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  1. Article ; Online: An innovative one step green supercritical CO

    Penoy, Noémie / Delma, Kouka Luc / Tonakpon, Hermane Avohou / Grignard, Bruno / Evrard, Brigitte / Piel, Géraldine

    International journal of pharmaceutics

    2022  Volume 627, Page(s) 122212

    Abstract: Budesonide and salbutamol-loaded liposomes were prepared using an innovative one step supercritical ... ...

    Abstract Budesonide and salbutamol-loaded liposomes were prepared using an innovative one step supercritical CO
    MeSH term(s) Liposomes/chemistry ; Carbon Dioxide/chemistry ; Trehalose ; Budesonide ; Albuterol ; Phosphatidylcholines ; Cholesterol ; Solvents ; Polyethylene Glycols ; Particle Size
    Chemical Substances Liposomes ; Carbon Dioxide (142M471B3J) ; Trehalose (B8WCK70T7I) ; Budesonide (51333-22-3) ; Albuterol (QF8SVZ843E) ; Phosphatidylcholines ; Cholesterol (97C5T2UQ7J) ; Solvents ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2022-09-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.122212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Development and optimization of a one step process for the production and sterilization of liposomes using supercritical CO

    Penoy, Noémie / Delma, Kouka Luc / Homkar, Nirmayi / Karim Sakira, Abdoul / Egrek, Sabrina / Sacheli, Rosalie / Sacré, Pierre-Yves / Grignard, Bruno / Hayette, Marie-Pierre / Somé, Touridomon Issa / Semdé, Rasmané / Evrard, Brigitte / Piel, Géraldine

    International journal of pharmaceutics

    2024  Volume 651, Page(s) 123769

    Abstract: Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that ... ...

    Abstract Liposomes are very interesting drug delivery systems for pharmaceutical and therapeutic purposes. However, liposome sterilization as well as their industrial manufacturing remain challenging. Supercritical carbon dioxide is an innovative technology that can potentially overcome these limitations. The aim of this study was to optimize a one-step process for producing and sterilizing liposomes using supercritical CO
    MeSH term(s) Humans ; Liposomes/chemistry ; Carbon Dioxide/chemistry ; Drug Delivery Systems ; Sterilization ; Infertility
    Chemical Substances Liposomes ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2024-01-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2024.123769
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Sterilization methods of liposomes: Drawbacks of conventional methods and perspectives.

    Delma, Kouka Luc / Lechanteur, Anna / Evrard, Brigitte / Semdé, Rasmané / Piel, Géraldine

    International journal of pharmaceutics

    2021  Volume 597, Page(s) 120271

    Abstract: Liposomes are targeted drug delivery systems that are of great pharmaceutical and therapeutic interest. Parenteral route is the main way used for liposome administration. In this case, their sterility is a requirement. However, due to the particular ... ...

    Abstract Liposomes are targeted drug delivery systems that are of great pharmaceutical and therapeutic interest. Parenteral route is the main way used for liposome administration. In this case, their sterility is a requirement. However, due to the particular sensitivity of liposomes and their tendency to physicochemical alterations, their sterilization remains a real challenge. Conventional sterilization methods such as heat, ethylene oxide, ultraviolet and gamma irradiations are considered as unsuitable for liposome sterilization and the recommended methods for obtaining sterility of liposomes are filtration and aseptic manufacturing. Unfortunately, these recommended methods are not without limitations. This review outlines the difficulties associated with the use of these different classical methods for obtaining liposome sterility. The effects on liposome physicochemical and biopharmaceutical characteristics as well as efficacy, toxicity and practical problems of these sterilization techniques have been discussed. The search for an alternative method being therefore necessary, the applicability of supercritical carbon dioxide (ScCO
    MeSH term(s) Drug Delivery Systems ; Filtration ; Liposomes ; Sterilization
    Chemical Substances Liposomes
    Language English
    Publishing date 2021-02-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2021.120271
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  4. Article ; Online: Use of supercritical CO

    Delma, Kouka Luc / Penoy, Noémie / Sakira, Abdoul Karim / Egrek, Sabrina / Sacheli, Rosalie / Grignard, Bruno / Hayette, Marie-Pierre / Issa Somé, Touridomon / Evrard, Brigitte / Semdé, Rasmané / Piel, Géraldine

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2023  Volume 183, Page(s) 112–118

    Abstract: The effects of four potential supercritical carbon dioxide ( ... ...

    Abstract The effects of four potential supercritical carbon dioxide (ScCO
    MeSH term(s) Liposomes ; Phospholipids ; Carbon Dioxide/pharmacology ; Hydrogen Peroxide ; Sterilization/methods
    Chemical Substances Liposomes ; Phospholipids ; Carbon Dioxide (142M471B3J) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2023.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1651: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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