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Article ; Online: Multi-UAV Path Planning in GPS and Communication Denial Environment.

Xu, Yahao / Wei, Yiran / Wang, Di / Jiang, Keyang / Deng, Hongbin

2023 Volume 23, Issue 6

Abstract: This paper proposes a feature fusion algorithm for solving the path planning problem of multiple unmanned aerial vehicles (UAVs) using GPS and communication denial conditions. Due to the blockage of GPS and communication, UAVs cannot obtain the precise ... ...

Abstract	This paper proposes a feature fusion algorithm for solving the path planning problem of multiple unmanned aerial vehicles (UAVs) using GPS and communication denial conditions. Due to the blockage of GPS and communication, UAVs cannot obtain the precise position of a target, which leads to the failure of path planning algorithms. This paper proposes a feature fusion proximal policy optimization (FF-PPO) algorithm based on deep reinforcement learning (DRL); the algorithm can fuse image recognition information with the original image, realizing the multi-UAV path planning algorithm without an accurate target location. In addition, the FF-PPO algorithm adopts an independent policy for multi-UAV communication denial environments, which enables the distributed control of UAVs such that multi-UAVs can realize the cooperative path planning task without communication. The success rate of our proposed algorithm can reach more than 90% in the multi-UAV cooperative path planning task. Finally, the feasibility of the algorithm is verified by simulations and hardware.
Language	English
Publishing date	2023-03-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23062997
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between circadian body temperature rhythm during the first 24 hours of ICU stay and 28-day mortality in elderly critically ill patients: A retrospective cohort study.

Deng, Hongbin / Yu, Xianqiang / Liu, Yang / Li, Weiqin / Fan, Jiemei

Chronobiology international

2023 Volume 40, Issue 9, Page(s) 1251–1260

Abstract: Disrupted circadian temperature rhythm is commonly observed in elderly patients in the intensive care unit (ICU), but the association between circadian temperature rhythm and mortality in elderly patients is unclear. Adult patients with a relatively ... ...

Abstract	Disrupted circadian temperature rhythm is commonly observed in elderly patients in the intensive care unit (ICU), but the association between circadian temperature rhythm and mortality in elderly patients is unclear. Adult patients with a relatively complete record of body temperature (BT) during the first 24 hours of ICU stay in the Multi-parameter Intelligent Monitoring in Intensive Care IV (MIMIC-IV) database were included in this retrospective cohort study. The circadian rhythm of body temperature was blunted as a ratio of the maximum BT between 12:00 and 24:00 divided by the minimum BT between 0:00 and 12:00, and we defined it as BT fluctuation ratio. The associations of BT fluctuation ratio with 28-day mortality were assessed separately using Cox proportional hazards model in elderly patients and non-elderly patients. The overall cohort comprised 12 767 patients. After adjusting for covariates, the analysis showed that the BT fluctuation ratio (%) was significantly associated with mortality at 28 days in total patients (hazard ratio: 1.044; 95% CI 1.001-1.088;
MeSH term(s)	Adult ; Humans ; Aged ; Middle Aged ; Circadian Rhythm ; Body Temperature ; Retrospective Studies ; Critical Illness ; Intensive Care Units
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2023.2259994
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Article ; Online: A Multilayer Graph for Multiagent Formation and Trajectory Tracking Control Based on MPC Algorithm.

Pan, Zhenhua / Sun, Zhongqi / Deng, Hongbin / Li, Dongfang

IEEE transactions on cybernetics

2022 Volume 52, Issue 12, Page(s) 13586–13597

Abstract: This article studies the formation and trajectory tracking control of multiagent systems. We present a novel multilayer graph for the multiagent system to enable extensibility of the interaction network. Based on the multilayer graph, a formation control ...

Abstract	This article studies the formation and trajectory tracking control of multiagent systems. We present a novel multilayer graph for the multiagent system to enable extensibility of the interaction network. Based on the multilayer graph, a formation control law by using the potential function approach is developed for autonomous formation, formation maintenance, collision, and obstacle avoidance. When the desired formation is achieved, the barycentric of the formation shape is viewed as a virtual leader, and a model predictive control (MPC) scheme is applied to the virtual leader for tracking a reference trajectory; meanwhile, the agents will maintain the desired angles and distances via the formation control law. By applying the proposed schemes, the tasks of formation maintenance and trajectory tracking in a constrained space are fulfilled. Comprehensive simulation studies under different environmental constraints and trajectories confirm the effectiveness of the proposed approaches in addressing the formation and trajectory tracking problems.
Language	English
Publishing date	2022-11-18
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2021.3119330
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Article: Electrochemical in-situ synthesis of Cu/ICM-101 films for functional energetic chips

Shu, Ling / Liu, Wei / Deng, Hong-Bin

Journal of materials science. 2022 May, v. 57, no. 19

2022

Abstract: Integrating energetic materials with microelectromechanical systems (MEMS) to realize miniaturized energetic chips has shown broad application prospects in micro-spacecraft, micro-satellites, ballistic correction munitions, and smart munitions. In this ... ...

