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  1. Book: Current topics in human genetics

    Deng, Hong-Wen

    studies in complex diseases

    2007  

    Author's details co-ed.-in-chief Hong-Wen Deng
    Keywords Genetic Diseases, Inborn / genetics ; Genetic Predisposition to Disease / genetics ; Genetics, Medical / methods
    Language English
    Size XII, 950 S. : Ill., graph. Darst.
    Publisher World Scientific
    Publishing place Singapore u.a.
    Publishing country Singapore
    Document type Book
    HBZ-ID HT015250304
    ISBN 978-981-270-472-6 ; 981-270-472-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 870 order for loan Magazin

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  2. Book: Current topics in osteoporosis

    Deng, Hong-Wen

    2005  

    Author's details ed. Hong-wen Deng
    Keywords Osteoporosis
    Language English
    Size X, 550 S. : graph. Darst.
    Publisher World Scientific
    Publishing place Singapore u.a.
    Publishing country Singapore
    Document type Book
    HBZ-ID HT014733603
    ISBN 981-256-153-6 ; 978-981-256-153-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 3537 order for loan Magazin

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  3. Book: Current topics in bone biology

    Deng, Hong-Wen

    2005  

    Author's details ed. Hong-wen Deng
    Language English
    Size X, 528 S. : Ill., graph. Darst.
    Publisher World Scientific
    Publishing place Singapore u.a.
    Publishing country Singapore
    Document type Book
    HBZ-ID HT014733524
    ISBN 981-256-209-5 ; 978-981-256-209-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 3538 order for loan Magazin

    Order via subito

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  4. Book ; Online ; E-Book: Application of clinical bioinformatics

    Wang, Xiangdong / Baumgartner, Christian / Shields, Denis C. / Deng, Hong-Wen / Beckmann, Jacques S.

    (Translational bioinformatics ; 11)

    2016  

    Author's details Xiangdong Wang, Christian Baumgartner, Denis C. Shields, Hong-Wen Deng, Jacques S. Beckmann editors
    Series title Translational bioinformatics ; 11
    Collection
    Keywords Computational Biology ; Medical Informatics Applications
    Language English
    Size 1 Online-Ressource (vi, 398 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Dordrecht
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019444930
    ISBN 978-94-017-7543-4 ; 9789401775410 ; 94-017-7543-5 ; 9401775419
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Beyond Amyloid: A Machine Learning-Driven Approach Reveals Properties of Potent GSK-3β Inhibitors Targeting Neurofibrillary Tangles.

    Nwadiugwu, Martin / Onwuekwe, Ikenna / Ezeanolue, Echezona / Deng, Hongwen

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Current treatments for Alzheimer's disease (AD) focus on slowing memory and cognitive decline, but none offer curative outcomes. This study aims to explore and curate the common properties of active, drug-like molecules that modulate glycogen synthase ... ...

    Abstract Current treatments for Alzheimer's disease (AD) focus on slowing memory and cognitive decline, but none offer curative outcomes. This study aims to explore and curate the common properties of active, drug-like molecules that modulate glycogen synthase kinase 3β (GSK-3β), a well-documented kinase with increased activity in tau hyperphosphorylation and neurofibrillary tangles-hallmarks of AD pathology. Leveraging quantitative structure-activity relationship (QSAR) data from the PubChem and ChEMBL databases, we employed seven machine learning models: logistic regression (LogR), k-nearest neighbors (KNN), random forest (RF), support vector machine (SVM), extreme gradient boosting (XGB), neural networks (NNs), and ensemble majority voting. Our goal was to correctly predict active and inactive compounds that inhibit GSK-3β activity and identify their key properties. Among the six individual models, the NN demonstrated the highest performance with a 79% AUC-ROC on unbalanced external validation data, while the SVM model was superior in accurately classifying the compounds. The SVM and RF models surpassed NN in terms of Kappa values, and the ensemble majority voting model demonstrated slightly better accuracy to the NN on the external validation data. Feature importance analysis revealed that hydrogen bonds, phenol groups, and specific electronic characteristics are important features of molecular descriptors that positively correlate with active GSK-3β inhibition. Conversely, structural features like imidazole rings, sulfides, and methoxy groups showed a negative correlation. Our study highlights the significance of structural, electronic, and physicochemical descriptors in screening active candidates against GSK-3β. These predictive features could prove useful in therapeutic strategies to understand the important properties of GSK-3β candidate inhibitors that may potentially benefit non-amyloid-based AD treatments targeting neurofibrillary tangles.
    MeSH term(s) Humans ; Neurofibrillary Tangles/metabolism ; Glycogen Synthase Kinase 3 beta ; tau Proteins/metabolism ; Neurons/metabolism ; Alzheimer Disease/pathology ; Amyloid ; Amyloidogenic Proteins/therapeutic use ; Phosphorylation
    Chemical Substances Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; tau Proteins ; Amyloid ; Amyloidogenic Proteins
    Language English
    Publishing date 2024-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Potential Molecular Mechanisms of Alzheimer’s Disease from Genetic Studies

