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Article ; Online: AI in emergency medicine publishing: Ethics and accessibility.

Hökenek, Nihat Müjdat / Demirhan, Recep

The American journal of emergency medicine

2024 Volume 78, Page(s) 225–226

MeSH term(s)	Humans ; Publishing ; Emergency Medicine
Language	English
Publishing date	2024-02-04
Publishing country	United States
Document type	Letter
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2024.02.007
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Article: The Effect Of Hospital Organization On Treatment During Covid-19 Pandemic

Demirhan, Recep

Southern Clinics of Istanbul Eurasia

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #925569
Database	COVID19

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Article ; Online: Differential Impact of Spread Through Air Spaces on Subtypes of Early-stage Lung Cancer.

Cimenoglu, Berk / Dogruyol, Talha / Buz, Mesut / Gecmen, Gonca / Kahraman, Selime / Demirhan, Recep

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 7, Page(s) 765–769

Abstract: Objective: To investigate the prognostic significance of STAS (Spread through air spaces) and its effect on survival in the various types of non-small cell lung cancer (NSCLC).: Study design: Descriptive analytical study. Place and Duration of the ... ...

Abstract	Objective: To investigate the prognostic significance of STAS (Spread through air spaces) and its effect on survival in the various types of non-small cell lung cancer (NSCLC). Study design: Descriptive analytical study. Place and Duration of the Study: Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkiye, between 2018 and 2021. Methodology: Early-stage lung cancer patients who underwent lobectomy were included. STAS was defined as presence of tumour cell clumps, solid nests or set of single cells located in airway spaces apart from the main tumour border and determined by pathological work-up. The clinical significance of STAS was investigated by means of histopathological subtype, tumour size, and maximum standardised uptake value (SUVmax) on PET-CT scan in early-stage lung cancer by grouping it as adenocarcinoma and non-adenocarcinoma. Five-year overall and disease-free survival, and recurrence were the outcome measures. Results: A total of 165 patients were included in the study. No recurrence was observed in 125 patients, 40 patients developed recurrence. Five-year overall survival (OS) was 69.6% in STAS (+) cohort and 74.5% in STAS (-) cohort (p=0.88). Five-year disease-free survival (DFS) was 51.1% in STAS (+) cohort and 73.1% for STAS (-) cohort (p=0.034). While the absence of STAS in the adenocarcinoma group was associated with better DFS, lower SUVMax and smaller tumour size, similar results were not found to be at statistically significant level in the non-adenocarcinoma group. Conclusion: STAS positivity makes a difference in DFS, tumour size and SUVmax, especially in adenocarcinoma, however, it does not create a significant difference in survival or clinic pathological features in the non-adenocarcinoma. Key words: Lung Cancer, Lobectomy, Spread through air spaces, Survival, Prognosis.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Adenocarcinoma of Lung ; Positron Emission Tomography Computed Tomography ; Neoplasm Staging ; Retrospective Studies ; Neoplasm Invasiveness/pathology ; Prognosis ; Adenocarcinoma/pathology ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2023-07-03
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.07.765
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Article: A Comparison of Incremental Running Field and Treadmill Tests in Young Soccer Players.

Köklü, Yusuf / Alemdaroğlu, Utku / Demirhan, Ramazan / Arslan, Yunus

Journal of human kinetics

2020 Volume 73, Page(s) 193–201

Abstract: The purpose of this study was to compare the incremental running tests performed by young soccer players on a treadmill (Tr) and in the field ( ... ...

Abstract	The purpose of this study was to compare the incremental running tests performed by young soccer players on a treadmill (Tr) and in the field (FT
Language	English
Publishing date	2020-07-21
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2503989-1
ISSN	1899-7562 ; 1640-5544
ISSN (online)	1899-7562
ISSN	1640-5544
DOI	10.2478/hukin-2019-0143
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Article ; Online: Airway management strategies for the Covid 19 patients: A brief narrative review.

Saracoglu, Kemal T / Saracoglu, Ayten / Demirhan, Recep

Journal of clinical anesthesia

2020 Volume 66, Page(s) 109954

MeSH term(s)	Airway Management/methods ; COVID-19 ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Humans ; Intubation, Intratracheal/methods ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy
Keywords	covid19
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Letter ; Review
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2020.109954
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Article ; Online: Short-Term Outcomes of Fiberoptic Bronchoscopy-guided Resection and Anastomosis Control in Thoracic Surgery.

