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Article ; Online: Impacts de la pandémie de Covid-19 sur les enfants et adolescents.

Trebossen, Vincent / Khoury, Élie / Delorme, Richard

2023 Volume 72, Issue 10, Page(s) 1067–1070

Abstract: IMPACTS OF THE COVID-19 PANDEMIC ON CHILDREN AND ADOLESCENTS. The Covid-19 pandemic and the lockdown measures taken to limit the spread of the virus have caused significant changes in the daily lives of the whole population including children and ... ...

Title translation	Impacts of the covid-19 pandemic on children and adolescents.
Abstract	IMPACTS OF THE COVID-19 PANDEMIC ON CHILDREN AND ADOLESCENTS. The Covid-19 pandemic and the lockdown measures taken to limit the spread of the virus have caused significant changes in the daily lives of the whole population including children and adolescents. School closure and physical distancing significantly interfere with their learning and social life deeply impacting their health and education. The most vulnerable children (personal history of mental health or neurodevelopmental disorders, chronic physical illness) were also those the most significantly affected by the Sars-CoV-2 pandemic. However, data remains scarce today, and it remains a major challenge to conduct longitudinal studies that will enable the development of primary prevention programs in the general population and secondary prevention programs in already affected children.
MeSH term(s)	Humans ; Child ; Adolescent ; COVID-19 ; SARS-CoV-2 ; Pandemics/prevention & control ; Communicable Disease Control ; Mental Health
Language	French
Publishing date	2023-02-22
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Inhibition functions can be improved in children with autism spectrum disorders: An eye-tracking study.

Caldani, Simona / Humeau, Elise / Delorme, Richard / Bucci, Maria Pia

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

2023 Volume 83, Issue 5, Page(s) 431–441

Abstract: Cognitive remediation therapy interventions could improve cognitive functioning in subjects with autism. To investigate the benefit of a short cognitive training rehabilitation in children with autism spectrum disorder (ASD) on pursuit and fixation ... ...

Abstract	Cognitive remediation therapy interventions could improve cognitive functioning in subjects with autism. To investigate the benefit of a short cognitive training rehabilitation in children with autism spectrum disorder (ASD) on pursuit and fixation performances. We recruited two groups (G1 and G2) of 30 children with ASD, sex-, IQ- and age-matched (mean 11.6 ± 0.5 years), and pursuit and fixation eye movements were recorded twice at T1 and T2. Between T1 and T2, a 10-min cognitive training was performed by the G1 group only, whereas the G2 group had a 10-min of rest. For all children with ASD enrolled in the study, there was a positive correlation between restricted and repetitive behaviour scores of both Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) and the number of saccades recorded during the fixation task at T1. At T1, oculomotor performances were similar for both groups of ASD children (G1 and G2). At T2, we observed a significant reduction in the number of saccades made during both pursuit and fixation tasks. Our findings underlined the importance to promote cognitive training rehabilitation for children with ASD, leading to a better performance in inhibitory and attention functioning responsible for pursuit and fixation eye movement's performance.
MeSH term(s)	Female ; Humans ; Male ; Attention/physiology ; Autism Spectrum Disorder/physiopathology ; Autism Spectrum Disorder/rehabilitation ; Cognitive Training ; Data Analysis ; Eye Movements/physiology ; Eye-Tracking Technology ; Fixation, Ocular/physiology ; Psychomotor Performance ; Pursuit, Smooth/physiology ; Saccades/physiology ; Stroop Test ; Time Factors ; Child
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Controlled Clinical Trial ; Journal Article
ZDB-ID	605533-3
ISSN	1873-474X ; 0736-5748
ISSN (online)	1873-474X
ISSN	0736-5748
DOI	10.1002/jdn.10276
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Zs.A 1883: Show issues

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Article ; Online: Dysfunction in inhibition and executive capabilities in children with autism spectrum disorder: An eye tracker study on memory guided saccades.

Caldani, Simona / Humeau, Elise / Delorme, Richard / Bucci, Maria Pia

Applied neuropsychology. Child

2022 Volume 12, Issue 2, Page(s) 131–136

Abstract: Background: Dysmetria in children with autism spectrum disorders is considered depend on executive dysfunctions. To explore the impact of inhibitory control and working memory on oculomotor performance in children with autism spectrum disorder (ASD), we ...

