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  1. Article: Exploring the Evidence: Symptom Burden in Chronic Kidney Disease.

    Clark-Cutaia, Maya N / Rivera, Eleanor / Iroegbu, Christin / Arneson, Gavin / Deng, Rebecca / Anastasi, Joyce K

    Nephrology nursing journal : journal of the American Nephrology Nurses' Association

    2022  Volume 49, Issue 3, Page(s) 227–255

    Abstract: Chronic kidney disease (CKD) is more prevalent in individuals with obesity, diabetes mellitus, or hypertension. Individuals with CKD are prone to kidney failure, with symptom experiences that rival those of patients with cancer. We explored symptom ... ...

    Abstract Chronic kidney disease (CKD) is more prevalent in individuals with obesity, diabetes mellitus, or hypertension. Individuals with CKD are prone to kidney failure, with symptom experiences that rival those of patients with cancer. We explored symptom burden in individuals with CKD via a systematic review of 30 quantitative and qualitative articles. The most common CKD symptoms were fatigue, weakness, pain, sleep disturbances and itchy skin. Instruments used to assess symptoms were the Kidney Disease Quality of Life (KDQOL)-36, the Palliative Outcome Symptom-Scale renal (POS-r)-13, and the Dialysis Symptom Index (DSI)-10. The included qualitative studies expand and expound on the quantitative data presented. This article describes the prevalence of symptom burden in individuals with CKD in relation to psychosocial and demographic factors and discuss the importance of symptom management.
    MeSH term(s) Fatigue/etiology ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Palliative Care ; Quality of Life/psychology ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 2008177-7
    ISSN 1526-744X ; 8750-0779
    ISSN 1526-744X ; 8750-0779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2539: Show issues Location:
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  2. Article ; Online: Severe neighborhood deprivation and nursing home staffing in the United States.

    Falvey, Jason R / Hade, Erinn M / Friedman, Steven / Deng, Rebecca / Jabbour, Joelle / Stone, Robyn I / Travers, Jasmine L

    Journal of the American Geriatrics Society

    2022  Volume 71, Issue 3, Page(s) 711–719

    Abstract: Background: Low nursing home staffing in the United States is a growing safety concern. Socioeconomic deprivation in the local areas surrounding a nursing home may be a barrier to improving staffing rates but has been poorly studied. Thus, the objective ...

    Abstract Background: Low nursing home staffing in the United States is a growing safety concern. Socioeconomic deprivation in the local areas surrounding a nursing home may be a barrier to improving staffing rates but has been poorly studied. Thus, the objective of this paper was to assess the relationship between neighborhood deprivation and nursing home staffing in the United States.
    Methods: This cross-sectional study used 2018 daily payroll-based staffing records and address data for 12,609 nursing homes in the United States linked with resident assessment data. Our primary exposure of interest was severe economic deprivation at the census block group (neighborhood) level, defined as an area deprivation index score ≥85/100. The primary outcome was hours worked per resident-day among nursing home employees providing direct resident care. Marginal linear regression models and generalized estimating equations with robust sandwich-type standard errors were used to estimate associations between severe neighborhood deprivation and staffing rates.
    Results: Compared to less deprived neighborhoods, unadjusted staffing rates in facilities located within severely deprived neighborhoods were 38% lower for physical and occupational therapists, 30% lower for registered nurses (RNs), and 5% lower for certified nursing assistants. No disparities in licensed practical nurse (LPN) staffing were observed. In models with state-level and rurality fixed effects and clustered on the county, a similar pattern of disparities was observed. Specifically, RN staffing per 100 resident-days was significantly lower in facilities located within severely deprived neighborhoods as compared to those in less deprived areas (mean difference: 5.6 fewer hours, 95% confidence interval [CI] 4.2-6.9). Disparities of lower magnitude were observed for other clinical disciplines except for LPNs.
    Conclusions: Significant staffing disparities were observed within facilities located in severely deprived neighborhoods. Targeted interventions, including workforce recruitment and retention efforts, may be needed to improve staffing levels for nursing homes in deprived neighborhoods.
    MeSH term(s) Humans ; United States ; Cross-Sectional Studies ; Nursing Homes ; Nursing Staff ; Skilled Nursing Facilities ; Workforce ; Personnel Staffing and Scheduling
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.17990
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  3. Article ; Online: The Challenges, Joys, and Career Satisfaction of Women Graduates of the Robert Wood Johnson Clinical Scholars Program 1973-2011.

