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  1. Article ; Online: Methylene Blue Pretreatment Protects Against Repeated Neonatal Isoflurane Exposure-Induced Brain Injury and Memory Loss.

    Wu, Chongyun / Deng, Qianting / Zhu, Ling / Liu, Timon Cheng-Yi / Duan, Rui / Yang, Luodan

    Molecular neurobiology

    2024  

    Abstract: Perioperative neurocognitive impairment (PND) is a common medical complication in the postoperative period. General anesthesia through volatile anesthetics poses a high risk of POCD. Moreover, the developing brain is especially vulnerable to anesthesia- ... ...

    Abstract Perioperative neurocognitive impairment (PND) is a common medical complication in the postoperative period. General anesthesia through volatile anesthetics poses a high risk of POCD. Moreover, the developing brain is especially vulnerable to anesthesia-induced neurotoxicity. Therefore, finding a practical approach to prevent or alleviate neonatal isoflurane (ISO) exposure-induced brain injury and cognitive decline is essential for reducing medical complications following major surgery during the early postnatal period. Using a repeated neonatal ISO exposure-induced PND rat model, we investigated the effects of methylene blue (MB) pretreatment on repeated neonatal isoflurane exposure-induced brain injury and memory loss. Intraperitoneal injection of low-dose MB (1 mg/kg) was conducted three times 24 h before each ISO exposure. The Barnes maze and novel objection test were conducted to assess learning and memory. Immunofluorescence staining, F-Jade C staining, TUNEL staining, and Western blot analysis were performed to determine mitochondrial fragmentation, neuronal injury, degeneration, and apoptosis. Evans blue extravasation assay, total antioxidant capacity assay, MDA assay kit, and related inflammatory assay kits were used to test blood-brain barrier (BBB) disruption, antioxidant capacity, and neuroinflammation. Behavioral tests revealed that MB pretreatment significantly ameliorated ISO exposure-induced cognitive deficits. In addition, MB pretreatment alleviates neuronal injury, apoptosis, and degeneration. Furthermore, the BBB integrity was preserved by MB pretreatment. Additional studies revealed that ISO-induced excessive mitochondrial fragmentation, oxidative stress, and neuroinflammation were significantly attenuated by MB pretreatment in the PND rat model. Our findings suggest that MB pretreatment alleviates ISO exposure-induced brain injury and memory loss for the first time, supporting MB pretreatment as a promising approach to protect the brain against neonatal ISO exposure-induced postoperative cognitive dysfunction.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-03931-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Microglia and Astrocytes in Alzheimer's Disease: Significance and Summary of Recent Advances.

    Deng, Qianting / Wu, Chongyun / Parker, Emily / Liu, Timon Cheng-Yi / Duan, Rui / Yang, Luodan

    Aging and disease

    2023  

    Abstract: Alzheimer's disease, one of the most common forms of dementia, is characterized by a slow progression of cognitive impairment and neuronal loss. Currently, approved treatments for AD are hindered by various side effects and limited efficacy. Despite ... ...

    Abstract Alzheimer's disease, one of the most common forms of dementia, is characterized by a slow progression of cognitive impairment and neuronal loss. Currently, approved treatments for AD are hindered by various side effects and limited efficacy. Despite considerable research, practical treatments for AD have not been developed. Increasing evidence shows that glial cells, especially microglia and astrocytes, are essential in the initiation and progression of AD. During AD progression, activated resident microglia increases the ability of resting astrocytes to transform into reactive astrocytes, promoting neurodegeneration. Extensive clinical and molecular studies show the involvement of microglia and astrocyte-mediated neuroinflammation in AD pathology, indicating that microglia and astrocytes may be potential therapeutic targets for AD. This review will summarize the significant and recent advances of microglia and astrocytes in the pathogenesis of AD in three parts. First, we will review the typical pathological changes of AD and discuss microglia and astrocytes in terms of function and phenotypic changes. Second, we will describe microglia and astrocytes' physiological and pathological role in AD. These roles include the inflammatory response, "eat me" and "don't eat me" signals, Aβ seeding, propagation, clearance, synapse loss, synaptic pruning, remyelination, and demyelination. Last, we will review the pharmacological and non-pharmacological therapies targeting microglia and astrocytes in AD. We conclude that microglia and astrocytes are essential in the initiation and development of AD. Therefore, understanding the new role of microglia and astrocytes in AD progression is critical for future AD studies and clinical trials. Moreover, pharmacological, and non-pharmacological therapies targeting microglia and astrocytes, with specific studies investigating microglia and astrocyte-mediated neuronal damage and repair, may be a promising research direction for future studies regarding AD treatment and prevention.
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0907
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  3. Article ; Online: Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia.

