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  1. Article: Sol-Gel-Derived Fibers Based on Amorphous

    Christ, Bastian / Glaubitt, Walther / Berberich, Katrin / Weigel, Tobias / Probst, Jörn / Sextl, Gerhard / Dembski, Sofia

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 8

    Abstract: The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of ... ...

    Abstract The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiO
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15082752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Establishing and testing a robot-based platform to enable the automated production of nanoparticles in a flexible and modular way.

    Dembski, Sofia / Schwarz, Thomas / Oppmann, Maximilian / Bandesha, Shahbaz Tareq / Schmid, Jörn / Wenderoth, Sarah / Mandel, Karl / Hansmann, Jan

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11440

    Abstract: Robotic systems facilitate relatively simple human-robot interaction for non-robot experts, providing the flexibility to implement different processes. In this context, shorter process times, as well as an increased product and process quality could be ... ...

    Abstract Robotic systems facilitate relatively simple human-robot interaction for non-robot experts, providing the flexibility to implement different processes. In this context, shorter process times, as well as an increased product and process quality could be achieved. Robots short time-consuming processes, take over ergonomically unfavorable tasks and work efficiently all the time. In addition, flexible production is possible while maintaining or even increasing safety. This study describes the successful development of a dual-arm robot-based modular infrastructure and the establishment of an automated process for the reproducible production of nanoparticles. As proof of concept, a manual synthesis protocol for silica nanoparticle preparation with a diameter of about 200 nm as building blocks for photonic crystals was translated into a fully automated process. All devices and components of the automated system were optimized and adapted according to the synthesis requirements. To demonstrate the benefit of the automated nanoparticle production, manual (synthesis done by lab technicians) and automated syntheses were benchmarked. To this end, different processing parameters (time of synthesis procedure, accuracy of dosage etc.) and the properties of the produced nanoparticles were compared. We demonstrate that the use of the robot not only increased the synthesis accuracy and reproducibility but reduced the personnel time and costs up to 75%.
    Language English
    Publishing date 2023-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38535-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C

    Koruga, Djuro / Stanković, Ivana / Matija, Lidija / Kuhn, Dietmar / Christ, Bastian / Dembski, Sofia / Jevtić, Nenad / Janać, Jelena / Pavlović, Vladimir / De Wever, Bart

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 5

    Abstract: In order to maximally reduce the toxicity of fullerenol (the first derivative of ... ...

    Abstract In order to maximally reduce the toxicity of fullerenol (the first derivative of C
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14050480
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  4. Conference proceedings ; Online: Characterization of different thawing mechanisms of fibroblast cell-containing tissue models by Mueller polarimetry and statistical analysis

    Ivanov, Deyan / Hoeppel, Anika / Schwebler, Julian / Lotz, Christian / Dembski, Sofia / Ossikovski, Razvigor / Novikova, Tatiana

    2023  

    Abstract: Long-term storage and cryopreservation of biological tissues is a global challenge in the fields of regenerative medicine, tissue engineering and implants, because of the formation of large ice crystals that may damage cellular membranes and ... ...

    Abstract Long-term storage and cryopreservation of biological tissues is a global challenge in the fields of regenerative medicine, tissue engineering and implants, because of the formation of large ice crystals that may damage cellular membranes and extracellular matrix (ECM) of collagen. In our studies different thawing mechanisms were tested to achieve more uniform warming of 3D in vitro tissue models, prepared from magnetic nanoparticles (NPs)-modified 3D electrospun nanofiber fleeces and fibroblasts. 3D tissue models frozen in liquid nitrogen were defrosted either with water bath or with radio-frequency (RF) inductive heating of the magnetic NPs and their morphology was compared to that of a non-frozen tissue model using a transmission Mueller microscope and thin sections of all three types of tissue models. Our results demonstrate a sensitivity of the polarimetric parameters obtained with the differential decomposition of Mueller matrices to small changes in sample morphology caused by the different thawing methods. A detailed statistical analysis proved the statistical significance of the experimental data from the three groups of all tissue models.
    Keywords cryopreservation ; fibroblast cells ; Mueller polarimetry ; statistical analysis ; DDC::500 Naturwissenschaften und Mathematik::570 Biowissenschaften ; Biologie::572 Biochemie ; DDC::500 Naturwissenschaften und Mathematik::540 Chemie
    Subject code 571
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Sol-Gel-Derived Fibers Based on Amorphous α-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold

    Christ, Bastian / Glaubitt, Walther / Berberich, Katrin / Weigel, Tobias / Probst, Jörn / Sextl, Gerhard / Dembski, Sofia

    2022  

    Abstract: The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiOx particles and coatings via the sol-gel ... ...

