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  1. Article: The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection.

    Deng, Silu / Graham, Marion L / Chen, Xian-Ming

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Protozoan parasites, such ... ...

    Abstract Protozoan parasites, such as
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cryptosporidium parvum

    Graham, Marion L / Li, Min / Gong, Ai-Yu / Deng, Silu / Jin, Kehua / Wang, Shuhong / Chen, Xian-Ming

    Frontiers in immunology

    2023  Volume 14, Page(s) 1205468

    Abstract: ... ...

    Abstract Cryptosporidium
    MeSH term(s) Child ; Humans ; Animals ; Mice ; Antiparasitic Agents ; Cryptosporidium parvum/genetics ; RNA, Long Noncoding/genetics ; Cryptosporidiosis/genetics ; Cryptosporidium/genetics ; Anti-Infective Agents ; Epithelial Cells
    Chemical Substances Antiparasitic Agents ; RNA, Long Noncoding ; Anti-Infective Agents
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1205468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense

    He, Wei / Li, Juan / Gong, Ai-Yu / Deng, Silu / Li, Min / Wang, Yang / Mathy, Nicholas W. / Feng, Yaoyu / Xiao, Lihua / Chen, Xian-Ming

    Microorganisms. 2021 Jan. 12, v. 9, no. 1

    2021  

    Abstract: Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against ... ...

    Abstract Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against Cryptosporidium infection. To counteract host defense response, Cryptosporidium has developed strategies of immune evasion to promote parasitic replication and survival within epithelial cells, but the underlying mechanisms are largely unclear. Using various models of intestinal cryptosporidiosis, we found that Cryptosporidium infection caused suppression of mitogen-activated protein kinase (MAPK) signaling in infected murine intestinal epithelial cells. Whereas expression levels of most genes encoding the key components of the MAPK signaling pathway were not changed in infected intestinal epithelial cells, we detected a significant downregulation of p38/Mapk, MAP kinase-activated protein kinase 2 (Mk2), and Mk3 genes in infected host cells. Suppression of MAPK signaling was associated with an impaired intestinal epithelial defense against C. parvum infection. Our data suggest that cryptosporidial infection may suppress intestinal epithelial cell MAPK signaling associated with the evasion of host antimicrobial defense.
    Keywords Cryptosporidium parvum ; cryptosporidiosis ; defense mechanisms ; disease resistance ; epithelial cells ; gene expression regulation ; host-parasite relationships ; immune evasion ; intestinal mucosa ; mice ; mitogen-activated protein kinase ; protozoal infections ; signal transduction
    Language English
    Dates of publication 2021-0112
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    Note golden set
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9010151
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses.

    Deng, Silu / He, Wei / Gong, Ai-Yu / Li, Min / Wang, Yang / Xia, Zijie / Zhang, Xin-Tiang / Huang Pacheco, Andrew S / Naqib, Ankur / Jenkins, Mark / Swanson, Patrick C / Drescher, Kristen M / Strauss-Soukup, Juliane K / Belshan, Michael / Chen, Xian-Ming

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1456

    Abstract: Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no fully effective therapy available for the infection. Type II and III ... ...

    Abstract Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no fully effective therapy available for the infection. Type II and III interferon (IFN) responses are important determinants of susceptibility to infection but the role for type I IFN response remains obscure. Cryptosporidium parvum virus 1 (CSpV1) is a double-stranded RNA (dsRNA) virus harbored by Cryptosporidium spp. Here we show that intestinal epithelial conditional Ifnar1
    MeSH term(s) Animals ; Mice ; Antiparasitic Agents/metabolism ; Antiparasitic Agents/pharmacology ; Cryptosporidiosis/etiology ; Cryptosporidiosis/parasitology ; Cryptosporidiosis/virology ; Cryptosporidium/pathogenicity ; Cryptosporidium/virology ; Cryptosporidium parvum/pathogenicity ; Cryptosporidium parvum/virology ; Host-Parasite Interactions/genetics ; Interferon Type I/metabolism ; Interferon Type I/pharmacology ; Double Stranded RNA Viruses/metabolism
    Chemical Substances Antiparasitic Agents ; Interferon Type I
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37129-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Long Non-Coding RNA Nostrill Regulates Transcription of Irf7 Through Interaction With NF-κB p65 to Enhance Intestinal Epithelial Defense Against