    Nwadiugwu, Martin / Shen, Hui / Deng, Hong-wen

    Biology (Basel). 2023 Apr. 15, v. 12, no. 4

    2023  

    Abstract: The devastating effects of Alzheimer’s disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to ... ...

    Abstract The devastating effects of Alzheimer’s disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to identify common causes of molecular imbalance in AD and their potential mechanisms for continuing research. A narrative synthesis of molecular mechanisms in AD from primary studies that employed single-cell sequencing (scRNA-seq) or spatial genomics was conducted using Embase and PubMed databases. We found that differences in molecular mechanisms in AD could be grouped into four key categories: sex-specific features, early-onset features, aging, and immune system pathways. The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. What changed from previous findings in contrast to results obtained were explored to find potential factors for AD-modifying investigations.
    Keywords bile acids ; catabolism ; cholesterol ; cognition ; genomics ; immune system ; mucosa ; neurons
    Language English
    Dates of publication 2023-0415
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12040602
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Potential Molecular Mechanisms of Alzheimer's Disease from Genetic Studies.

    Nwadiugwu, Martin / Shen, Hui / Deng, Hong-Wen

    Biology

    2023  Volume 12, Issue 4

    Abstract: The devastating effects of Alzheimer's disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to ... ...

    Abstract The devastating effects of Alzheimer's disease (AD) are yet to be ameliorated due to the absence of curative treatment options. AD is an aging-related disease that affects cognition, and molecular imbalance is one of its hallmarks. There is a need to identify common causes of molecular imbalance in AD and their potential mechanisms for continuing research. A narrative synthesis of molecular mechanisms in AD from primary studies that employed single-cell sequencing (scRNA-seq) or spatial genomics was conducted using Embase and PubMed databases. We found that differences in molecular mechanisms in AD could be grouped into four key categories: sex-specific features, early-onset features, aging, and immune system pathways. The reported causes of molecular imbalance were alterations in bile acid (BA) synthesis, PITRM1, TREM2, olfactory mucosa (OM) cells, cholesterol catabolism, NFkB, double-strand break (DSB) neuronal damage, P65KD silencing, tau and APOE expression. What changed from previous findings in contrast to results obtained were explored to find potential factors for AD-modifying investigations.
    Language English
    Publishing date 2023-04-15
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12040602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Somatomotor-visual resting state functional connectivity increases after 2 years in the UK Biobank longitudinal cohort.

    Orlichenko, Anton / Su, Kuan-Jui / Shen, Hui / Deng, Hong-Wen / Wang, Yu-Ping

    Journal of medical imaging (Bellingham, Wash.)

    2024  Volume 11, Issue 2, Page(s) 24010

    Abstract: Purpose: Functional magnetic resonance imaging (fMRI) and functional connectivity (FC) have been used to follow aging in both children and older adults. Robust changes have been observed in children, in which high connectivity among all brain regions ... ...

    Abstract Purpose: Functional magnetic resonance imaging (fMRI) and functional connectivity (FC) have been used to follow aging in both children and older adults. Robust changes have been observed in children, in which high connectivity among all brain regions changes to a more modular structure with maturation. We examine FC changes in older adults after 2 years of aging in the UK Biobank (UKB) longitudinal cohort.
    Approach: We process fMRI connectivity data using the Power264 atlas and then test whether the average internetwork FC changes in the 2722-subject longitudinal cohort are statistically significant using a Bonferroni-corrected
    Results: We find a 6.8% average increase in somatomotor network (SMT)-visual network (VIS) connectivity from younger to older scans (corrected
    Conclusions: We conclude that SMT-VIS connectivity increases with age in the UKB longitudinal cohort and that resting state FC increases with age in the UKB cross-sectional cohort.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4302
    ISSN 2329-4302
    DOI 10.1117/1.JMI.11.2.024010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.

