Article ; Online: Anti-inflammatory steroids from the stems of Solanum nigrum L
Phytochemistry. 2023 June, v. 210 p.113667-
2023
Abstract: Sixteen previously undescribed steroidal sapogenins along with two known ones were isolated from the stems of Solanum nigrum L. (Solanaceae). Their structures were identified using a combination of 1D and 2D NMR, HR-ESI-MS spectroscopy, the Mosher method, ...
| Abstract | Sixteen previously undescribed steroidal sapogenins along with two known ones were isolated from the stems of Solanum nigrum L. (Solanaceae). Their structures were identified using a combination of 1D and 2D NMR, HR-ESI-MS spectroscopy, the Mosher method, and X-ray diffraction analysis. Compounds 1–8 have an unusual F ring and 9–12 have a derived A ring, both of which are rare skeletons found in natural products. The biological evaluation showed that the isolated steroids exhibited inhibition of nitric oxide in the LPS-induced RAW 264.7 macrophages with IC₅₀ values from 7.4 to 41.3 μM. Further studies revealed that compounds 6 and 10 exhibited anti-inflammatory activity by blocking the nuclear translocation of NF-κB, and down-regulating the expression of iNOS, COX-2, IL-1β, and IL-6 in a concentration-dependent manner. These results suggest that the stems of S. nigrum may serve as a source of anti-inflammatory agents for use in healthy or medicinal products. |
|---|---|
| Keywords | Solanum nigrum ; X-ray diffraction ; anti-inflammatory activity ; biological assessment ; interleukin-6 ; macrophages ; nitric oxide ; plant biochemistry ; sapogenins ; spectroscopy ; Solanum nigrum L. ; Solanaceae ; steroid ; 23,26-epoxyfurostanoids ; 4-oxa-A-homo-5α-spirostan-3-one ; anti-inflammatory |
| Language | English |
| Dates of publication | 2023-06 |
| Publishing place | Elsevier Ltd |
| Document type | Article ; Online |
| ZDB-ID | 208884-8 |
| ISSN | 1873-3700 ; 0031-9422 |
| ISSN (online) | 1873-3700 |
| ISSN | 0031-9422 |
| DOI | 10.1016/j.phytochem.2023.113667 |
| Database | NAL-Catalogue (AGRICOLA) |
More links
Kategorien
In stock of ZB MED Bonn / Germany
| Z 1586: Show issues | ||||
| Z 8.5: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.