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Article ; Online: How do you manage the peritoneal opening during TAMIS procedure?

Rega, D / Delrio, P

2023 Volume 27, Issue 11, Page(s) 1135–1136

MeSH term(s)	Humans ; Transanal Endoscopic Surgery/methods ; Peritoneum/surgery ; Rectal Neoplasms ; Minimally Invasive Surgical Procedures/methods
Language	English
Publishing date	2023-08-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2083309-X
ISSN	1128-045X ; 1123-6337
ISSN (online)	1128-045X
ISSN	1123-6337
DOI	10.1007/s10151-023-02851-w
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Zs.A 5842: Show issues

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Article ; Online: Incidental diagnosis and intra-operative treatment of left paraduodenal hernia in a patient undergoing ultra-low rectal anterior resection-a video vignette.

Filotico, Marcello / Ambrosio, Luisa / Rega, Daniela / Maniscalco, Marilisa / Pace, Ugo / Delrio, Paolo

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2024

Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Letter
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16974
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Zs.A 5799: Show issues

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Article ; Online: Comment on "Minimally Invasive Surgery and the Novel Coronavirus Outbreak: Lessons Learned in China and Italy".

Muratore, Andrea / Delrio, Paolo

Annals of surgery

2020 Volume 274, Issue 6, Page(s) e765–e766

MeSH term(s)	COVID-19 ; China/epidemiology ; Disease Outbreaks ; Humans ; Italy/epidemiology ; Minimally Invasive Surgical Procedures ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000003971
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Article ; Online: The Spectrum of Malnutrition/Cachexia/Sarcopenia in Oncology According to Different Cancer Types and Settings: A Narrative Review.

Bossi, Paolo / Delrio, Paolo / Mascheroni, Annalisa / Zanetti, Michela

Nutrients

2021 Volume 13, Issue 6

Abstract: Nutritional status in oncological patients may differ according to several modifiable and non-modifiable factors. Knowledge of the epidemiology of malnutrition/cachexia/sarcopenia may help to manage these complications early in the course of treatment, ... ...

Abstract	Nutritional status in oncological patients may differ according to several modifiable and non-modifiable factors. Knowledge of the epidemiology of malnutrition/cachexia/sarcopenia may help to manage these complications early in the course of treatment, potentially impacting patient quality of life, treatment intensity, and disease outcome. Therefore, this narrative review aimed to critically evaluate the current evidence on the combined impact of tumor- and treatment-related factors on nutritional status and to draw some practical conclusions to support the multidisciplinary management of malnutrition in cancer patients. A comprehensive literature search was performed from January 2010 to December 2020 using different combinations of pertinent keywords and a critical evaluation of retrieved literature papers was conducted. The results show that the prevalence of weight loss and associated symptoms is quite heterogeneous and needs to be assessed with recognized criteria, thus allowing a clear classification and standardization of therapeutic interventions. There is a large range of variability influenced by age and social factors, comorbidities, and setting of cures (community-dwelling versus hospitalized patients). Tumor subsite is one of the major determinants of malnutrition, with pancreatic, esophageal, and other gastroenteric cancers, head and neck, and lung cancers having the highest prevalence. The advanced stage is also linked to a higher risk of developing malnutrition, as an expression of the relationship between tumor burden, inflammatory status, reduced caloric intake, and malabsorption. Finally, treatment type influences the risk of nutritional issues, both for locoregional approaches (surgery and radiotherapy) and for systemic treatment. Interestingly, personalized approaches based on the selection of the most predictive malnutrition definitions for postoperative complications according to cancer type and knowledge of specific nutritional problems associated with some new agents may positively impact disease course. Sharing common knowledge between oncologists and nutritionists may help to better address and treat malnutrition in this population.
MeSH term(s)	Cachexia/epidemiology ; Cachexia/etiology ; Humans ; Malnutrition/epidemiology ; Malnutrition/etiology ; Medical Oncology/statistics & numerical data ; Neoplasms/complications ; Neoplasms/physiopathology ; Nutrition Assessment ; Nutritional Status ; Prevalence ; Risk Factors ; Sarcopenia/epidemiology ; Sarcopenia/etiology
Language	English
Publishing date	2021-06-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13061980
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Article: Comment on "Minimally Invasive Surgery and the Novel Coronavirus Outbreak: Lessons Learned in China and Italy"

Muratore, Andrea / Delrio, Paolo

Ann. surg

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #325882
Database	COVID19

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Article ; Online: Bowel preparation for elective colorectal resection: multi-treatment machine learning analysis on 6241 cases from a prospective Italian cohort.

Catarci, Marco / Guadagni, Stefano / Masedu, Francesco / Ruffo, Giacomo / Viola, Massimo Giuseppe / Borghi, Felice / Garulli, Gianluca / Pirozzi, Felice / Delrio, Paolo / De Luca, Raffaele / Baldazzi, Gianandrea / Scatizzi, Marco

International journal of colorectal disease

2024 Volume 39, Issue 1, Page(s) 53

Abstract: Background: Current evidence concerning bowel preparation before elective colorectal surgery is still controversial. This study aimed to compare the incidence of anastomotic leakage (AL), surgical site infections (SSIs), and overall morbidity (any ... ...

