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Article: Efficacy and safety of intravenous tranexamic acid in total shoulder arthroplasty: A meta-analysis.

Deng, Hua-Mei

World journal of clinical cases

2023 Volume 11, Issue 13, Page(s) 2992–3001

Abstract: Background: Total shoulder arthroplasty (TSA) results in a large amount of perioperative blood loss due to severe trauma.: Aim: To investigate the safety and efficacy of intravenous tranexamic acid (TXA) in TSA.: Methods: We searched the PubMed, ... ...

Abstract	Background: Total shoulder arthroplasty (TSA) results in a large amount of perioperative blood loss due to severe trauma. Aim: To investigate the safety and efficacy of intravenous tranexamic acid (TXA) in TSA. Methods: We searched the PubMed, Cochrane Library, Embase and Web of Science databases for randomized controlled trials (RCTs) on the use of TXA in TSA. And all the results were checked and assessed by Reference Citation Analysis (https://www.referencecitationanalysis.com/). A meta-analysis was performed with Review Manager 5.3 to calculate the odds ratio (OR) or weighted mean difference (WMD) of related outcome indicators. Results: A total of 5 RCTs with level 1 evidence were included. There were 369 cases, with 186 in the TXA group and 183 in the placebo group. The meta-analysis showed that TXA can significantly reduce total blood loss during the perioperative period [WMD = -249.56, 95% confidence interval (CI): -347.6 to -151.52, Conclusion: The application of intravenous TXA in the perioperative period of TSA can significantly reduce the total volume of perioperative blood loss and reduce the incidence of adverse reactions, so TXA is worthy of widespread clinical use.
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i13.2992
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Article ; Online: Identification and treatment of persistent small airway dysfunction in paediatric patients with asthma: a retrospective cohort study.

Zhang, Lulu / Fu, Zhou / Deng, Hua / Xie, Qin / Wu, Wenjie

BMC pulmonary medicine

2024 Volume 24, Issue 1, Page(s) 94

Abstract: Background: Asthma is a common respiratory disease. In asthma, the small airways have more intensive inflammation and prominent airway remodelling, compared to the central airways. We aimed to investigate the predictive value of risk factors and the ... ...

Abstract	Background: Asthma is a common respiratory disease. In asthma, the small airways have more intensive inflammation and prominent airway remodelling, compared to the central airways. We aimed to investigate the predictive value of risk factors and the fractional concentration of exhaled nitric oxide (FeNO) for persistent small airway dysfunction (p-SAD), and compare the effects of different treatment modalities. Methods: This retrospective cohort study included 248 children with asthma (aged 4-11 years). Binary logistic regression was used to analyse the risk factors for p-SAD. Correlations among FEV Results: Asthmatic children with older age of receiving the regular treatment (OR 1.782, 95% CI 1.082-2.935), with younger age at the time of onset of suspected asthma symptoms (OR 0.602, 95% CI 0.365-0.993), with longer duration of using ICS or ICS/LABA (OR 1.642, 95% CI 1.170-2.305) and with worse asthma control (OR 3.893, 95% CI 1.699-8.922) had increased risk for p-SAD. Significant negative correlations of small airway function parameters with FeNO at a 200 mL/s flow rate (FeNO Conclusions: Paediatric asthma with p-SAD is associated with older age at receiving regular treatment, younger age at the time of onset of suspected asthma symptoms, longer duration of using ICS or ICS/LABA, worse asthma control, and higher FeNO
MeSH term(s)	Humans ; Child ; Anti-Asthmatic Agents/therapeutic use ; Nitric Oxide ; Retrospective Studies ; Administration, Inhalation ; Asthma/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Drug Therapy, Combination
Chemical Substances	Anti-Asthmatic Agents ; Nitric Oxide (31C4KY9ESH) ; Adrenal Cortex Hormones
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-024-02907-z
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Article ; Online: Enhanced removal performance of magnesium-modified biochar for cadmium in wastewaters: Role of active functional groups, processes, and mechanisms.

Li, Anyu / Ye, Chenghui / Jiang, Yanhong / Deng, Hua

Bioresource technology

2023 Volume 386, Page(s) 129515

Abstract: In this study, a series of biochar products with different active functional groups were developed by one-pot coprecipitation method, including magnesium-modified biochar (MgBC) and functional group-grafted MgBC (Cys@MgBC, Try@MgBC, and Glu@MgBC), for ... ...

