Early

    Gatt, Dvir / Shaw, Michelle / Wee, Wallace / Solomon, Melinda / Dell, Sharon D / Ratjen, Felix

    Annals of the American Thoracic Society

    2023  Volume 20, Issue 6, Page(s) 854–860

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Child ; Humans ; Pseudomonas Infections/complications ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/diagnosis ; Retrospective Studies ; Cystic Fibrosis/drug therapy ; Arthritis, Psoriatic/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Tobramycin ; Pseudomonas aeruginosa ; Ciliary Motility Disorders
    Chemical Substances Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202210-858OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mortality of Pediatric Surgical Lung Biopsies in Ontario, Canada, 2000-2019.

    Wee, Wallace B / Shapera, Shane / To, Teresa / Chiu, Priscilla P L / Dell, Sharon D / Fisher, Jolene H

    Annals of the American Thoracic Society

    2024  Volume 21, Issue 5, Page(s) 767–773

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Ontario/epidemiology ; Male ; Female ; Child ; Biopsy/statistics & numerical data ; Child, Preschool ; Adolescent ; Infant ; Risk Factors ; Lung Diseases/pathology ; Lung Diseases/mortality ; Lung Diseases/surgery ; Lung/pathology ; Lung/surgery ; Infant, Newborn ; Logistic Models ; Retrospective Studies
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202304-306OC
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  4. Article ; Online: Severe disease due to CCDC40 gene variants and the perils of late diagnosis in primary ciliary dyskinesia.

    Ghandourah, Hasan / Dell, Sharon D

    BMJ case reports

    2018  Volume 2018

    Abstract: Primary ciliary dyskinesia (PCD) can manifest in the neonatal period with severe respiratory distress. We describe a child with PCD who presented at term with severe neonatal respiratory distress, persistent right upper lobe collapse and failure to ... ...

    Abstract Primary ciliary dyskinesia (PCD) can manifest in the neonatal period with severe respiratory distress. We describe a child with PCD who presented at term with severe neonatal respiratory distress, persistent right upper lobe collapse and failure to thrive who underwent lobectomy prior to the diagnosis of PCD at the age of 3 years. This case report illustrates the severe spectrum of lung disease associated with coiled-coil domain containing protein 40 (CCDC40) gene variants in patients with PCD.
    MeSH term(s) Delayed Diagnosis ; Diagnosis, Differential ; Female ; Humans ; Infant, Newborn ; Kartagener Syndrome/diagnosis ; Lung/pathology ; Mutation ; Pneumonectomy ; Proteins/genetics ; Respiratory Distress Syndrome, Newborn/etiology ; Tomography, X-Ray Computed
    Chemical Substances CCDC40 protein, human ; Proteins
    Language English
    Publishing date 2018-09-12
    Publishing country England
    Document type Journal Article ; Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-224964
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  5. Article ; Online: Development and Validation of an Algorithm for Quality Grading of Pediatric Spirometry: A Quality Improvement Initiative.

    Perrem, Lucy / Wilson, David / Dell, Sharon D / Ratjen, Felix

    Annals of the American Thoracic Society

    2021  Volume 19, Issue 1, Page(s) 74–81

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Algorithms ; Child ; Forced Expiratory Volume ; Humans ; Quality Improvement ; Spirometry ; Vital Capacity
    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202103-382QI
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Full-Term Neonatal Respiratory Distress and Chronic Lung Disease.

    Chowdhury, Naema / Giles, B Louise / Dell, Sharon D

    Pediatric annals

    2019  Volume 48, Issue 4, Page(s) e175–e181

    Abstract: Respiratory distress occurs in 5% to 7% of live births at term gestation. Most cases are mild and transient and can be attributed to transient tachypnea of the newborn or "wet lung." Severe respiratory distress is often due to nonpulmonary causes such as ...

    Abstract Respiratory distress occurs in 5% to 7% of live births at term gestation. Most cases are mild and transient and can be attributed to transient tachypnea of the newborn or "wet lung." Severe respiratory distress is often due to nonpulmonary causes such as sepsis or congenital heart disease. Occasionally, term neonatal respiratory distress is associated with an inherited primary lung disease such as primary ciliary dyskinesia or surfactant metabolism defects. These lung diseases have characteristic presentations in the neonatal period and are important to recognize, as they necessitate different management approaches and have lifelong implications. Suspicion for these diseases should prompt referral to a pediatric pulmonologist. [Pediatr Ann. 2019;48(4):e175-e181.].
    MeSH term(s) Chronic Disease ; Humans ; Infant, Newborn ; Lung/pathology ; Respiratory Distress Syndrome, Newborn/diagnosis ; Respiratory Distress Syndrome, Newborn/etiology ; Term Birth
    Language English
    Publishing date 2019-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20190328-01
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    Zs.A 1347: Show issues Location:
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  7. Article ; Online: Going beyond the chest X-ray: Investigating laterality defects in primary ciliary dyskinesia.