    Tan, Hang-Jing / Deng, Zi-Heng / Zhang, Chun / Deng, Hong-Wen / Xiao, Hong-Mei

    Cell cycle (Georgetown, Tex.)

    2024  Volume 22, Issue 21-22, Page(s) 2436–2448

    Abstract: Endometriosis is a benign high prevalent disease exhibiting malignant features. However, the underlying pathogenesis and key molecules of endometriosis remain unclear. By integrating and analysis of existing expression profile datasets, we identified ... ...

    Abstract Endometriosis is a benign high prevalent disease exhibiting malignant features. However, the underlying pathogenesis and key molecules of endometriosis remain unclear. By integrating and analysis of existing expression profile datasets, we identified coxsackie and adenovirus receptor (CXADR), as a novel key gene in endometriosis. Based on the results of immunohistochemistry (IHC), we confirmed significant down-regulation of CXADR in ectopic endometrial tissues obtained from women with endometriosis compared with healthy controls. Further
    MeSH term(s) Female ; Humans ; Cell Adhesion Molecules ; Cell Line, Tumor ; Cell Movement ; Endometriosis/genetics ; Epithelial-Mesenchymal Transition ; Glycogen Synthase Kinase 3 beta ; Phosphoprotein Phosphatases/pharmacology ; Phosphoric Monoester Hydrolases ; Proto-Oncogene Proteins c-akt/metabolism ; Snail Family Transcription Factors/genetics ; Snail Family Transcription Factors/metabolism
    Chemical Substances Cell Adhesion Molecules ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; PHLPP2 protein, human (EC 3.1.3.16) ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Snail Family Transcription Factors ; CLMP protein, human
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2023.2296242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Unveiling the link between physical activity levels and dementia risk: Insights from the UK Biobank study.

    Hu, Mingyue / Zhang, Kai / Su, Kuan-Jui / Qin, Tian / Shen, Hui / Deng, Hong-Wen

    Psychiatry research

    2024  Volume 336, Page(s) 115875

    Abstract: Background: There is limited information on the mixture effect and weights of light physical activity (LPA), moderate physical activity (MPA), and vigorous physical activity (VPA) on dementia risk.: Methods: A prospective cohort study was conducted ... ...

    Abstract Background: There is limited information on the mixture effect and weights of light physical activity (LPA), moderate physical activity (MPA), and vigorous physical activity (VPA) on dementia risk.
    Methods: A prospective cohort study was conducted based on the UK Biobank dataset. We included participants aged at least 45 years old without dementia at baseline between 2006-2010. The weighted quantile sum regression was used to explore the mixture effect and weights of three types of physical activity on dementia risk.
    Results: This study includes 354,123 participants, with a mean baseline age of 58.0-year-old and 52.4 % of female participants. During a median follow-up time of 12.5 years, 5,136 cases of dementia were observed. The mixture effect of LPA, MPA, and VPA on dementia was statistically significant (β: -0.0924, 95 % Confidence Interval (CI): (-0.1402, -0.0446), P < 0.001), with VPA (weight: 0.7922) contributing most to a lower dementia risk, followed by MPA (0.1939). For Alzheimer's disease, MPA contributed the most (0.8555); for vascular dementia, VPA contributed the most (0.6271).
    Conclusion: For Alzheimer's disease, MPA was identified as the most influential factor, while VPA stood out as the most impactful for vascular dementia.
    MeSH term(s) Humans ; Female ; Exercise ; Male ; United Kingdom/epidemiology ; Dementia/epidemiology ; Middle Aged ; Aged ; Prospective Studies ; Biological Specimen Banks ; Risk Factors ; Alzheimer Disease/epidemiology ; Dementia, Vascular/epidemiology ; UK Biobank
    Language English
    Publishing date 2024-03-28
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2024.115875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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