Abstract	Background: Dysmetria in children with autism spectrum disorders is considered depend on executive dysfunctions. To explore the impact of inhibitory control and working memory on oculomotor performance in children with autism spectrum disorder (ASD), we used the memory guided saccade (MGS) paradigm. Method: We enrolled in our study a group of 26 children with ASD and in a group of 26 children age-, sex-, and IQ-matched of with typically development, using only one single delay period and one single stimulus amplitude. We recorded with a video eye-tracker system- the latency and the accuracy of the MGS as well as the number of anticipatory saccades during the MGS paradigm. Results: Children with ASD displayed significant increased latency ( Conclusion: These abnormalities may underline the executive dysfunctions frequently reported in ASD: the increased latency and the decreased amplitude of memory guides saccades may be related to planning and working memory impairments; the increased number of anticipatory saccades may be linked to a deficit in inhibitory control.
MeSH term(s)	Humans ; Child ; Autism Spectrum Disorder ; Saccades ; Memory, Short-Term ; Inhibition, Psychological
Language	English
Publishing date	2022-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673759-0
ISSN	2162-2973 ; 2162-2965
ISSN (online)	2162-2973
ISSN	2162-2965
DOI	10.1080/21622965.2022.2042300
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Zs.A 6962: Show issues

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Article ; Online: Impact of IDO activation and alterations in the kynurenine pathway on hyperserotonemia, NAD

Launay, Jean-Marie / Delorme, Richard / Pagan, Cécile / Callebert, Jacques / Leboyer, Marion / Vodovar, Nicolas

Translational psychiatry

2023 Volume 13, Issue 1, Page(s) 380

Abstract: Hyperserotonemia is the most replicated biochemical anomaly associated with autism spectrum disorder (ASD) and has been reported in 35-46% of individuals with ASD. Serotonin is synthesised from the essential amino acid tryptophan (TRP). However, the main ...

Abstract	Hyperserotonemia is the most replicated biochemical anomaly associated with autism spectrum disorder (ASD) and has been reported in 35-46% of individuals with ASD. Serotonin is synthesised from the essential amino acid tryptophan (TRP). However, the main catabolic route of TRP is the kynurenine pathway (KP), which competes with serotonin synthesis when indoleamine dioxygenase (IDO) is activated. Using the same cohort of individuals with ASD, we used to report extensive studies of the serotonin/melatonin pathway, and found increased kynurenine (KYN), suggesting IDO activation in 58.7% of individuals with ASD (159/271), supported by a strong negative correlation between KYN/TRP ratio and miR-153-3p plasma levels, which negatively regulates IDO. IDO activation was associated with normoserotonemia, suggesting that IDO activation could mask hyperserotonemia which meant that hyperserotonemia, if not masked by IDO activation, could be present in ~94% of individuals with ASD. We also identified several KP alterations, independent of IDO status. We observed a decrease in the activity of 3-hydroxyanthranilate dioxygenase which translated into the accumulation of the aryl hydrocarbon receptor (AhR) selective ligand cinnabarinic acid, itself strongly positively correlated with the AhR target stanniocalcin 2. We also found a deficit in NAD
MeSH term(s)	Humans ; Kynurenine ; NAD ; Serotonin ; Receptors, Aryl Hydrocarbon ; Autism Spectrum Disorder ; Tryptophan/metabolism ; Dioxygenases ; Neuropeptides ; MicroRNAs
Chemical Substances	Kynurenine (343-65-7) ; NAD (0U46U6E8UK) ; Serotonin (333DO1RDJY) ; Receptors, Aryl Hydrocarbon ; Tryptophan (8DUH1N11BX) ; Dioxygenases (EC 1.13.11.-) ; Neuropeptides ; MIRN153 microRNA, human ; MicroRNAs
Language	English
Publishing date	2023-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-023-02687-w
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Article ; Online: Meta-analysis of personal and familial co-occurrence of Attention Deficit/Hyperactivity Disorder and Bipolar Disorder.