    Kalet, Adina / Lusk, Penelope / Rockfeld, Jennifer / Schwartz, Kate / Fletcher, Kathlyn E / Deng, Rebecca / Bickell, Nina A

    Journal of general internal medicine

    2020  Volume 35, Issue 8, Page(s) 2258–2265

    Abstract: Background: To ensure a next generation of female leaders in academia, we need to understand challenges they face and factors that enable fellowship-prepared women to thrive. We surveyed woman graduates of the Robert Wood Johnson Clinical Scholars ... ...

    Abstract Background: To ensure a next generation of female leaders in academia, we need to understand challenges they face and factors that enable fellowship-prepared women to thrive. We surveyed woman graduates of the Robert Wood Johnson Clinical Scholars Program (CSP) from 1976 to 2011 regarding their experiences, insights, and advice to women entering the field.
    Methods: We surveyed every CSP woman graduate through 2012 (n = 360) by email and post. The survey, 12 prompts requiring open text responses, explored current work situation, personal definitions of success, job negotiations, career regrets, feelings about work, and advice for others. Four independent reviewers read overlapping subsets of the de-identified data, iteratively created coding categories, and defined and refined emergent themes.
    Results: Of the 360 cohort, 108 (30%) responded. The mean age of respondents was 45 (range 32 to 65), 85% are partnered, and 87% have children (average number of children 2.15, range 1 to 5). We identified 11 major code categories and conducted a thematic analysis. Factors common to very satisfied respondents include personally meaningful work, schedule flexibility, spousal support, and collaborative team research. Managing professional-personal balance depended on career stage, clinical specialty, and children's age. Unique to women who completed the CSP prior to 1995 were descriptions of "atypical" paths with career transitions motivated by discord between work and personal ambitions and the emphasis on the importance of maintaining relevance and remaining open to opportunities in later life.
    Conclusions: Women CSP graduates who stayed in academic medicine are proud to have pursued meaningful work despite challenges and uncertain futures. They thrived by remaining flexible and managing change while remaining true to their values. We likely captured the voices of long-term survivors in academic medicine. Although transferability of these findings is uncertain, these voices add to the national discussion about retaining clinical researchers and keeping women academics productive and engaged.
    MeSH term(s) Career Choice ; Child ; Fellowships and Scholarships ; Female ; Happiness ; Humans ; Job Satisfaction ; Personal Satisfaction ; Research Personnel ; Surveys and Questionnaires
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-05715-3
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    Zs.A 2205: Show issues Location:
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  4. Article ; Online: Uptake and Removal of Uranium by and from Human Teeth.

    Younes, Ali / Ali, Jafar Sunga / Duda, Artem / Alliot, Cyrille / Huclier-Markai, Sandrine / Wang, Jasmine / Kabalan, Fatima / Nemirovsky, David / Deng, Rebecca / Nur, Mohamed Tousif / Cao, Minhua / Groveman, Samuel / Drain, Charles Michael / Alexandratos, Spiro D

    Chemical research in toxicology

    2021  Volume 34, Issue 3, Page(s) 880–891

    Abstract: Uranium-238 ( ...

    Abstract Uranium-238 (
    MeSH term(s) Durapatite/chemistry ; Durapatite/metabolism ; Humans ; Hydrogen-Ion Concentration ; Tooth/chemistry ; Tooth/metabolism ; Uranium/chemistry ; Uranium/isolation & purification ; Uranium/metabolism
    Chemical Substances Uranium (4OC371KSTK) ; Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639353-6
    ISSN 1520-5010 ; 0893-228X
    ISSN (online) 1520-5010
    ISSN 0893-228X
    DOI 10.1021/acs.chemrestox.0c00503
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    Zs.A 2320: Show issues Location:
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  5. Article ; Online: Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.

