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  1. Book ; Conference proceedings: Osteoporosis

    Deluca, Hector F.

    physiological basis, assessment, and treatment ; proceedings of the Nineteenth Steenbock Symposium held June 5 through June 8, 1989, at the University of Wisconsin-Madison, U.S.A

    1990  

    Event/congress Harry Steenbock Symposium (19, 1989, MadisonWis.)
    Author's details ed. by Hector F. DeLuca
    Keywords Osteoporosis / congresses ; Osteoporose
    Subject Knochenrarefikation ; Osteoporosis
    Size XXIX, 346 S. : Ill., graph. Darst.
    Edition 1. print.
    Publisher Elsevier
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003637739
    ISBN 0-444-01526-4 ; 978-0-444-01526-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 6194 order for loan Magazin

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  2. Article: The development of a bone- and parathyroid-specific analog of vitamin D: 2-methylene-19-Nor-(20S)-1α,25-dihydroxyvitamin D3.

    Deluca, Hector F

    BoneKEy reports

    2014  Volume 3, Page(s) 514

    Abstract: The goal of synthetic chemists in the vitamin D field has been to produce an analog(s) of 1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3) that is selective for a specific function. The accumulation of structure/function information has led to the synthesis of ... ...

    Abstract The goal of synthetic chemists in the vitamin D field has been to produce an analog(s) of 1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3) that is selective for a specific function. The accumulation of structure/function information has led to the synthesis of two analogs that are both selective and more potent than 1,25-(OH)2D3, that is, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD) and 2α-methyl-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2AMD). In vivo, the efficacy of 2MD is approximately equal to that of 1,25-(OH)2D3 in intestinal calcium transport but is 30- to 100-fold more active in bone mobilization. In vitro, 2MD supports new bone synthesis at 10(-12) M, whereas 1,25-(OH)2D3 is active at 10(-8) M. Similarly, 2MD is two orders of magnitude more potent than 1,25-(OH)2D3 in stimulating osteoclastogenesis and osteoclastic bone resorption. 2MD also markedly increases bone mass and bone strength of ovariectomized female rats. In postmenopausal women, 2MD significantly increases markers of both bone formation and resorption but has minimal effect on bone mass. Thus, in patients who are undergoing primarily remodeling rather than modeling (rat), the increased resorption largely counteracts the increased bone formation. So far, 2MD has not been tested for reduction of fractures in this population. However, its selectivity includes the parathyroid gland. Thus in the 5/6-nephrectomy model of chronic renal failure, 2MD is much more potent than currently available vitamin D compounds used to suppress secondary hyperparathyroidism of renal failure without causing hypercalcemia. It is currently in phase 2B trials in patients on dialysis.
    Language English
    Publishing date 2014-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2816308-4
    ISSN 2047-6396
    ISSN 2047-6396
    DOI 10.1038/bonekey.2014.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: History of the discovery of vitamin D and its active metabolites.

    Deluca, Hector F

    BoneKEy reports

    2014  Volume 3, Page(s) 479

    Abstract: Before the twentieth century, it was not possible to describe the essentials of a diet that could support life, growth and reproduction of higher animals. The discovery of vitamin A by McCollum and Davis in 1913 ushered in the era of accessory food ... ...

    Abstract Before the twentieth century, it was not possible to describe the essentials of a diet that could support life, growth and reproduction of higher animals. The discovery of vitamin A by McCollum and Davis in 1913 ushered in the era of accessory food substances culminating in the achievement of that goal. It included the discovery of vitamin D and its production in skin caused by ultraviolet light. This was followed by a description of its actions at the physiological level that resulted in a healthy skeleton and beyond. To carry out these functions, vitamin D is converted to a hormone that acts through a nuclear receptor. The findings leading to this concept and their importance to biology and medicine are presented.
    Language English
    Publishing date 2014-01-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2816308-4
    ISSN 2047-6396
    ISSN 2047-6396
    DOI 10.1038/bonekey.2013.213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Guest editor's introduction.

    Deluca, Hector F

    Archives of biochemistry and biophysics

    2012  Volume 523, Issue 1, Page(s) 1

    MeSH term(s) Molecular Biology ; Safety ; Vitamin D/adverse effects ; Vitamin D/metabolism
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2012-07-01
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2012.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: OSTEOPOROSIS

    Deluca, Hector F.

