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  1. Article ; Online: 2-DG Regulates Immune Imbalance on the Titanium Surface after Debridement.

    Liu, Xingchen / Deng, Shudan / Xie, Jiaxin / Xu, Chunxin / Huang, Zhuwei / Huang, Baoxin / Chen, Zhuofan / Chen, Shoucheng

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Peri-implantitis requires clinical treatments comprised of mechanical and chemical debridement to remove bacterial biofilms. Bone regeneration on the titanium surface after debridement has been a topical issue of peri-implantitis treatments. Increasing ... ...

    Abstract Peri-implantitis requires clinical treatments comprised of mechanical and chemical debridement to remove bacterial biofilms. Bone regeneration on the titanium surface after debridement has been a topical issue of peri-implantitis treatments. Increasing evidence has revealed that the immune microenvironment plays a key role in regulating the bone regeneration process. However, it remains unclear what kind of immune microenvironment the titanium surface induces after debridement. In the study, model titanium surface after debridement was prepared via biofilm induction and mechanical and chemical debridement in vitro. Then, the macrophages and naïve CD4
    MeSH term(s) Humans ; Peri-Implantitis/therapy ; Debridement ; Titanium/chemistry ; Biofilms ; Bone Regeneration ; Dental Implants ; Surface Properties
    Chemical Substances Titanium (D1JT611TNE) ; Dental Implants
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation.

    Luo, Pu / Huang, Ruoxuan / Wu, You / Liu, Xingchen / Shan, Zhengjie / Gong, Li / Deng, Shudan / Liu, Haiwen / Fang, Jinghan / Wu, Shiyu / Wu, Xiayi / Liu, Quan / Chen, Zetao / Yeung, Kelvin W K / Qiao, Wei / Chen, Shoucheng / Chen, Zhuofan

    Bioactive materials

    2023  Volume 28, Page(s) 95–111

    Abstract: With the discovery of the pivotal role of macrophages in tissue regeneration through shaping the tissue immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterials. Decellularized extracellular ... ...

    Abstract With the discovery of the pivotal role of macrophages in tissue regeneration through shaping the tissue immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterials. Decellularized extracellular matrix (dECM) has been extensively used in the clinical treatment of tissue injury due to its favorable biocompatibility and similarity to the native tissue environment. However, most reported decellularization protocols may cause damage to the native structure of dECM, which undermines its inherent advantages and potential clinical applications. Here, we introduce a mechanically tunable dECM prepared by optimizing the freeze-thaw cycles. We demonstrated that the alteration in micromechanical properties of dECM resulting from the cyclic freeze-thaw process contributes to distinct macrophage-mediated host immune responses to the materials, which are recently recognized to play a pivotal role in determining the outcome of tissue regeneration. Our sequencing data further revealed that the immunomodulatory effect of dECM was induced via the mechnotrasduction pathways in macrophages. Next, we tested the dECM in a rat skin injury model and found an enhanced micromechanical property of dECM achieved with three freeze-thaw cycles significantly promoted the M2 polarization of macrophages, leading to superior wound healing. These findings suggest that the immunomodulatory property of dECM can be efficiently manipulated by tailoring its inherent micromechanical properties during the decellularization process. Therefore, our mechanics-immunomodulation-based strategy provides new insights into the development of advanced biomaterials for wound healing.
    Language English
    Publishing date 2023-05-17
    Publishing country China
    Document type Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2023.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Balance between the CMC/ACP Nanocomplex and Blood Assimilation Orchestrates Immunomodulation of the Biomineralized Collagen Matrix.

    Su, Mengxi / Li, Chuangji / Deng, Shudan / Xu, Leyao / Shan, Zhengjie / Xing, Yihan / Li, Xiyan / Li, Ye / Liu, Xingchen / Zhong, Xinyi / Chen, Kaidi / Chen, Shoucheng / Liu, Quan / Wu, Xiayi / Chen, Zetao / Wu, Shiyu / Chen, Zhuofan

    ACS applied materials & interfaces

    2023  Volume 15, Issue 50, Page(s) 58166–58180

    Abstract: Calcium phosphate-based biomineralized biomaterials have broad application prospects. However, the immune response and foreign body reactions elicited by biomineralized materials have drawn substantial attention recently, contrary to the immune ... ...

    Abstract Calcium phosphate-based biomineralized biomaterials have broad application prospects. However, the immune response and foreign body reactions elicited by biomineralized materials have drawn substantial attention recently, contrary to the immune microenvironment optimization concept. Therefore, it is important to clarify the immunomodulation properties of biomineralized materials. Herein, we prepared the biomineralized collagen matrix (BCM) and screened the key immunomodulation factor carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) nanocomplex. The immunomodulation effect of the BCM was investigated in vitro and in vivo. The BCM triggered evident inflammatory responses and cascade foreign body reactions by releasing the CMC/ACP nanocomplex, which activated the potential TLR4-MAPK/NF-κB pathway, compromising the collagen matrix biocompatibility. By contrast, blocking the CMC/ACP nanocomplex release via the blood assimilation process of the BCM mitigated the inflammation and foreign body reactions, enhancing biocompatibility. Hence, the immunomodulation of the BCM was orchestrated by the balance between the CMC/ACP nanocomplex and the blood assimilation process. Controlling the release of the CMC/ACP nanocomplex to accord the biological effects of ACP with the temporal regenerative demands is key to developing advanced biomineralized materials.
    MeSH term(s) Humans ; Collagen ; Biocompatible Materials/pharmacology ; NF-kappa B ; Immunity ; Foreign Bodies ; Calcium Phosphates
    Chemical Substances Collagen (9007-34-5) ; Biocompatible Materials ; NF-kappa B ; Calcium Phosphates
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c12390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite.