    Abstract The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiOx particles and coatings via the sol-gel process has frequently been published. However, synthesis protocols of sol-gel-derived TiOx fibers are hardly known. In this publication, the authors present a synthesis and fabrication of purely sol-gel-derived TiOx fiber fleeces starting from the liquid sol-gel precursor titanium ethylate (TEOT). Here, the α-hydroxy-carboxylic acid lactic acid (LA) was used as a chelating ligand to reduce the reactivity towards hydrolysis of TEOT enabling a spinnable sol. The resulting fibers were processed into a non-woven fleece, characterized with FTIR, 13C-MAS-NMR, XRD, and screened with regard to their stability in physiological solution. They revealed an unexpected dependency between the LA content and the dissolution behavior. Finally, in vitro cell culture experiments proved their potential suitability as an open-mesh structured scaffold material, even for challenging applications such as therapeutic medicinal products (ATMPs).

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    Keywords dry spinning ; scaffold ; sol-gel chemistry ; DDC::500 Naturwissenschaften und Mathematik::540 Chemie
    Subject code 620
    Language English
    Publishing date 2022-04-02
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Digital histology of tissue with Mueller microscopy and FastDBSCAN

    Lee, Hee Ryung / Lotz, Christian / Groeber-Becker, Florian Kai / Dembski, Sofia / Novikova, Tatiana

    2022  

    Abstract: 9616 ... 9624 ... We present the results of the automated post-processing of Mueller microscopy images of skin tissue models with a new fast version of the algorithm of density-based spatial clustering of applications with noise (FastDBSCAN) and discuss the ... ...

    Abstract 9616

    9624

    We present the results of the automated post-processing of Mueller microscopy images of skin tissue models with a new fast version of the algorithm of density-based spatial clustering of applications with noise (FastDBSCAN) and discuss the advantages of its implementation for digital histology of tissue. We demonstrate that using the FastDBSCAN algorithm, one can produce the diagnostic segmentation of high resolution images of tissue by several orders of magnitude faster and with high accuracy (>97%) compared to the original version of the algorithm.

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    Keywords Histology ; Skin tissue ; Tissue models ; Microscopy images ; Mueller ; DDC::600 Technik ; Medizin ; angewandte Wissenschaften::610 Medizin und Gesundheit::611 Menschliche Anatomie ; Zytologie ; Histologie
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Biomimetic Connection of Transcutaneous Implants with Skin.

    Weigel, Tobias / Christ, Bastian / Dembski, Sofia / Ewald, Andrea / Groneberg, Dieter / Hansmann, Jan / Luxenhofer, Robert / Metzger, Marco / Walles, Heike / Willy, Christian / Groeber-Becker, Florian / Probst, Jörn

    Advanced healthcare materials

    2023  Volume 12, Issue 30, Page(s) e2301131

    Abstract: Bacterial infection is a crucial complication in implant restoration, in particular in permanent skin-penetrating implants. Therein, the resulting gap between transcutaneous implant and skin represents a permanent infection risk, limiting the field of ... ...

    Abstract Bacterial infection is a crucial complication in implant restoration, in particular in permanent skin-penetrating implants. Therein, the resulting gap between transcutaneous implant and skin represents a permanent infection risk, limiting the field of application and the duration of application. To overcome this limitation, a tight physiological connection is required to achieve a biological and mechanical welding for a long-term stable closure including self-healing probabilities. This study describes a new approach, wherein the implant is connected covalently to a highly porous electrospun fleece featuring physiological dermal integration potential. The integrative potential of the scaffold is shown in vitro and confirmed in vivo, further demonstrating tissue integration by neovascularization, extracellular matrix formation, and prevention of encapsulation. To achieve a covalent connection between fleece and implant surface, self-initiated photografting and photopolymerization of hydroxyethylmethacrylate is combined with a new crosslinker (methacrylic acid coordinated titanium-oxo clusters) on proton-abstractable implant surfaces. For implant modification, the attached fleece is directed perpendicular from the implant surface into the surrounding dermal tissue. First in vitro skin implantations demonstrate the implants' dermal integration capability as well as wound closure potential on top of the fleece by epithelialization, establishing a bacteria-proof and self-healing connection of skin and transcutaneous implant.
    MeSH term(s) Humans ; Biomimetics ; Prostheses and Implants ; Skin ; Titanium ; Neovascularization, Pathologic ; Surface Properties
    Chemical Substances Titanium (D1JT611TNE)
    Language English
    Publishing date 2023-09-13
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202301131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Evaluation of the cytotoxic and genotoxic potential of printer toner particles in a 3D air-liquid interface, primary cell-based nasal tissue model.

