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  1. Article ; Online: A Novel Near-IR Absorbing Ruthenium(II) Complex as Photosensitizer for Photodynamic Therapy and its Cetuximab Bioconjugates.

    Martínez-Alonso, Marta / Gandioso, Albert / Thibaudeau, Chloé / Qin, Xue / Arnoux, Philippe / Demeubayeva, Nurikamal / Guérineau, Vincent / Frochot, Céline / Jung, Alain C / Gaiddon, Christian / Gasser, Gilles

    Chembiochem : a European journal of chemical biology

    2023  Volume 24, Issue 15, Page(s) e202300203

    Abstract: A novel Ru(II) cyclometalated photosensitizer (PS), Ru- ... ...

    Abstract A novel Ru(II) cyclometalated photosensitizer (PS), Ru-NH
    MeSH term(s) Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry ; Cetuximab/pharmacology ; Ruthenium/chemistry ; Coordination Complexes/chemistry ; Photochemotherapy
    Chemical Substances Photosensitizing Agents ; Cetuximab (PQX0D8J21J) ; Ruthenium (7UI0TKC3U5) ; Coordination Complexes
    Language English
    Publishing date 2023-07-05
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ru(II)-Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near-Infrared Light.

    Gandioso, Albert / Izquierdo-García, Eduardo / Mesdom, Pierre / Arnoux, Philippe / Demeubayeva, Nurikamal / Burckel, Pierre / Saubaméa, Bruno / Bosch, Manel / Frochot, Céline / Marchán, Vicente / Gasser, Gilles

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 61, Page(s) e202301742

    Abstract: Light-activated treatments, such as photodynamic therapy (PDT), provide temporal and spatial control over a specific cytotoxic response by exploiting toxicity differences between irradiated and dark conditions. In this work, a novel strategy for ... ...

    Abstract Light-activated treatments, such as photodynamic therapy (PDT), provide temporal and spatial control over a specific cytotoxic response by exploiting toxicity differences between irradiated and dark conditions. In this work, a novel strategy for developing near infrared (NIR)-activatable Ru(II) polypyridyl-based photosensitizers (PSs) was successfully developed through the incorporation of symmetric heptamethine cyanine dyes in the metal complex via a phenanthrimidazole ligand. Owing to their strong absorption in the NIR region, the PSs could be efficiently photoactivated with highly penetrating NIR light (770 nm), leading to high photocytotoxicities towards several cancer cell lines under both normoxic and hypoxic conditions. Notably, our lead PS (Ru-Cyn-1), which accumulated in the mitochondria, exhibited a good photocytotoxic activity under challenging low-oxygen concentration (2 % O
    MeSH term(s) Humans ; Photosensitizing Agents/pharmacology ; Photochemotherapy ; Coordination Complexes/pharmacology ; Coloring Agents ; Neoplasms/drug therapy ; Ruthenium/pharmacology
    Chemical Substances Photosensitizing Agents ; Coordination Complexes ; Coloring Agents ; Ruthenium (7UI0TKC3U5)
    Language English
    Publishing date 2023-09-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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