Abstract	Integrating energetic materials with microelectromechanical systems (MEMS) to realize miniaturized energetic chips has shown broad application prospects in micro-spacecraft, micro-satellites, ballistic correction munitions, and smart munitions. In this work, a new type of MEMS compatible Cu/ICM-101 energetic film was successfully fabricated on copper substrates by in-situ electrochemical synthesis, the morphology and ignition property of which can be effectively controlled by adjusting the voltage and electrochemical deposition time. The morphology, composition, thermal properties, and ignition performance of as-prepared Cu/ICM-101 films were characterized by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and pulsed laser. The results show that the as-prepared Cu/ICM-101 films possesses nano porous framework structure with an exothermic heat of 1800.9 J·g⁻¹ and a thermal decomposition peak temperature of 256.4 °C. In addition, the flame height and ignition duration of which reach 10 mm and 300 μs, respectively. This work provides a reference for the integration and application of energetic materials in MEMS systems.
Keywords	X-ray diffraction ; electric potential difference ; electrochemistry ; electrosynthesis ; heat production ; microsatellite repeats ; temperature ; thermal degradation
Language	English
Dates of publication	2022-05
Size	p. 8845-8853.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-022-07258-w
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A Robust Planar Marker-Based Visual SLAM.

Wang, Zhoubo / Zhang, Zhenhai / Zhu, Wei / Hu, Xuehai / Deng, Hongbin / He, Guang / Kang, Xiao

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 2

Abstract: Many visual SLAM systems are generally solved using natural landmarks or optical flow. However, due to textureless areas, illumination change or motion blur, they often acquire poor camera poses or even fail to track. Additionally, they cannot obtain ... ...

Abstract	Many visual SLAM systems are generally solved using natural landmarks or optical flow. However, due to textureless areas, illumination change or motion blur, they often acquire poor camera poses or even fail to track. Additionally, they cannot obtain camera poses with a metric scale in the monocular case. In some cases (such as when calibrating the extrinsic parameters of camera-IMU), we prefer to sacrifice the flexibility of such methods to improve accuracy and robustness by using artificial landmarks. This paper proposes enhancements to the traditional SPM-SLAM, which is a system that aims to build a map of markers and simultaneously localize the camera pose. By placing the markers in the surrounding environment, the system can run stably and obtain accurate camera poses. To improve robustness and accuracy in the case of rotational movements, we improve the initialization, keyframes insertion and relocalization. Additionally, we propose a novel method to estimate marker poses from a set of images to solve the problem of planar-marker pose ambiguity. Compared with the state-of-art, the experiments show that our system achieves better accuracy in most public sequences and is more robust than SPM-SLAM under rotational movements. Finally, the open-source code is publicly available and can be found at GitHub.
MeSH term(s)	Algorithms ; Imaging, Three-Dimensional/methods ; Software ; Movement ; Photic Stimulation
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23020917
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Collaborative obstacle avoidance algorithm of multiple bionic snake robots in fluid based on IB-LBM.

Li, Dongfang / Deng, Hongbin / Pan, Zhenhua / Xiu, Yang

ISA transactions

2021 Volume 122, Page(s) 271–280

Abstract: This paper presents a collaborative obstacle avoidance algorithm of multiple bionic snake robots in fluid based on IB-LBM. The method can make the multiple bionic snake robots avoid different obstacles in the fluid under the control of the improved ... ...