Geyik, Fatih Dogu / Dogruyol, Talha / Kahraman, Selime / Arslan, Gulten / Saracoglu, Kemal Tolga / Demirhan, Recep

Surgical laparoscopy, endoscopy & percutaneous techniques

2022 Volume 32, Issue 6, Page(s) 673–676

Abstract: Background: In thoracic surgery practice, bronchial closure and anastomosis are relatively easy in technical terms; however, it is also the procedure that is most open to the development of complications with high morbidity. This study aimed to ... ...

Abstract	Background: In thoracic surgery practice, bronchial closure and anastomosis are relatively easy in technical terms; however, it is also the procedure that is most open to the development of complications with high morbidity. This study aimed to investigate the effect of simultaneous evaluation of bronchial closure under fiberoptic bronchoscopy guidance during lung resection on the development of complications. Materials and methods: Patients aged over 18 years who underwent elective lung resection in our clinic between 2017 and 2021 were included in the study. Postoperative complications were recorded and statistically analyzed. Results: The mean age of the patients was 61.4±10.4 years, and 267 patients were male (75.4%) and 87 (24.6%) were female. Thoracotomy was performed in 258 (72.9%) patients and lung resection with the video-assisted thoracoscopic surgery technique in 96 (27.1%) patients. During the follow-up, complications were observed during the first 30 days in 78 (22.0%) of the patients and later in 9 (2.5%). Surgical mortality occurred in 11 patients (3.1%), and the rate of readmission to the intensive care unit was 5.6% (n=20). Conclusion: We consider that the control of the resection line with the active use of fiberoptic bronchoscopy during surgery is important for the prevention of the development of bronchial morbidity. Complications in the early period can be reduced by ensuring that the remaining bronchus is not narrowed, there are no residual stump structures that may disrupt the bronchial line, such as cartilage, and bronchial washing is frequently undertaken.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Bronchoscopy/adverse effects ; Thoracic Surgery ; Thoracic Surgery, Video-Assisted/methods ; Bronchi/surgery ; Anastomosis, Surgical/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Lung Neoplasms/surgery ; Pneumonectomy/methods ; Retrospective Studies
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000001107
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Article: Is intensive care necessary after major thoracic surgery? A propensity score-matched study.

Dogruyol, Talha / Kahraman, Selime / Dogruyol, Sinem / Buz, Mesut / Cimenoglu, Berk / Ozdemir, Attila / Dogu Geyik, Fatih / Demirhan, Recep

Turk gogus kalp damar cerrahisi dergisi

2023 Volume 31, Issue 2, Page(s) 229–238

Abstract: Background: This study aims to compare the surgical results, complications, mortality rates, and inpatient costs in two patient groups followed, whether in the intensive care unit or general ward after a major thoracic procedure and to examine clinical ... ...

Abstract	Background: This study aims to compare the surgical results, complications, mortality rates, and inpatient costs in two patient groups followed, whether in the intensive care unit or general ward after a major thoracic procedure and to examine clinical and surgical factors related to the development of complications. Methods: Between January 2018 and June 2021, a total of 485 patients (150 males, 335 females; mean age: 58.3±13.2 years; range, 22 to 86 years) who underwent a major thoracic surgery in our clinic were retrospectively analyzed. The patients were divided into two groups as the intensive care unit patients (n=254) and general ward patients (n=231). In the former group, the patients were followed in the intensive care unit for a day, while in the general ward group, the patients were taken directly to the ward. The groups were compared after propensity score matching. All patients were analyzed for risk factors of morbidity development. Results: After propensity score matching, 246 patients were enrolled including 123 patients in each group. There was no statistically significant difference between the groups in any features except for late morbidity, and inpatient costs were higher in the intensive care unit group (p<0.05). In the multivariate analysis, age, American Society of Anesthesiologists Class 3, and secondary malignancy were found to be associated with morbidity (p<0.05). Conclusion: In experienced centers, it is both safe and costeffective to follow almost all of the major thoracic surgery patients postoperatively in the general ward.
Language	English
Publishing date	2023-04-28
Publishing country	Turkey
Document type	Journal Article
ISSN	1301-5680
ISSN	1301-5680
DOI	10.5606/tgkdc.dergisi.2023.23501
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Article ; Online: Foreign Body Reaction Mimicking Lymph Node Metastasis is Not Rare After Lung Cancer Resection.

