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Article ; Online: Interchangeable Role of Motor Cortex and Reafference for the Stable Execution of an Orofacial Action.

Elbaz, Michaël A / Demers, Maxime / Kleinfeld, David / Ethier, Christian / Deschênes, Martin

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 30, Page(s) 5521–5536

Abstract: Animals interact with their environment through mechanically active, mobile sensors. The efficient use of these sensory organs implies the ability to track their position; otherwise, perceptual stability or prehension would be profoundly impeded. The ... ...

Abstract	Animals interact with their environment through mechanically active, mobile sensors. The efficient use of these sensory organs implies the ability to track their position; otherwise, perceptual stability or prehension would be profoundly impeded. The nervous system may keep track of the position of a sensorimotor organ via two complementary feedback mechanisms-peripheral reafference (external, sensory feedback) and efference copy (internal feedback). Yet, the potential contributions of these mechanisms remain largely unexplored. By training male rats to place one of their vibrissae within a predetermined angular range without contact, a task that depends on knowledge of vibrissa position relative to their face, we found that peripheral reafference is not required. The presence of motor cortex is not required either, except in the absence of peripheral reafference to maintain motor stability. Finally, the red nucleus, which receives descending inputs from motor cortex and cerebellum and projects to facial motoneurons, is critically involved in the execution of the vibrissa positioning task. All told, our results point toward the existence of an internal model that requires either peripheral reafference or motor cortex to optimally drive voluntary motion.
MeSH term(s)	Rats ; Animals ; Male ; Motor Cortex ; Motor Neurons/physiology ; Nervous System Physiological Phenomena ; Cerebellum/physiology ; Vibrissae/physiology ; Somatosensory Cortex/physiology
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.2089-22.2023
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Article ; Online: A brainstem circuit for the expression of defensive facial reactions in rat.

Callado Pérez, Amalia / Demers, Maxime / Fassihi, Arash / Moore, Jeffrey D / Kleinfeld, David / Deschênes, Martin

Current biology : CB

2023 Volume 33, Issue 18, Page(s) 4030–4035.e3

Abstract: The brainstem houses neuronal circuits that control homeostasis of vital functions. These include the depth and rate of ... ...

Abstract	The brainstem houses neuronal circuits that control homeostasis of vital functions. These include the depth and rate of breathing
MeSH term(s)	Rats ; Animals ; Apnea ; Ammonia ; Brain Stem/physiology ; Vagus Nerve ; Neurons
Chemical Substances	Ammonia (7664-41-7)
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.08.041
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Article ; Online: A vibrissa pathway that activates the limbic system.

Elbaz, Michaël / Callado Perez, Amalia / Demers, Maxime / Zhao, Shengli / Foo, Conrad / Kleinfeld, David / Deschenes, Martin

eLife

2022 Volume 11

Abstract: Vibrissa sensory inputs play a central role in driving rodent behavior. These inputs transit through the sensory trigeminal nuclei, which give rise to the ascending lemniscal and paralemniscal pathways. While lemniscal projections are somatotopically ... ...

Abstract	Vibrissa sensory inputs play a central role in driving rodent behavior. These inputs transit through the sensory trigeminal nuclei, which give rise to the ascending lemniscal and paralemniscal pathways. While lemniscal projections are somatotopically mapped from brainstem to cortex, those of the paralemniscal pathway are more widely distributed. Yet the extent and topography of paralemniscal projections are unknown, along with the potential role of these projections in controlling behavior. Here, we used viral tracers to map paralemniscal projections. We find that this pathway broadcasts vibrissa-based sensory signals to brainstem regions that are involved in the regulation of autonomic functions and to forebrain regions that are involved in the expression of emotional reactions. We further provide evidence that GABAergic cells of the Kölliker-Fuse nucleus gate trigeminal sensory input in the paralemniscal pathway via a mechanism of presynaptic or extrasynaptic inhibition.
MeSH term(s)	Afferent Pathways/physiology ; Animals ; Brain Stem/physiology ; Electrophysiology ; Limbic System/physiology ; Optogenetics ; Rats ; Rats, Long-Evans ; Trigeminal Nuclei/physiology ; Vibrissae/physiology
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.72096
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Article: Impaired Motor Learning Following a Pain Episode in Intact Rats.