    RECENT ADVANCES IN PATHOGENESIS AND TREATMENT

    1981  

    Author's details ED. BY HECTOR F. DELUCA
    Keywords OSTEOPOROSIS / ETIOLOGY / CONGRESSES ; OSTEOPOROSIS / THERAPY / CONGRESSES
    Size XXII, 506 S.
    Publisher UNIVERSITY PARK PRESS
    Publishing place BALTIMORE, MD
    Document type Book
    Note 'PROCEEDINGS OF THE 10TH STEENBOCK SYMPOSIUM HELD AT THE UNIVERSITY OF WISCONSIN - MADISON, JUNE 9-12, 1980
    HBZ-ID HT002630054
    ISBN 0-8391-1630-6 ; 978-0-8391-1630-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1982 A 1813 order for loan Magazin

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  6. Book: Pediatric diseases related to calcium

    Deluca, Hector F.

    1980  

    Keywords Calcium Metabolism Disorders / in infancy & childhood
    Language English
    Size XXV, 449 S.
    Publisher Blackwell
    Publishing place Oxford
    Document type Book
    HBZ-ID HT002806178
    ISBN 0-632-00664-1 ; 978-0-632-00664-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1984 A 1763 order for loan Magazin

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  7. Book: Biochemistry

    Deluca, Hector F.

    (Topics in current chemistry ; 83)

    1979  

    Author's details [Hector F. DeLuca ...]
    Series title Topics in current chemistry ; 83
    Collection
    Keywords BIOCHEMISTRY ; Aminoglykosidantibiotikum ; Cytochrom P-450 ; Vitamin-D-Gruppe ; Biochemie
    Subject Biologische Chemie ; Vitamin D ; Antirachitisches Vitamin ; Calciferol ; Cholesterin Monooxygenase ; EC 1.14.15.6 ; Cytochrom-P450-System ; NADPH-Cytochrom-P450-Reductase ; CYP 450 ; P-450 ; Unspezifische Monooxygenase ; EC 1.14.14.1 ; Aminoglykoside ; Aminoglykosid-Antibiotikum ; Aminoglycosid-Antibiotikum
    Size 178 S. : graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT000929707
    ISBN 3-540-09312-5 ; 0-387-09312-5 ; 978-3-540-09312-1 ; 978-0-387-09312-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1980 A 1449 order for loan Magazin

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  8. Book: The fat soluble vitamins

    Deluca, Hector F.

    (Handbook of lipid research ; 2)

    1978  

    Author's details ed. by Hector F. DeLuca
    Series title Handbook of lipid research ; 2
    Collection
    Keywords VITAMIN A ; VITAMIN D ; VITAMIN E ; VITAMIN K ; Vitamin-K-Gruppe ; Vitamin E ; Vitamin-D-Gruppe ; Vitamin-A-Gruppe ; Fettlösliches Vitamin
    Subject Vitamin D ; Antirachitisches Vitamin ; Calciferol ; Tocopherol ; Vitamin K
    Size XII, 287 S.
    Publisher Plenum Press
    Publishing place New York u.a.
    Document type Book
    HBZ-ID HT001095371
    ISBN 0-306-33582-4 ; 978-0-306-33582-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1979 A 1952 order for loan Magazin

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  9. Book: The vitamin D system in the regulation of calcium and phosphorus metabolism

    Deluca, Hector F.

    (W. O. Atwater memorial lecture ; 11)

    1979  

    Author's details H. F. DeLuca
    Series title W. O. Atwater memorial lecture ; 11
    The ... W. O. Atwater memorial lecture
    Collection The ... W. O. Atwater memorial lecture
    Size S. 161 - 193
    Edition Reprint.
    Publishing place Washington
    Publishing country United States
    Document type Book
    Note Aus: Nutrition reviews ; 37,6. 1979
    HBZ-ID HT006578736
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    878/2329 order for loan Geschlossenes Magazin (U2)

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  10. Book: Vitamin D

    Deluca, Hector F.

    metabolism and function

    (MONOGRAPHS ON ENDOCRINOLOGY ; VOL. 13)

    1979  

    Author's details H. F. DeLuca
    Series title MONOGRAPHS ON ENDOCRINOLOGY ; VOL. 13
    Monographs on endocrinology
    Collection Monographs on endocrinology
    Keywords VITAMIN D / METABOLISM ; VITAMIN D / PHYSIOLOGY ; Vitamin-D-Gruppe
    Subject Vitamin D ; Antirachitisches Vitamin ; Calciferol
    Size VIII, 80 S. : 14 ILL.
    Publisher Springer
    Publishing place BERLIN, HEIDELBERG, NEW YORK
    Document type Book
    HBZ-ID HT000929350
    ISBN 3-540-09182-3 ; 0-387-09182-3 ; 978-3-540-09182-0 ; 978-0-387-09182-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1979 A 1949 order for loan Magazin

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