Article ; Online: Sulfur Switches for Responsive Peptide Materials.
2024 Volume 57, Issue 5, Page(s) 661–669
Abstract: ConspectusThere is considerable recent interest in the synthesis and development of peptide-based materials as mimics of natural biological assemblies that utilize proteins and peptides to form organized structures and develop beneficial properties. Due ... ...
| Abstract | ConspectusThere is considerable recent interest in the synthesis and development of peptide-based materials as mimics of natural biological assemblies that utilize proteins and peptides to form organized structures and develop beneficial properties. Due to their potential compatibility with living organisms, synthetic peptide materials are also being developed for applications such as cell grafting, therapeutic delivery, and implantable diagnostic devices. One desirable feature for such applications is the ability to design materials that can respond to stimuli by changes in their structure or properties under biologically relevant conditions. Peptide and protein assemblies can respond to stimuli, such as changes in temperature, solution pH, ions present in media, or interactions with other biomacromolecules. An exciting area of emerging research is focused on how biology uses the chemistry of sulfur-containing amino acids as a means to regulate biological processes. These concepts have been utilized and expanded in recent years to enable the development of peptide materials with readily switchable properties.The incorporation of sulfur atoms in polypeptides, peptides, and proteins provides unique sites that can be used to alter the physical and biological properties of these materials. Sulfur-containing amino acid residues, most often cysteine and methionine, are able to undergo a variety of selective chemical and enzyme-mediated reactions, which can be broadly characterized as redox or alkylation processes. These reactions often proceed under physiologically relevant conditions, can be reversible, and are significant in that they can alter residue polarity as well as conformations of peptide chains. These sulfur-based reactions are able to switch molecular and macromolecular properties of peptides and proteins in living systems and recently have been applied to synthetic peptide materials. Naturally occurring "sulfur switches" can be reversible or irreversible and are often triggered by enzymatic activity. Sulfur switches in peptide materials can also be triggered |
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| MeSH term(s) | Amines ; Amino Acids ; Cysteine ; Peptides/chemistry ; Proteins/chemistry ; Sulfur |
| Chemical Substances | Amines ; Amino Acids ; Cysteine (K848JZ4886) ; Peptides ; Proteins ; Sulfur (70FD1KFU70) |
| Language | English |
| Publishing date | 2024-02-19 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 1483291-4 |
| ISSN | 1520-4898 ; 0001-4842 |
| ISSN (online) | 1520-4898 |
| ISSN | 0001-4842 |
| DOI | 10.1021/acs.accounts.3c00626 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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