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  1. Article ; Online: Faecalibacterium duncaniae

    Chollet, Loïc / Heumel, Séverine / Deruyter, Lucie / Bouilloux, Fabrice / Delval, Lou / Robert, Véronique / Gevaert, Marie-Hélène / Pichavant, Muriel / Sencio, Valentin / Robil, Cyril / Wolowczuk, Isabelle / Sokol, Harry / Auger, Sandrine / Douablin, Alexandre / Langella, Philippe / Chatel, Jean-Marc / Grangette, Corinne / Trottein, François

    Frontiers in immunology

    2024  Volume 15, Page(s) 1347676

    Abstract: The gut-lung axis is critical during viral respiratory infections such as influenza. Gut dysbiosis during infection translates into a massive drop of microbially produced short-chain fatty acids (SCFAs). Among them, butyrate is important during influenza ...

    Abstract The gut-lung axis is critical during viral respiratory infections such as influenza. Gut dysbiosis during infection translates into a massive drop of microbially produced short-chain fatty acids (SCFAs). Among them, butyrate is important during influenza suggesting that microbiome-based therapeutics targeting butyrate might hold promises. The butyrate-producing bacterium
    MeSH term(s) Mice ; Animals ; Humans ; Influenza, Human ; Dysbiosis/microbiology ; RNA, Ribosomal, 16S/genetics ; Fatty Acids, Volatile ; Butyrates ; Faecalibacterium/genetics ; Probiotics
    Chemical Substances RNA, Ribosomal, 16S ; Fatty Acids, Volatile ; Butyrates
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1347676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Depletion of preexisting B-cell lymphoma 2-expressing senescent cells before vaccination impacts antigen-specific antitumor immune responses in old mice.

    Cobanoglu, Ozmen / Delval, Lou / Ferrari, Daniele / Deruyter, Lucie / Heumel, Séverine / Wolowczuk, Isabelle / Hussein, Abir / Menevse, Ayse Nur / Bernard, David / Beckhove, Philip / Alves, Frauke / Trottein, François

    Aging cell

    2023  Volume 22, Issue 12, Page(s) e14007

    Abstract: The age-related decline in immunity reduces the effectiveness of vaccines in older adults. Immunosenescence is associated with chronic, low-grade inflammation, and the accumulation of senescent cells. The latter express Bcl-2 family members (providing ... ...

    Abstract The age-related decline in immunity reduces the effectiveness of vaccines in older adults. Immunosenescence is associated with chronic, low-grade inflammation, and the accumulation of senescent cells. The latter express Bcl-2 family members (providing resistance to cell death) and exhibit a pro-inflammatory, senescence-associated secretory phenotype (SASP). Preexisting senescent cells cause many aging-related disorders and therapeutic means of eliminating these cells have recently gained attention. The potential consequences of senescent cell removal on vaccine efficacy in older individuals are still ignored. We used the Bcl-2 family inhibitor ABT-263 to investigate the effects of pre-vaccination senolysis on immune responses in old mice. Two different ovalbumin (OVA)-containing vaccines (containing a saponin-based or a CpG oligodeoxynucleotide adjuvant) were tested. ABT-263 depleted senescent cells (apoptosis) and ablated the basal and lipopolysaccharide-induced production of SASP-related factors in old mice. Depletion of senescent cells prior to vaccination (prime/boost) had little effect on OVA-specific antibody and T-cell responses (slightly reduced and augmented, respectively). We then used a preclinical melanoma model to test the antitumor potential of senolysis before vaccination (prime with the vaccine and OVA boost by tumor cells). Surprisingly, ABT-263 treatment abrogated the vaccine's ability to protect against B16 melanoma growth in old animals, an effect associated with reduced antigen-specific T-cell responses. Some, but not all, of the effects were age-specific, which suggests that preexisting senescent cells were partly involved. Hence, depletion of senescent cells modifies immune responses to vaccines in some settings and caution should be taken when incorporating senolytics into vaccine-based cancer therapies.
    MeSH term(s) Animals ; Mice ; Vaccination ; Cancer Vaccines/pharmacology ; Cellular Senescence ; Immunity ; Proto-Oncogene Proteins c-bcl-2
    Chemical Substances navitoclax (XKJ5VVK2WD) ; Cancer Vaccines ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.14007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6581: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection.

