Article ; Online: Exploring the antifungal potential of Annona muricata leaf extract-loaded hydrogel in treating vulvovaginal candidiasis.
Colloids and surfaces. B, Biointerfaces
2024 Volume 238, Page(s) 113919
Abstract: Vulvovaginal candidiasis, mostly caused by Candida albicans, remains a prevalent concern in women's health. Annona muricata L. (Annonaceae), a plant native from Brazil, is well-known for its therapeutic potential, including antitumor, anti-inflammatory, ... ...
| Abstract | Vulvovaginal candidiasis, mostly caused by Candida albicans, remains a prevalent concern in women's health. Annona muricata L. (Annonaceae), a plant native from Brazil, is well-known for its therapeutic potential, including antitumor, anti-inflammatory, and antimicrobial properties. This study presents an innovative hydrogel formulation containing the ethanolic extract from A. muricata leaves designed to control C. albicans in an in vivo model of vulvovaginal candidiasis. Here, we report the development, thermal, physicochemical and rheological characterization of a Carbopol®-based hydrogel containing A. muricata extract. Furthermore, we evaluated its activity in a vulvovaginal candidiasis in vivo model. Thermal analyses indicated that the addition of the extract increased the polymer-polymer and polymer-solvent interactions.Rheological analysis showed a decrease in the viscosity and elasticity of the formulation as the A. muricata extract concentration increased, suggesting a liquid-like behavior. After treatment with the Carbopol®-based hydrogel with A. muricata, our in vivo results showed a significant reduction in vulvovaginal fungal burden and infection, as well as a reduction in mucosal inflammation. The current research opens up possibilities for the application of the Carbopol®-based hydrogel with A. muricata as a natural therapeutic option for the treatment of vulvovaginal candidiasis. |
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| MeSH term(s) | Annona/chemistry ; Candidiasis, Vulvovaginal/drug therapy ; Candidiasis, Vulvovaginal/microbiology ; Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; Female ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Candida albicans/drug effects ; Animals ; Rheology ; Microbial Sensitivity Tests ; Mice |
| Chemical Substances | Antifungal Agents ; Plant Extracts ; Hydrogels |
| Language | English |
| Publishing date | 2024-04-15 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 1500523-9 |
| ISSN | 1873-4367 ; 0927-7765 |
| ISSN (online) | 1873-4367 |
| ISSN | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2024.113919 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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