Abstract	Background: Current evidence concerning bowel preparation before elective colorectal surgery is still controversial. This study aimed to compare the incidence of anastomotic leakage (AL), surgical site infections (SSIs), and overall morbidity (any adverse event, OM) after elective colorectal surgery using four different types of bowel preparation. Methods: A prospective database gathered among 78 Italian surgical centers in two prospective studies, including 6241 patients who underwent elective colorectal resection with anastomosis for malignant or benign disease, was re-analyzed through a multi-treatment machine-learning model considering no bowel preparation (NBP; No. = 3742; 60.0%) as the reference treatment arm, compared to oral antibiotics alone (oA; No. = 406; 6.5%), mechanical bowel preparation alone (MBP; No. = 1486; 23.8%), or in combination with oAB (MoABP; No. = 607; 9.7%). Twenty covariates related to biometric data, surgical procedures, perioperative management, and hospital/center data potentially affecting outcomes were included and balanced into the model. The primary endpoints were AL, SSIs, and OM. All the results were reported as odds ratio (OR) with 95% confidence intervals (95% CI). Results: Compared to NBP, MBP showed significantly higher AL risk (OR 1.82; 95% CI 1.23-2.71; p = .003) and OM risk (OR 1.38; 95% CI 1.10-1.72; p = .005), no significant differences for all the endpoints were recorded in the oA group, whereas MoABP showed a significantly reduced SSI risk (OR 0.45; 95% CI 0.25-0.79; p = .008). Conclusions: MoABP significantly reduced the SSI risk after elective colorectal surgery, therefore representing a valid alternative to NBP.
MeSH term(s)	Humans ; Prospective Studies ; Anastomosis, Surgical ; Anastomotic Leak/etiology ; Machine Learning ; Colorectal Neoplasms/surgery ; Italy/epidemiology
Language	English
Publishing date	2024-04-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-024-04627-6
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Article ; Online: Current status on response to treatment in locally advanced rectal cancer: what the radiologist should know.

Granata, V / Grassi, R / Fusco, R / Izzo, F / Brunese, L / Delrio, P / Avallone, A / Pecori, B / Petrillo, A

European review for medical and pharmacological sciences

2020 Volume 24, Issue 23, Page(s) 12050–12062

Abstract: The assessment of tumor response, after neoadjuvant radiochemotherapy (nCRT), allows stratifying the patient in order to consider the proper therapeutical management. Histopathology analysis of the surgical specimen is considered the gold standard to ... ...

Abstract	The assessment of tumor response, after neoadjuvant radiochemotherapy (nCRT), allows stratifying the patient in order to consider the proper therapeutical management. Histopathology analysis of the surgical specimen is considered the gold standard to assess tumour response and the definition of a complete cancer response is related to the clinical and endoscopic features, by direct evaluation of the rectal wall. However, imaging studies, especially Magnetic Resonance Imaging (MRI) have provided additional parameters, as the evaluation of nodal or mesorectal status. MRI provides a radiological tumour regression grade (mrTRG) that is correlated with the pathologic tumor regression grade (pTRG). Functional MRI parameters have additional impending in early prediction of the efficacy of therapy and can be valuable in drug development processes. Some of functional methodologies are already part of clinical practice: diffusion-weighted MRI (DW-MRI) and perfusion imaging (dynamic contrast enhanced MRI [DCE-MRI]). Other technologies, such as radiomics with MRI are still in the experimental phase. An adequate radiological report describing the restaging of rectal cancer after nCRT should be a "structured report" to improve communication in a multidisciplinary team.
MeSH term(s)	Chemoradiotherapy, Adjuvant ; Humans ; Magnetic Resonance Imaging ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/therapy ; Radiologists ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/therapy
Language	English
Publishing date	2020-12-18
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202012_23994
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Article ; Online: Synchronous robotic right hemicolectomy and subtotal gastrectomy.

Carbone, Fabio / Pace, Ugo / Albino, Vittorio / Leongito, Maddalena / Delrio, Paolo

Updates in surgery

2020 Volume 72, Issue 4, Page(s) 1273–1277

Abstract: About 4% of patients with stomach cancer diagnosis have synchronous colorectal cancer and some of these patients may require a synchronous surgical resection. So far, only few minimally invasive series of synchronous resections have been described. We ... ...