    Meyer, Till Jasper / Tekin, Nursen / Hense, Peter / Ehret-Kasemo, Totta / Lodes, Nina / Stöth, Manuel / Ickrath, Pascal / Gehrke, Thomas / Hagen, Rudolf / Dembski, Sofia / Peer, Michael / Steinke, Maria R / Scherzad, Agmal / Hackenberg, Stephan

    Toxicology letters

    2023  Volume 379, Page(s) 1–10

    Abstract: Printer toner particles (TPs) are a common, potentially hazardous substance, with an unclear toxicological impact on the respiratory mucosa. Most of the airways surface is covered by a ciliated respiratory mucosa, therefore appropriate tissue models of ... ...

    Abstract Printer toner particles (TPs) are a common, potentially hazardous substance, with an unclear toxicological impact on the respiratory mucosa. Most of the airways surface is covered by a ciliated respiratory mucosa, therefore appropriate tissue models of the respiratory epithelium with a high in vivo correlation are necessary for in vitro evaluation of airborne pollutants toxicology and the impact on the functional integrity. The aim of this study is the evaluation of TPs toxicology in a human primary cell-based air-liquid-interface (ALI) model of respiratory mucosa. The TPs were analyzed and characterized by scanning electron microscopy, pyrolysis and X-ray fluorescence spectrometry. ALI models of 10 patients were created using the epithelial cells and fibroblasts derived from nasal mucosa samples. TPs were applied to the ALI models via a modified Vitrocell® cloud and submerged in the dosing 0.89 - 892.96 µg/ cm
    MeSH term(s) Humans ; Benzene ; Epithelial Cells ; Nasal Mucosa ; Respiratory Mucosa ; Cilia
    Chemical Substances Benzene (J64922108F)
    Language English
    Publishing date 2023-03-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 433788-8
    ISSN 1879-3169 ; 0378-4274
    ISSN (online) 1879-3169
    ISSN 0378-4274
    DOI 10.1016/j.toxlet.2023.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1367: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC)

    Koruga, Djuro / Stanković, Ivana / Matija, Lidija / Kuhn, Dietmar / Christ, Bastian / Dembski, Sofia / Jevtić, Nenad / Janać, Jelena / Pavlović, Vladimir / Wever, Bart de

    2024  

    Abstract: In order to maximally reduce the toxicity of fullerenol (the first derivative of C60, FD-C60), and increase its biomedical efficiency, the second derivative SD-C60 (3HFWC, Hyper-Harmonized Hydroxylated Fullerene Water Complex) was created. Several ... ...

    Abstract In order to maximally reduce the toxicity of fullerenol (the first derivative of C60, FD-C60), and increase its biomedical efficiency, the second derivative SD-C60 (3HFWC, Hyper-Harmonized Hydroxylated Fullerene Water Complex) was created. Several different methods were applied in the comparative characterization of FD-C60 and SD-C60 with the same OH groups in their core. FD-C60 as an individual structure was about 1.3 nm in size, while SD-C60 as an individual structure was 10-30 nm in size. Based on ten physicochemical methods and techniques, FD-C60 and SD-C60 were found to be two different substances in terms of size, structure, and physicochemical properties; FD-C60, at 100 °C, had endothermic characteristics, while SD-C60, at 133 °C, had exothermic characteristics; FD-C60 did not have water layers, while SD-C60 had water layers; the zeta potential of FD-C60 was -25.85 mV, while it was -43.29 mV for SD-C60. SD-C60 is a promising substance for use in cosmetics and pharmaceuticals.

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    Keywords AFM/MFM ; endothermic/exothermic properties ; first derivate C60 ; fullerene C60 ; NMR ; second derivate C60 ; TEM ; TGA/DTA-MS-FTIR ; XRD ; zeta potential ; DDC::500 Naturwissenschaften und Mathematik::570 Biowissenschaften ; Biologie
    Subject code 540
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online ; Thesis: Synthese und Charakterisierung von II-VI-Halbleiter-Nanopartikeln in unterschiedlicher Umgebung

    Dembski, Sofia Viktorovna

    2007  

    Author's details vorgelegt von Sofia Viktorovna Dembski
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Würzburg, 2007
    Database Former special subject collection: coastal and deep sea fishing

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