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  1. Article: Maternally Inherited Essential Hypertension May Be Associated with the Mutations in Mitochondrial tRNA

    Wang, Chun / Deng, Xin / Li, Lei / Li, Mei

    Pharmacogenomics and personalized medicine

    2024  Volume 17, Page(s) 13–26

    Abstract: Background: Mitochondrial DNA (mtDNA) mutations are associated with essential hypertension (EH), but the molecular mechanism remains largely unknown.: Objective: The aim of this study is to explore the association between mtDNA mutations and EH.: ... ...

    Abstract Background: Mitochondrial DNA (mtDNA) mutations are associated with essential hypertension (EH), but the molecular mechanism remains largely unknown.
    Objective: The aim of this study is to explore the association between mtDNA mutations and EH.
    Methods: Two maternally inherited families with EH are underwent clinical, genetic and biochemical assessments. mtDNA mutations are screened by PCR-Sanger sequencing and phylogenetic, and bioinformatics analyses are performed to evaluate the pathogenicity of mtDNA mutations. We also generate cytoplasmic hybrid (cybrid) cell lines to analysis mitochondrial functions.
    Results: Matrilineal relatives exhibit variable degree of clinical phenotypes. Molecular analysis reveals the presence of m.A14693G and m.A14696G mutations in two pedigrees. Notably, the m.A14693G mutation occurs at position 54 in the TψC loop of tRNA
    Conclusion: The m.A14696G and m.A14693G mutations lead to failure in tRNA
    Language English
    Publishing date 2024-01-09
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S436235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Glucose-Assisted Synthesis of Porous, Urchin-like Co

    Deng, Xin / Zhang, Xiao / Long, Xiaochuan / Liu, Xiaopeng

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 6

    Abstract: ... The ... ...

    Abstract The Co
    Language English
    Publishing date 2024-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17061364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The occurrence of asthma in an extensive-stage small-cell lung cancer patient after combination therapy with atezolizumab and anlotinib: a case report.

    Deng, Wang / Chen, Juan / Deng, Xin-Yu

    Frontiers in immunology

    2024  Volume 15, Page(s) 1333850

    Abstract: Background: Extensive-stage small-cell lung cancer (ES-SCLC) is highly malignant, with early metastasis and high recurrence. Since therapeutic options are limited, ES-SCLC has a characteristically short survival period and extremely poor prognosis. A ... ...

    Abstract Background: Extensive-stage small-cell lung cancer (ES-SCLC) is highly malignant, with early metastasis and high recurrence. Since therapeutic options are limited, ES-SCLC has a characteristically short survival period and extremely poor prognosis. A combination of immune checkpoint inhibitors (ICIs) and anti-angiogenic drugs can achieve promising efficacy and safety in patients with ES-SCLC as a second-line or subsequent treatment, extending survival to some extent. However, the clinical outcomes remain mostly unsatisfactory and are sometimes affected by treatment-related adverse events.
    Case presentation: A 57-year-old woman with ES-SCLC was administered a combination therapy of atezolizumab (a PD-L1 inhibitor) and anlotinib [an oral multi-targeted tyrosine kinase inhibitor (TKI)]. She survived for 22 months, with no disease progression during the 28 courses of therapy. Unexpectedly, despite having no history of asthma, the patient developed asthma while receiving this regimen. This is possibly related to T-cell activation and the tumor immune microenvironment, which induce allergic inflammation after PD-L1 blockade.
    Conclusions: This is the first report of an asthma-negative ES-SCLC patient who developed asthma after receiving atezolizumab plus anlotinib. Although this combination therapy may effectively extend survival in SCLC patients, asthmatic symptoms should be closely monitored.
    MeSH term(s) Female ; Humans ; Middle Aged ; Lung Neoplasms/drug therapy ; Combined Modality Therapy ; Asthma/drug therapy ; Immune Checkpoint Inhibitors/adverse effects ; Small Cell Lung Carcinoma/drug therapy ; Tumor Microenvironment ; Indoles ; Quinolines ; Antibodies, Monoclonal, Humanized
    Chemical Substances anlotinib ; atezolizumab (52CMI0WC3Y) ; Immune Checkpoint Inhibitors ; Indoles ; Quinolines ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1333850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model.

    Deng, Xin / Hu, Zhengqing

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 792089

    Abstract: Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine. Adult mice were deafened chemically, followed by ... ...