Cimenoglu, Berk / Dogruyol, Talha / Ozdemir, Attila / Buz, Mesut / Ece, Dilek / Comert, Sevda Sener / Demirhan, Recep

The Thoracic and cardiovascular surgeon

2023 Volume 72, Issue 3, Page(s) 235–241

Abstract: Background: Mediastinal lymphadenopathies with high 18-fluorodeoxyglucose uptake in patients previously operated on for lung cancer are alarming for recurrence and necessitate invasive diagnostic procedures. Peroperative placement of oxidized cellulose ...

Abstract	Background: Mediastinal lymphadenopathies with high 18-fluorodeoxyglucose uptake in patients previously operated on for lung cancer are alarming for recurrence and necessitate invasive diagnostic procedures. Peroperative placement of oxidized cellulose to control minor bleeding may lead to a metastasis-like image through a foreign body reaction within the dissected mediastinal lymph node field at postoperative examinations. In this study, we investigated clinicopathological features and the frequency of foreign body reaction mimicking mediastinal lymph node metastasis. Methods: Patients who underwent surgery for lung cancer between January 2016 and August 2021 and who were subsequently evaluated for mediastinal recurrence with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) were included. Patients were grouped according to the results of EBUS-TBNA as metastasis, foreign body, and reactive. Clinicopathological features of these patients were compared and characteristics of patients in the foreign body group were scrutinized. Results: EBUS-TBNA was performed on a total of 34 patients during their postoperative follow-up due to suspicion of mediastinal recurrence. EBUS-TBNA pathological workup revealed metastasis in 18 (52.9%), foreign body reaction in 10 (29.4%) and reactive lymph nodes in 6 (17.6%) patients. Mean maximum standardized uptake value (SUVMax) for metastasis group and foreign body group were 9.39 ± 4.69 and 5.48 ± 2.54, respectively ( Conclusion: Foreign body reaction mimicking mediastinal lymph node metastasis is not uncommon. Iatrogenic cause of mediastinal lymphadenopathy is related to earlier presentation and lower SUVMax compared with metastatic lymphadenopathy.
MeSH term(s)	Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lymphatic Metastasis/pathology ; Treatment Outcome ; Mediastinum/pathology ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymphadenopathy/pathology ; Mediastinal Diseases/pathology ; Foreign-Body Reaction/diagnosis ; Foreign-Body Reaction/etiology ; Foreign-Body Reaction/pathology ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/etiology ; Foreign Bodies/surgery ; Retrospective Studies ; Bronchoscopy
Language	English
Publishing date	2023-08-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/a-2161-0690
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Article ; Online: Coinfection in SARS-CoV-2 Infected Children Patients.

Karaaslan, Ayşe / Çetin, Ceren / Akın, Yasemin / Demir Tekol, Serap / Söbü, Elif / Demirhan, Recep

Journal of infection in developing countries

2021 Volume 15, Issue 6, Page(s) 761–765

Abstract: Introduction: The aim of this study is to determine the coinfections with other respiratory pathogens in SARS-CoV-2 infected children patients in a pediatric unit in Istanbul.: Methodology: This retrospective descriptive study was conducted in a 1000- ...

Abstract	Introduction: The aim of this study is to determine the coinfections with other respiratory pathogens in SARS-CoV-2 infected children patients in a pediatric unit in Istanbul. Methodology: This retrospective descriptive study was conducted in a 1000-bedded tertiary education and research hospital in Istanbul. All children hospitalized with the diagnosis of SARS-CoV-2 infection had been investigated for respiratory agents in nasopharyngeal secretions. Laboratory confirmation of SARS-CoV-2 and the other respiratory pathogens were performed using reverse transcriptase-polymerase chain reaction (RT-PCR). Results: A total of 209 hospitalized children with suspected SARS-CoV-2 infection between March 2020-May 2020 were enrolled in this study. Among 209 children, 93 (44.5%) were RT-PCR positive for SARS-CoV-2 infection, and 116 (55.5%) were RT-PCR negative. The most common clinical symptoms in all children with SARS-CoV-2 infection were fever (68.8%) and cough (57.0%). The other clinical symptoms in decreasing rates were headache (10.8%), myalgia (5.4%), sore throat (3.2%), shortness of breath (3.2%), diarrhea (2.2%) and abdominal pain in one child. In 7 (7.5%) patients with SARS-CoV-2 infection, coinfection was detected. Two were with rhinovirus/enterovirus, two were with Coronavirus NL63, one was with adenovirus, and one was with Mycoplasma pneumoniae. In one patient, two additional respiratory agents (rhinovirus/enterovirus and adenovirus) were detected. There was a significantly longer hospital stay in patients with coinfection (p = 0.028). Conclusions: Although the coinfection rate was low in SARS-CoV-2 infected patients in our study, we found coinfection as a risk factor for length of hospital stay in the coinfected patient group.
MeSH term(s)	Adenoviridae/genetics ; Adolescent ; COVID-19/diagnosis ; COVID-19/microbiology ; COVID-19/virology ; Child ; Child, Preschool ; Coinfection/diagnosis ; Coinfection/epidemiology ; Coinfection/microbiology ; Coinfection/virology ; Hospitalization/statistics & numerical data ; Humans ; Length of Stay/statistics & numerical data ; Mycoplasma pneumoniae/genetics ; Mycoplasma pneumoniae/isolation & purification ; Nasopharynx/microbiology ; Nasopharynx/virology ; Qualitative Research ; Respiratory System/microbiology ; Respiratory System/virology ; Retrospective Studies ; SARS-CoV-2/genetics ; Tertiary Care Centers/statistics & numerical data ; Turkey/epidemiology ; Viruses/classification ; Viruses/genetics ; Viruses/isolation & purification
Language	English
Publishing date	2021-06-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.14314
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Article ; Online: Acute Limb Ischemia in Hospitalized COVID-19 Patients.