Khoury, Elie / Acquaviva, Eric / Purper-Ouakil, Diane / Delorme, Richard / Ellul, Pierre

Neuroscience and biobehavioral reviews

2023 Volume 146, Page(s) 105050

Abstract: Background: Attention Deficit Disorder / Hyperactivity (ADHD) and Bipolar Disorder (BD) are highly comorbid disorders. Studies have raised the hypothesis of shared genetic, neurobiological, and clinical factors. This would entail an excess risk of co- ... ...

Abstract	Background: Attention Deficit Disorder / Hyperactivity (ADHD) and Bipolar Disorder (BD) are highly comorbid disorders. Studies have raised the hypothesis of shared genetic, neurobiological, and clinical factors. This would entail an excess risk of co-occurrence of both disorders. Objective: We present the first meta-analysis of individual and familial associations between ADHD and BD. Methods: From 2688 references, 59 were included, with a total of 550,379 ADHD patients, 57,799 BD patients and 12,608,137 controls. Results: Personal history of ADHD increased the risk of BD (OR = 6.06), and conversely individuals with BD had an increased risk of ADHD (OR = 8.94). First-degree relatives of ADHD patients had an increased risk of BD (OR = 1.94). Offspring of individuals with BD had a higher risk for ADHD (OR = 2.33). Finally, first-degree relatives of BD patients had an increased risk of ADHD (OR = 2.71). Conclusion: We show a clear epidemiological overlap between ADHD and BD, as well as a strong familial association which advocates in favor of a more systematic screening.
MeSH term(s)	Humans ; Bipolar Disorder/genetics ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Neurobiology ; Comorbidity
Language	English
Publishing date	2023-01-17
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2023.105050
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Zs.A 1371: Show issues

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Article ; Online: Children with a history of both maternal immune activation and prematurity are not at increased risk of ADHD symptoms.

Ellul, Pierre / Wallez, Solène / Acquaviva, Eric / Rosenzwajg, Michelle / Klatzmann, David / Delorme, Richard / Melchior, Maria

European child & adolescent psychiatry

2023

Abstract: Maternal autoimmune diseases (AID) are risk factors for Attention Deficit Hyperactivity Disorder (ADHD). Animal studies suggest that maternal immune activation (MIA) is a disease primer for ADHD, with second environmental factor precipitating the onset ... ...

Abstract	Maternal autoimmune diseases (AID) are risk factors for Attention Deficit Hyperactivity Disorder (ADHD). Animal studies suggest that maternal immune activation (MIA) is a disease primer for ADHD, with second environmental factor precipitating the onset of the disease. Prematurity is also a major risk factor for ADHD. In this study, we sought to explore the interaction between parental AID and prematurity on ADHD risk in a community sample. Children of AID parents born prematurely appeared at increased odds of ADHD but these two risk factors do not appear to be additive (OR 1.39 [95 CI 0.75; 2.46]). Longitudinal studies with larger numbers of participants are needed.
Language	English
Publishing date	2023-08-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1118299-4
ISSN	1435-165X ; 1018-8827 ; 1433-5719
ISSN (online)	1435-165X
ISSN	1018-8827 ; 1433-5719
DOI	10.1007/s00787-023-02276-8
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Zs.A 3524: Show issues

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Article ; Online: Pilot study to explore poor visual searching capabilities in children with ADHD: a tablet-based computerized test battery study.

Aflalo, Joanna / Caldani, Simona / Acquaviva, Eric / Moscoso, Ana / Delorme, Richard / Bucci, Maria Pia

Nordic journal of psychiatry

2023 Volume 77, Issue 5, Page(s) 491–497

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Child ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Pilot Projects ; Neuropsychological Tests ; Cognitive Dysfunction
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1104974-1
ISSN	1502-4725 ; 0803-9488 ; 0029-1455
ISSN (online)	1502-4725
ISSN	0803-9488 ; 0029-1455
DOI	10.1080/08039488.2022.2162122
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Zs.B 719: Show issues

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Article: Known-groups and convergent validity of the theory of mind task battery in children with autism spectrum disorder.

Gosling, Corentin J / Cartigny, Ariane / Stevanovic, Dejan / Moutier, Sylvain / Delorme, Richard / Attwood, Tony

The British journal of clinical psychology

2023 Volume 62, Issue 2, Page(s) 525–535

Abstract: Objectives: One of the most promising Theory of Mind (ToM) tests developed for children with ASD is the Theory of Mind Task Battery (ToM-TB). Still, additional psychometric properties of this tool need to be assessed. The main objective of this ... ...

