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  1. Article ; Online: 2 grams versus 1 gram rituximab as maintenance schedule in multiple sclerosis, neuromyelitis optica spectrum disorders and related diseases: What B-cell repopulation data tell us.

    Rual, Celso / Biotti, Damien / Lepine, Zoe / Delourme, Adrien / Berre, Juliette Le / Treiner, Emmanuel / Ciron, Jonathan

    Multiple sclerosis and related disorders

    2023  Volume 71, Page(s) 104563

    Abstract: Background: Rituximab (RTX) is largely used as a long-term maintenance therapy in various inflammatory neurological diseases. Reducing the dose of maintenance therapy of RTX from 2 grams every 6 months (traditional regimen) to 1 gram every 6 months ( ... ...

    Abstract Background: Rituximab (RTX) is largely used as a long-term maintenance therapy in various inflammatory neurological diseases. Reducing the dose of maintenance therapy of RTX from 2 grams every 6 months (traditional regimen) to 1 gram every 6 months (reduced regimen) is a widely applied practice, with the assumption that it decreases the risk of side effects while maintaining efficacy.
    Methods: In order to better describe the biological consequences of this strategy, we retrospectively compared, in a single center, the B-cell count after the traditional regimen and after the reduced regimen in patients who underwent both (n = 161).
    Results: The rate of patients with B-cell repopulation was not significantly different between traditional and reduced regimens (9.9% vs 15.6%, p = 0.18). Among the 145 patients who did not have B-cell repopulation following the traditional regimen, B-cell repopulation following the reduced regimen occurred in only 16 cases (11.0%) and was usually slight: 11/16 patients had only 1% of CD19+ cells.
    Conclusion: These data emphasize the relevance of 1 g of RTX as maintenance therapy and the fact that 2 g of RTX is generally an overtreatment in inflammatory neurological diseases.
    MeSH term(s) Humans ; Rituximab/adverse effects ; Neuromyelitis Optica/drug therapy ; Neuromyelitis Optica/chemically induced ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/chemically induced ; Immunologic Factors/adverse effects ; Retrospective Studies
    Chemical Substances Rituximab (4F4X42SYQ6) ; Immunologic Factors
    Language English
    Publishing date 2023-02-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2023.104563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Kappa-index: Real-life evaluation of a new tool for multiple sclerosis diagnosis.

    Marlas, Mathilde / Bost, Chloé / Dorcet, Guillaume / Delourme, Adrien / Biotti, Damien / Ciron, Jonathan / Renaudineau, Yves / Puissant-Lubrano, Bénédicte

    Clinical immunology (Orlando, Fla.)

    2022  Volume 241, Page(s) 109066

    Abstract: The intrathecal production of oligoclonal immunoglobulin bands (OCB) is a prognostic factor for multiple sclerosis (MS) evolution in clinically isolated syndrome (CIS) patients and a diagnostic factor for MS. The kappa free light chain (K)-index ... ...

    Abstract The intrathecal production of oligoclonal immunoglobulin bands (OCB) is a prognostic factor for multiple sclerosis (MS) evolution in clinically isolated syndrome (CIS) patients and a diagnostic factor for MS. The kappa free light chain (K)-index represents a quantitative automated alternative to OCB. We retrospectively evaluated OCB and K-index results in 274 patients with MS (n = 48) or CIS (n = 29) at diagnosis, non-MS inflammatory central nervous diseases (n = 35), and non-inflammatory central/peripheral nervous diseases (n = 162). Several cut-offs were established: a pathophysiological cut-off (K-index: 3.3) useful for differential diagnosis (negative predictive value for MS >99%), an optimised cut-off (K-index: 9.1) with better sensitivity and equivalent specificity than OCB for the diagnosis of MS, and a high-risk cut-off (K-index: >55.0) allowing prediction of MS (specificity 100%). We developed a scaled interpretation of the K-index and we discuss the usefulness of testing OCB only when the K-index is positive >3.3 to obtain a better specificity.
    MeSH term(s) Biomarkers ; Demyelinating Diseases/diagnosis ; Humans ; Immunoglobulin Light Chains ; Immunoglobulin kappa-Chains ; Multiple Sclerosis/diagnosis ; Retrospective Studies
    Chemical Substances Biomarkers ; Immunoglobulin Light Chains ; Immunoglobulin kappa-Chains
    Language English
    Publishing date 2022-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2022.109066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 880: Show issues Location:
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  3. Article ; Online: Rotavirus meningitis in an adult with transient aphasia.

