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  1. Article ; Online: Pneumococcal coinfection in COVID-19 patients.

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Mandal, Amit K J / Missouris, Constantinos G

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 177–179

    MeSH term(s) Aged, 80 and over ; COVID-19/complications ; Coinfection/microbiology ; Coinfection/virology ; Fatal Outcome ; Humans ; Male ; Pneumonia, Pneumococcal/complications ; SARS-CoV-2 ; Streptococcus pneumoniae
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26278
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    Zs.A 1320: Show issues Location:
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  2. Article ; Online: Risky behaviour: a rare complication of an uncommon disease in a returning traveller.

    Pimenta, Dominic / Democratis, Jane

    BMJ case reports

    2013  Volume 2013

    Abstract: A 49-year-old man with a history of hypertension and no known drug allergies was admitted with a 4-day history of fever, general malaise, sore throat and diarrhoea. Eleven days ago, he had returned from a 2-week adventure holiday to South Africa. On ... ...

    Abstract A 49-year-old man with a history of hypertension and no known drug allergies was admitted with a 4-day history of fever, general malaise, sore throat and diarrhoea. Eleven days ago, he had returned from a 2-week adventure holiday to South Africa. On admission, he was noted to have a creatinine 392 µmol/L, alanine aminotransferase 133 IU/L, alkaline phosphatase 211 IU/L and platelets 151×10(9)/L. A differential diagnosis of suspected leptospirosis or bacterial sepsis was made and he was started on ceftriaxone. Two hours later he became hypotensive, tachypnoeic with severe myalgia and a temperature of 41°C, type I respiratory failure and metabolic acidosis. There was no stridor, facial swelling or rash. A diagnosis of Jarisch-Herxheimer reaction was made. A second dose of ceftriaxone was given without any reaction. The patient thereafter completed 7 days of doxycycline. PCR confirmed leptospirosis and subsequent leptospirosis IgM was positive. He improved clinically with treatment and was discharged after 10 days of admission.
    MeSH term(s) DNA, Bacterial/analysis ; Diagnosis, Differential ; England/epidemiology ; Humans ; Leptospira/genetics ; Leptospirosis/diagnosis ; Leptospirosis/ethnology ; Male ; Middle Aged ; Polymerase Chain Reaction ; Risk-Taking ; South Africa/ethnology ; Travel
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2013-10-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-201075
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  3. Article ; Online: COVID-19 in three people living with HIV in the United Kingdom.

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Merricks, Rhona / Mandal, Amit K J / Missouris, Constantinos G

    Journal of medical virology

    2020  Volume 93, Issue 1, Page(s) 107–109

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Coinfection ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV-1 ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; United Kingdom/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26178
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  4. Article ; Online: Kikuchi-Fujimoto disease.

    Dalton, Julian / Shaw, Robert / Democratis, Jane

    Lancet (London, England)

    2014  Volume 383, Issue 9922, Page(s) 1098

    MeSH term(s) Adult ; Diagnosis, Differential ; Female ; Fever of Unknown Origin/etiology ; Hemorrhagic Fever, Ebola/diagnosis ; Histiocytic Necrotizing Lymphadenitis/complications ; Histiocytic Necrotizing Lymphadenitis/diagnosis ; Humans ; Malaria/diagnosis ; Travel ; Typhus, Epidemic Louse-Borne/diagnosis ; Uganda
    Language English
    Publishing date 2014-03-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(14)60262-2
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    Ua VI Zs.5: Show issues Location:
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    Zs.MG 94: Show issues

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  6. Article ; Online: Pneumococcal coinfection in COVID‐19 patients

    Toombs, Jessica M. / Van den Abbeele, Koenraad / Democratis, Jane / Mandal, Amit K. J. / Missouris, Constantinos G.

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26278
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Long-term outcome and risk factors for late mortality in Gram-negative bacteraemia: a retrospective cohort study.

    Baltas, Ioannis / Stockdale, Thomas / Tausan, Matija / Kashif, Areeba / Anwar, Javeria / Anvar, Junaid / Koutoumanou, Eirini / Sidebottom, David / Garcia-Arias, Veronica / Wright, Melanie / Democratis, Jane

    Journal of global antimicrobial resistance

    2021  Volume 25, Page(s) 187–192

    Abstract: Objectives: The long-term outcomes of patients following Gram-negative bacteraemia (GNB) are poorly understood. Here we describe a cohort of patients with GNB over a 2-year period and determine factors associated with late mortality (death between Days ... ...