Abstract	Objectives: One of the most promising Theory of Mind (ToM) tests developed for children with ASD is the Theory of Mind Task Battery (ToM-TB). Still, additional psychometric properties of this tool need to be assessed. The main objective of this preregistered study was to investigate the known-groups and convergent validities of the ToM-TB compared to a well-established test used to assess ToM in children with ASD (the Strange Stories Test; SST). Methods: A total of 68 school-aged children were recruited (34 children with ASD and 34 children with typical development). The groups were matched on sex and age, and on both receptive language abilities and overall cognitive functioning. Results: Regarding the known-groups validity, we found group differences in the performance on the ToM-TB and SST. Additional analyses revealed that this result tended to be more robust for the ToM-TB than for the SST. Regarding convergent validity, we showed that the ToM-TB and SST correlated strongly, for children with ASD and children with typical development. In contrast, we found small correlations of these two tests with social competence in daily life. No evidence was found for greater known-groups or convergent validity of one test compared to the other. Conclusion: Our data confirmed the relevance of the ToM-TB and the SST for the assessment of ToM in school-aged children. Future studies should continue to assess the psychometric qualities of various ToM tests to provide reliable information to best guide researchers and clinicians when choosing optimal neuropsychological tools.
MeSH term(s)	Humans ; Child ; Autism Spectrum Disorder/psychology ; Theory of Mind ; Cognition
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	625324-6
ISSN	2044-8260 ; 0144-6657
ISSN (online)	2044-8260
ISSN	0144-6657
DOI	10.1111/bjc.12420
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Zs.A 185/a: Show issues

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Article ; Online: Temporal Trends in Suicide Attempts Among Children in the Decade Before and During the COVID-19 Pandemic in Paris, France.

Cousien, Anthony / Acquaviva, Eric / Kernéis, Solen / Yazdanpanah, Yazdan / Delorme, Richard

JAMA network open

2021 Volume 4, Issue 10, Page(s) e2128611

MeSH term(s)	Adolescent ; COVID-19/prevention & control ; COVID-19/psychology ; Child ; Cross-Sectional Studies ; Female ; Health Policy ; Humans ; Male ; Paris ; Suicide, Attempted/psychology ; Suicide, Attempted/trends ; Urban Health/trends
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article ; Observational Study
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2021.28611
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Article ; Online: Parental autoimmune and autoinflammatory disorders as multiple risk factors for common neurodevelopmental disorders in offspring: a systematic review and meta-analysis.

Ellul, Pierre / Acquaviva, Eric / Peyre, Hugo / Rosenzwajg, Michelle / Gressens, Pierre / Klatzmann, David / Delorme, Richard

Translational psychiatry

2022 Volume 12, Issue 1, Page(s) 112

Abstract: Epidemiological studies have raised concerns about the risk of neurodevelopmental disorders (NDD) in children of patients with autoimmune or inflammatory disorders (AID). The pathophysiological pathways underlying this association are still unknown and ... ...

Abstract	Epidemiological studies have raised concerns about the risk of neurodevelopmental disorders (NDD) in children of patients with autoimmune or inflammatory disorders (AID). The pathophysiological pathways underlying this association are still unknown and little is known about the specific and distinct risk of each AID. To explore these questions, we investigated the association between the occurrences of several NDD in the offspring of mothers or fathers with different IDA. We conducted a meta-analysis-PROSPERO (CRD42020159250)-examining the risk of NDD in the offspring of mothers or fathers with AID. We performed specific analyses separately in fathers or mothers of NDD patients as well as subgroup analyses for each NDD and AID. We searched MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, and Web of Science Core Collection published until December 2021. From an initial pool of 2074 potentially relevant references, 14 studies were included, involving more than 1,400,000 AID and 10,000,000 control parents, 180,000 children with NDD and more than 14,000,000 control children. We found AID in mothers (Adjusted OR 1.27 [95% CI 1.03; 1.57] p = 0.02, [I
MeSH term(s)	Child ; Child of Impaired Parents ; Female ; Humans ; Mothers ; Neurodevelopmental Disorders/epidemiology ; Parents ; Risk Factors
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-022-01843-y
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