Abstract	In this study, a series of biochar products with different active functional groups were developed by one-pot coprecipitation method, including magnesium-modified biochar (MgBC) and functional group-grafted MgBC (Cys@MgBC, Try@MgBC, and Glu@MgBC), for effective adsorption of cadmium (Cd(II)) from wastewaters. These biochars exhibited excellent removal performance for Cd(II), particularly Cys@MgBC, whose maximum Cd(II) adsorption capacity reached 223.7 mg g
MeSH term(s)	Cadmium/chemistry ; Wastewater ; Magnesium ; Charcoal/chemistry ; Adsorption
Chemical Substances	Cadmium (00BH33GNGH) ; biochar ; Wastewater ; Magnesium (I38ZP9992A) ; methylglyoxal bis(cyclohexylamidinohydrazone) (114319-00-5) ; Charcoal (16291-96-6)
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129515
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Article ; Online: Advances in the study of cholinergic circuits in the central nervous system.

He, Ganghua / Li, Yang / Deng, Hua / Zuo, Hongyan

Annals of clinical and translational neurology

2023 Volume 10, Issue 12, Page(s) 2179–2191

Abstract: Objective: Further understanding of the function and regulatory mechanism of cholinergic neural circuits and related neurodegenerative diseases.: Methods: This review summarized the research progress of the central cholinergic nervous system, ... ...

Abstract	Objective: Further understanding of the function and regulatory mechanism of cholinergic neural circuits and related neurodegenerative diseases. Methods: This review summarized the research progress of the central cholinergic nervous system, especially for the cholinergic circuit of the medial septal nucleus-hippocampus, vertical branch of diagonal band-hippocampus, basal nucleus of Meynert-cerebral cortex cholinergic loop, amygdala, pedunculopontine nucleus, and striatum-related cholinergic loops. Results: The extensive and complex fiber projection of cholinergic neurons form the cholinergic neural circuits, which regulate several nuclei in the brain through neurotransmission and participate in learning and memory, attention, emotion, movement, etc. The loss of cholinergic neurotransmitters, the reduction, loss, and degeneration of cholinergic neurons or abnormal theta oscillations and cholinergic neural circuits can induce cognitive disorders such as AD, PD, PDD, and DLB. Interpretation: The projection and function of cholinergic fibers in some nuclei and the precise regulatory mechanisms of cholinergic neural circuits in the brain remain unclear. Further investigation of cholinergic fiber projections in various brain regions and the underlying mechanisms of the neural circuits are expected to open up new avenues for the prevention and treatment of senile neurodegenerative diseases.
MeSH term(s)	Humans ; Central Nervous System ; Hippocampus ; Cerebral Cortex ; Neurodegenerative Diseases ; Cholinergic Agents
Chemical Substances	Cholinergic Agents
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2740696-9
ISSN	2328-9503 ; 2328-9503
ISSN (online)	2328-9503
ISSN	2328-9503
DOI	10.1002/acn3.51920
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Article ; Online: Design of a Multi-Mode Mechanical Finger Based on Linkage and Tendon Fusion Transmission.

Zhang, Yi / Zhao, Qian / Deng, Hua / Xu, Xiaolei

Biomimetics (Basel, Switzerland)

2023 Volume 8, Issue 3

Abstract: Today, most humanoid mechanical fingers use an underactuated mechanism driven by linkages or tendons, with only a single and fixed grasping trajectory. This paper proposes a new multi-mode humanoid finger mechanism based on linkage and tendon fusion ... ...

Abstract	Today, most humanoid mechanical fingers use an underactuated mechanism driven by linkages or tendons, with only a single and fixed grasping trajectory. This paper proposes a new multi-mode humanoid finger mechanism based on linkage and tendon fusion transmission, which is embedded with an adjustable-length tendon mechanism to achieve three types of grasping mode. The structural parameters of the mechanism are optimized according to the kinematic and static models. Furthermore, a discussion was conducted on how to set the speed ratio of the linkage driving motor and the tendon driving motor to adjust the length and tension of the tendon, in order to achieve the switching of the shape-adaptive, coupled-adaptive, and variable coupling-adaptive grasping modes. Finally, the multi-mode functionality of the proposed finger mechanism was verified through multiple grasping experiments.
Language	English
Publishing date	2023-07-17
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics8030316
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Article ; Online: Continuous Grasping Force Estimation With Surface EMG Based on Huxley-Type Musculoskeletal Model.