    Collercandy, Nived / Migueres, Marion / Hallak, Benjamin / Garnier, Camille / Rousset, Stella / Delourme, Adrien / Delobel, Pierre / Martin-Blondel, Guillaume

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 123, Page(s) 52–53

    Abstract: We identified an additional case of documented Rotavirus meningitis in an adult with full medical history. A previously healthy 37-year-old patient presented herself for transient aphasia associated with fever and headaches at the end of a one-week ... ...

    Abstract We identified an additional case of documented Rotavirus meningitis in an adult with full medical history. A previously healthy 37-year-old patient presented herself for transient aphasia associated with fever and headaches at the end of a one-week history of gastroenteritis. Cerebrospinal fluid (CSF) analysis revealed lymphocytic meningitis, and treatment with aciclovir was initiated. Rotavirus A reverse transcription-polymerase chain reaction (RT-PCR) was positive in CSF and the patient's stools in favor of Rotavirus meningitis. Testing for other viruses was negative. Magnetic resonance imaging (MRI) showed no signs of encephalitis. Aphasia was resolutive in less than 12 hours, and no neurological symptoms relapsed. All symptoms evolved favorably despite aciclovir discontinuation. Viral sequencing methods have recently identified unexpected viruses as potential causative agents in meningitis, including Rotavirus. We confirm the detectability of Rotavirus in the analysis of CSF in the context of Rotavirus gastroenteritis in an adult. This case suggests postviral headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) syndrome may be linked to previously undetected direct viral infection of the central nervous system. Therefore, clinicians should consider Rotavirus meningitis in diagnosing meningitis associated with gastroenteritis in adults.
    MeSH term(s) Acyclovir ; Adult ; Aphasia/complications ; Gastroenteritis/complications ; Gastroenteritis/diagnosis ; Headache/cerebrospinal fluid ; Headache/diagnosis ; Headache/etiology ; Humans ; Meningitis/complications ; Rotavirus
    Chemical Substances Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2022-07-08
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Cerebrospinal Fluid IL-17A Could Predict Acute Disease Severity in Non-NMDA-Receptor Autoimmune Encephalitis.

    Levraut, Michael / Bourg, Véronique / Capet, Nicolas / Delourme, Adrien / Honnorat, Jérôme / Thomas, Pierre / Lebrun-Frenay, Christine

    Frontiers in immunology

    2021  Volume 12, Page(s) 673021

    Abstract: Introduction: Most of our knowledge into autoimmune encephalitis (AE) comes from N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis. The concentrations of cytokines in cerebrospinal fluid (CSF) including IL-17A have been found to be increased and ... ...

    Abstract Introduction: Most of our knowledge into autoimmune encephalitis (AE) comes from N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis. The concentrations of cytokines in cerebrospinal fluid (CSF) including IL-17A have been found to be increased and associated with poor outcome. However, data on the cytokine concentration in CSF and its correlation with outcome is lacking for other types of AE.
    Objective: To report the concentrations of CSF sIL-2R, IL-6, IL-8, IL-10 and IL-17A and to correlate it with acute disease severity and the 1-year outcome in non-NMDAR AE.
    Methods: We measured the CSF concentration of each cytokine in 20 AE patients, and compared IL-6 and IL-17A concentrations with 13 patients with CNS demyelinating diseases and 20 non-inflammatory controls. Patients were > 18yr and had at least 1-year clinical follow-up. Intracellular and NMDAR antibody (Ab) -mediated encephalitis were excluded. A mRS ≤ 2 was retained as a 1-year good outcome.
    Results: The IL-17A concentration in CSF was higher in AE patients than in both control groups (
    Conclusion: Our results show that CSF IL-17A could be interesting to assess initial severity in non-NMDAR AE. Thus, CSF IL-17A could be an interesting therapeutic target and be useful to assess early selective immunosuppressive therapy.
    MeSH term(s) Aged ; Autoimmune Diseases of the Nervous System/cerebrospinal fluid ; Autoimmune Diseases of the Nervous System/immunology ; Autoimmune Diseases of the Nervous System/pathology ; Biomarkers/cerebrospinal fluid ; Encephalitis/cerebrospinal fluid ; Encephalitis/immunology ; Encephalitis/pathology ; Female ; Humans ; Interleukin-17/cerebrospinal fluid ; Male ; Middle Aged
    Chemical Substances Biomarkers ; IL17A protein, human ; Interleukin-17
    Language English
    Publishing date 2021-05-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.673021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Marburg Multiple Sclerosis Variant: Complete Remission with Very Early Administration of Mitoxantrone-A Case Report.