    Wu, You / Chen, Shoucheng / Luo, Pu / Deng, Shudan / Shan, Zhengjie / Fang, Jinghan / Liu, Xingchen / Xie, Jiaxin / Liu, Runheng / Wu, Shiyu / Wu, Xiayi / Chen, Zetao / Yeung, Kelvin W K / Liu, Quan / Chen, Zhuofan

    Acta biomaterialia

    2022  Volume 143, Page(s) 159–172

    Abstract: Biogenic collagen membranes have been widely used as soft tissue barriers in guided bone regeneration (GBR) and guided tissue regeneration (GTR). Nevertheless, their clinical performance remains unsatisfactory because of their low mechanical strength and ...

    Abstract Biogenic collagen membranes have been widely used as soft tissue barriers in guided bone regeneration (GBR) and guided tissue regeneration (GTR). Nevertheless, their clinical performance remains unsatisfactory because of their low mechanical strength and fast degradation rate in vivo. Although cross-linking with chemical agents is effective and reliable for prolonging the degradation time of collagen membranes, some adverse effects including potential cytotoxicity and undesirable tissue integration have been observed during this process. As a fundamental nutritional trace element, zinc plays an active role in promoting the growth of cells and regulating the degradation of the collagen matrix. Herein, a biogenic collagen membrane was cross-linked with glutaraldehyde-alendronate to prolong its degradation time. The physiochemical and biological properties were enhanced by the incorporation of zinc-doped nanohydroxyapatite (nZnHA), with the native structure of collagen preserved. Specifically, the cross-linking combined with the incorporation of 1% and 2% nZnHA seemed to endow the membrane with the most appropriate biocompatibility and tissue integration capability among the cross-linked membranes, as well as offering a degradation period of six weeks in a rat subcutaneous model. Thus, improving the clinical performance of biogenic collagen membranes by cross-linking together with the incorporation of nZnHA is a promising strategy for the improvement of biogenic collagen membranes. STATEMENT OF SIGNIFICANCE: The significance of this research includes.
    MeSH term(s) Absorbable Implants ; Animals ; Bone Regeneration ; Collagen/chemistry ; Collagen/pharmacology ; Durapatite/pharmacology ; Membranes, Artificial ; Rats ; Zinc/pharmacology
    Chemical Substances Membranes, Artificial ; Collagen (9007-34-5) ; Durapatite (91D9GV0Z28) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enhanced sensitivity of optical fiber vibration sensor based on radio-frequency Michelson interferometer.

    Deng, Ming / Zhang, Tianheng / Nan, Xinhao / Tang, Yangxu / Feng, Danqi / Guo, Nan / Deng, Shudan / Zhu, Tao

    Optics letters

    2020  Volume 46, Issue 24, Page(s) 6079–6082

    Abstract: We propose and demonstrate a new scheme for enhancing the sensitivity of an optical fiber vibration sensor based on microwave interferometry, which is realized by an incoherent optical Michelson interferometer (MI). The sensing arm of the MI is sensitive ...

    Abstract We propose and demonstrate a new scheme for enhancing the sensitivity of an optical fiber vibration sensor based on microwave interferometry, which is realized by an incoherent optical Michelson interferometer (MI). The sensing arm of the MI is sensitive to environmental vibration; this will cause changes in the phase of the reflection spectra in the microwave domain. The phase sensitivity can be improved by adjusting the power ratio of the two beams in the interferometer and the driving frequency of the modulator. The system can overcome the problem of interference fading so that it is immune to environmental disturbance. The proposed scheme has merits of simplicity and compact configuration, and may provide a new type of high-precision fiber sensor for measuring vibration, temperature, strain, and so on.
    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.445425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Significant East Asian Affinity of the Sichuan Hui Genomic Structure Suggests the Predominance of the Cultural Diffusion Model in the Genetic Formation Process.

    Liu, Yan / Yang, Junbao / Li, Yingxiang / Tang, Renkuan / Yuan, Didi / Wang, Yicheng / Wang, Peixin / Deng, Shudan / Zeng, Simei / Li, Hongliang / Chen, Gang / Zou, Xing / Wang, Mengge / He, Guanglin

    Frontiers in genetics

    2021  Volume 12, Page(s) 626710

    Abstract: The ancestral origin and genomic history of Chinese Hui people remain to be explored due to the paucity of genome-wide data. Some evidence argues that an eastward migration of Central Asians gave rise to modern Hui people, which is referred to as ... ...

    Abstract The ancestral origin and genomic history of Chinese Hui people remain to be explored due to the paucity of genome-wide data. Some evidence argues that an eastward migration of Central Asians gave rise to modern Hui people, which is referred to as the
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.626710
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