Xu, Xiaolei / Deng, Hua / Zhang, Yi / Chen, Jingwei

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2023 Volume 31, Page(s) 346–355

Abstract: Continuous grasping force estimation based on electromyography (EMG) signals, is very useful in practical applications including prosthetic control and human force observation. However, implementing the practical grasping force estimation usually ... ...

Abstract	Continuous grasping force estimation based on electromyography (EMG) signals, is very useful in practical applications including prosthetic control and human force observation. However, implementing the practical grasping force estimation usually considers a trade-off between the computational precision and resources. Specifically, the estimation based on the Huxley-type muscle model reaches detailed approximation of physiological process at a cost of larger computational resources for solving nonlinear partial differential equations while the counterpart with a traditional Hill-type muscle model. In this article, we achieve the grasping force estimation based on a reduced Huxley-type musculoskeletal model with high accuracy yet low time delay. Leveraging on a balanced truncation method, we further reduce the dimensionality of the spectral method solution in the Huxley-type musculoskeletal model for the model simplification. In addition, we introduce the Kalman filter method to process the EMG signals obtained by an armband, yielding better real-time performances and accuracy compared to the signal treatment using the traditional EMG filter method. Moreover, we also implement an effective identification of the model parameters using a particle swarm method. Finally, we trained the model on the first day and made grasping force estimation experiments involved with three participants over the course of a month. We envision that this effective and practical method would further improve the practical applications in the field of grasping force estimation.
MeSH term(s)	Humans ; Electromyography/methods ; Hand Strength ; Muscle, Skeletal/physiology
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2022.3214866
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Article ; Online: Enhanced removal performance of magnesium-modified biochar for cadmium in wastewaters: Role of active functional groups, processes, and mechanisms

Li, Anyu / Ye, Chenghui / Jiang, Yanhong / Deng, Hua

Bioresource Technology. 2023 Oct., v. 386 p.129515-

2023

Abstract	In this study, a series of biochar products with different active functional groups were developed by one-pot coprecipitation method, including magnesium-modified biochar (MgBC) and functional group-grafted MgBC (Cys@MgBC, Try@MgBC, and Glu@MgBC), for effective adsorption of cadmium (Cd(II)) from wastewaters. These biochars exhibited excellent removal performance for Cd(II), particularly Cys@MgBC, whose maximum Cd(II) adsorption capacity reached 223.7 mg g⁻¹. The highly active and weakly crystalline Mg could adsorb Cd(II) through precipitation and ion exchange, which was further promoted by the introduced functional groups through complexation and precipitation. After 120 d of natural process, the immobilization efficiency of Cd(II) by Cys@MgBC, Try@MgBC, and Glu@MgBC was still maintained at 98.7%, 95.2%, and 82.7% respectively. This study proposes and clarifies the complexation mechanism of functional group-grafted Mg-modified biochar for heavy metals, providing new insights into the practical application of these biochars.
Keywords	adsorption ; biochar ; cadmium ; coprecipitation ; ion exchange ; technology ; wastewater ; Active functional groups ; Magnesium-modified biochar ; Heavy metal ; Long-term stability ; Removal mechanisms
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129515
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12.

Sun, Chuanhui / Deng, Hua / Li, Qiuying / Wang, Peng / Chen, Yujiang / Sun, Yanan / Han, Changsong

Functional & integrative genomics

2024 Volume 24, Issue 3, Page(s) 78

Abstract: Transcriptional factor HOXB9, a part of the HOX gene family, plays a crucial role in the development of diverse cancer types. This study aimed to elucidate the regulatory mechanism of HOXB9 on the proliferation and invasion of laryngeal squamous cell ... ...