    Mathy, Nicholas W / Deng, Silu / Gong, Ai-Yu / Li, Min / Wang, Yang / Burleigh, Olivia / Kochvar, Andrew / Whiteford, Erin R / Shibata, Annemarie / Chen, Xian-Ming

    Frontiers in immunology

    2022  Volume 13, Page(s) 863957

    Abstract: The cells of the intestinal epithelium establish the frontline for host defense against pathogens in the gastrointestinal tract and play a vital role in the initiation of the immune response. Increasing evidence supports the role of long non-coding RNAs ( ...

    Abstract The cells of the intestinal epithelium establish the frontline for host defense against pathogens in the gastrointestinal tract and play a vital role in the initiation of the immune response. Increasing evidence supports the role of long non-coding RNAs (lncRNAs) as critical regulators of diverse cellular processes, however, their role in antimicrobial host defense is incompletely understood. In this study, we provide evidence that the lncRNA Nostrill is upregulated in the intestinal epithelium following infection by
    MeSH term(s) Anti-Infective Agents ; Cryptosporidiosis/genetics ; Cryptosporidiosis/parasitology ; Cryptosporidium/genetics ; Cryptosporidium/metabolism ; Cryptosporidium parvum/genetics ; Humans ; NF-kappa B/metabolism ; RNA, Long Noncoding/genetics
    Chemical Substances Anti-Infective Agents ; NF-kappa B ; RNA, Long Noncoding
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.863957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A host cell long noncoding RNA NR_033736 regulates type I interferon-mediated gene transcription and modulates intestinal epithelial anti-Cryptosporidium defense.

    Li, Juan / Jin, Kehua / Li, Min / Mathy, Nicholas W / Gong, Ai-Yu / Deng, Silu / Martins, Gislaine A / Sun, Mingfei / Strauss-Soukup, Juliane K / Chen, Xian-Ming

    PLoS pathogens

    2021  Volume 17, Issue 1, Page(s) e1009241

    Abstract: The gastrointestinal epithelium guides the immune system to differentiate between commensal and pathogenic microbiota, which relies on intimate links with the type I IFN signal pathway. Epithelial cells along the epithelium provide the front line of host ...

    Abstract The gastrointestinal epithelium guides the immune system to differentiate between commensal and pathogenic microbiota, which relies on intimate links with the type I IFN signal pathway. Epithelial cells along the epithelium provide the front line of host defense against pathogen infection in the gastrointestinal tract. Increasing evidence supports the regulatory potential of long noncoding RNAs (lncRNAs) in immune defense but their role in regulating intestinal epithelial antimicrobial responses is still unclear. Cryptosporidium, a protozoan parasite that infects intestinal epithelial cells, is an important opportunistic pathogen in AIDS patients and a common cause of diarrhea in young children in developing countries. Recent advances in Cryptosporidium research have revealed a strong type I IFN response in infected intestinal epithelial cells. We previously identified a panel of host cell lncRNAs that are upregulated in murine intestinal epithelial cells following microbial challenge. One of these lncRNAs, NR_033736, is upregulated in intestinal epithelial cells following Cryptosporidium infection and displays a significant suppressive effect on type I IFN-controlled gene transcription in infected host cells. NR_033736 can be assembled into the ISGF3 complex and suppresses type I IFN-mediated gene transcription. Interestingly, upregulation of NR_033736 itself is triggered by the type I IFN signaling. Moreover, NR_033736 modulates epithelial anti-Cryptosporidium defense. Our data suggest that upregulation of NR_033736 provides negative feedback regulation of type I IFN signaling through suppression of type I IFN-controlled gene transcription, and consequently, contributing to fine-tuning of epithelial innate defense against microbial infection.
    MeSH term(s) Animals ; Animals, Newborn ; Cryptosporidiosis/immunology ; Cryptosporidiosis/parasitology ; Cryptosporidium/immunology ; Diarrhea/immunology ; Diarrhea/parasitology ; Epithelial Cells/parasitology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/parasitology ; Humans ; Interferon Type I/metabolism ; Intestinal Mucosa/immunology ; Intestinal Mucosa/parasitology ; Intestines/parasitology ; Mice ; RNA, Long Noncoding/genetics ; Signal Transduction ; Transcription, Genetic ; Up-Regulation
    Chemical Substances Interferon Type I ; RNA, Long Noncoding
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1009241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense.