    Capet, Nicolas / Levraut, Michael / Delourme, Adrien / Thomel-Rocchi, Oceane / Bourg, Véronique / Cabre, Philippe / Vandenbos, Fanny / Mondot, Lydiane / Lebrun-Frenay, Christine

    Neurology and therapy

    2021  Volume 11, Issue 1, Page(s) 507–513

    Abstract: Marburg variant is a severe and fulminant pseudotumor form of multiple sclerosis (MS) with high morbidity and mortality rates. Because of its scarcity, it remains incompletely characterized and physicians' experiences will influence the treatment. We ... ...

    Abstract Marburg variant is a severe and fulminant pseudotumor form of multiple sclerosis (MS) with high morbidity and mortality rates. Because of its scarcity, it remains incompletely characterized and physicians' experiences will influence the treatment. We report the inflammatory explosive case of a 31-year-old woman presenting with rapid neurological degradation of histology proven Marburg's disease, successfully treated with early administration of Mitoxantrone (MITX). To our knowledge, it is the first case describing complete remission after MITX in a biopsy-proven condition.
    Language English
    Publishing date 2021-12-02
    Publishing country New Zealand
    Document type Journal Article
    ISSN 2193-8253
    ISSN 2193-8253
    DOI 10.1007/s40120-021-00308-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Glucocorticoid use as a cause of non-cellular immune response to SARS-Cov2 Spike in patients with immune system diseases.

    Renaudineau, Yves / Sailler, Laurent / Abravanel, Florence / Izopet, Jacques / Delourme, Adrien / Biotti, Damien / Ciron, Jonathan / Treiner, Emmanuel / Congy-Jolivet, Nicolas / Bost, Chloé / Blancher, Antoine

    Journal of autoimmunity

    2022  Volume 133, Page(s) 102912

    Abstract: Disease modifying therapies compromise immune response to SARS-Cov2 or its vaccine in patients with immune system diseases (ISD). Therefore, analysis of the humoral and cellular responses against Spike is of utmost importance to manage ISD patients. A ... ...

    Abstract Disease modifying therapies compromise immune response to SARS-Cov2 or its vaccine in patients with immune system diseases (ISD). Therefore, analysis of the humoral and cellular responses against Spike is of utmost importance to manage ISD patients. A single-center retrospective study was conducted to evaluate the impact of COVID-19 immunization in 87 ISD patients and 81 healthy controls. We performed a whole blood interferon gamma release assay using SARS-Cov2 Spike and Nucleocapsid recombinant proteins in order to evaluate T-cell memory response, and an IgG anti-Spike ELISA to evaluate humoral response. Cellular (26.4%) and humoral (44.8%) responses were negative against Spike in ISD patients following COVID-19 immunization. In univariate analysis, an anti-Spike T cell defective response was associated with the use of glucocorticoids (Odds ratio [OR] = 10.0; p < 10
    MeSH term(s) Humans ; Middle Aged ; Glucocorticoids/therapeutic use ; RNA, Viral ; Retrospective Studies ; COVID-19 ; SARS-CoV-2 ; Immune System Diseases ; Antibodies ; Immunity ; Serum Albumin
    Chemical Substances Glucocorticoids ; RNA, Viral ; Antibodies ; Serum Albumin
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2022.102912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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