Huot-Lavoie, Maxime / Ting, Windsor Kwan-Chun / Demers, Maxime / Mercier, Catherine / Ethier, Christian

Frontiers in neurology

2019 Volume 10, Page(s) 927

Abstract: Motor learning and pain are important factors influencing rehabilitation. Despite being mostly studied independently from each other, important interactions exist between them in the context of spinal cord injury, whether to the spinal cord or the body. ... ...

Abstract	Motor learning and pain are important factors influencing rehabilitation. Despite being mostly studied independently from each other, important interactions exist between them in the context of spinal cord injury, whether to the spinal cord or the body. Ongoing or recent past episodes of nociceptive activity can prevent motor learning in spinalized rats. In intact animals, it has been proposed that supraspinal activity could counter the repressive effect of nociception on motor system plasticity, but this has not yet been verified in behavioral conditions. The aim of this study was to test whether a recent episode of nociception affects subsequent motor learning in intact animals. We trained rodents to walk on a custom-made horizontal ladder. After initial training, the rats underwent a week-long rest, during which they were randomly assigned to a control group, or one out of two pain conditions. Nociceptive stimuli of different durations were induced through capsaicin or Complete Freund's Adjuvant injections and timed so that the mechanical hypersensitivity had entirely subsided by the end of the resting period. Training then resumed on a modified version of the horizontal ladder. We evaluated the animals' ability to adapt to the modified task by measuring their transit time and paw misplacements over 4 days. Our results show that prior pain episodes do affect motor learning in neurologically intact rats. Motor learning deficits also seem to be influenced by the duration of the pain episode. Rats receiving a subcutaneous injection of capsaicin displayed immediate signs of mechanical hypersensitivity, which subsided rapidly. Nonetheless, they still showed learning deficits 24 h after injection. Rats who received a Complete Freund's Adjuvant injection displayed mechanical hypersensitivity for up to 7 days during the resting period. When trained on the modified ladder task upon returning to normal sensitivity levels, these rats exhibited more prolonged motor learning deficits, extending over 3 days. Our results suggest that prior pain episodes can negatively influence motor learning, and that the duration of the impairment relates to the duration of the pain episode. Our results highlight the importance of addressing pain together with motor training after injury.
Language	English
Publishing date	2019-08-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2019.00927
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Article ; Online: Feedforward inhibition determines the angular tuning of vibrissal responses in the principal trigeminal nucleus.

Bellavance, Marie-Andrée / Demers, Maxime / Deschênes, Martin

The Journal of neuroscience : the official journal of the Society for Neuroscience

2010 Volume 30, Issue 3, Page(s) 1057–1063

Abstract: Trigeminal neurons that relay vibrissal messages to the thalamus receive input from first-order afferents that are tuned to different directions of whisker motion. This raises the question of how directional tuning is maintained in central relay stations ...

Abstract	Trigeminal neurons that relay vibrissal messages to the thalamus receive input from first-order afferents that are tuned to different directions of whisker motion. This raises the question of how directional tuning is maintained in central relay stations of the whisker system. In the present study we performed a detailed analysis of the angular tuning properties of cells in the principal trigeminal nucleus of the rat. We found that stimulus direction systematically influences response latency, so that the degree of directional tuning and the preferred deflection angle computed with first-spike latency yielded results nearly similar to those obtained with spike counts. Furthermore, we found that inhibition sharpens directional selectivity, and that pharmacological blockade of inhibition markedly decreases the angular tuning of cellular responses. These results indicate that the angular tuning of cells in the first relay station of the vibrissal system is determined by fast feedforward inhibition, which shapes excitatory inputs at the very beginning of synaptic integration.
MeSH term(s)	Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Electric Stimulation/methods ; GABA Antagonists/pharmacology ; Glycine Agents/pharmacology ; Male ; Neural Inhibition/physiology ; Neurons/drug effects ; Neurons/physiology ; Orientation/physiology ; Physical Stimulation/methods ; Pyridazines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Reaction Time/drug effects ; Reaction Time/physiology ; Strychnine/pharmacology ; Trigeminal Nuclei/cytology ; Trigeminal Nuclei/physiology ; Vibrissae/physiology
Chemical Substances	GABA Antagonists ; Glycine Agents ; Pyridazines ; gabazine (99460MG420) ; Strychnine (H9Y79VD43J)
Language	English
Publishing date	2010-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.4805-09.2010
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Article ; Online: Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement.