    Xiao, Haopeng / Bozi, Luiz H M / Sun, Yizhi / Riley, Christopher L / Philip, Vivek M / Chen, Mandy / Li, Jiaming / Zhang, Tian / Mills, Evanna L / Emont, Margo P / Sun, Wenfei / Reddy, Anita / Garrity, Ryan / Long, Jiani / Becher, Tobias / Vitas, Laura Potano / Laznik-Bogoslavski, Dina / Ordonez, Martha / Liu, Xinyue /
    Chen, Xiong / Wang, Yun / Liu, Weihai / Tran, Nhien / Liu, Yitong / Zhang, Yang / Cypess, Aaron M / White, Andrew P / He, Yuchen / Deng, Rebecca / Schöder, Heiko / Paulo, Joao A / Jedrychowski, Mark P / Banks, Alexander S / Tseng, Yu-Hua / Cohen, Paul / Tsai, Linus T / Rosen, Evan D / Klein, Samuel / Chondronikola, Maria / McAllister, Fiona E / Van Bruggen, Nick / Huttlin, Edward L / Spiegelman, Bruce M / Churchill, Gary A / Gygi, Steven P / Chouchani, Edward T

    Cell

    2022  Volume 185, Issue 24, Page(s) 4654–4673.e28

    Abstract: Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable mechanisms of BAT regulation over ... ...

    Abstract Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable mechanisms of BAT regulation over physiology. Here, we perform deep quantitative proteomics of BAT across a cohort of 163 genetically defined diversity outbred mice, a model that parallels the genetic and phenotypic variation found in humans. We leverage this diversity to define the functional architecture of the outbred BAT proteome, comprising 10,479 proteins. We assign co-operative functions to 2,578 proteins, enabling systematic discovery of regulators of BAT. We also identify 638 proteins that correlate with protection from, or sensitivity to, at least one parameter of metabolic disease. We use these findings to uncover SFXN5, LETMD1, and ATP1A2 as modulators of BAT thermogenesis or adiposity, and provide OPABAT as a resource for understanding the conserved mechanisms of BAT regulation over metabolic physiology.
    MeSH term(s) Humans ; Mice ; Animals ; Adipose Tissue, Brown/metabolism ; Proteome/metabolism ; Thermogenesis/physiology ; Adiposity ; Obesity/metabolism ; Mice, Inbred C57BL ; Proto-Oncogene Proteins/metabolism
    Chemical Substances Proteome ; LETMD1 protein, human ; Proto-Oncogene Proteins
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.10.003
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    Zs.A 1167: Show issues Location:
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  6. Article ; Online: Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.

    Ma, Liang / Chen, Zehua / Huang, Da Wei / Kutty, Geetha / Ishihara, Mayumi / Wang, Honghui / Abouelleil, Amr / Bishop, Lisa / Davey, Emma / Deng, Rebecca / Deng, Xilong / Fan, Lin / Fantoni, Giovanna / Fitzgerald, Michael / Gogineni, Emile / Goldberg, Jonathan M / Handley, Grace / Hu, Xiaojun / Huber, Charles /
    Jiao, Xiaoli / Jones, Kristine / Levin, Joshua Z / Liu, Yueqin / Macdonald, Pendexter / Melnikov, Alexandre / Raley, Castle / Sassi, Monica / Sherman, Brad T / Song, Xiaohong / Sykes, Sean / Tran, Bao / Walsh, Laura / Xia, Yun / Yang, Jun / Young, Sarah / Zeng, Qiandong / Zheng, Xin / Stephens, Robert / Nusbaum, Chad / Birren, Bruce W / Azadi, Parastoo / Lempicki, Richard A / Cuomo, Christina A / Kovacs, Joseph A

    Nature communications

    2016  Volume 7, Page(s) 10740

    Abstract: Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near ... ...

    Abstract Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with substantial reductions of ribosomal RNA genes, transporters, transcription factors and many metabolic pathways, but contain expansions of surface proteins, especially a unique and complex surface glycoprotein superfamily, as well as proteases and RNA processing proteins. Unexpectedly, the key fungal cell wall components chitin and outer chain N-mannans are absent, based on genome content and experimental validation. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses.
    MeSH term(s) Adaptation, Biological ; Animals ; Cell Wall/metabolism ; Genome, Fungal ; Host-Pathogen Interactions/genetics ; Humans ; Lung/microbiology ; Metabolic Networks and Pathways/genetics ; Mice ; Multigene Family ; Pneumocystis carinii/genetics ; Pneumocystis carinii/metabolism ; Rats ; Synteny
    Language English
    Publishing date 2016-02-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ISSN 2041-1723
    ISSN (online) 2041-1723
    DOI 10.1038/ncomms10740
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