Abstract	About 4% of patients with stomach cancer diagnosis have synchronous colorectal cancer and some of these patients may require a synchronous surgical resection. So far, only few minimally invasive series of synchronous resections have been described. We investigated the feasibility and safety of the synchronous robotic resection of the right colon and stomach malignancies, trying to identify a standardised and reproducible technique. It is essential to carefully plan the operation and the trocars positioning to minimise the number of robotic dockings and be able to operate comfortably. Herein, we describe our approach, which is safe and effective in terms of minimal invasiveness and oncological radicality. Robotic surgery could be used with even more advantage in complex multi-organ resections, providing the surgeon with a better vision, a more accurate dissection and longer instruments, to offer the patient all the benefits of a minimal invasive surgery.
MeSH term(s)	Adenocarcinoma/surgery ; Colectomy/methods ; Colon/surgery ; Colorectal Neoplasms/surgery ; Feasibility Studies ; Gastrectomy/methods ; Humans ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/methods ; Robotic Surgical Procedures/methods ; Stomach/surgery ; Stomach Neoplasms/surgery ; Treatment Outcome
Keywords	covid19
Language	English
Publishing date	2020-08-27
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-020-00866-8
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Article ; Online: Nutritional support in surgical oncology: A survey by SICO in collaboration with the Intersociety Italian Working Group for Nutritional Support in Cancer Patients.

Grieco, Michele / Delrio, Paolo / Lorenzon, Laura / Agnes, Amedea Luciana / Caccialanza, Riccardo / Pedrazzoli, Paolo / Santoro, Gloria / Roviello, Franco / Carlini, Massimo

Surgical oncology

2022 Volume 43, Page(s) 101788

Abstract: Purpose: Nutritional support is a keystone component in perioperative care in patients undergoing oncological surgery with a direct impact on surgical outcomes. This study aimed to evaluate how nutritional support in the surgical setting is managed and ... ...

Abstract	Purpose: Nutritional support is a keystone component in perioperative care in patients undergoing oncological surgery with a direct impact on surgical outcomes. This study aimed to evaluate how nutritional support in the surgical setting is managed and applied in Italian hospitals. Methods: A national survey was designed by the Italian Society of Surgical Oncology (SICO) and disseminated in early 2021. The results were analyzed for the entire population and for comparing the following different subgroups: northern vs. southern regions; high-volume vs. low-volume centers; and junior vs. senior surgeons. Results: Out of the 141 responses collected from all Italian regions, 43.2% of the participants worked in a surgical unit where nutritional status evaluations and interventions were not routinely practiced, although the key features (nutritional counseling, oral supplementation, enteral and parenteral nutrition) were available in 77.3% of the hospitals. Among the participating centers, the ERAS protocol was systematically applied in only 29.5% of cases, and in 25.5% of cases, most of the items were followed, although not systematically. Among the surgeons who practiced in compliance with the ERAS pathways, almost half of the participants declared that the protocol was applied only for low-risk patients. No significant differences were documented when comparing Italian regions, high-volume vs. low-volume institutions or junior vs. senior participants. Conclusion: Nutritional support in oncological surgery is frequently neglected in Italian hospitals, regardless of the geographic distribution and volumes of the institutions. A cultural change and an improvement in the availability of nutritional services are needed for widespread implementation.
MeSH term(s)	Humans ; Italy/epidemiology ; Neoplasms/surgery ; Nutritional Support ; Perioperative Care ; Surgical Oncology
Language	English
Publishing date	2022-06-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1107810-8
ISSN	1879-3320 ; 0960-7404
ISSN (online)	1879-3320
ISSN	0960-7404
DOI	10.1016/j.suronc.2022.101788
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Article ; Online: Radiological assessment of peritoneal carcinomatosis: a primer for resident.

Granata, V / Fusco, R / Venanzio Setola, S / Sassaroli, C / De Franciscis, S / Delrio, P / Danti, G / Grazzini, G / Faggioni, L / Gabelloni, M / Ottaiano, A / Greggi, S / Patrone, R / Palaia, R / Petrillo, A / Izzo, F

European review for medical and pharmacological sciences

2022 Volume 26, Issue 8, Page(s) 2875–2890

Abstract: The imaging has critical responsibility in the assessment of peritoneal lesions along with estimating the overall extent. Valuing disease burden is crucial for selection of combining cytoreductive surgery (CRS) and intraperitoneal hyperthermic ... ...

Abstract	The imaging has critical responsibility in the assessment of peritoneal lesions along with estimating the overall extent. Valuing disease burden is crucial for selection of combining cytoreductive surgery (CRS) and intraperitoneal hyperthermic chemotherapy (HIPEC) treatment. An approach that combines the strength of several imaging tools and increases diagnostic accuracy, should be chosen, even if the preferred imaging tool in patients with suspected Peritoneal Carcinomatosis (PC) is CT. The outcomes of PC are mainly correlated to tumor spread, localization, and lesion size. Accurate assessment of these features is critical for prognosis and treatment planning. These data can be evaluated by Peritoneal Cancer Index (PCI), a quantitative index suggested by Harman and Sugarbaker. Additionally, precise predictive biomarkers should be established to predict PC in patients at risk. The radiomics analysis could predict PC throughout the evaluation of cancers heterogeneity.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Humans ; Hyperthermia, Induced/methods ; Hyperthermic Intraperitoneal Chemotherapy ; Peritoneal Neoplasms/diagnostic imaging ; Peritoneal Neoplasms/therapy
Language	English
Publishing date	2022-04-19
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202204_28619
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