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  1. Article ; Online: Current role of staple line reinforcement in 30-day outcomes of primary laparoscopic sleeve gastrectomy: an analysis of MBSAQIP data, 2015-2016 PUF.

    Demeusy, Andrew / Sill, Anne / Averbach, Andrew

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2018  Volume 14, Issue 10, Page(s) 1454–1461

    Abstract: Background: Laparoscopic sleeve gastrectomy (LSG) has become a dominant bariatric procedure. In the past, significant leak rates prompted the search for staple line reinforcement (SLR) techniques. Previous analysis of the Metabolic and Bariatric Surgery ...

    Abstract Background: Laparoscopic sleeve gastrectomy (LSG) has become a dominant bariatric procedure. In the past, significant leak rates prompted the search for staple line reinforcement (SLR) techniques. Previous analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database for all LSG suggested a detrimental influence of SLR on leak rates and overall morbidity.
    Objective: To investigate the relationship between various SLR techniques and bougie size with 30-day outcomes.
    Setting: Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program-accredited bariatric surgery hospitals.
    Methods: Using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program 2015 to 2016 Participant Use File data, primary LSG cases were divided into study groups based on surgical techniques. All variables were reported in the Participant Use File except leak rate and overall morbidity, which had to be derived. Multiple bivariate analyses were used to analyze the 30-day outcomes.
    Results: A total of 198,339 primary LSG operations were included and grouped into No SLR (23.0%), SLR (54.2%), oversewn staple line (9.5%), and a combination of SLR + oversewn staple line (13.3%). There were no statistical differences between study groups in mortality, overall morbidity, or leak rate. Bleeding and reoperation rates were statistically higher in the No SLR group. Bougie size was not associated with change in leak rates.
    Conclusion: Primary LSG is a safe procedure with low morbidity and mortality rates. SLR is associated with decreased rates of bleeding and reoperations but does not affect leak rates. The selection of SLR technique should be left to the surgeon's discretion with an understanding of the associated risks, benefits, and costs.
    MeSH term(s) Adult ; Anastomotic Leak/prevention & control ; Bariatric Surgery/methods ; Bariatric Surgery/mortality ; Bariatric Surgery/statistics & numerical data ; Female ; Gastrectomy/methods ; Gastrectomy/mortality ; Gastrectomy/statistics & numerical data ; Humans ; Laparoscopy/methods ; Laparoscopy/mortality ; Laparoscopy/statistics & numerical data ; Male ; Obesity, Morbid/mortality ; Obesity, Morbid/surgery ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/mortality ; Reoperation/statistics & numerical data ; Retrospective Studies ; Surgical Stapling/methods ; Surgical Stapling/mortality ; Surgical Stapling/statistics & numerical data ; Treatment Outcome ; United States/epidemiology
    Language English
    Publishing date 2018-07-05
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2018.06.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Intrahepatic pancreatic pseudocyst: A review of the world literature.

    Demeusy, Andrew / Hosseini, Motahar / Sill, Anne M / Cunningham, Steven C

    World journal of hepatology

    2016  Volume 8, Issue 35, Page(s) 1576–1583

    Abstract: Aim: To investigate and summarize the literature regarding the diagnosis and management of intrahepatic pancreatic pseudocysts (IHPP).: Methods: A literature search was performed using PubMed (MEDLINE) and Google Scholar databases, followed by a ... ...

    Abstract Aim: To investigate and summarize the literature regarding the diagnosis and management of intrahepatic pancreatic pseudocysts (IHPP).
    Methods: A literature search was performed using PubMed (MEDLINE) and Google Scholar databases, followed by a manual review of reference lists to ensure that no articles were missed. All articles, case reports, systematic reviews, letters to editors, and abstracts were analyzed and tabulated. Bivariate analyses were performed, with significance accepted at
    Results: We found 41 published articles describing 54 cases since the 1970s, with a fairly steady rate of publication. Patients were predominantly male, with a mean age of 49 years. In 42% of published cases, the IHPP was the only reported pseudocyst, but 58% also had concurrent pseudocysts in other extrapancreatic locations. Average IHPP size was 9.5 cm and they occurred most commonly (48%) in the left hemiliver. Nearly every reported case was managed with an intervention, most with a single intervention, but some required up to three interventions. Percutaneous treatment with either simple aspiration or with an indwelling drain were the most common interventions, frequently performed along with stenting of the pancreatic duct. The size of the IHPP correlated significantly with both the duration of treatment (
    Conclusion: Diagnosis of IHPP is difficult and often missed. Initial size and WBC are predictive of the treatment required. With appropriate intervention, most patients achieve resolution.
    Language English
    Publishing date 2016-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v8.i35.1576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implications of gallbladder cholesterolosis and cholesterol polyps?

    Dairi, Saif / Demeusy, Andrew / Sill, Anne M / Patel, Shirali T / Kowdley, Gopal C / Cunningham, Steven C

    The Journal of surgical research

    2016  Volume 200, Issue 2, Page(s) 467–472

    Abstract: Background: The clinical significance of cholesterolosis has not been well established but there are some provocative, if not robust, studies of the role it may play in the pathophysiology of pancreatitis and biliary dyskinesia, as well as ... ...

    Abstract Background: The clinical significance of cholesterolosis has not been well established but there are some provocative, if not robust, studies of the role it may play in the pathophysiology of pancreatitis and biliary dyskinesia, as well as hypercholesterolemia. Our aim was to take advantage of a very large cholecystectomy (CCY) database to support or refute these potentially important reported associations.
    Materials and methods: A retrospective review of 6868 patients who underwent CCY from 2001-2013 was performed. Comparisons were made using the student t-test for continuous and chi-square analysis for categorical, variables.
    Results: Among patients for whom the CCY was the primary operation, 1053 (18%) had cholesterolosis and 4596 did not. Compared to those without cholesterolosis, those with cholesterolosis were no more likely to have elevated cholesterol levels (P = 0.64) nor low gallbladder ejection fraction (P = 0.2). To evaluate cholesterolosis as a cause of pancreatitis, all patients with gallstones were eliminated, leaving 639 patients. Among these, not only was cholesterolosis not associated with more pancreatitis, but rather there was not a single patient with or without cholesterolosis who had pancreatitis.
    Conclusions: Despite prior reports of associations between cholesterolosis and elevated serum cholesterol, depressed ejection fraction, and increased risk of pancreatitis, careful analysis of this current, larger data set does not support these associations. Any patient with stones or sludge, or with biliary dyskinesia, and appropriate symptoms, should be considered for CCY, with or without suspected cholesterolosis.
    MeSH term(s) Adult ; Aged ; Biliary Dyskinesia/etiology ; Biomarkers/metabolism ; Cholecystectomy ; Cholesterol/metabolism ; Databases, Factual ; Female ; Gallbladder Diseases/complications ; Gallbladder Diseases/metabolism ; Humans ; Hypercholesterolemia/etiology ; Male ; Middle Aged ; Pancreatitis/etiology ; Polyps/complications ; Polyps/metabolism ; Retrospective Studies
    Chemical Substances Biomarkers ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2015.08.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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