Bellavance, Marie-Andrée / Takatoh, Jun / Lu, Jinghao / Demers, Maxime / Kleinfeld, David / Wang, Fan / Deschênes, Martin

Neuron

2017 Volume 95, Issue 3, Page(s) 673–682.e4

Abstract: Animals employ active touch to optimize the acuity of their tactile sensors. Prior experimental results and models lead to the hypothesis that sensory inputs are used in a recurrent manner to tune the position of the sensors. A combination of ... ...

Abstract	Animals employ active touch to optimize the acuity of their tactile sensors. Prior experimental results and models lead to the hypothesis that sensory inputs are used in a recurrent manner to tune the position of the sensors. A combination of electrophysiology, intersectional genetic viral labeling and manipulation, and classical tracing allowed us to identify second-order sensorimotor loops that control vibrissa movements by rodents. Facial motoneurons that drive intrinsic muscles to protract the vibrissae receive a short latency inhibitory input, followed by synaptic excitation, from neurons located in the oralis division of the trigeminal sensory complex. In contrast, motoneurons that retract the mystacial pad and indirectly retract the vibrissae receive only excitatory input from interpolaris cells that further project to the thalamus. Silencing this feedback alters retraction. The observed pull-push circuit at the lowest-level sensorimotor loop provides a mechanism for the rapid modulation of vibrissa touch during exploration of peri-personal space.
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Brain Stem/physiology ; Feedback ; Female ; Male ; Mice ; Motor Neurons/metabolism ; Movement/physiology ; Rats, Long-Evans ; Thalamus/physiology ; Touch/physiology ; Vibrissae/physiology
Language	English
Publishing date	2017-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2017.06.045
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Article ; Online: Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement.

Bellavance, Marie-Andrée / Takatoh, Jun / Lu, Jinghao / Demers, Maxime / Kleinfeld, David / Wang, Fan / Deschênes, Martin

Neuron

2017 Volume 95, Issue 3, Page(s) 722–723

Language	English
Publishing date	2017-08-04
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2017.07.022
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Article ; Online: Muscles involved in naris dilation and nose motion in rat.

Deschênes, Martin / Haidarliu, Sebastian / Demers, Maxime / Moore, Jeffrey / Kleinfeld, David / Ahissar, Ehud

Anatomical record (Hoboken, N.J. : 2007)

2014 Volume 298, Issue 3, Page(s) 546–553

Abstract: In a number of mammals muscle dilator nasi (naris) has been described as a muscle that reduces nasal airflow resistance by dilating the nostrils. Here we show that in rats the tendon of this muscle inserts into the aponeurosis above the nasal cartilage. ... ...

Abstract	In a number of mammals muscle dilator nasi (naris) has been described as a muscle that reduces nasal airflow resistance by dilating the nostrils. Here we show that in rats the tendon of this muscle inserts into the aponeurosis above the nasal cartilage. Electrical stimulation of this muscle raises the nose and deflects it laterally towards the side of stimulation, but does not change the size of the nares. In alert head-restrained rats, electromyographic recordings of muscle dilator nasi reveal that it is active during nose motion rather than nares dilation. Together these results suggest an alternative role for the muscle dilator nasi in directing the nares for active odor sampling rather than dilating the nares. We suggest that dilation of the nares results from contraction of muscles of the maxillary division of muscle nasolabialis profundus. This muscle group attaches to the outer wall of the nasal cartilage and to the plate of the mystacial pad. Contraction of these muscles exerts a dual action: it pulls the lateral nasal cartilage outward, thus dilating the naris, and drags the plate of the mystacial pad rostrally to produce a slight retraction of the vibrissae. On the basis of these results, we propose that muscle dilator nasi of the rat should be re-named muscle deflector nasi, and that the maxillary parts of muscle nasolabialis profundus should be referred to as muscle dilator nasi.
MeSH term(s)	Animals ; Male ; Muscle, Skeletal/anatomy & histology ; Muscle, Skeletal/physiology ; Nose/anatomy & histology ; Nose/physiology ; Rats, Wistar
Language	English
Publishing date	2014-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.23053
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Article ; Online: Inhibition, Not Excitation, Drives Rhythmic Whisking.

