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  1. Article ; Online: Management of Bipolar Disorder During the Perinatal Period.

    Demers, Christopher J / Walker, Rebecca / Rossi, Nicole M / Bradford, Heather M

    Nursing for women's health

    2022  Volume 27, Issue 1, Page(s) 42–52

    Abstract: Bipolar disorder (BPD) is a lifelong mental health condition characterized by symptoms of mania, depression, and often anxiety. BPD can have detrimental consequences for individuals during pregnancy and the postpartum period, as well as for their ... ...

    Abstract Bipolar disorder (BPD) is a lifelong mental health condition characterized by symptoms of mania, depression, and often anxiety. BPD can have detrimental consequences for individuals during pregnancy and the postpartum period, as well as for their offspring. This is often due to underdiagnosis and/or misdiagnosis as unipolar depression. There is a high incidence of first episodes of BPD in pregnant and postpartum persons. Perinatal care providers need to routinely screen for BPD and assess for relapse among those with a previous diagnosis during the pregnancy and postpartum periods. Medication management is complex and must be considered in the context of an individual's risk factors and perceptions about treatment as well as the limited evidence regarding fetal safety, using a shared decision-making model. Collaboration, consultation, and/or referral to mental health care providers are essential for managing acute and chronic BPD symptoms.
    MeSH term(s) Pregnancy ; Female ; Humans ; Bipolar Disorder/diagnosis ; Bipolar Disorder/drug therapy ; Parturition ; Postpartum Period/psychology ; Anxiety Disorders ; Anxiety
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2275619-X
    ISSN 1751-486X ; 1751-4851
    ISSN (online) 1751-486X
    ISSN 1751-4851
    DOI 10.1016/j.nwh.2022.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4732: Show issues Location:
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  2. Article ; Online: Directing the spatial patterning of motor neuron differentiation in engineered microenvironments.

    Demers, Christopher J / Cox, Greg / Collins, Scott D / Smith, Rosemary L

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2017  Volume 2016, Page(s) 477–480

    Abstract: Embryonic development of the spinal cord proceeds through a carefully orchestrated temporal and spatial sequence of chemical cues to provide precise patterning of adult cell types. Recreating this complex microenvironment in a standard cell culture dish ... ...

    Abstract Embryonic development of the spinal cord proceeds through a carefully orchestrated temporal and spatial sequence of chemical cues to provide precise patterning of adult cell types. Recreating this complex microenvironment in a standard cell culture dish is difficult, if not impossible. In this paper, a microfluidic device is used to recapitulate, in vitro, the graded patterning events which occur during early spinal cord development. The microdevice design is developed using COMSOL modeling, with which the spatiotemporal profiles of multiple, diffusible morphogens are simulated. Four independently addressed source/sinks are employed to generate two overlapping orthogonal gradients within a cell culture chamber, mimicking the dorsoventral and anteroposterior axes of the developing embryo. Mouse embryonic stem cells are directed therein to differentiate into motor neurons in a spatially organized manner, reminiscent of a neural tube.
    MeSH term(s) Animals ; Cell Culture Techniques ; Cell Differentiation ; Cell Engineering/instrumentation ; Cellular Microenvironment ; Female ; Lab-On-A-Chip Devices ; Mice ; Motor Neurons/cytology ; Pregnancy
    Language English
    Publishing date 2017-03-08
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2016.7590743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development-on-chip: in vitro neural tube patterning with a microfluidic device.

    Demers, Christopher J / Soundararajan, Prabakaran / Chennampally, Phaneendra / Cox, Gregory A / Briscoe, James / Collins, Scott D / Smith, Rosemary L

    Development (Cambridge, England)

    2016  Volume 143, Issue 11, Page(s) 1884–1892

    Abstract: Embryogenesis is a highly regulated process in which the precise spatial and temporal release of soluble cues directs differentiation of multipotent stem cells into discrete populations of specialized adult cell types. In the spinal cord, neural ... ...

    Abstract Embryogenesis is a highly regulated process in which the precise spatial and temporal release of soluble cues directs differentiation of multipotent stem cells into discrete populations of specialized adult cell types. In the spinal cord, neural progenitor cells are directed to differentiate into adult neurons through the action of mediators released from nearby organizing centers, such as the floor plate and paraxial mesoderm. These signals combine to create spatiotemporal diffusional landscapes that precisely regulate the development of the central nervous system (CNS). Currently, in vivo and ex vivo studies of these signaling factors present some inherent ambiguity. In vitro methods are preferred for their enhanced experimental clarity but often lack the technical sophistication required for biological realism. In this article, we present a versatile microfluidic platform capable of mimicking the spatial and temporal chemical environments found in vivo during neural tube development. Simultaneous opposing and/or orthogonal gradients of developmental morphogens can be maintained, resulting in neural tube patterning analogous to that observed in vivo.
    MeSH term(s) Animals ; Body Patterning ; Cell Differentiation ; Computer Simulation ; Equipment Design ; Lab-On-A-Chip Devices ; Mice, Transgenic ; Motor Neurons/cytology ; Neural Tube/embryology ; Neural Tube/metabolism ; Time Factors ; Time-Lapse Imaging ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2016-07-07
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.126847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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