    He, Wei / Li, Juan / Gong, Ai-Yu / Deng, Silu / Li, Min / Wang, Yang / Mathy, Nicholas W / Feng, Yaoyu / Xiao, Lihua / Chen, Xian-Ming

    Microorganisms

    2021  Volume 9, Issue 1

    Language English
    Publishing date 2021-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9010151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: m

    Xia, Zijie / Xu, Jihao / Lu, Eugene / He, Wei / Deng, Silu / Gong, Ai-Yu / Strass-Soukup, Juliane / Martins, Gislaine A / Lu, Guoqing / Chen, Xian-Ming

    Frontiers in immunology

    2021  Volume 12, Page(s) 705232

    Abstract: Increasing evidence supports that N6-methyladenosine ( ... ...

    Abstract Increasing evidence supports that N6-methyladenosine (m
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/physiology ; AlkB Homolog 5, RNA Demethylase/antagonists & inhibitors ; AlkB Homolog 5, RNA Demethylase/biosynthesis ; AlkB Homolog 5, RNA Demethylase/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/biosynthesis ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Animals ; CRISPR-Cas Systems ; Cryptosporidiosis/immunology ; Cryptosporidium parvum/immunology ; Epithelium/immunology ; GTP Phosphohydrolases/biosynthesis ; GTP Phosphohydrolases/genetics ; GTP-Binding Proteins/biosynthesis ; GTP-Binding Proteins/genetics ; Gene Expression Regulation/immunology ; Humans ; Immunity, Innate ; Intestinal Mucosa/cytology ; Intestinal Mucosa/immunology ; Methylation ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; RNA Interference ; RNA Processing, Post-Transcriptional ; RNA, Messenger/immunology ; RNA, Small Interfering/genetics
    Chemical Substances NF-kappa B ; RNA, Messenger ; RNA, Small Interfering ; N-methyladenosine (CLE6G00625) ; ALKBH5 protein, human (EC 1.14.11.-) ; ALKBH5 protein, mouse (EC 1.14.11.-) ; AlkB Homolog 5, RNA Demethylase (EC 1.14.11.-) ; FTO protein, mouse (EC 1.14.11.-) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33) ; GTP Phosphohydrolases (EC 3.6.1.-) ; GTP-Binding Proteins (EC 3.6.1.-) ; Igtp protein, mouse (EC 3.6.1.-) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.705232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense.

    Gong, Ai-Yu / Wang, Yang / Li, Min / Zhang, Xin-Tian / Deng, Silu / Chen, Jessie M / Lu, Eugene / Mathy, Nicholas W / Martins, Gislaine A / Strauss-Soukup, Juliane K / Chen, Xian-Ming

    mBio

    2021  Volume 12, Issue 5, Page(s) e0212721

    Abstract: Interferon (IFN) signaling is key to mucosal immunity in the gastrointestinal tract, but cellular regulatory elements that determine interferon gamma (IFN-γ)-mediated antimicrobial defense in intestinal epithelial cells are not fully understood. We ... ...

    Abstract Interferon (IFN) signaling is key to mucosal immunity in the gastrointestinal tract, but cellular regulatory elements that determine interferon gamma (IFN-γ)-mediated antimicrobial defense in intestinal epithelial cells are not fully understood. We report here that a long noncoding RNA (lncRNA), GenBank accession no. XR_001779380, was increased in abundance in murine intestinal epithelial cells following infection by
    MeSH term(s) Age Factors ; Animals ; Cryptosporidiosis/genetics ; Cryptosporidiosis/immunology ; Cryptosporidiosis/parasitology ; Cryptosporidium parvum/genetics ; Cryptosporidium parvum/physiology ; Epithelial Cells/immunology ; Epithelial Cells/parasitology ; Humans ; Immunity, Mucosal ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/parasitology ; Mice ; NF-kappa B/genetics ; NF-kappa B/immunology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/immunology ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/immunology
    Chemical Substances NF-kappa B ; RNA, Long Noncoding ; Toll-Like Receptor 4 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02127-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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