    Deng, Qianting / Wu, Chongyun / Liu, Timon Cheng-Yi / Duan, Rui / Yang, Luodan

    Experimental neurology

    2023  Volume 367, Page(s) 114450

    Abstract: Neonatal hypoxic-ischemic encephalopathy (HIE) is the primary reason for neonatal mortality and prolonged disablement. Currently, hypothermia is the only approved clinical treatment available for HIE. However, hypothermia's limited therapeutic efficacy ... ...

    Abstract Neonatal hypoxic-ischemic encephalopathy (HIE) is the primary reason for neonatal mortality and prolonged disablement. Currently, hypothermia is the only approved clinical treatment available for HIE. However, hypothermia's limited therapeutic efficacy and adverse effects suggest an urgent need to advance our knowledge of its molecular pathogenesis and develop novel therapies. The leading cause of HIE is impaired cerebral blood flow and oxygen deprivation-initiated primary and secondary energy failure. Lactate was traditionally regarded as a marker of energy failure or a waste product of anaerobic glycolysis. Recently, the beneficial aspects of lactate as supplementary energy for neurons have been demonstrated. Under the conditions of HI, lactate supports various functions of neuronal cells, including learning and memory formation, motor coordination, and somatosensory. Furthermore, lactate contributes to the regeneration of blood vessels and has shown its beneficial effects on the immune system. This review first introduces the hypoxic or ischemic events-induced fundamental pathophysiological changes in HIE and then discusses the potential neuroprotective properties of lactate for the treatment and prevention of HIE. Finally, we discuss the possible protective mechanisms of lactate in the context of the pathological features of perinatal HIE. We conclude that exogenous and endogenous lactate exert neuroprotective effects in HIE. Lactate administration may be a potential approach to treating HIE injury.
    MeSH term(s) Infant, Newborn ; Humans ; Hypothermia, Induced ; Lactic Acid/pharmacology ; Hypothermia/complications ; Hypothermia/therapy ; Hypoxia-Ischemia, Brain/complications ; Hypoxia/complications ; Ischemia/complications ; Ischemia/therapy
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 184: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Crop pest image classification based on improved densely connected convolutional network.

    Peng, Hongxing / Xu, Huiming / Gao, Zongmei / Zhou, Zhiyan / Tian, Xingguo / Deng, Qianting / He, Huijun / Xian, Chunlong

    Frontiers in plant science

    2023  Volume 14, Page(s) 1133060

    Abstract: Introduction: Crop pests have a great impact on the quality and yield of crops. The use of deep learning for the identification of crop pests is important for crop precise management.: Methods: To address the lack of data set and poor classification ... ...

    Abstract Introduction: Crop pests have a great impact on the quality and yield of crops. The use of deep learning for the identification of crop pests is important for crop precise management.
    Methods: To address the lack of data set and poor classification accuracy in current pest research, a large-scale pest data set named HQIP102 is built and the pest identification model named MADN is proposed. There are some problems with the IP102 large crop pest dataset, such as some pest categories are wrong and pest subjects are missing from the images. In this study, the IP102 data set was carefully filtered to obtain the HQIP102 data set, which contains 47,393 images of 102 pest classes on eight crops. The MADN model improves the representation capability of DenseNet in three aspects. Firstly, the Selective Kernel unit is introduced into the DenseNet model, which can adaptively adjust the size of the receptive field according to the input and capture target objects of different sizes more effectively. Secondly, in order to make the features obey a stable distribution, the Representative Batch Normalization module is used in the DenseNet model. In addition, adaptive selection of whether to activate neurons can improve the performance of the network, for which the ACON activation function is used in the DenseNet model. Finally, the MADN model is constituted by ensemble learning.
    Results: Experimental results show that MADN achieved an accuracy and F1Score of 75.28% and 65.46% on the HQIP102 data set, an improvement of 5.17 percentage points and 5.20 percentage points compared to the pre-improvement DenseNet-121. Compared with ResNet-101, the accuracy and F1Score of MADN model improved by 10.48 percentage points and 10.56 percentage points, while the parameters size decreased by 35.37%. Deploying models to cloud servers with mobile application provides help in securing crop yield and quality.
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1133060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization.