    Heumel, Séverine / de Rezende Rodovalho, Vinícius / Urien, Charlotte / Specque, Florian / Brito Rodrigues, Patrícia / Robil, Cyril / Delval, Lou / Sencio, Valentin / Descat, Amandine / Deruyter, Lucie / Ferreira, Stéphanie / Gomes Machado, Marina / Barthelemy, Adeline / Angulo, Fabiola Silva / Haas, Joel T / Goosens, Jean François / Wolowczuk, Isabelle / Grangette, Corinne / Rouillé, Yves /
    Grimaud, Ghjuvan / Lenski, Marie / Hennart, Benjamin / Ramirez Vinolo, Marco Aurélio / Trottein, François

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2325067

    Abstract: The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-associated changes ...

    Abstract The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-associated changes in the composition and metabolism of the mouse gut microbiota. We observed several taxonomic-level changes on day (D)7 post-infection, including a marked reduction in the abundance of members of the
    MeSH term(s) Humans ; Animals ; Mice ; Propionates ; Influenza, Human ; Gastrointestinal Microbiome ; Tryptophan ; Actinobacteria ; Inflammation ; Polyamines
    Chemical Substances propionic acid (JHU490RVYR) ; Propionates ; Tryptophan (8DUH1N11BX) ; Polyamines
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2325067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters.

    Delval, Lou / Hantute-Ghesquier, Aline / Sencio, Valentin / Flaman, Jean Michel / Robil, Cyril / Angulo, Fabiola Silva / Lipskaia, Larissa / Çobanoğlu, Ozmen / Lacoste, Anne-Sophie / Machelart, Arnaud / Danneels, Adeline / Corbin, Mathieu / Deruyter, Lucie / Heumel, Séverine / Idziorek, Thierry / Séron, Karin / Sauve, Florent / Bongiovanni, Antonino / Prévot, Vincent /
    Wolowczuk, Isabelle / Belouzard, Sandrine / Saliou, Jean-Michel / Gosset, Philippe / Bernard, David / Rouillé, Yves / Adnot, Serge / Duterque-Coquillaud, Martine / Trottein, François

    Nature aging

    2023  Volume 3, Issue 7, Page(s) 829–845

    Abstract: Older age is one of the strongest risk factors for severe COVID-19. In this study, we determined whether age-associated cellular senescence contributes to the severity of experimental COVID-19. Aged golden hamsters accumulate senescent cells in the lungs, ...

    Abstract Older age is one of the strongest risk factors for severe COVID-19. In this study, we determined whether age-associated cellular senescence contributes to the severity of experimental COVID-19. Aged golden hamsters accumulate senescent cells in the lungs, and the senolytic drug ABT-263, a BCL-2 inhibitor, depletes these cells at baseline and during SARS-CoV-2 infection. Relative to young hamsters, aged hamsters had a greater viral load during the acute phase of infection and displayed higher levels of sequelae during the post-acute phase. Early treatment with ABT-263 lowered pulmonary viral load in aged (but not young) animals, an effect associated with lower expression of ACE2, the receptor for SARS-CoV-2. ABT-263 treatment also led to lower pulmonary and systemic levels of senescence-associated secretory phenotype factors and to amelioration of early and late lung disease. These data demonstrate the causative role of age-associated pre-existing senescent cells on COVID-19 severity and have clear clinical relevance.
    MeSH term(s) Cricetinae ; Animals ; SARS-CoV-2 ; COVID-19 ; Viral Load ; Lung ; Mesocricetus ; Inflammation ; Cellular Senescence
    Chemical Substances navitoclax (XKJ5VVK2WD)
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2662-8465
    ISSN (online) 2662-8465
    DOI 10.1038/s43587-023-00442-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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