    Wee, Wallace B / Kaspy, Kimberley R / Sawras, Michael G / Knowles, Michael R / Zariwala, Maimoona A / Leigh, Margaret W / Dell, Sharon D / Shapiro, Adam J

    Pediatric pulmonology

    2022  Volume 57, Issue 5, Page(s) 1318–1324

    Abstract: Background: Organ laterality defects in primary ciliary dyskinesia (PCD) are common, ranging from complete mirror image organ arrangement, situs inversus totalis (SIT), to situs ambiguus (SA), which falls along the spectrum of situs solitus (SS) and SIT. ...

    Abstract Background: Organ laterality defects in primary ciliary dyskinesia (PCD) are common, ranging from complete mirror image organ arrangement, situs inversus totalis (SIT), to situs ambiguus (SA), which falls along the spectrum of situs solitus (SS) and SIT. Targeted investigations for organ laterality defects are not universally recommended in PCD consensus statements. Without investigations beyond chest radiography (CXR), clinically significant defects may go undetected leading to increased morbidity. We hypothesize that clinically significant SA defects remain undetected on CXR and targeted investigations are needed to detect various laterality defects associated with morbidity.
    Methods: This retrospective study collected data from PCD clinics at two Canadian children's hospitals from 2012 to 2020. Participants <30 years old with a confirmed or clinical diagnosis of PCD were enrolled. CXR images were reviewed, and reports of other targeted investigations, including chest computed tomography, abdominal ultrasound, echocardiogram, upper gastrointestinal series, and splenic function studies, were extracted from medical records. Situs classifications from CXR alone versus CXR with add-on targeted investigations were compared using Cochran's q and McNemar tests.
    Results: One hundred and fifty-nine PCD patients were included, median age at PCD diagnosis of 6.1 years (range: 0-28). The situs classification differed significantly from CXR images alone versus CXR with add-on targeted investigations (p < 0.001); SS 88 (55%) versus 75 (47%), SIT 59 (37%) versus 46 (29%), and SA 12 (8%) versus 38 (24%). Identified SA defects were cardiovascular (21, 13%), intestinal (9, 6%), and/or splenic (16,10%).
    Conclusions: In PCD patients, clinically significant SA defects may not be detected by CXR alone. Our results suggest that the routine use of CXR with add-on targeted investigations may be justified.
    MeSH term(s) Adult ; Canada ; Child ; Ciliary Motility Disorders ; Humans ; Kartagener Syndrome/complications ; Kartagener Syndrome/diagnostic imaging ; Radiography ; Respiration Disorders/complications ; Retrospective Studies ; Situs Inversus/diagnostic imaging ; X-Rays
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25853
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    Zs.A 2143: Show issues Location:
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  8. Article ; Online: Association of factors with childhood asthma and allergic diseases using latent class analysis.

    To, Teresa / Borkhoff, Cornelia M / Anderson, Laura N / Birken, Catherine S / Dell, Sharon D / Janus, Magdalena / Maguire, Jonathon L / Moraes, Theo J / Parkin, Patricia C / Subbarao, Padmaja / Van Dam, Anne / Guttman, Beverly / Terebessy, Emilie / Zhang, Kimball / Zhu, Jingqin

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6874

    Abstract: We hypothesize that children characterized by deprived factors have poorer health outcomes. We aim to identify clustering of determinants and estimate risk of early childhood diseases. This 1993-2019 longitudinal cohort study combines three Canadian ... ...