    Abstract Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a DNA demethylating agent 5-azacytidine. Adult mice were deafened chemically, followed by injection of 5-azacytidine or vehicle into the inner ear. Functionality of regenerated hair cells was evaluated by expression of hair cell proteins, auditory brainstem response (ABR), and distortion-product otoacoustic emission (DPOAE) tests for 6 weeks. In the vehicle-treated group, no cells expressed the hair cell-specific protein myosin VIIa in the cochlea, whereas numerous myosin VIIa-expressing cells were found in the 5-azacytidine-treated cochlea, suggesting the regeneration of auditory hair cells. Moreover, regenerated hair cells were co-labeled with functional proteins espin and prestin. Expression of ribbon synapse proteins suggested synapse formation between new hair cells and neurons. In hearing tests, progressive improvements in ABR [5-30 dB sound pressure level (SPL)] and DPOAE (5-20 dB) thresholds were observed in 5-azacytidine-treated mice. In vehicle-treated mice, there were <5 dB threshold changes in hearing tests. This study demonstrated the ability of 5-azacytidine to promote the functional regeneration of auditory hair cells in a mature mouse model
    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.792089
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  5. Article: Omadacycline for the treatment of severe pneumonia caused by

    Wang, Dao-Xin / Xiao, Ling-Xi / Deng, Xin-Yu / Deng, Wang

    Frontiers in medicine

    2024  Volume 10, Page(s) 1207534

    Abstract: Introduction: Chlamydia psittaci: Methods: Sixteen patients with severe psittacosis pneumonia with ARDS were selected between September 2021 and October 2022. They were diagnosed using mNGS and treated with omadacycline. Retrospective analysis of ... ...

    Abstract Introduction: Chlamydia psittaci
    Methods: Sixteen patients with severe psittacosis pneumonia with ARDS were selected between September 2021 and October 2022. They were diagnosed using mNGS and treated with omadacycline. Retrospective analysis of clinical manifestations, laboratory data, disease progression, diagnostic tool, treatment, and prognosis was summarized.
    Results: Common symptoms included fever, dyspnea, and cough. All patients developed ARDS, accompanied by septic shock (43.7%) and pulmonary embolism (43.7%). Laboratory data showed normal leucocytes, increased creatine kinase isoenzyme, and decreased albumin with liver dysfunction in most patients. All patients had increased neutrophils, C-reactive protein, procalcitonin, and D-dimer with decreased lymphocytes. Airspace consolidation, ground glass opacity, and pleural effusion were found on chest CT. mNGS results were obtained in 24-48 h to identify the diagnosis of Chlamydia psittacosis. All patients received mechanical ventilation with omadacycline treatment. Fourteen patients experienced complete recovery, while the other two patients died from multidrug-resistant bacterial infection and renal failure.
    Conclusion: mNGS has a significant value in the diagnosis of
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1207534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk factor analysis of changes in blood flow in the A1 segment of the anterior cerebral artery after flow-diverter coverage of it.

    Ma, WuLin / Deng, Xin / Chen, JunFan / Guo, XinBin

    Neurosurgical review

    2024  Volume 47, Issue 1, Page(s) 74

    Abstract: Few studies have explored the effect of a flow-diverter device (FD) on blood flow in the A1 segment of the anterior cerebral artery (ACA), after treatment of intracranial aneurysms in the bifurcation region of the internal carotid artery (ICA). The main ... ...

    Abstract Few studies have explored the effect of a flow-diverter device (FD) on blood flow in the A1 segment of the anterior cerebral artery (ACA), after treatment of intracranial aneurysms in the bifurcation region of the internal carotid artery (ICA). The main objective of this article is to investigate the factors that affect A1 blood flow after FD covers the A1 artery. This is a single-center, retrospective study. Data were collected retrospectively from our center, and patients whose FDs were placed for treatment from the terminal of the ICA to the M1 segment were analyzed. A total of 42 patients were included in the study. Immediate post-procedural angiography following device placement revealed decreased blood flow in the A1 of 15 (35.7%) patients and complete occlusion of the A1 segment in 11 (26.2%) patients. During an average follow-up period of 9.8 months, the A1 segment was ultimately occluded in 25 patients (59.5%) and decreased blood flow in 4 patients (9.5%). When using FD to cover the A1 artery for the treatment of intracranial aneurysms, patients with preoperative opening of the anterior communicating artery (AcomA) are more prone to occlusion or decreased blood flow of the A1 artery, compared to patients without opening.
    MeSH term(s) Humans ; Anterior Cerebral Artery/surgery ; Retrospective Studies ; Intracranial Aneurysm/therapy ; Treatment Outcome ; Hemodynamics ; Embolization, Therapeutic ; Stents
    Language English
    Publishing date 2024-02-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-024-02306-2
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    Zs.A 1445: Show issues Location:
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  7. Article ; Online: Deep M

    Deng, Xin / Xu, Jingyi / Gao, Fangyuan / Sun, Xiancheng / Xu, Mai

    IEEE transactions on pattern analysis and machine intelligence

    2024  Volume 46, Issue 5, Page(s) 2770–2787

    Abstract: For multi-modal image processing, network interpretability is essential due to the complicated dependency across modalities. Recently, a promising research direction for interpretable network is to incorporate dictionary learning into deep learning ... ...

