Article ; Online: Progesterone effects on vaginal cytokines in women with a history of preterm birth.
PloS one
2018 Volume 13, Issue 12, Page(s) e0209346
Abstract: Objective: To determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth.: Methods: A prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and ... ...
| Abstract | Objective: To determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth. Methods: A prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and carrying a singleton pregnancy was conducted from June 2016 to August 2017 after IRB approval. Women in the progesterone arm had a history of preterm birth and received weekly intramuscular 17-hydroxyprogesterone caproate. Controls comprised of women with healthy, uncomplicated pregnancies. Excluded were women with vaginitis, diabetes mellitus, hypertension, or other chronic diseases affecting the immune response. A vaginal wash was performed at enrollment, at 26-28 weeks, and at 35-36 weeks gestation. Samples underwent semi-quantitative detection of human inflammatory markers. Immunofluorescence pixel density data was analyzed and a P value <0.05 was considered significant. Results: There were 39 women included, 10 with a prior preterm birth and 29 controls. The baseline demographics and pregnancy outcomes for both groups were similar in age, parity, race, BMI, gestational age at delivery, mode of delivery, and birth weight. Enrollment cytokines in women with a prior preterm birth, including IL-1 alpha (39.2±25.1% versus 26.1±13.2%; P = 0.04), IL-1 beta (47.9±26.4% versus 24.9±17%; P<0.01), IL-2 (16.7±9.3% versus 11.3±6.3%; P = 0.03), and IL-13 (16.9±12.4% versus 8.2±7.4%; P = 0.01) were significantly elevated compared to controls. In the third trimester the cytokine densities for IL-1 alpha (26.0±18.2% versus 22.3±12.0%; P = 0.49), IL-1 beta (31.8±15.9% versus 33.1±16.8%; P = 0.84), IL-2 (10.0±8.4% versus 10.9±5.9%; P = 0.71), and IL-13 (9.1±5.9% versus 10.0±6.5%; P = 0.71) were all statistically similar between the progesterone arm and controls, respectively. Conclusion: There is an increased cytokine presence in vaginal washings of women at risk for preterm birth which appears to be modified following the administration of 17- hydroxyprogesterone caproate to levels similar to healthy controls. |
|---|---|
| MeSH term(s) | 17 alpha-Hydroxyprogesterone Caproate/administration & dosage ; Administration, Intravaginal ; Adolescent ; Adult ; Female ; Gene Expression Regulation/drug effects ; Gestational Age ; Humans ; Immunity, Innate/drug effects ; Infant, Newborn ; Interleukin-13/genetics ; Interleukin-1alpha/genetics ; Interleukin-1beta/genetics ; Interleukin-2/genetics ; Pregnancy ; Premature Birth/drug therapy ; Premature Birth/genetics ; Premature Birth/pathology ; Progesterone/administration & dosage ; Progestins/metabolism ; Prospective Studies ; Vagina/drug effects ; Vagina/metabolism ; Vagina/pathology |
| Chemical Substances | Interleukin-13 ; Interleukin-1alpha ; Interleukin-1beta ; Interleukin-2 ; Progestins ; 17 alpha-Hydroxyprogesterone Caproate (276F2O42F5) ; Progesterone (4G7DS2Q64Y) |
| Language | English |
| Publishing date | 2018-12-31 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1932-6203 |
| ISSN (online) | 1932-6203 |
| DOI | 10.1371/journal.pone.0209346 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.