    Abstract We hypothesize that children characterized by deprived factors have poorer health outcomes. We aim to identify clustering of determinants and estimate risk of early childhood diseases. This 1993-2019 longitudinal cohort study combines three Canadian pediatric cohorts and their families. Mothers and children are clustered using latent class analysis (LCA) by 16 indicators in three domains (maternal and newborn; socioeconomic status [SES] and neighbourhood; environmental exposures). Hazard ratios (HR) of childhood asthma, allergic rhinitis (AR), and eczema are quantified with Cox proportional hazard (PH) regression. Rate ratios (RR) of children's health services use (HSU) are estimated with Poisson regression. Here we report the inclusion of 15,724 mother-child pairs; our LCA identifies four mother-clusters. Classes 1 and 2 mothers are older (30-40 s), non-immigrants with university education, living in high SES neighbourhoods; Class 2 mothers have poorer air quality and less greenspace. Classes 3 and 4 mothers are younger (20-30 s), likely an immigrant/refugee, with high school-to-college education, living in lower SES neighborhoods with poorer air quality and less greenspace. Children's outcomes differ by Class, in comparison to Class 1. Classes 3 and 4 children have higher risks of asthma (HR 1.24, 95% CI 1.11-1.37 and HR 1.39, 95% CI 1.22-1.59, respectively), and similar higher risks of AR and eczema. Children with AR in Class 3 have 20% higher all-cause physician visits (RR = 1.20, 95% CI 1.10-1.30) and those with eczema have 18% higher all-cause emergency department visits (RR = 1.18, 95% CI 1.09-1.28) and 14% higher all-cause physician visits (RR = 1.14, 95% CI 1.09-1.19). Multifactorial-LCA mother-clusters may characterize associations of children's health outcomes and care, adjusting for interrelationships.
    MeSH term(s) Infant, Newborn ; Female ; Humans ; Child ; Child, Preschool ; Longitudinal Studies ; Latent Class Analysis ; Canada ; Asthma/epidemiology ; Asthma/etiology ; Eczema/epidemiology ; Rhinitis, Allergic/epidemiology
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56805-9
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  9. Article ; Online: Neighborhood Material Deprivation Is Associated with Childhood Asthma Development: Analysis of Prospective Administrative Data.

    Simons, Elinor / Dell, Sharon D / Moineddin, Rahim / To, Teresa

    Canadian respiratory journal

    2019  Volume 2019, Page(s) 6808206

    Abstract: Rationale: Material deprivation has been proposed as a more comprehensive measure of socioeconomic status than parental income. Stronger associations between childhood emergency department visits for asthma and air pollution have been demonstrated among ...

    Abstract Rationale: Material deprivation has been proposed as a more comprehensive measure of socioeconomic status than parental income. Stronger associations between childhood emergency department visits for asthma and air pollution have been demonstrated among children living in neighborhoods with high levels of deprivation, but the associations with asthma development and ongoing asthma are not known.
    Objectives: We determined the associations between neighborhood material deprivation and the development of new and ongoing childhood asthma.
    Methods: Prospectively collected administrative data housed at the Institute for Clinical Evaluative Sciences were examined for Toronto children born from 1997 to 2003. Neighborhood material deprivation, comprising no high school graduation, lone parent families, government transfers, unemployment, low income, and homes needing major repairs, was reported in the Ontario Marginalization Index. Incident asthma was defined by the time of entry into the Ontario Asthma Surveillance Information System (OASIS) database. We measured the risk of incident asthma using Cox proportional hazards models and the associations between ongoing asthma visits and deprivation by year of life with generalized linear mixed models.
    Results: OASIS asthma criteria were met for 21% of the 326,383 children. After adjustment for characteristics strongly associated with asthma, including male sex, prematurity, obesity, and atopic conditions other than asthma, children with high birth neighborhood deprivation were at increased risk of incident asthma (HR 1.11; 95% CI, 1.09-1.13). High deprivation in a given year of life was associated with increased odds of ongoing asthma during that year of life (OR 1.03; 95% CI, 1.02-1.05).
    Conclusions: Children living in high-deprivation neighborhoods are at increased risk of incident and ongoing asthma. This study suggests that neighborhood material deprivation may represent a helpful tool for evaluating the effects of disparities in health and social advantages on the likelihood of developing and continuing to need healthcare visits for ongoing childhood asthma.
    MeSH term(s) Adolescent ; Asthma/epidemiology ; Child ; Female ; Humans ; Male ; Maternal Deprivation ; Ontario/epidemiology ; Prospective Studies ; Residence Characteristics
    Language English
    Publishing date 2019-05-19
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1213103-9
    ISSN 1916-7245 ; 1198-2241
    ISSN (online) 1916-7245
    ISSN 1198-2241
    DOI 10.1155/2019/6808206
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  10. Article: Primary ciliary dyskinesia: Myths and realities.

    Dell, Sharon D

    Paediatrics & child health

    2008  Volume 13, Issue 8, Page(s) 668–670

    Language English
    Publishing date 2008-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2106767-3
    ISSN 1918-1485 ; 1205-7088
    ISSN (online) 1918-1485
    ISSN 1205-7088
    DOI 10.1093/pch/13.8.668
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