    Abstract For multi-modal image processing, network interpretability is essential due to the complicated dependency across modalities. Recently, a promising research direction for interpretable network is to incorporate dictionary learning into deep learning through unfolding strategy. However, the existing multi-modal dictionary learning models are both single-layer and single-scale, which restricts the representation ability. In this paper, we first introduce a multi-scale multi-modal convolutional dictionary learning ( M
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2023.3334624
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  8. Article ; Online: The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.

    Deng, Xin / Liu, Zhen / Wang, Baosheng / Ma, Jia / Meng, Xiangpeng

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2024  Volume 38, Issue 7, Page(s) e23581

    Abstract: Human DEAD/H box RNA helicase DDX6 acts as an oncogene in several different types of cancer, where it participates in RNA processing. Nevertheless, the role of DDX6 in pancreatic cancer (PC), together with the underlying mechanism, has yet to be fully ... ...

    Abstract Human DEAD/H box RNA helicase DDX6 acts as an oncogene in several different types of cancer, where it participates in RNA processing. Nevertheless, the role of DDX6 in pancreatic cancer (PC), together with the underlying mechanism, has yet to be fully elucidated. In the present study, compared with adjacent tissues, the level of DDX6 was abnormally increased in human PC tissues, and this increased level of expression was associated with poor prognosis. Furthermore, the role of DDX6 in PC was investigated by overexpressing or silencing the DDX6 in the PC cell lines, SW1990 and PaTu-8988t. A xenograft model was established by injecting nude mice with either DDX6-overexpressing or DDX6-silenced SW1990 cells. DDX6 overexpression promoted the proliferation and cell cycle transition, inhibited the cell apoptosis of PC cells, and accelerated tumor formation, whereas DDX6 knockdown elicited the opposite effects. DDX6 exerted positive effects on PC. RNA immunoprecipitation assay showed that DDX6 bound to kinesin family member C1 (KIFC1) mRNA, which was further confirmed by RNA pull-down assay. These results suggested that DDX6 positively regulated the expression of KIFC1. KIFC1 overexpression enhanced the proliferative capability of PC cells with DDX6 knockdown and inhibited their apoptosis. By contrast, DDX6 overexpression reversed the inhibitory effect of KIFC1 silencing on tumor proliferation. Subsequently, the transcription factor Yin Yang 1 (YY1) was shown to negatively regulate DDX6 at both the mRNA and protein levels. Dual-luciferase reporter assay verified that YY1 targeted the promoter of DDX6 and inhibited its transcription. High expression levels of YY1 decreased the proliferation of PC cells and promoted cell apoptosis, although these effects were reversed by DDX6 overexpression. Taken together, YY1 may target the DDX6/KIFC1 axis, thereby negatively regulating its expression, leading to an inhibitory effect on pancreatic tumor.
    MeSH term(s) Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Proliferation ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Gene Expression Regulation, Neoplastic ; Mice, Nude ; MicroRNAs/genetics ; Pancreatic Neoplasms/pathology ; Proto-Oncogene Proteins/metabolism ; RNA, Messenger ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
    Chemical Substances DDX6 protein, human (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13) ; MicroRNAs ; Proto-Oncogene Proteins ; RNA, Messenger ; YY1 protein, human ; YY1 Transcription Factor
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202400166R
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    Zs.A 2266: Show issues Location:
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  9. Article ; Online: Protocol for integrated analysis of bacterial RNA-seq and ChIP-seq data for establishing a co-expression network.

    Ding, Yiqing / Li, Jingwei / Li, Tianmin / Deng, Xin

    STAR protocols

    2023  Volume 4, Issue 2, Page(s) 102322

    Abstract: Transcriptomic data and ChIP-seq data from bacteria are systematically analyzed and efficiently combined. We describe the software environment for analysis and the download and installation methods. Furthermore, we describe the analytical process and ... ...

    Abstract Transcriptomic data and ChIP-seq data from bacteria are systematically analyzed and efficiently combined. We describe the software environment for analysis and the download and installation methods. Furthermore, we describe the analytical process and present the corresponding mini-test data, which can be conveniently restored and reproduced by users. Moreover, we provide the script for data consolidation, which allows multiple files to be rapidly merged. Overall, this protocol presents software parameters, R codes, and in-house Perl scripts for analyzing bacterial multi-omics data. For complete details on the use and execution of this protocol, please refer to Xin et al.
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102322
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  10. Article ; Online: Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling Pathway.

    Deng, Xin / Wu, Qianfeng / Li, Dong / Liu, Youping

    Nutrition and cancer

    2023  Volume 75, Issue 6, Page(s) 1473–1484

    Abstract: Erianin, a natural compound extracted ... ...

    Abstract Erianin, a natural compound extracted from
    MeSH term(s) Humans ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/genetics ; Signal Transduction ; Cell Proliferation ; Cell Movement ; Apoptosis ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
    Chemical Substances Erianin ; Antineoplastic Agents
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2023.2205047
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