Abstract	This paper presents a collaborative obstacle avoidance algorithm of multiple bionic snake robots in fluid based on IB-LBM. The method can make the multiple bionic snake robots avoid different obstacles in the fluid under the control of the improved Serpenoid curve function. The proposed method has high parallelism, can simulate the complex non-linear phenomenon of the multiple snake robots, deal with the complex boundary conditions of the robot, and reduce the conversion of the computational grid. Firstly, a non-linear fluid model is established by LBM, which solves the non-linear problem that the classical Navier-Stokes equations cannot explain the random motion. Secondly, the force source boundary model of multiple bionic snake robots is established by IBM, which saves the calculation time, improves the calculation efficiency and system stability. After that, each bionic snake robot is given a special force to make the robots collaborate with each other and non-colliding with each other in the process of the obstacle avoidance. Finally, through simulation experiments, the trajectory of multiple bionic snake robots avoiding different number of the obstacles in the fluid is analyzed and the collaborative obstacle avoidance process of multiple bionic snake robots in fluid is observed. The validity of the collaborative obstacle avoidance algorithm of multiple bionic snake robots in fluid based on the IB-LBM is verified.
MeSH term(s)	Algorithms ; Bionics ; Computer Simulation ; Motion ; Robotics/methods
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012746-7
ISSN	1879-2022 ; 0019-0578
ISSN (online)	1879-2022
ISSN	0019-0578
DOI	10.1016/j.isatra.2021.04.048
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Azobenzene-Based Linker Strategy for Selective Activation of Antibody-Drug Conjugates.

Xiao, Dian / Liu, Lianqi / Xie, Fei / Dong, Jingwen / Wang, Yanming / Xu, Xin / Zhong, Wu / Deng, Hongbin / Zhou, Xinbo / Li, Song

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 16, Page(s) e202310318

Abstract: Existing antibody-drug conjugate (ADC) linkers, whether cleavable or non-cleavable, are designed to release highly toxic payloads or payload derivatives upon internalisation of the ADCs into cells. However, clinical studies have shown that only <1 % of ... ...

Abstract	Existing antibody-drug conjugate (ADC) linkers, whether cleavable or non-cleavable, are designed to release highly toxic payloads or payload derivatives upon internalisation of the ADCs into cells. However, clinical studies have shown that only <1 % of the dosed ADCs accumulate in tumour cells. The remaining >99 % of ADCs are nonspecifically distributed in healthy tissue cells, thus inevitably leading to off-target toxicity. Herein, we describe an intelligent tumour-specific linker strategy to address these limitations. A tumour-specific linker is constructed by introducing a hypoxia-activated azobenzene group as a toxicity controller. We show that this azobenzene-based linker is non-cleavable in healthy tissues (O
MeSH term(s)	Humans ; Antineoplastic Agents/pharmacology ; Immunoconjugates ; Azo Compounds ; Neoplasms ; Cell Line, Tumor ; Tumor Microenvironment
Chemical Substances	Antineoplastic Agents ; Immunoconjugates ; azobenzene (F0U1H6UG5C) ; Azo Compounds
Language	English
Publishing date	2024-03-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202310318
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Article ; Online: U-shaped association between serum triglyceride levels and mortality among septic patients: An analysis based on the MIMIC-IV database.

Xiao, Min / Deng, Hongbin / Mao, Wenjian / Liu, Yang / Yang, Qi / Liu, Yuxiu / Fan, Jiemei / Li, Weiqin / Liu, Dadong

PloS one

2023 Volume 18, Issue 11, Page(s) e0294779

Abstract: Background: Sepsis is characterized by upregulated lipolysis in adipose tissue and a high blood triglyceride (TG) level. It is still debated whether serum TG level is related to mortality in septic patients. The aim of this study is to investigate the ... ...

Abstract	Background: Sepsis is characterized by upregulated lipolysis in adipose tissue and a high blood triglyceride (TG) level. It is still debated whether serum TG level is related to mortality in septic patients. The aim of this study is to investigate the association between serum TG level and mortality in septic patients admitted to the intensive care unit (ICU). Methods: Data from adult septic patients (≥18 years) admitted to the ICU for the first time were obtained from the Multiparameter Intelligent Monitoring in Intensive Care IV (MIMIC-IV) database. The patients' serum TG levels that were measured within the first week after ICU admission were extracted for statistical analysis. The endpoints were 28-day, ICU and in-hospital mortality. Results: A total of 2,782 septic patients were included. Univariate analysis indicated that the relationship between serum TG levels and the risk of mortality was significantly nonlinear. Both the Lowess smoothing technique and restricted cubic spline analyses revealed a U-shaped association between serum TG levels and mortality among septic patients. The lowest mortality rate was associated with a serum TG level of 300-500 mg/dL. Using 300∼500 mg/dL as the reference range, we found that both hypo-TG (<300 mg/dL) and hyper-TG (≥500 mg/dL) were associated with increased mortality. The result was further adjusted by Cox regression with and without the inclusion of some differential covariates. Conclusions: There was a U-shaped association between serum TG and mortality in septic ICU patients. The optimal concentration of serum TG levels in septic ICU patients is 300-500 mg/dL.
MeSH term(s)	Adult ; Humans ; Shock, Septic ; Sepsis ; Critical Care ; Intensive Care Units ; Hospital Mortality ; Retrospective Studies
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0294779
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Reirradiation of Whole Brain for Recurrent Brain Metastases: A Case Report of Lung Cancer With 12-Year Survival.