    Feng, Shu / Wu, Chongyun / Zou, Peibin / Deng, Qianting / Chen, Zhe / Li, Meng / Zhu, Ling / Li, Fanghui / Liu, Timon Cheng-Yi / Duan, Rui / Yang, Luodan

    Theranostics

    2023  Volume 13, Issue 10, Page(s) 3434–3450

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Mice ; Rats ; Alzheimer Disease/drug therapy ; Amyloid beta-Peptides/genetics ; Astrocytes/pathology ; Disease Models, Animal ; High-Intensity Interval Training ; Mice, Transgenic ; Neurodegenerative Diseases/pathology ; Phenotype
    Chemical Substances Amyloid beta-Peptides ; Aqp4 protein, rat ; Aqp4 protein, mouse
    Language English
    Publishing date 2023-06-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.81951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Photobiomodulation therapy alleviates repeated closed head injury-induced anxiety-like behaviors.

    Chen, Zhe / Li, Meng / Wu, Chongyun / Su, Yanlin / Feng, Shu / Deng, Qianting / Zou, Peibin / Liu, Timon Cheng-Yi / Duan, Rui / Yang, Luodan

    Journal of biophotonics

    2023  Volume 17, Issue 2, Page(s) e202300343

    Abstract: Repeated closed head injury (rCHI) is one of the most common brain injuries. Although extensive studies have focused on how to treat rCHI-induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI-induced ... ...

    Abstract Repeated closed head injury (rCHI) is one of the most common brain injuries. Although extensive studies have focused on how to treat rCHI-induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI-induced anxiety has received little research attention. The current study was designed to assess the effects of photobiomodulation (PBM) therapy in preventing anxiety following rCHI. The rCHI disease model was constructed by administering three repeated closed-head injuries within an interval 5 days. 2-min daily PBM therapy using an 808 nm continuous wave laser at 350 mW/cm
    MeSH term(s) Humans ; Low-Level Light Therapy ; Apoptosis ; Neurons ; Anxiety/etiology ; Anxiety/prevention & control ; Head Injuries, Closed
    Language English
    Publishing date 2023-11-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202300343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6723: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Integrating stimulus-organism-response model and theory of planned behavior to explore athletes’ intention to receive the COVID-19 vaccine booster—A moderated mediation model

    Zhan, Wenpeng / Deng, Qianting / Nguyen, Van Bac / Duc Anh, Tran Phan / Na, Phan Danh / Shia, An-Shin / Ku, Gordon Chih-Ming

    medRxiv

    Abstract: This study aims to investigate the factors influencing athletes9 intention to receive the COVID-19 vaccine booster in Mainland China by integrating the stimulus-organization-response (SOR) model and theory of planned behavior (TPB) as the theoretical ... ...

    Abstract This study aims to investigate the factors influencing athletes9 intention to receive the COVID-19 vaccine booster in Mainland China by integrating the stimulus-organization-response (SOR) model and theory of planned behavior (TPB) as the theoretical framework. Purposive sampling was used to select respondents from the National Games of the People9s Republic of China. Hard-copy questionnaires were utilized to collect data, resulting in 981 valid responses. Descriptive analysis and partial least squares structural equation modeling were used to analyze the data. The findings reveal that athletes9 subjective norm and knowledge significantly influence attitude, commitment, and perceived behavioral control. Attitude, commitment, and perceived behavioral control are verified as full mediators between subjective norm, knowledge, and intention to receive the COVID-19 vaccine booster. Knowledge to commitment is the most powerful path to predict athletes9 intention to receive the COVID-19 vaccine booster. Motivation moderates the relationships between knowledge, attitude, commitment, and perceived behavioral control. The integrating model9s explanatory power is 83.2%. Athletes9 knowledge is crucial in shaping a positive attitude, commitment, and perceived control, enhancing their intention to get the COVID-19 vaccine booster.
    Keywords covid19
    Language English
    Publishing date 2023-11-13
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.11.13.23298480
    Database COVID19

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