    Abstract Objectives: The long-term outcomes of patients following Gram-negative bacteraemia (GNB) are poorly understood. Here we describe a cohort of patients with GNB over a 2-year period and determine factors associated with late mortality (death between Days 31 and 365 after detection of bacteraemia).
    Methods: This was a single-centre, retrospective, observational cohort study of 789 patients with confirmed Escherichia coli, Klebsiella spp. or Pseudomonas aeruginosa bacteraemia with a follow-up of 1 year. Multivariable survival analysis was used to determine risk factors for late mortality in patients who survived the initial 30-day period of infection.
    Results: Overall, 1-year all-cause mortality was 36.2%, with 18.1% of patients dying within 30 days and 18.1% of patients suffering late mortality. An adverse antimicrobial resistance profile [hazard ratio (HR) = 1.095 per any additional antimicrobial category, 95% confidence interval (CI) 1.018-1.178; P = 0.014] and infection with P. aeruginosa (HR = 2.08, 95% CI 1.11-3.88; P = 0.022) were independent predictors of late mortality. Other significant factors included Charlson comorbidity index and length of hospitalisation after the index blood culture.
    Conclusion: Patients with GNB have a poor long-term prognosis. Risk factors for greater mortality at 1 year include co-morbidity, length of hospitalisation, and infecting organism and its resistance profile.
    MeSH term(s) Bacteremia ; Cohort Studies ; Gram-Negative Bacterial Infections ; Humans ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-04-02
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7165
    ISSN (online) 2213-7173
    ISSN 2213-7165
    DOI 10.1016/j.jgar.2021.03.019
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  8. Article ; Online: Impact of antibiotic timing on mortality from Gram-negative bacteraemia in an English district general hospital: the importance of getting it right every time.

    Baltas, Ioannis / Stockdale, Thomas / Tausan, Matija / Kashif, Areeba / Anwar, Javeria / Anvar, Junaid / Koutoumanou, Eirini / Sidebottom, David / Garcia-Arias, Veronica / Wright, Melanie / Democratis, Jane

    The Journal of antimicrobial chemotherapy

    2020  Volume 76, Issue 3, Page(s) 813–819

    Abstract: Objectives: There is limited evidence that empirical antimicrobials affect patient-oriented outcomes in Gram-negative bacteraemia. We aimed to establish the impact of effective antibiotics at four consecutive timepoints on 30 day all-cause mortality and ...

    Abstract Objectives: There is limited evidence that empirical antimicrobials affect patient-oriented outcomes in Gram-negative bacteraemia. We aimed to establish the impact of effective antibiotics at four consecutive timepoints on 30 day all-cause mortality and length of stay in hospital.
    Methods: We performed a multivariable survival analysis on 789 patients with Escherichia coli, Klebsiella spp. and Pseudomonas aeruginosa bacteraemias. Antibiotic choices at the time of the blood culture (BC), the time of medical clerking and 24 and 48 h post-BC were reviewed.
    Results: Patients that received ineffective empirical antibiotics at the time of the BC had higher risk of mortality before 30 days (HR = 1.68, 95% CI = 1.19-2.38, P = 0.004). Mortality was higher if an ineffective antimicrobial was continued by the clerking doctor (HR = 2.73, 95% CI = 1.58-4.73, P < 0.001) or at 24 h from the BC (HR = 1.83, 95% CI = 1.05-3.20, P = 0.033) when compared with patients who received effective therapy throughout. Hospital-onset infections, 'high inoculum' infections and elevated C-reactive protein, lactate and Charlson comorbidity index were independent predictors of mortality. Effective initial antibiotics did not statistically significantly reduce length of stay in hospital (-2.98 days, 95% CI = -6.08-0.11, P = 0.058). The primary reasons for incorrect treatment were in vitro antimicrobial resistance (48.6%), initial misdiagnosis of infection source (22.7%) and non-adherence to hospital guidelines (15.7%).
    Conclusions: Consecutive prescribing decisions affect mortality from Gram-negative bacteraemia.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Escherichia coli ; Escherichia coli Infections/drug therapy ; Gram-Negative Bacterial Infections/drug therapy ; Hospitals, General ; Humans ; Retrospective Studies ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-12-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa478
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    Zs.A 1197: Show issues Location:
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  9. Article: COVID-19 in 3 people living with HIV in the United Kingdom

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Merricks, Rhona / Mandal, Amit K J / Missouris, Constantinos G

    J. med. virol

    Abstract: We would like to report the clinical characteristics of 3 people living with HIV (PLWH) in the United Kingdom within the context of coronavirus disease 2019 (COVID-19). Our institution serves a population of 500,000 with a prevalence of HIV at 0.34%. At ... ...

    Abstract We would like to report the clinical characteristics of 3 people living with HIV (PLWH) in the United Kingdom within the context of coronavirus disease 2019 (COVID-19). Our institution serves a population of 500,000 with a prevalence of HIV at 0.34%. At of the time of writing, 5th June 2020, only 3 PLWH tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on nasopharyngeal swab specimen using Real-Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) have required admission to hospital. This article is protected by copyright. All rights reserved.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32542706
    Database COVID19

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  10. Article: COVID-19 in three people living with HIV in the United Kingdom

    Toombs, Jessica M / Van den Abbeele, Koenraad / Democratis, Jane / Merricks, Rhona / Mandal, Amit K J / Missouris, Constantinos G

    J. med. virol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #598648
    Database COVID19

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