Li, Minmin / Song, Yanbo / Li, Longhao / Qin, Jian / Deng, Hongbin / Zhang, Tao

Frontiers in oncology

2021 Volume 11, Page(s) 780581

Abstract: Whole brain radiotherapy (WBRT) for brain metastases (BMs) was considered to be dose limited. Reirradiation of WBRT for recurrent BM has always been challenged. Here, we report a patient with multiple BMs of non-small-cell lung cancer (NSCLC), who ... ...

Abstract	Whole brain radiotherapy (WBRT) for brain metastases (BMs) was considered to be dose limited. Reirradiation of WBRT for recurrent BM has always been challenged. Here, we report a patient with multiple BMs of non-small-cell lung cancer (NSCLC), who received two courses of WBRT at the interval of 5 years with the cumulative administration dose for whole brain as 70 Gy and a boost for the local site as 30 Gy. Furthermore, after experiencing relapse in the brain, he underwent extra gamma knife (GK) radiotherapy for local brain metastasis for the third time after 5 years. The overall survival was 12 years since he was initially diagnosed with NSCLC with multiple brain metastases. Meanwhile, each time of radiotherapy brought a good tumor response to brain metastasis. Outstandingly, during the whole survival, he had a good quality of life (QoL) with Karnofsky Performance Score (KPS) above 80. Even after the last GK was executed, he had just a mild neurocognitive defect. In conclusion, with the cautious evaluation of a patient, we suggest that reirradiation of WBRT could be a choice, and the cumulative radiation dose of the brain may be individually modified.
Language	English
Publishing date	2021-11-26
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.780581
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Article: Dynamic Nomogram for Predicting Thrombocytopenia in Adults with Acute Pancreatitis.

Deng, Hongbin / Yu, Xianqiang / Gao, Kun / Liu, Yang / Tong, Zhihui / Liu, Yuxiu / Li, Weiqin

Journal of inflammation research

2021 Volume 14, Page(s) 6657–6667

Abstract: Objective: Thrombocytopenia increases the risk of hemorrhage in patients with acute pancreatitis (AP), leading to poor clinical outcomes. Currently, there is no reliable tool for the early assessment of thrombocytopenia in these patients. We aimed to ... ...

Abstract	Objective: Thrombocytopenia increases the risk of hemorrhage in patients with acute pancreatitis (AP), leading to poor clinical outcomes. Currently, there is no reliable tool for the early assessment of thrombocytopenia in these patients. We aimed to develop a nomogram based on available clinical parameters and validate its efficacy in predicting thrombocytopenia. Methods: This was a retrospective study. All the data were extracted from an electronic database from May 2018 to May 2019. Patients with a diagnosis of AP and staying in the intensive care unit for more than 3 days were retrospectively analyzed. A clinical signature was built based on reproducible features, using the least absolute shrinkage and selection operator method (LASSO), and logistic regression established the model (P < 0.05). Nomogram performance was determined by its discrimination, calibration, and clinical usefulness. Results: A total of 594 eligible patients were enrolled, of whom 399 were allocated to the training sets and the 195 in the test sets. The clinical features, including blood urea nitrogen (BUN), fibrinogen (FIB), and antithrombase III, were significantly associated with the incidence of thrombocytopenia after acute pancreatitis (p < 0.05) in training sets. The individualized nomogram showed good discrimination in the training sample (area under the receiver operating characteristic curve [AUC], 0.881) and in the validation sample (AUC, 0.883) with good calibration. Conclusion: The proposed nomogram has good performance for predicting thrombocytopenia in patients with acute pancreatitis and may facilitate clinical decision-making.
Language	English
Publishing date	2021-12-08
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S339981
Database	MEDical Literature Analysis and Retrieval System OnLINE

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