Deschênes, Martin / Takatoh, Jun / Kurnikova, Anastasia / Moore, Jeffrey D / Demers, Maxime / Elbaz, Michael / Furuta, Takahiro / Wang, Fan / Kleinfeld, David

Neuron

2016 Volume 90, Issue 2, Page(s) 374–387

Abstract: Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Bötzinger complex (preBötC) and the vibrissa-related region of the intermediate reticular ... ...

Abstract	Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Bötzinger complex (preBötC) and the vibrissa-related region of the intermediate reticular formation (vIRt). We examine how these oscillators synergize to control sniffing and whisking. We find that the vIRt contains glycinergic/GABAergic cells that rhythmically inhibit vibrissa facial motoneurons. As a basis for the entrainment of whisking by breathing, but not vice versa, we provide evidence for unidirectional connections from the preBötC to the vIRt. The preBötC further contributes to the control of the mystacial pad. Lastly, we show that bilateral synchrony of whisking relies on the respiratory rhythm, consistent with commissural connections between preBötC cells. These data yield a putative circuit in which the preBötC acts as a master clock for the synchronization of vibrissa, pad, and snout movements, as well as for the bilateral synchronization of whisking.
MeSH term(s)	Animals ; Biological Clocks/physiology ; GABAergic Neurons/physiology ; Glycine/physiology ; Motor Neurons/physiology ; Neural Inhibition/physiology ; Neural Pathways/physiology ; Neurons/physiology ; Periodicity ; Rats ; Respiration ; Reticular Formation/physiology ; Vibrissae/physiology
Chemical Substances	Glycine (TE7660XO1C)
Language	English
Publishing date	2016-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2016.03.007
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Article ; Online: Hierarchy of orofacial rhythms revealed through whisking and breathing.

Moore, Jeffrey D / Deschênes, Martin / Furuta, Takahiro / Huber, Daniel / Smear, Matthew C / Demers, Maxime / Kleinfeld, David

Nature

2013 Volume 497, Issue 7448, Page(s) 205–210

Abstract: Whisking and sniffing are predominant aspects of exploratory behaviour in rodents. Yet the neural mechanisms that generate and coordinate these and other orofacial motor patterns remain largely uncharacterized. Here we use anatomical, behavioural, ... ...

Abstract	Whisking and sniffing are predominant aspects of exploratory behaviour in rodents. Yet the neural mechanisms that generate and coordinate these and other orofacial motor patterns remain largely uncharacterized. Here we use anatomical, behavioural, electrophysiological and pharmacological tools to show that whisking and sniffing are coordinated by respiratory centres in the ventral medulla. We delineate a distinct region in the ventral medulla that provides rhythmic input to the facial motor neurons that drive protraction of the vibrissae. Neuronal output from this region is reset at each inspiration by direct input from the pre-Bötzinger complex, such that high-frequency sniffing has a one-to-one relationship with whisking, whereas basal respiration is accompanied by intervening whisks that occur between breaths. We conjecture that the respiratory nuclei, which project to other premotor regions for oral and facial control, function as a master clock for behaviours that coordinate with breathing.
MeSH term(s)	Animals ; Biological Clocks/physiology ; Face/anatomy & histology ; Face/physiology ; Female ; Head Movements/physiology ; Kainic Acid/administration & dosage ; Kainic Acid/pharmacology ; Male ; Medulla Oblongata/cytology ; Medulla Oblongata/physiology ; Muscle, Skeletal/physiology ; Rats ; Rats, Long-Evans ; Respiration ; Smell/physiology ; Vibrissae/innervation ; Vibrissae/physiology
Chemical Substances	Kainic Acid (SIV03811UC)
Language	English
Publishing date	2013-04-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature12076
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