Topcu, Ahmet Can / Ozturk-Altunyurt, Gozde / Akman, Dilara / Batirel, Ayse / Demirhan, Recep

Annals of vascular surgery

2021 Volume 74, Page(s) 88–94

Abstract: Background: COVID-19 is a multisystemic disorder. Hematologic and cardiovascular involvement of COVID-19 causes thromboembolic events across multiple organs which mainly manifest as venous thromboembolism, and rarely, peripheral arterial thromboembolic ... ...

Abstract	Background: COVID-19 is a multisystemic disorder. Hematologic and cardiovascular involvement of COVID-19 causes thromboembolic events across multiple organs which mainly manifest as venous thromboembolism, and rarely, peripheral arterial thromboembolic events. In-situ thrombosis of a healthy, non-atherosclerotic native artery is rare, and COVID-19 has been reported to be a cause of this phenomenon. We aimed to report our institutional experience with COVID-19 patients who developed acute limb ischemia (ALI) during hospitalization or after discharge. Methods: This was a single-center cross-sectional study. Records of all patients ≥18 years of age admitted to a tertiary center with a confirmed diagnosis of COVID-19 infection between September 1 and December 31, 2020 were retrospectively examined. Data regarding patient demographics, co-morbidities and outcomes were collected. Patients were followed-up during index hospitalization and for 30 days postdischarge. Acute limb ischemia was diagnosed by means of duplex ultrasound and computed tomography angiography in the presence of a clinical suspicion. Results: A total of 681 consecutive patients (38.5% women) were hospitalized with a confirmed diagnosis of COVID-19 during the study period. Median age was 63 years (IQR, 52-74). In-hospital mortality occurred in 94 (13.8%) patients. Ninety (13.2%) patients required intensive care unit admission at some point of their hospital stay. Six (0.9%) patients (one woman) with a median age of 62 years experienced ALI (IQR, 59-64.3). All patients were receiving low molecular weight heparin when they developed ALI. The median of duration between COVID-19 diagnosis and ALI symptom onset was 13 days (IQR, 11.3-14). Three patients underwent emergent surgical thrombectomy combined with systemic anticoagulation, and 3 received systemic anticoagulation alone. Two patients with ALI did not survive to hospital discharge. Among survivors, 1 patient underwent bilateral major amputations, and another underwent a minor amputation within 1 month of hospital discharge. Symptoms of ALI completely resolved in 2 patients without sequelae. Conclusions: COVID-19 is a multisystemic disorder with involvement of hematologic and cardiovascular systems. Despite widespread use of thromboprophylaxis, hospitalized patients with COVID-19 are at increased risk of ALI, and subsequent limb loss or even death.
MeSH term(s)	Acute Disease ; Aged ; Amputation, Surgical ; Anticoagulants/therapeutic use ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/therapy ; Cross-Sectional Studies ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Ischemia/diagnostic imaging ; Ischemia/etiology ; Ischemia/mortality ; Ischemia/therapy ; Limb Salvage ; Male ; Middle Aged ; Patient Discharge ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/etiology ; Peripheral Arterial Disease/mortality ; Peripheral Arterial Disease/therapy ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Thrombectomy ; Time Factors ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-04-02
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2021.03.003
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