Abstract	Transcriptional factor HOXB9, a part of the HOX gene family, plays a crucial role in the development of diverse cancer types. This study aimed to elucidate the regulatory mechanism of HOXB9 on the proliferation and invasion of laryngeal squamous cell carcinoma (LSCC) cells to provide guidance for the development and prognosis of LSCC. The CRISPR/Cas9 method was employed in LSCC cell lines to knock out the HOXB9 gene and validate its effects on the proliferation, migration, invasion, and regulation of LSCC cells. CCK-8 and flow cytometry were used to detect cell viability and proliferation; Tunnel was used to detect cell apoptosis, and transwell was used to detect cell migration and invasion. The effect of HOXB9 on tumor growth was tested in nude mice. The downstream target genes regulated by HOXB9 were screened by microarray analysis and verified by Western blotting, immunohistochemistry, chromatin immunoprecipitation, and double-luciferase reporter assays. The current research investigated molecular pathways governed by HOXB9 in the development of LSCC. Additionally, both laboratory- and living-organism-based investigations revealed that disrupting the HOXB9 gene through the CRISPR/CAS9 mechanism restrained cellular growth, movement, and infiltration, while enhancing cellular apoptosis. Detailed analyses of LSCC cell strains and human LSCC samples revealed that HOXB9 promoted LSCC progression by directly elevating the transcriptional activity of MMP12. HOXB9 could influence changes in LSCC cell functions, and the mechanism of action might be exerted through its downstream target gene, MMP12.
MeSH term(s)	Animals ; Humans ; Mice ; Carcinoma, Squamous Cell/genetics ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Genes, Homeobox ; Head and Neck Neoplasms/genetics ; Homeodomain Proteins/genetics ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/metabolism ; Laryngeal Neoplasms/pathology ; Matrix Metalloproteinase 12/genetics ; Matrix Metalloproteinase 12/metabolism ; Mice, Nude ; Squamous Cell Carcinoma of Head and Neck/genetics
Chemical Substances	Homeodomain Proteins ; HOXB9 protein, human ; Matrix Metalloproteinase 12 (EC 3.4.24.65) ; MMP12 protein, human (EC 3.4.24.65)
Language	English
Publishing date	2024-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-024-01357-4
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Zs.A 5230: Show issues

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Article ; Online: Thermal Annealing Induced Surface Oxygen Vacancy Clusters in α-MnO

Lu, Yuqin / Deng, Hua / Pan, Tingting / Zhang, Changbin / He, Hong

ACS applied materials & interfaces

2023

Abstract: Catalytic ozonation has gained considerable interest in volatile organic compound (VOC) elimination due to its mild reaction conditions. However, the low activity and mineralization rate of VOCs over catalysts hinder its practical application. Herein, a ... ...

Abstract	Catalytic ozonation has gained considerable interest in volatile organic compound (VOC) elimination due to its mild reaction conditions. However, the low activity and mineralization rate of VOCs over catalysts hinder its practical application. Herein, a series of α-MnO
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c21120
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Article ; Online: Effects of receptor properties on particle internalization through receptor-mediated endocytosis.

Billah, Md Muhtasim / Deng, Hua / Dutta, Prashanta / Liu, Jin

Soft matter

2023 Volume 19, Issue 31, Page(s) 5907–5915

Abstract: Receptor-mediated endocytosis (RME) is a highly complex process carried out by bioparticles, such as viruses and drug carriers, to enter cells. The discovery of both clathrin-dependent and clathrin-free pathways makes the RME process even more intriguing. ...

Abstract	Receptor-mediated endocytosis (RME) is a highly complex process carried out by bioparticles, such as viruses and drug carriers, to enter cells. The discovery of both clathrin-dependent and clathrin-free pathways makes the RME process even more intriguing. Numerical models have been developed to facilitate the exploration of the process. However, the impacts of the receptor properties on RME have been less studied partially due to the oversimplifications of the receptor models. In this paper, we implement a stochastic model to systematically investigate the effects of mechanical (receptor flexure), geometrical (receptor length) and biochemical (ligand-receptor cutoff) properties of receptors, on RME with and without the existence of clathrin. Our simulation results show that the receptor's flexural rigidity plays an important role in RME with clathrin. There is a threshold beyond which particle internalization will not occur. Without clathrin, it is very difficult to achieve complete endocytosis with ligand-receptor interactions alone. A shorter receptor length and longer ligand-receptor reaction cutoff promote the formation of ligand-receptor bonds and facilitate particle internalization. Complete internalization can only be obtained with an extremely short receptor length and long reaction cutoff. Therefore, there are most likely some additional mechanisms to drive the membrane deformation in clathrin-free RME. Our results yield important fundamental insights into RME and provide crucial guidance when correlating the simulation results with experimental observations.
MeSH term(s)	Ligands ; Endocytosis ; Clathrin/metabolism
Chemical Substances	Ligands ; Clathrin
Language	English
Publishing date	2023-08-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d3sm00149k
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